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Apart from its known functions in oxidative stress and inflammation, new evidence has emerged revealing that H2S carries out physiological functions by targeting proteins, enzymes, and transcription factors through a post-translational modification known as persulfidation. This review article provides a critical overview of the current state of the literature addressing the role of H2S in obesity-associated metabolic disturbances, with particular emphasis on its mechanisms of action in obesity, diabetes, non-alcoholic fatty liver disease (NAFLD), and cardiovascular diseases.<\/jats:p>","DOI":"10.3390\/antiox10050633","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T12:47:07Z","timestamp":1619009227000},"page":"633","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["The Impact of H2S on Obesity-Associated Metabolic Disturbances"],"prefix":"10.3390","volume":"10","author":[{"given":"Ferran","family":"Comas","sequence":"first","affiliation":[{"name":"Department of Diabetes, Endocrinology and Nutrition, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Girona (IdIBGi), CIBEROBN (CB06\/03\/010) and Instituto de Salud Carlos III (ISCIII), 17007 Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2883-511X","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Moreno-Navarrete","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Nutrition, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Girona (IdIBGi), CIBEROBN (CB06\/03\/010) and Instituto de Salud Carlos III (ISCIII), 17007 Girona, Spain"},{"name":"Department of Medical Sciences, Universitat de Girona, 17003 Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1089\/ars.2016.6909","article-title":"Gasotransmitter Heterocellular Signaling","volume":"26","author":"Kolluru","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1089\/152308603768295249","article-title":"The Gasotransmitter Role of Hydrogen Sulfide","volume":"5","author":"Wang","year":"2003","journal-title":"Antioxid. Redox Signal."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.coph.2019.07.001","article-title":"Gasotransmitters in Health and Disease: A Mitochondria-Centered View","volume":"45","author":"Hendriks","year":"2019","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Yang, G., Sener, A., Ji, Y., Pei, Y., and Pluth, M.D. (2016). Gasotransmitters in Biology and Medicine: Molecular Mechanisms and Drug Targets. Oxid. Med. Cell. Longev., 2016.","DOI":"10.1155\/2016\/4627308"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"re2","DOI":"10.1126\/scisignal.268re2","article-title":"Signaling by Gasotransmitters","volume":"2","author":"Mustafa","year":"2009","journal-title":"Sci. Signal."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.neuint.2013.09.003","article-title":"Physiological Role of Hydrogen Sulfide and Polysulfide in the Central Nervous System","volume":"63","author":"Kimura","year":"2013","journal-title":"Neurochem. Int."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"17977","DOI":"10.1073\/pnas.0705710104","article-title":"Hydrogen Sulfide Mediates the Vasoactivity of Garlic","volume":"104","author":"Benavides","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"9741","DOI":"10.1074\/jbc.M113.517995","article-title":"Hydrogen Sulfide Suppresses Oxidized Low-Density Lipoprotein (Ox-LDL)-Stimulated Monocyte Chemoattractant Protein 1 Generation from Macrophages via the Nuclear Factor \u039ab (NF-\u03baB) Pathway","volume":"289","author":"Du","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cell.2014.11.048","article-title":"Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits","volume":"160","author":"Hine","year":"2015","journal-title":"Cell"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrd2425","article-title":"Hydrogen Sulphide and Its Therapeutic Potential","volume":"6","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine \u03b3-Lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1089\/ars.2011.4005","article-title":"Hydrogen Sulfide in the Mammalian Cardiovascular System","volume":"17","author":"Liu","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Nagpure, B.V., and Bian, J.S. (2016). Interaction of Hydrogen Sulfide with Nitric Oxide in the Cardiovascular System. Oxid. Med. Cell. Longev., 2016.","DOI":"10.1155\/2016\/6904327"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1089\/ars.2010.3517","article-title":"Hydrogen Sulfide: Neurophysiology and Neuropathology","volume":"15","author":"Hu","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/978-3-319-18144-8_10","article-title":"Brain, Learning, and Memory: Role of H2S in Neurodegenerative Diseases","volume":"230","author":"Nagpure","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3233\/JAD-2011-110128","article-title":"A New Hope for Neurodegeneration: Possible Role of Hydrogen Sulfide","volume":"24","author":"Gong","year":"2011","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ars.2017.7058","article-title":"A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer?","volume":"31","author":"Cao","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/978-3-319-18144-8_12","article-title":"Hydrogen Sulfide and Cancer","volume":"230","author":"Hellmich","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1089\/ars.2005.7.813","article-title":"The Role of Cystathionine \u03b2-Synthase in Homocysteine Metabolism","volume":"7","author":"Jhee","year":"2005","journal-title":"Antioxid. Redox Signal."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"11601","DOI":"10.1074\/jbc.M808026200","article-title":"H2S Biogenesis by Human Cystathionine \u03b3-Lyase Leads to the Novel Sulfur Metabolites Lanthionine and Homolanthionine and Is Responsive to the Grade of Hyperhomocysteinemia","volume":"284","author":"Chiku","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/ars.2008.2253","article-title":"3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide and Bound Sulfane Sulfur in the Brain","volume":"11","author":"Shibuya","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/bph.14446","article-title":"Regulators of the Transsulfuration Pathway","volume":"176","author":"Sbodio","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.tips.2018.02.007","article-title":"Cysteine Metabolism in Neuronal Redox Homeostasis","volume":"39","author":"Paul","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.redox.2015.04.004","article-title":"Thiol Redox Homeostasis in Neurodegenerative Disease","volume":"5","author":"McBean","year":"2015","journal-title":"Redox Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"13005","DOI":"10.1021\/bi001088w","article-title":"The Quantitatively Important Relationship between Homocysteine Metabolism and Glutathione Synthesis by the Transsulfuration Pathway and Its Regulation by Redox Changes","volume":"39","author":"Mosharov","year":"2000","journal-title":"Biochemistry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.abb.2004.08.037","article-title":"Redox Regulation and Reaction Mechanism of Human Cystathionine-\u03b2-Synthase: A PLP-Dependent Hemesensor Protein","volume":"433","author":"Banerjee","year":"2005","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrm3391","article-title":"H2S Signalling through Protein Sulfhydration and beyond","volume":"13","author":"Paul","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.tibs.2015.08.007","article-title":"H2S: A Novel Gasotransmitter That Signals by Sulfhydration","volume":"40","author":"Paul","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10545-009-9006-9","article-title":"Dealing with Methionine\/homocysteine Sulfur: Cysteine Metabolism to Taurine and Inorganic Sulfur","volume":"34","author":"Stipanuk","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s00018-016-2406-8","article-title":"H2S Biosynthesis and Catabolism: New Insights from Molecular Studies","volume":"74","author":"Rose","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s00726-014-1700-8","article-title":"Primary Hepatocytes from Mice Lacking Cysteine Dioxygenase Show Increased Cysteine Concentrations and Higher Rates of Metabolism of Cysteine to Hydrogen Sulfide and Thiosulfate","volume":"46","author":"Jurkowska","year":"2014","journal-title":"Amino Acids"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"225","DOI":"10.4062\/biomolther.2017.251","article-title":"Effects and Mechanisms of Taurine as a Therapeutic Agent","volume":"26","author":"Schaffer","year":"2018","journal-title":"Biomol. Ther."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fendo.2013.00087","article-title":"Production of Hydrogen Sulfide from D-Cysteine and Its Therapeutic Potential","volume":"4","author":"Shibuya","year":"2013","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Shibuya, N., Koike, S., Tanaka, M., Ishigami-Yuasa, M., Kimura, Y., Ogasawara, Y., Fukui, K., Nagahara, N., and Kimura, H. (2013). A Novel Pathway for the Production of Hydrogen Sulfide from D-Cysteine in Mammalian Cells. Nat. Commun., 4.","DOI":"10.1038\/ncomms2371"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-019-0431-5","article-title":"Non-Enzymatic Hydrogen Sulfide Production from Cysteine in Blood Is Catalyzed by Iron and Vitamin B6","volume":"2","author":"Yang","year":"2019","journal-title":"Commun. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/(SICI)1097-010X(19981015)282:3<310::AID-JEZ4>3.0.CO;2-P","article-title":"Sulfur Reduction by Human Erythrocytes","volume":"282","author":"Searcy","year":"1998","journal-title":"J. Exp. Zool."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Olson, K.R., DeLeon, E.R., Gao, Y., Hurley, K., Sadauskas, V., Batz, C., and Stoy, G.F. (2013). Thiosulfate: A Readily Accessible Source of Hydrogen Sulfide in Oxygen Sensing. Am. J. Physiol. Regul. Integr. Comp. Physiol., 305.","DOI":"10.1152\/ajpregu.00421.2012"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/FJC.0b013e3181ac8e12","article-title":"S-Propargyl-Cysteine Protects Both Adult Rat Hearts and Neonatal Cardiomyocytes from Ischemia\/hypoxia Injury: The Contribution of the Hydrogen Sulfide-Mediated Pathway","volume":"54","author":"Wang","year":"2009","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s40273-014-0243-x","article-title":"The Epidemiology of Obesity: A Big Picture","volume":"33","author":"Hruby","year":"2015","journal-title":"Pharmacoeconomics"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and Metabolic Disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1007\/s00125-010-1761-5","article-title":"Adiposity Is a Major Determinant of Plasma Levels of the Novel Vasodilator Hydrogen Sulphide","volume":"53","author":"Whiteman","year":"2010","journal-title":"Diabetologia"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Geng, B., Cai, B., Liao, F., Zheng, Y., Zeng, Q., Fan, X., Gong, Y., Yang, J., Cui, Q.H., and Tang, C. (2013). Increase or Decrease Hydrogen Sulfide Exert Opposite Lipolysis, but Reduce Global Insulin Resistance in High Fatty Diet Induced Obese Mice. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0073892"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bbalip.2016.03.001","article-title":"Cystathionine \u03b3 Lyase-Hydrogen Sulfide Increases Peroxisome Proliferator-Activated Receptor \u03b3 Activity by Sulfhydration at C139 Site Thereby Promoting Glucose Uptake and Lipid Storage in Adipocytes","volume":"1861","author":"Cai","year":"2016","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bbalip.2017.11.008","article-title":"Cystathionine Gamma-Lyase\/hydrogen Sulfide System Is Essential for Adipogenesis and Fat Mass Accumulation in Mice","volume":"1863","author":"Yang","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.2047-6310.2014.221.x","article-title":"Breathprints of Childhood Obesity: Changes in Volatile Organic Compounds in Obese Children Compared with Lean Controls","volume":"10","author":"Alkhouri","year":"2015","journal-title":"Pediatr. Obes."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41366-020-00696-z","article-title":"Morbidly Obese Subjects Show Increased Serum Sulfide in Proportion to Fat Mass","volume":"45","author":"Comas","year":"2021","journal-title":"Int. J. Obes."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1039\/D0FO01960G","article-title":"A Comparison Study of the Influence of Milk Protein versus Whey Protein in High-Protein Diets on Adiposity in Rats","volume":"12","author":"Ren","year":"2021","journal-title":"Food Funct."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1021\/acs.chemrev.7b00205","article-title":"Chemical Biology of H2S Signaling through Persulfidation","volume":"118","author":"Filipovic","year":"2018","journal-title":"Chem. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"ra72","DOI":"10.1126\/scisignal.2000464","article-title":"HS Signals through Protein S-Sulfhydration","volume":"2","author":"Mustafa","year":"2009","journal-title":"Sci. Signal."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.neuint.2019.01.027","article-title":"Signaling by Hydrogen Sulfide (H2S) and Polysulfides (H2SN) in the Central Nervous System","volume":"126","author":"Kimura","year":"2019","journal-title":"Neurochem. Int."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-3-319-18144-8_2","article-title":"Persulfidation (S-Sulfhydration) and H2S","volume":"230","author":"Filipovic","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nri2975","article-title":"Mitochondria in Innate Immune Responses","volume":"11","author":"West","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00005-013-0235-0","article-title":"Mitochondria as Oxidative Signaling Organelles in T-Cell Activation: Physiological Role and Pathological Implications","volume":"61","author":"Krammer","year":"2013","journal-title":"Arch. Immunol. Ther. Exp. (Warsz.)"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.tcb.2011.06.008","article-title":"Taking A \u201cgood\u201d look at Free Radicals in the Aging Process","volume":"21","author":"Hekimi","year":"2011","journal-title":"Trends Cell Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nature04634","article-title":"Reactive Oxygen Species Have a Causal Role in Multiple Forms of Insulin Resistance","volume":"440","author":"Houstis","year":"2006","journal-title":"Nature"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.lfs.2009.02.026","article-title":"Oxidative Stress and Metabolic Syndrome","volume":"84","author":"Roberts","year":"2009","journal-title":"Life Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI21625","article-title":"Increased Oxidative Stress in Obesity and Its Impact on Metabolic Syndrome","volume":"114","author":"Furukawa","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_58","first-page":"385","article-title":"Relationship of Oxidative Stress with Obesity and Its Role in Obesity Induced Metabolic Syndrome","volume":"58","author":"Sankhla","year":"2012","journal-title":"Clin. Lab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1093\/ajcn\/85.5.1385","article-title":"Long-Term Fish Consumption Is Associated with Protection against Arrhythmia in Healthy Persons in a Mediterranean Region\u2014The ATTICA Study","volume":"85","author":"Chrysohoou","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s13105-012-0154-2","article-title":"Oxidative Stress and Inflammation Interactions in Human Obesity","volume":"68","author":"Ryan","year":"2012","journal-title":"J. Physiol. Biochem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1475-2891-12-18","article-title":"Antioxidant Enzymes Activities in Obese Tunisian Children","volume":"12","author":"Sfar","year":"2013","journal-title":"Nutr. J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3945\/jn.113.183137","article-title":"Low Serum Concentrations of Carotenoids and Vitamin E Are Associated with High Adiposity in Mexican-American Children","volume":"144","author":"Gunanti","year":"2014","journal-title":"J. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Amirkhizi, F., Siassi, F., Djalali, M., and Shahraki, S.H. (2014). Impaired Enzymatic Antioxidant Defense in Erythrocytes of Women with General and Abdominal Obesity. Obes. Res. Clin. Pract., 8.","DOI":"10.1016\/j.orcp.2012.07.004"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.numecd.2011.01.008","article-title":"The Association of Fasting Plasma Sulfur-Containing Compounds with BMI, Serum Lipids and Apolipoproteins","volume":"22","author":"Elshorbagy","year":"2012","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Elshorbagy, A.K., Valdivia-Garcia, M., Refsum, H., and Butte, N. (2012). The Association of Cysteine with Obesity, Inflammatory Cytokines and Insulin Resistance in Hispanic Children and Adolescents. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0044166"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.cmet.2019.10.007","article-title":"Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration","volume":"30","author":"Zivanovic","year":"2019","journal-title":"Cell Metab."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.cmet.2017.05.003","article-title":"Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production","volume":"25","author":"Hine","year":"2017","journal-title":"Cell Metab."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/nature07216","article-title":"Puzzles, Promises and a Cure for Ageing","volume":"454","author":"Vijg","year":"2008","journal-title":"Nature"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Tam, B.T., Morais, J.A., and Santosa, S. (2020). Obesity and Ageing: Two Sides of the Same Coin. Obes. Rev., 21.","DOI":"10.1111\/obr.12991"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Comas, F., Latorre, J., Ortega, F., Arnoriaga Rodr\u00edguez, M., Kern, M., Lluch, A., Ricart, W., Bl\u00fcher, M., Gotor, C., and Romero, L.C. (2021). Activation of Endogenous H2S Biosynthesis or Supplementation with Exogenous H2S Enhances Adipose Tissue Adipogenesis and Preserves Adipocyte Physiology in Humans. Antioxid. Redox Signal.","DOI":"10.1089\/ars.2020.8206"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/MOP.0b013e32833a8d6e","article-title":"The Role and Importance of Brown Adipose Tissue in Energy Homeostasis","volume":"22","author":"Cypess","year":"2010","journal-title":"Curr. Opin. Pediatr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1079\/PNS200194","article-title":"Physiological Role of Adipose Tissue: White Adipose Tissue as an Endocrine and Secretory Organ","volume":"60","author":"Trayhurn","year":"2001","journal-title":"Proc. Nutr. Soc."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbrc.2009.01.059","article-title":"Hydrogen Sulfide from Adipose Tissue Is a Novel Insulin Resistance Regulator","volume":"380","author":"Feng","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1097\/HJH.0b013e328330a900","article-title":"Hydrogen Sulfide Derived from Periadventitial Adipose Tissue Is a Vasodilator","volume":"27","author":"Fang","year":"2009","journal-title":"J. Hypertens."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1139\/cjpp-2013-0001","article-title":"Endogenous Hydrogen Sulfide in Perivascular Adipose Tissue: Role in the Regulation of Vascular Tone in Physiology and pathology1","volume":"91","year":"2013","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.phrs.2017.09.023","article-title":"Reduced Adipose Tissue H2S in Obesity","volume":"128","author":"Katsouda","year":"2018","journal-title":"Pharmacol. Res."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Be\u0142towski, J., and Jamroz-W\u00edsniewska, A. (2017). Hydrogen Sulfide in the Adipose Tissue-Physiology, Pathology and a Target for Pharmacotherapy. Molecules, 22.","DOI":"10.3390\/molecules22010063"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Tsai, C.Y., Peh, M.T., Feng, W., Dymock, B.W., and Moore, P.K. (2015). Hydrogen Sulfide Promotes Adipogenesis in 3T3L1 Cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0119511"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/1476-511X-13-155","article-title":"Involvement of CSE\/ H2S in High Glucose Induced Aberrant Secretion of Adipokines in 3T3-L1 Adipocytes","volume":"13","author":"Pan","year":"2014","journal-title":"Lipids Health Dis."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Randi, E.B., Casili, G., Jacquemai, S., and Szabo, C. (2021). Selenium-Binding Protein 1 (Selenbp1) Supports Hydrogen Sulfide Biosynthesis and Adipogenesis. Antioxidants, 10.","DOI":"10.3390\/antiox10030361"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/acer.13398","article-title":"Protective Effects of Diallyl Sulfide Against Ethanol-Induced Injury in Rat Adipose Tissue and Primary Human Adipocytes","volume":"41","author":"Kema","year":"2017","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_82","first-page":"575","article-title":"Aged Black Garlic Extract Regulates Lipid Metabolism by Inhibiting Lipogenesis and Promoting Lipolysis in Mature 3T3-L1 Adipocytes","volume":"27","author":"Nam","year":"2018","journal-title":"Food Sci. Biotechnol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.bbrc.2019.10.192","article-title":"Sulfhydration of Perilipin 1 Is Involved in the Inhibitory Effects of Cystathionine Gamma Lyase\/hydrogen Sulfide on Adipocyte Lipolysis","volume":"521","author":"Ding","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"851","DOI":"10.5114\/aoms.2016.58928","article-title":"Obesity & Inflammation: The Linking Mechanism & the Complications","volume":"13","author":"Ellulu","year":"2017","journal-title":"Arch. Med. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.6064\/2012\/159680","article-title":"Role of Hydrogen Sulfide in the Pathology of Inflammation","volume":"2012","author":"Bhatia","year":"2012","journal-title":"Scientifica"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.isci.2018.09.014","article-title":"M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry","volume":"8","author":"Chauhan","year":"2018","journal-title":"iScience"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"ra128","DOI":"10.1126\/scisignal.aac7135","article-title":"Depletion of H2S during Obesity Enhances Store-Operated Ca2+ Entry in Adipose Tissue Macrophages to Increase Cytokine Production","volume":"8","author":"Velmurugan","year":"2015","journal-title":"Sci. Signal."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Comas, F., Latorre, J., Cuss\u00f3, O., Ortega, F., Lluch, A., Sabater, M., Castells-Nobau, A., Ricart, W., Ribas, X., and Costas, M. (2019). Hydrogen Sulfide Impacts on Inflammation-Induced Adipocyte Dysfunction. Food Chem. Toxicol., 131.","DOI":"10.1016\/j.fct.2019.05.051"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"8152","DOI":"10.1002\/jcp.27603","article-title":"Insulin Resistance: Review of the Underlying Molecular Mechanisms","volume":"234","author":"Yaribeygi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1126\/science.1230721","article-title":"Pleiotropic Actions of Insulin Resistance and Inflammation in Metabolic Homeostasis","volume":"339","author":"Odegaard","year":"2013","journal-title":"Science"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e219","DOI":"10.1038\/emm.2016.6","article-title":"Pancreatic Regulation of Glucose Homeostasis","volume":"48","author":"Wu","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"ref_92","unstructured":"Mann, E., Sunni, M., and Bellin, M.D. (2020). Secretion of Insulin in Response to Diet and Hormones. Pancreapedia Exocrine Pancreas Knowl. Base."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1113\/jphysiol.2005.097642","article-title":"Activation of KATP Channels by H2S in Rat Insulin-Secreting Cells and the Underlying Mechanisms","volume":"569","author":"Yang","year":"2005","journal-title":"J. Physiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1677\/JOE-07-0184","article-title":"Hydrogen Sulphide Reduces Insulin Secretion from HIT-T15 Cells by a KATP Channel-Dependent Pathway","volume":"195","author":"Ali","year":"2007","journal-title":"J. Endocrinol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1254\/jphs.11R01CP","article-title":"Significance of Hydrogen Sulfide Production in the Pancreatic \u03b2-Cell","volume":"116","author":"Taniguchi","year":"2011","journal-title":"J. Pharmacol. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.bbrc.2005.06.021","article-title":"Streptozotocin-Induced Diabetes in the Rat Is Associated with Enhanced Tissue Hydrogen Sulfide Biosynthesis","volume":"333","author":"Yusuf","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1582-4934.2007.00024.x","article-title":"Hydrogen Sulfide Acts as a Mediator of Inflammation Inacute Pancreatitis: In Vitro Studies Using Isolated Mouse Pancreatic Acinar Cells","volume":"11","author":"Tamizhselvi","year":"2007","journal-title":"J. Cell. Mol. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/labinvest.2008.109","article-title":"Pancreatic Islet Overproduction of H2S and Suppressed Insulin Release in Zucker Diabetic Rats","volume":"89","author":"Wu","year":"2009","journal-title":"Lab. Investig."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.febslet.2008.12.026","article-title":"Glucose-Induced Production of Hydrogen Sulfide May Protect the Pancreatic Beta-Cells from Apoptotic Cell Death by High Glucose","volume":"583","author":"Kaneko","year":"2008","journal-title":"FEBS Lett."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.2337\/db05-1082","article-title":"L-Cysteine Inhibits Insulin Release from the Pancreatic \u03b2-Cell: Possible Involvement of Metabolic Production of Hydrogen Sulfide, a Novel Gasotransmitter","volume":"55","author":"Kaneko","year":"2006","journal-title":"Diabetes"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Tomita, M., Nagahara, N., and Ito, T. (2016). Expression of 3-Mercaptopyruvate Sulfurtransferase in the Mouse. Molecules, 21.","DOI":"10.3390\/molecules21121707"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Bronowicka-Adamska, P., Hutsch, T., Gawrys-Kopczynska, M., Maksymiuk, K., and Wr\u00f3bel, M. (2019). Hydrogen Sulfide Formation in Experimental Model of Acute Pancreatitis. Acta Biochim. Pol., 66.","DOI":"10.18388\/abp.2019_2900"},{"key":"ref_103","first-page":"416","article-title":"Liver Glucose Metabolism in Humans","volume":"36","year":"2016","journal-title":"Biosci. Rep."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/jgh.12389","article-title":"Effects of Treatment with Hydrogen Sulfide on Methionine-Choline Deficient Diet-Induced Non-Alcoholic Steatohepatitis in Rats","volume":"29","author":"Luo","year":"2014","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1089\/ars.2013.5354","article-title":"Cystathionine \u03b3-Lyase Deficiency Protects Mice from Galactosamine\/lipopolysaccharide-Induced Acute Liver Failure","volume":"20","author":"Shirozu","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.niox.2014.03.002","article-title":"Effect of Feeding a High Fat Diet on Hydrogen Sulfide (H2S) Metabolism in the Mouse","volume":"41","author":"Peh","year":"2014","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1139\/cjpp-2013-0106","article-title":"High-Fat Diet Stimulates Hepatic Cystathionine \u03b2-Synthase and Cystathionine \u03b3-Lyase Expression","volume":"91","author":"Hwang","year":"2013","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"11767","DOI":"10.1074\/jbc.M113.524645","article-title":"Decreased Cystathionine-\u03b3-Lyase (CSE) Activity in Livers of Type 1 Diabetic Rats and Peripheral Blood Mononuclear Cells (PBMC) of Type 1 Diabetic Patients","volume":"289","author":"Manna","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S1734-1140(13)71053-3","article-title":"Metformin Raises Hydrogen Sulfide Tissue Concentrations in Various Mouse Organs","volume":"65","author":"Somogyi","year":"2013","journal-title":"Pharmacol. Reports"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1210\/en.2012-1658","article-title":"Hydrogen Sulfide Impairs Glucose Utilization and Increases Gluconeogenesis in Hepatocytes","volume":"154","author":"Zhang","year":"2013","journal-title":"Endocrinology"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1089\/ars.2015.6369","article-title":"Decreased Gluconeogenesis in the Absence of Cystathionine Gamma-Lyase and the Underlying Mechanisms","volume":"24","author":"Untereiner","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1016\/j.bbamcr.2014.08.005","article-title":"Hydrogen Sulfide Mitigates Hyperglycemic Remodeling via Liver Kinase B1-Adenosine Monophosphate-Activated Protein Kinase Signaling","volume":"1843","author":"Kundu","year":"2014","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1096\/fj.201801894R","article-title":"Cystathionine \u0393-lyase Deficiency Aggravates Obesity-related Insulin Resistance via FoxO1-dependent Hepatic Gluconeogenesis","volume":"33","author":"Guo","year":"2019","journal-title":"FASEB J."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1089\/ars.2012.4645","article-title":"Hydrogen Sulfide Protects against Cellular Senescence via S-Sulfhydration of keap1 and Activation of Nrf2","volume":"18","author":"Yang","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1089\/ars.2012.4944","article-title":"The Gasotransmitter Hydrogen Sulfide Induces Nrf2-Target Genes by Inactivating the keap1 Ubiquitin Ligase Substrate Adaptor through Formation of a Disulfide Bond between Cys-226 and Cys-613","volume":"19","author":"Hourihan","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"R77","DOI":"10.1530\/JOE-16-0211","article-title":"Adipose Tissue in Control of Metabolism","volume":"231","author":"Luo","year":"2016","journal-title":"J. Endocrinol."},{"key":"ref_117","first-page":"82","article-title":"Insulin Signalling in Human Adipose Tissue. Archives of Physiology and Biochemistry","volume":"112","author":"Laviola","year":"2006","journal-title":"J. Metab. Dis."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.2337\/diab.46.11.1667","article-title":"Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles","volume":"46","author":"Rea","year":"1997","journal-title":"Diabetes"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/cbf.2920","article-title":"Endogenous CSE\/H2S System Mediates TNF-\u03b1-Induced Insulin Resistance in 3T3-L1 Adipocytes","volume":"31","author":"Huang","year":"2013","journal-title":"Cell Biochem. Funct."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"42324","DOI":"10.1074\/jbc.M112.407833","article-title":"Vitamin D up-Regulates Glucose Transporter 4 (GLUT4) Translocation and Glucose Utilization Mediated by Cystathionine-\u03b3-Lyase (CSE) Activation and H2S Formation in 3T3L1 Adipocytes","volume":"287","author":"Manna","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"39848","DOI":"10.1074\/jbc.M111.270884","article-title":"Hydrogen Sulfide and L-Cysteine Increase Phosphatidylinositol 3,4,5-Trisphosphate (PIP3) and Glucose Utilization by Inhibiting Phosphatase and Tensin Homolog (PTEN) Protein and Activating Phosphoinositide 3-Kinase (PI3K)\/serine\/threonine Protein Kinase (AKT)\/protein Kinase C\u03c2\/\u03bb (PKC\u03c2\/\u03bb) in 3T3l1 Adipocytes","volume":"286","author":"Manna","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1089\/ars.2012.5024","article-title":"Hydrogen Sulfide Treatment Promotes Glucose Uptake by Increasing Insulin Receptor Sensitivity and Ameliorates Kidney Lesions in Type 2 Diabetes","volume":"19","author":"Xue","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"E1756","DOI":"10.1210\/jc.2011-0615","article-title":"Preferential Fat Deposition in Subcutaneous versus Visceral Depots Is Associated with Insulin Sensitivity","volume":"96","author":"McLaughlin","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.brainresrev.2004.06.003","article-title":"The Formation of Skeletal Muscle Myotubes Requires Functional Membrane Receptors Activated by Extracellular ATP","volume":"47","author":"Araya","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/cphy.c190029","article-title":"Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake","volume":"10","author":"Merz","year":"2020","journal-title":"Compr. Physiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1096\/fj.09-143651","article-title":"Regulation of Homocysteine Metabolism and Methylation in Human and Mouse Tissues","volume":"24","author":"Chen","year":"2010","journal-title":"FASEB J."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"930","DOI":"10.3760\/cma.j.issn.0366-6999.20122485","article-title":"Hydrogen Sulfide Is Endogenously Generated in Rat Skeletal Muscle and Exerts a Protective Effect against Oxidative Stress","volume":"126","author":"Du","year":"2013","journal-title":"Chin. Med. J."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.niox.2014.11.012","article-title":"Role of Hydrogen Sulfide in Skeletal Muscle Biology and Metabolism","volume":"46","author":"Veeranki","year":"2015","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1080\/10715762.2018.1431626","article-title":"Hydrogen Sulfide Increases Glutathione Biosynthesis, and Glucose Uptake and Utilisation in C2C12 Mouse Myotubes","volume":"52","author":"Parsanathan","year":"2018","journal-title":"Free Radic. Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"9362","DOI":"10.1111\/jcmm.15587","article-title":"Hydrogen Sulphide Ameliorating Skeletal Muscle Atrophy in Db\/db Mice via Muscle RING Finger 1 S-Sulfhydration","volume":"24","author":"Lu","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S2213-8587(18)30154-2","article-title":"Non-Alcoholic Fatty Liver Disease: Causes, Diagnosis, Cardiometabolic Consequences, and Treatment Strategies","volume":"7","author":"Stefan","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.3892\/ijmm.2016.2771","article-title":"Effect of Endotoxemia in Mice Genetically Deficient in Cystathionine-\u03b3-Lyase, Cystathionine-\u03b2-Synthase or 3-Mercaptopyruvate Sulfurtransferase","volume":"38","author":"Ahmad","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1089\/ars.2010.3781","article-title":"The Quantitative Significance of the Transsulfuration Enzymes for H 2S Production in Murine Tissues","volume":"15","author":"Kabil","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/SHK.0b013e3182252ee7","article-title":"The Liver as a Central Regulator of Hydrogen Sulfide","volume":"36","author":"Norris","year":"2011","journal-title":"Shock"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.niox.2014.02.006","article-title":"Hydrogen Sulfide and the Liver","volume":"41","author":"Mani","year":"2014","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0168-8278(99)80033-6","article-title":"Mitochondrial Abnormalities in Non-Alcoholic Steatohepatitis","volume":"31","author":"Caldwell","year":"1999","journal-title":"J. Hepatol."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Masarone, M., Rosato, V., Dallio, M., Gravina, A.G., Aglitti, A., Loguercio, C., Federico, A., and Persico, M. (2018). Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease. Oxid. Med. Cell. Longev., 2018.","DOI":"10.1155\/2018\/9547613"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1136\/gutjnl-2017-313778","article-title":"Fatty Acids Promote Fatty Liver Disease via the Dysregulation of 3-Mercaptopyruvate Sulfurtransferase\/hydrogen Sulfide Pathway","volume":"67","author":"Li","year":"2017","journal-title":"Gut"},{"key":"ref_139","first-page":"E925","article-title":"Hydrogen Sulfide Reduces Serum Triglyceride by Activating Liver Autophagy via the AMPK-mTOR Pathway","volume":"309","author":"Sun","year":"2015","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.fct.2011.11.030","article-title":"Garlic Oil Alleviated Ethanol-Induced Fat Accumulation via Modulation of SREBP-1, PPAR-A, and CYP2E1","volume":"50","author":"Zeng","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1002\/hep4.1271","article-title":"Mitochondrial Oxidative Stress and Antioxidants Balance in Fatty Liver Disease","volume":"2","year":"2018","journal-title":"Hepatol. Commun."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2020.02.025","article-title":"Role of Oxidative Stress in the Pathogenesis of Nonalcoholic Fatty Liver Disease","volume":"152","author":"Chen","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1089\/ars.2007.1957","article-title":"Redox Regulation of Cell Survival","volume":"10","author":"Trachootham","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"ref_144","first-page":"e13065","article-title":"The Biologic Effect of Hydrogen Sulfide and Its Function in Various Diseases","volume":"97","author":"Xiao","year":"2018","journal-title":"Medicine (USA)"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/WOX.0b013e3182439613","article-title":"Oxidative Stress and Antioxidant Defense","volume":"5","author":"Birben","year":"2012","journal-title":"World Allergy Organ. J."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ars.2008.2282","article-title":"Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria","volume":"12","author":"Kimura","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/CIRCRESAHA.117.308903","article-title":"Reducing the Global Burden of Cardiovascular Disease, Part 1: The Epidemiology and Risk Factors","volume":"121","author":"Joseph","year":"2017","journal-title":"Circ. Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1016\/j.jacc.2019.10.009","article-title":"The Global Burden of Cardiovascular Diseases and Risk Factors: 2020 and Beyond","volume":"74","author":"Mensah","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1161\/CIRCULATIONAHA.118.033484","article-title":"Epidemic of Cardiovascular Disease in China Current Perspective and Prospects for the Future","volume":"138","author":"Shen","year":"2018","journal-title":"Circulation"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev-pathmechdis-012419-032544","article-title":"Cardiovascular Disease, Aging, and Clonal Hematopoiesis","volume":"15","author":"Evans","year":"2020","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_151","first-page":"927","article-title":"Atherosclerosis: Process, Indicators, Risk Factors and New Hopes","volume":"5","author":"Setorki","year":"2014","journal-title":"Int. J. Prev. Med."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Marchio, P., Guerra-Ojeda, S., Vila, J.M., Aldasoro, M., Victor, V.M., and Mauricio, M.D. (2019). Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation. Oxid. Med. Cell. Longev., 2019.","DOI":"10.1155\/2019\/8563845"},{"key":"ref_153","first-page":"1","article-title":"Atherosclerosis","volume":"5","author":"Libby","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1097\/00004872-200310000-00015","article-title":"The Role of Hydrogen Sulfide Generation in the Pathogenesis of Hypertension in Rats Induced by Inhibition of Nitric Oxide Synthase","volume":"21","author":"Zhong","year":"2003","journal-title":"J. Hypertens."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The Vasorelaxant Effect of H2S as a Novel Endogenous Gaseous KATP Channel Opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Cheng, Y., Ndisang, J.F., Tang, G., Cao, K., and Wang, R. (2004). Hydrogen Sulfide-Induced Relaxation of Resistance Mesenteric Artery Beds of Rats. Am. J. Physiol. Hear. Circ. Physiol., 287.","DOI":"10.1152\/ajpheart.00331.2004"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/CIRCRESAHA.114.300505","article-title":"Emergence of Hydrogen Sulfide as an Endogenous Gaseous Signaling Molecule in Cardiovascular Disease","volume":"114","author":"Polhemus","year":"2014","journal-title":"Circ. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00011-015-0844-7","article-title":"Association of Hydrogen Sulfide with Alterations of Monocyte Chemokine Receptors, CCR2 and CX3CR1 in Patients with Coronary Artery Disease","volume":"64","author":"Gao","year":"2015","journal-title":"Inflamm. Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/MNH.0000000000000206","article-title":"Hydrogen Sulfide in Hypertension","volume":"25","author":"Hillebrands","year":"2016","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.cardfail.2012.04.011","article-title":"Total Plasma Sulfide in Congestive Heart Failure","volume":"18","author":"Glavnik","year":"2012","journal-title":"J. Card. Fail."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Casin, K.M., and Calvert, J.W. (2021). Harnessing the Benefits of Endogenous Hydrogen Sulfide to Reduce Cardiovascular Disease. Antioxidants, 10.","DOI":"10.3390\/antiox10030383"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Scammahorn, J.J., Nguyen, I.T.N., Bos, E.M., van Goor, H., and Joles, J.A. (2021). Fighting Oxidative Stress with Sulfur: Hydrogen Sulfide in the Renal and Cardiovascular Systems. Antioxidants, 10.","DOI":"10.3390\/antiox10030373"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Zhao, S., Li, X., Li, X., Wei, X., and Wang, H. (2021). Hydrogen Sulfide Plays an Important Role in Diabetic Cardiomyopathy. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.627336"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Testai, L., Citi, V., Martelli, A., Brogi, S., and Calderone, V. (2020). Role of Hydrogen Sulfide in Cardiovascular Ageing. Pharmacol. Res., 160.","DOI":"10.1016\/j.phrs.2020.105125"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jare.2020.05.015","article-title":"Role of Hydrogen Sulfide in Endothelial Dysfunction: Pathophysiology and Therapeutic Approaches","volume":"27","author":"Citi","year":"2021","journal-title":"J. Adv. Res."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S0006-291X(03)00256-0","article-title":"The Regulatory Effect of Hydrogen Sulfide on Hypoxic Pulmonary Hypertension in Rats","volume":"302","author":"Zhang","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbrc.2003.11.081","article-title":"The Possible Role of Hydrogen Sulfide on the Pathogenesis of Spontaneous Hypertension in Rats","volume":"313","author":"Yan","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.pharep.2014.04.004","article-title":"Exogenous Hydrogen Sulfide Causes Different Hemodynamic Effects in Normotensive and Hypertensive Rats via Neurogenic Mechanisms","volume":"66","author":"Sikora","year":"2014","journal-title":"Pharmacol. Reports"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.niox.2014.11.013","article-title":"Hydrogen Sulfide Is Involved in Dexamethasone-Induced Hypertension in Rat","volume":"46","author":"Mitidieri","year":"2015","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/cvr\/cvu026","article-title":"Hydrogen Sulfide Accounts for the Peripheral Vascular Effects of Zofenopril Independently of ACE Inhibition","volume":"102","author":"Bucci","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.niox.2015.01.004","article-title":"Down-Regulated CBS\/H2S Pathway Is Involved in High-Salt-Induced Hypertension in Dahl Rats","volume":"46","author":"Huang","year":"2015","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"C537","DOI":"10.1152\/ajpcell.00329.2016","article-title":"Vascular Biology of Hydrogen Sulfide","volume":"312","author":"Kanagy","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/hr.2014.125","article-title":"Hydrogen Sulfide Treatment Reduces Blood Pressure and Oxidative Stress in Angiotensin II-Induced Hypertensive Mice","volume":"38","author":"Hart","year":"2015","journal-title":"Hypertens. Res."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/CIRCULATIONAHA.107.753467","article-title":"Characterization of a Novel, Water-Soluble Hydrogen Sulfide-Releasing Molecule (GYY4137): New Insights into the Biology of Hydrogen Sulfide","volume":"117","author":"Li","year":"2008","journal-title":"Circulation"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1291\/hypres.31.1619","article-title":"Regulatory Effect of Hydrogen Sulfide on Vascular Collagen Content in Spontaneously Hypertensive Rats","volume":"31","author":"Zhao","year":"2008","journal-title":"Hypertens. Res."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Corvino, A., Frecentese, F., Magli, E., Perissutti, E., Santagada, V., Scognamiglio, A., Caliendo, G., Fiorino, F., and Severino, B. (2021). Trends in H2S-Donors Chemistry and Their Effects in Cardiovascular Diseases. Antioxidants, 10.","DOI":"10.3390\/antiox10030429"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/ptr.4796","article-title":"A Review of the Cardiovascular Benefits and Antioxidant Properties of Allicin","volume":"27","author":"Chan","year":"2013","journal-title":"Phyther. Res."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.vph.2013.11.003","article-title":"Pharmacological Characterization of the Vascular Effects of Aryl Isothiocyanates: Is Hydrogen Sulfide the Real Player?","volume":"60","author":"Martelli","year":"2014","journal-title":"Vascul. Pharmacol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1016\/j.bmc.2012.02.028","article-title":"Thioglycine and L-Thiovaline: Biologically Active H 2S-Donors","volume":"20","author":"Zhou","year":"2012","journal-title":"Bioorganic Med. Chem."},{"key":"ref_180","first-page":"1145","article-title":"shu Plasma Hydrogen Sulfide and Homocysteine Levels in Hypertensive Patients with Different Blood Pressure Levels and Complications","volume":"35","author":"Sun","year":"2007","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi [Chin. J. Cardiovasc. Dis.]"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1113\/JP270054","article-title":"Evidence for a Functional Vasodilatatory Role for Hydrogen Sulphide in the Human Cutaneous Microvasculature","volume":"593","author":"Kutz","year":"2015","journal-title":"J. Physiol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cbi.2014.04.006","article-title":"Hydrogen Sulfide in Hemostasis: Friend or Foe?","volume":"217","author":"Olas","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bbrc.2010.04.061","article-title":"Endogenous Hydrogen Sulfide Is Involved in the Pathogenesis of Atherosclerosis","volume":"396","author":"Qiao","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1161\/CIRCULATIONAHA.113.002208","article-title":"Decreased Endogenous Production of Hydrogen Sulfide Accelerates Atherosclerosis","volume":"127","author":"Mani","year":"2013","journal-title":"Circulation"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1161\/CIRCRESAHA.114.302721","article-title":"Mechanisms of Plaque Formation and Rupture","volume":"114","author":"Bentzon","year":"2014","journal-title":"Circ. Res."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Senoner, T., and Dichtl, W. (2019). Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?. Nutrients, 11.","DOI":"10.3390\/nu11092090"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1745-7254.2006.00283.x","article-title":"Hydrogen Sulfide Ameliorates Vascular Calcification Induced by Vitamin D3 plus Nicotine in Rats 1","volume":"27","author":"Wu","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"H711","DOI":"10.1152\/ajpheart.00724.2016","article-title":"Cystathionine \u03b3-Lyase Protects Vascular Endothelium: A Role for Inhibition of Histone Deacetylase 6","volume":"312","author":"Leucker","year":"2017","journal-title":"Am. J. Physiol. Hear. Circ. Physiol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1161\/CIRCULATIONAHA.118.034757","article-title":"Cystathionine \u03b3 Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis","volume":"139","author":"Bibli","year":"2019","journal-title":"Circulation"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1056\/NEJMra1216063","article-title":"Mechanisms of Acute Coronary Syndromes and Their Implications for Therapy","volume":"368","author":"Libby","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s11936-008-0049-2","article-title":"Strategies to Reverse Atherosclerosis: An Imaging Perspective","volume":"10","author":"Thompson","year":"2008","journal-title":"Curr. Treat. Options Cardiovasc. Med."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S1734-1140(11)70414-5","article-title":"Atorvastatin Affects the Tissue Concentration of Hydrogen Sulfide in Mouse Kidneys and Other Organs","volume":"63","author":"Somogyi","year":"2011","journal-title":"Pharmacol. Reports"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.phrs.2010.10.011","article-title":"Differential Effects of Statins on Endogenous H2S Formation in Perivascular Adipose Tissue","volume":"63","author":"Atanasova","year":"2011","journal-title":"Pharmacol. Res."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.phrs.2014.06.006","article-title":"Statins Upregulate Cystathionine \u03b3-Lyase Transcription and H 2S Generation via Activating Akt Signaling in Macrophage","volume":"87","author":"Xu","year":"2014","journal-title":"Pharmacol. Res."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"13135","DOI":"10.1039\/C5CC03927D","article-title":"A Novel Fluorescent Probe for Imaging Endogenous Hydrogen Sulphide via the CSE Enzymatic Pathway","volume":"51","author":"Zhang","year":"2015","journal-title":"Chem. Commun."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"8490","DOI":"10.1021\/jacs.5b03248","article-title":"F\u00f6rster Resonance Energy Transfer Switchable Self-Assembled Micellar Nanoprobe: Ratiometric Fluorescent Trapping of Endogenous H2S Generation via Fluvastatin-Stimulated Upregulation","volume":"137","author":"Zhao","year":"2015","journal-title":"J. Am. Chem. Soc."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/10\/5\/633\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:50:43Z","timestamp":1760161843000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/10\/5\/633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,21]]},"references-count":196,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5]]}},"alternative-id":["antiox10050633"],"URL":"https:\/\/doi.org\/10.3390\/antiox10050633","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,21]]}}}