{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:48:04Z","timestamp":1780332484188,"version":"3.54.1"},"reference-count":48,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>This research was designed to investigate the metabolite profiling, phenolics and flavonoids content and the potential antioxidant, antibacterial and nematicidal activities of \u201cyellow-brown resins\u201d from Larrea divaricata Cav (LdRe) and L. nitida Cav (LnRe). Metabolite profiling was obtained using an ultrahigh resolution liquid chromatography orbitrap MS analysis (UHPLC-ESI-OT-MS). The antioxidant properties were screened by four methods: 2,2-diphenyl-1-picrylhydrazyl assay (DPPH), trolox equivalent antioxidant activity assay (TEAC), ferric-reducing antioxidant power assay (FRAP) and lipid peroxidation in erythrocytes (LP). The antibacterial activity was evaluated according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. In addition, the potential combinatory effect was analyzed with the fractional inhibitory concentration index (FICI) values using the checkerboard design. The nematicidal activity was carried out according to a standardized protocol. LdRe and LnRe showed a strong capture of the DPPH radical withvalues around 8.4 \u00b5g resin\/mL; FRAP (1.69\u20131.94 mgTE\/ g resin), TEAC (1.08\u20131.09 mgTE\/g resin) and LP (81\u201382% at 100 \u00b5g of resin\/mL) assays. A strong antimicrobial activity was displayed by both resins against methicillin-sensitive Staphylococcus aureus ATCC 25923(MSSA) and methicillin-resistant S. aureus ATCC 43300(MRSA) (MICs = 16\u201332 \u00b5g resin\/mL). Additionally, the combination of LdRe or LnRe with the antibiotic cefotaxime showed an indifferent effect (FICI values = 1\u20131.25), however, this combinationcould be a potential strategy to reduce the drug doses, and in this way can be a potential alternative to reduce bacterial resistance. On the other hand, the resins showed a scarce nematicidal potential toward J2 Meloidogyne incognita; an important nematode infecting horticultural crops. Phenolics compounds were identified by UHPLC-PDA-OT-MS analysis, updating the knowledge on the chemical profile of these species. These results, together with the high content of quantified phenolics and flavonoids, allow the phenolics-enriched resins of these two Larrea species to be considered as a promising sustainable source of compounds of pharmacological interest.<\/jats:p>","DOI":"10.3390\/antiox10020185","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T09:03:45Z","timestamp":1611824625000},"page":"185","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["UHPLC-ESI-OT-MS Phenolics Profiling, Free Radical Scavenging, Antibacterial and Nematicidal Activities of \u201cYellow-Brown Resins\u201d from Larrea spp."],"prefix":"10.3390","volume":"10","author":[{"given":"Jessica","family":"G\u00f3mez","sequence":"first","affiliation":[{"name":"Instituto de Biotecnolog\u00eda-Instituto de Ciencias B\u00e1sicas, Universidad Nacional de San Juan, Av. Libertador General San Mart\u00edn 1109 (O), San Juan CP 5400, Argentina"},{"name":"CONICET (Consejo Nacional de Ciencia y Tecnolog\u00eda), CABA, Buenos Aires C1405DJR, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4552-3123","authenticated-orcid":false,"given":"Mario J.","family":"Simirgiotis","sequence":"additional","affiliation":[{"name":"Instituto de Farmacia, Facultad de Ciencias, Campus Isla Teja, Universidad Austral de Chile, Valdivia 5090000, Chile"},{"name":"Center for Interdisciplinary Studies on the Nervous System (CISNe), Universidad Austral de Chile, Valdivia 5090000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"Manrique","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnolog\u00eda-Instituto de Ciencias B\u00e1sicas, Universidad Nacional de San Juan, Av. Libertador General San Mart\u00edn 1109 (O), San Juan CP 5400, Argentina"},{"name":"CONICET (Consejo Nacional de Ciencia y Tecnolog\u00eda), CABA, Buenos Aires C1405DJR, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8895-2799","authenticated-orcid":false,"given":"Mauricio","family":"Pi\u00f1eiro","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnolog\u00eda-Instituto de Ciencias B\u00e1sicas, Universidad Nacional de San Juan, Av. Libertador General San Mart\u00edn 1109 (O), San Juan CP 5400, Argentina"},{"name":"CONICET (Consejo Nacional de Ciencia y Tecnolog\u00eda), CABA, Buenos Aires C1405DJR, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5851-5582","authenticated-orcid":false,"given":"Beatriz","family":"Lima","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnolog\u00eda-Instituto de Ciencias B\u00e1sicas, Universidad Nacional de San Juan, Av. Libertador General San Mart\u00edn 1109 (O), San Juan CP 5400, Argentina"},{"name":"CONICET (Consejo Nacional de Ciencia y Tecnolog\u00eda), CABA, Buenos Aires C1405DJR, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1803-9272","authenticated-orcid":false,"given":"Jorge","family":"B\u00f3rquez","sequence":"additional","affiliation":[{"name":"Laboratorio de Productos Naturales Depto. de Qu\u00edmica, Facultad de Ciencias, Universidad de Antofagasta, Av. Coloso S-N, Antofagasta 1240000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4076-3999","authenticated-orcid":false,"given":"Gabriela E.","family":"Feresin","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnolog\u00eda-Instituto de Ciencias B\u00e1sicas, Universidad Nacional de San Juan, Av. Libertador General San Mart\u00edn 1109 (O), San Juan CP 5400, Argentina"},{"name":"CONICET (Consejo Nacional de Ciencia y Tecnolog\u00eda), CABA, Buenos Aires C1405DJR, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1955-4850","authenticated-orcid":false,"given":"Alejandro","family":"Tapia","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnolog\u00eda-Instituto de Ciencias B\u00e1sicas, Universidad Nacional de San Juan, Av. Libertador General San Mart\u00edn 1109 (O), San Juan CP 5400, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.foodres.2017.11.051","article-title":"Biological properties and pharmacological potential of plant exudates","volume":"105","author":"Malik","year":"2018","journal-title":"Food Res. 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