{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T05:28:59Z","timestamp":1776835739128,"version":"3.51.2"},"reference-count":77,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Hydrogen sulfide (H2S) is an endogenous, gaseous signaling molecule that plays a critical role in cardiac and vascular biology. H2S regulates vascular tone and oxidant defenses and exerts cytoprotective effects in the heart and circulation. Recent studies indicate that H2S modulates various components of metabolic syndrome, including obesity and glucose metabolism. This review will discuss studies exhibiting H2S -derived cardioprotective signaling in heart failure with reduced ejection fraction (HFrEF). We will also discuss the role of H2S in metabolic syndrome and heart failure with preserved ejection fraction (HFpEF).<\/jats:p>","DOI":"10.3390\/antiox10030485","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T11:18:38Z","timestamp":1616152718000},"page":"485","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Hydrogen Sulfide as a Potential Therapy for Heart Failure\u2014Past, Present, and Future"],"prefix":"10.3390","volume":"10","author":[{"given":"Kyle B.","family":"LaPenna","sequence":"first","affiliation":[{"name":"Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"},{"name":"Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Polhemus","sequence":"additional","affiliation":[{"name":"Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"},{"name":"Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jake E.","family":"Doiron","sequence":"additional","affiliation":[{"name":"Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"},{"name":"Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hunter A.","family":"Hidalgo","sequence":"additional","affiliation":[{"name":"Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"},{"name":"Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"},{"name":"Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Lefer","sequence":"additional","affiliation":[{"name":"Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"},{"name":"Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1016\/j.jacc.2017.08.074","article-title":"Heart failure with preserved, borderline, and reduced ejection fraction: 5-year outcomes","volume":"70","author":"Shah","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/768607","article-title":"The Cardioprotective Actions of Hydrogen Sulfide in Acute Myocardial Infarction and Heart Failure","volume":"2014","author":"Polhemus","year":"2014","journal-title":"Scientifica"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.jacbts.2018.08.011","article-title":"Hydrogen Sulfide Attenuates Renin Angiotensin and Aldosterone Pathological Signaling to Preserve Kidney Function and Improve Exercise Tolerance in Heart Failure","volume":"3","author":"Li","year":"2018","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1161\/CIRCULATIONAHA.112.000855","article-title":"H2S Protects Against Pressure Overload\u2013Induced Heart Failure via Upregulation of Endothelial Nitric Oxide Synthase","volume":"127","author":"Kondo","year":"2013","journal-title":"Circulation"},{"key":"ref_5","first-page":"1","article-title":"H2S attenuates oxidative stress via nrf2\/nf-\u03bab signaling to regulate restenosis after percutaneous transluminal angioplasty","volume":"246","author":"Ling","year":"2020","journal-title":"Exp. Biol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/CIRCULATIONAHA.109.920991","article-title":"Genetic and Pharmacologic Hydrogen Sulfide Therapy Attenuates Ischemia-Induced Heart Failure in Mice","volume":"122","author":"Calvert","year":"2010","journal-title":"Circulation"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"H1215","DOI":"10.1152\/ajpheart.00796.2012","article-title":"Hydrogen sulfide preconditions the db\/db diabetic mouse heart against ischemia-reperfusion injury by activating Nrf2 signaling in an Erk-dependent manner","volume":"304","author":"Peake","year":"2013","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1073\/pnas.1321871111","article-title":"Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent","volume":"111","author":"King","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"6510","DOI":"10.1111\/jcmm.15279","article-title":"The role of mitochondrial reactive oxygen species, NO and H2S in ischaemia\/reperfusion injury and cardioprotection","volume":"24","author":"Andreadou","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Bucci, M., Papapetropoulos, A., Vellecco, V., Zhou, Z., Zaid, A., Giannogonas, P., Cantalupo, A., Dhayade, S., Karalis, K.P., and Wang, R. (2012). Cgmp-dependent protein kinase contributes to hydrogen sulfide-stimulated vasorelaxation. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0053319"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"31888","DOI":"10.18632\/oncotarget.16649","article-title":"Sulfhydration-associated phosphodiesterase 5A dimerization mediates vasorelaxant effect of hydrogen sulfide","volume":"8","author":"Sun","year":"2017","journal-title":"Oncotarget"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1177\/0300060519847386","article-title":"Hydrogen sulfide-mediated endothelial function and the interaction with enos and pde5a activity in human internal mammary arteries","volume":"47","author":"Yuan","year":"2019","journal-title":"J. Int. Med. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/cvr\/cvq248","article-title":"Hydrogen sulfide interacts with nitric oxide in the heart: Possible involvement of nitroxyl","volume":"88","author":"Yong","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ars.2008.2282","article-title":"Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria","volume":"12","author":"Kimura","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"11749","DOI":"10.1002\/anie.201704117","article-title":"An esterase-sensitive prodrug approach for controllable delivery of persulfide species","volume":"70112","author":"Zheng","year":"2017","journal-title":"Angew. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1161\/CIRCHEARTFAILURE.113.000299","article-title":"Hydrogen Sulfide Attenuates Cardiac Dysfunction After Heart Failure Via Induction of Angiogenesis","volume":"6","author":"Polhemus","year":"2013","journal-title":"Circ. Heart Fail."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/1755-5922.12128","article-title":"A Novel Hydrogen Sulfide Prodrug, SG 1002, Promotes Hydrogen Sulfide and Nitric Oxide Bioavailability in Heart Failure Patients","volume":"33","author":"Polhemus","year":"2015","journal-title":"Cardiovasc. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11010-019-03577-w","article-title":"The cardioprotective effects of diallyl trisulfide on diabetic rats with ex vivo induced ischemia\/reperfusion injury","volume":"460","author":"Jeremic","year":"2019","journal-title":"Mol. Cell. Biochem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"101813","DOI":"10.1016\/j.redox.2020.101813","article-title":"Polysulfide-mediated sulfhydration of sirt1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 nf-\u03bab and stat3","volume":"38","author":"Sun","year":"2021","journal-title":"Redox Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1089\/ars.2012.5041","article-title":"Polysulfides link H2S to protein thiol oxidation","volume":"19","author":"Greiner","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_21","first-page":"E4651","article-title":"Key bioactive reaction products of the NO\/H2S interaction are S\/N-hybrid species, polysulfides, and nitroxyl","volume":"112","author":"Kuhnle","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1089\/ars.2020.8060","article-title":"SG1002 and Catenated Divalent Organic Sulfur Compounds as Promising Hydrogen Sulfide Prodrugs","volume":"33","author":"Gojon","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"C894","DOI":"10.1152\/ajpcell.00028.2016","article-title":"Cross talk between polysulfide and nitric oxide in rat peritoneal mast cells","volume":"310","author":"Moustafa","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1089\/ars.2009.2956","article-title":"Low Levels of Hydrogen Sulfide in the Blood of Diabetes Patients and Streptozotocin-Treated Rats Causes Vascular Inflammation?","volume":"12","author":"Jain","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e002368","DOI":"10.1161\/CIRCHEARTFAILURE.115.002368","article-title":"Sodium Sulfide Attenuates Ischemic-Induced Heart Failure by Enhancing Proteasomal Function in an Nrf2-Dependent Manner","volume":"9","author":"Shimizu","year":"2016","journal-title":"Circ. Heart Fail."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"H732","DOI":"10.1152\/ajpheart.00729.2016","article-title":"Analysis of decreases in systemic arterial pressure and heart rate in response to the hydrogen sulfide donor sodium sulfide","volume":"313","author":"Swan","year":"2017","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3892\/br.2013.87","article-title":"Hydrogen sulfide upregulates heme oxygenase-1 expression in rats with volume overload-induced heart failure","volume":"1","author":"Zhang","year":"2013","journal-title":"Biomed. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"H451","DOI":"10.1152\/ajpheart.00682.2009","article-title":"H2S ameliorates oxidative and proteolytic stresses and protects the heart against adverse remodeling in chronic heart failure","volume":"298","author":"Mishra","year":"2010","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"95425","DOI":"10.18632\/oncotarget.20729","article-title":"Gas signaling molecule hydrogen sulfide attenuates doxorubicin-induced dilated cardiomyopathy","volume":"8","author":"Yu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1124\/pr.117.014050","article-title":"International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors","volume":"69","author":"Szabo","year":"2017","journal-title":"Pharm. Rev."},{"key":"ref_31","first-page":"A16459","article-title":"A novel hydrogen sulfide donor, jk1, preserves left ventricular ejection fraction and improves hemodynamics in the setting of heart failure","volume":"136","author":"Li","year":"2017","journal-title":"Circulation"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.redox.2017.11.020","article-title":"Novel H2S-NO hybrid molecule (ZYZ-803) promoted synergistic effects against heart failure","volume":"15","author":"Wu","year":"2018","journal-title":"Redox. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.yjmcc.2015.07.028","article-title":"GYY4137 attenuates remodeling, preserves cardiac function and modulates the natriuretic peptide response to ischemia","volume":"87","author":"Lilyanna","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.3892\/mmr.2014.2901","article-title":"GYY4137, a hydrogen sulfide-releasing molecule, inhibits the inflammatory response by suppressing the activation of nuclear factor-kappa B and mitogen-activated protein kinases in Coxsackie virus B3-infected rat cardiomyocytes","volume":"11","author":"Wu","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/hr.2014.125","article-title":"Hydrogen sulfide treatment reduces blood pressure and oxidative stress in angiotensin II-induced hypertensive mice","volume":"38","author":"Hart","year":"2015","journal-title":"Hypertens. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/cvr\/cvv198","article-title":"Cystathionine \u03b3-lyase regulates arteriogenesis through NO-dependent monocyte recruitment","volume":"107","author":"Kolluru","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1161\/CIRCRESAHA.118.311134","article-title":"Evolution of Hydrogen Sulfide Therapeutics to Treat Cardiovascular Disease","volume":"123","author":"Li","year":"2018","journal-title":"Circ. Res."},{"key":"ref_38","first-page":"1497","article-title":"Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty","volume":"5","author":"Zhang","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11906-018-0812-z","article-title":"The Global Epidemic of the Metabolic Syndrome","volume":"20","author":"Saklayen","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13098-019-0503-1","article-title":"The prevalence of metabolic syndrome and its association with body fat distribution in middle-aged individuals from Indonesia and the Netherlands: A cross-sectional analysis of two population-based studies","volume":"12","author":"Sigit","year":"2020","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.2337\/diacare.28.7.1769","article-title":"Risks for All-Cause Mortality, Cardiovascular Disease, and Diabetes Associated with the Metabolic Syndrome: A summary of the evidence","volume":"28","author":"Ford","year":"2005","journal-title":"Diabetes Care"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1161\/01.CIR.0000140677.20606.0E","article-title":"Impact of the Metabolic Syndrome on Mortality from Coronary Heart Disease, Cardiovascular Disease, and All Causes in United States Adults","volume":"110","author":"Malik","year":"2004","journal-title":"Circulation"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Geng, B., Cai, B., Liao, F., Zheng, Y., Zeng, Q., Fan, X., Gong, Y., Yang, J., Cui, Q.H., and Tang, C. (2013). Increase or Decrease Hydrogen Sulfide Exert Opposite Lipolysis, but Reduce Global Insulin Resistance in High Fatty Diet Induced Obese Mice. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0073892"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Be\u0142towski, J., and Jamroz-Wi\u015bniewska, A. (2016). Hydrogen Sulfide in the Adipose Tissue\u2014Physiology, Pathology and a Target for Pharmacotherapy. Molecules, 22.","DOI":"10.3390\/molecules22010063"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.niox.2014.02.006","article-title":"Hydrogen sulfide and the liver","volume":"41","author":"Mani","year":"2014","journal-title":"Nitric. Oxide"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13618-014-0022-y","article-title":"Exogenous hydrogen sulfide mitigates the fatty liver in obese mice through improving lipid metabolism and antioxidant potential","volume":"5","author":"Wu","year":"2015","journal-title":"Med. Gas. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1136\/gutjnl-2017-313778","article-title":"Fatty acids promote fatty liver disease via the dysregulation of 3-mercaptopyruvate sulfurtransferase\/hydrogen sulfide pathway","volume":"67","author":"Li","year":"2017","journal-title":"Gut"},{"key":"ref_48","first-page":"1055","article-title":"Exogenous hydrogen sulfide inhibits high-glucose-induced injuries via regulating leptin\/leptin receptor signaling pathway in human umbilical vein endothelial cells","volume":"36","author":"Wu","year":"2016","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao J. South. Med. Univ."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11010-014-1997-3","article-title":"Exogenous hydrogen sulfide alleviates high glucose-induced cardiotoxicity via inhibition of leptin signaling in H9c2 cells","volume":"391","author":"Zhuang","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/oby.2002.150","article-title":"Plasma Adiponectin Levels in Overweight and Obese Asians","volume":"10","author":"Yang","year":"2002","journal-title":"Obes. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/1476-511X-13-155","article-title":"Involvement of CSE\/ H2S in high glucose induced aberrant secretion of adipokines in 3T3-L1 adipocytes","volume":"13","author":"Pan","year":"2014","journal-title":"Lipids Health Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2169\/internalmedicine.56.7403","article-title":"Clinical Implication of Plasma Hydrogen Sulfide Levels in Japanese Patients with Type 2 Diabetes","volume":"56","author":"Suzuki","year":"2017","journal-title":"Intern. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1089\/ars.2012.5024","article-title":"Hydrogen Sulfide Treatment Promotes Glucose Uptake by Increasing Insulin Receptor Sensitivity and Ameliorates Kidney Lesions in Type 2 Diabetes","volume":"19","author":"Xue","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bcp.2018.01.017","article-title":"Regulation of vascular tone homeostasis by NO and H2S: Implications in hypertension","volume":"149","author":"Gheibi","year":"2018","journal-title":"Biochem. Pharm."},{"key":"ref_55","first-page":"5097","article-title":"Hydrogen sulfide accelerates wound healing in diabetic rats","volume":"8","author":"Wang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"28827","DOI":"10.1074\/jbc.M114.596593","article-title":"Hydrogen Sulfide Alleviates Diabetic Nephropathy in a Streptozotocin-induced Diabetic Rat Model","volume":"289","author":"Zhou","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: Hypertension in mice with deletion of cystathionine \u03b3-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1152\/ajpheart.01193.2006","article-title":"Hydrogen sulfide mediates vasoactivity in an O2-dependent manner","volume":"292","author":"Koenitzer","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S0006-291X(03)00256-0","article-title":"The regulatory effect of hydrogen sulfide on hypoxic pulmonary hypertension in rats","volume":"302","author":"Zhang","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/FJC.0b013e31820eb7a1","article-title":"Hydrogen sulfide: A novel signaling molecule in the vascular system","volume":"58","author":"Liu","year":"2011","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/MNH.0b013e3283430651","article-title":"Signaling pathways for the vascular effects of hydrogen sulfide","volume":"20","author":"Wang","year":"2011","journal-title":"Curr. Opin. Nephrol. Hypertens"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"Embo J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1016\/j.jvs.2018.08.172","article-title":"Effects of a novel hydrogen sulfide prodrug in a porcine model of acute limb ischemia","volume":"69","author":"Rushing","year":"2019","journal-title":"J. Vasc. Surg."},{"key":"ref_64","first-page":"67","article-title":"Hydrogen sulfide protects endothelial nitric oxide function under conditions of acute oxidative stress in vitro","volume":"387","author":"Ng","year":"2013","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharm."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.yjmcc.2018.01.011","article-title":"Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK","volume":"116","author":"Shimizu","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Wen, Y.-D., Wang, H., Kho, S.-H., Rinkiko, S., Sheng, X., Shen, H.-M., and Zhu, Y.-Z. (2013). Hydrogen Sulfide Protects HUVECs against Hydrogen Peroxide Induced Mitochondrial Dysfunction and Oxidative Stress. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0053147"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s11897-013-0155-7","article-title":"The Emerging Epidemic of Heart Failure with Preserved Ejection Fraction","volume":"10","author":"Oktay","year":"2013","journal-title":"Curr. Heart Fail. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/CIRCRESAHA.115.302922","article-title":"Heart failure with preserved ejection fraction: Mechanisms, clinical features, and therapies","volume":"115","author":"Sharma","year":"2014","journal-title":"Circ. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1136\/bmj.321.7255.215","article-title":"Do patients with suspected heart failure and preserved left ventricular systolic function suffer from \u201cdiastolic heart failure\u201d or from misdiagnosis? A prospective descriptive study","volume":"321","author":"Caruana","year":"2000","journal-title":"BMJ"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e002477","DOI":"10.1161\/JAHA.115.002477","article-title":"Clinical Phenotypes in Heart Failure with Preserved Ejection Fraction","volume":"5","author":"Samson","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1161\/CIRCULATIONAHA.114.010637","article-title":"Phenomapping for Novel Classification of Heart Failure with Preserved Ejection Fraction","volume":"131","author":"Shah","year":"2015","journal-title":"Circulation"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1016\/j.jacc.2017.09.006","article-title":"Biological Phenotypes of Heart Failure with Preserved Ejection Fraction","volume":"70","author":"Lewis","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_73","first-page":"139","article-title":"The association of obesity and cardiometabolic traits with incident hfpef and hfref","volume":"176","author":"Savji","year":"2019","journal-title":"Physiol. Behav."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1124\/mol.118.113910","article-title":"Update on Gaseous Signaling Molecules Nitric Oxide and Hydrogen Sulfide: Strategies to Capture their Functional Activity for Human Therapeutics","volume":"96","author":"Bryan","year":"2019","journal-title":"Mol. Pharm."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.jacbts.2017.07.013","article-title":"Murine models of heart failure with preserved ejection fraction: A \u201cfishing expedition\u201d","volume":"2","author":"Backman","year":"2017","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1161\/CIRCHEARTFAILURE.113.000539","article-title":"Myocardial titin hypophosphorylation importantly contributes to heart failure with preserved ejection fraction in a rat metabolic risk model","volume":"6","author":"Hamdani","year":"2013","journal-title":"Circ. Heart Fail."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.bbagen.2013.05.037","article-title":"Chemical aspects of hydrogen sulfide measurements in physiological samples","volume":"1840","author":"Nagy","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA) Gen. 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