{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:48:36Z","timestamp":1790646516608,"version":"4.1.0"},"reference-count":179,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The brain needs more energy than other organs in the body. Mitochondria are the generator of vital power in the living organism. Not only do mitochondria sense signals from the outside of a cell, but they also orchestrate the cascade of subcellular events by supplying adenosine-5\u2032-triphosphate (ATP), the biochemical energy. It is known that impaired mitochondrial function and oxidative stress contribute or lead to neuronal damage and degeneration of the brain. This mini-review focuses on addressing how mitochondrial dysfunction and oxidative stress are associated with the pathogenesis of neurodegenerative disorders including Alzheimer\u2019s disease, amyotrophic lateral sclerosis, Huntington\u2019s disease, and Parkinson\u2019s disease. In addition, we discuss state-of-the-art computational models of mitochondrial functions in relation to oxidative stress and neurodegeneration. Together, a better understanding of brain disease-specific mitochondrial dysfunction and oxidative stress can pave the way to developing antioxidant therapeutic strategies to ameliorate neuronal activity and prevent neurodegeneration.<\/jats:p>","DOI":"10.3390\/antiox10020229","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T11:54:31Z","timestamp":1612353271000},"page":"229","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Power Failure of Mitochondria and Oxidative Stress in Neurodegeneration and Its Computational Models"],"prefix":"10.3390","volume":"10","author":[{"given":"JunHyuk","family":"Woo","sequence":"first","affiliation":[{"name":"Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea"},{"name":"Department of Physics and Astronomy and Center for Theoretical Physics, Seoul National University, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1254-768X","authenticated-orcid":false,"given":"Hyesun","family":"Cho","sequence":"additional","affiliation":[{"name":"Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YunHee","family":"Seol","sequence":"additional","affiliation":[{"name":"Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanhyeok","family":"Park","sequence":"additional","affiliation":[{"name":"Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Yousefian-Jazi","sequence":"additional","affiliation":[{"name":"Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Jae","family":"Hyeon","sequence":"additional","affiliation":[{"name":"Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junghee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Boston University Alzheimer\u2019s Disease Center, Boston University School of Medicine, Boston, MA 02118, USA"},{"name":"VA Boston Healthcare System, Boston, MA 02130, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6544-3732","authenticated-orcid":false,"given":"Hoon","family":"Ryu","sequence":"additional","affiliation":[{"name":"Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea"},{"name":"Department of Neurology, Boston University Alzheimer\u2019s Disease Center, Boston University School of Medicine, Boston, MA 02118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kety, S.S. 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