{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:41:59Z","timestamp":1789926119350,"version":"4.0.1"},"reference-count":140,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Currently, atherosclerosis, which affects the vascular bed of all vital organs and tissues, is considered as a leading cause of death. Most commonly, atherosclerosis involves coronary and peripheral arteries, which results in acute (e.g., myocardial infarction, lower extremities ischemia) or chronic (persistent ischemia leading to severe heart failure) consequences. All of them have a marked unfavorable impact on the quality of life and are associated with increased mortality and morbidity in human populations. Lower extremity artery disease (LEAD, also defined as peripheral artery disease, PAD) refers to atherosclerotic occlusive disease of the lower extremities, where partial or complete obstruction of peripheral arteries is observed. Decreased perfusion can result in ischemic pain, non-healing wounds, and ischemic ulcers, and significantly reduce the quality of life. However, the progressive atherosclerotic changes cause stimulation of tissue response processes, like vessel wall remodeling and neovascularization. These mechanisms of adapting the vascular network to pathological conditions seem to play a key role in reducing the impact of the changes limiting the flow of blood. Neovascularization as a response to ischemia induces sprouting and expansion of the endothelium to repair and grow the vessels of the circulatory system. Neovascularization consists of three different biological processes: vasculogenesis, angiogenesis, and arteriogenesis. Both molecular and environmental factors that may affect the process of development and growth of blood vessels were analyzed. Particular attention was paid to the changes taking place during LEAD. It is important to consider the molecular mechanisms underpinning vessel growth. These mechanisms will also be examined in the context of diseases commonly affecting blood vessel function, or those treatable in part by manipulation of angiogenesis. Furthermore, it may be possible to induce the process of blood vessel development and growth to treat peripheral vascular disease and wound healing. Reactive oxygen species (ROS) play an important role in regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. With regard to the repair processes taking place during diseases such as LEAD, prospective therapeutic methods have been described that could significantly improve the treatment of vessel diseases in the future. Summarizing, regenerative medicine holds the potential to transform the therapeutic methods in heart and vessel diseases treatment.<\/jats:p>","DOI":"10.3390\/antiox10050735","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T10:06:12Z","timestamp":1620381972000},"page":"735","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Molecular Mechanisms Associated with ROS-Dependent Angiogenesis in Lower Extremity Artery Disease"],"prefix":"10.3390","volume":"10","author":[{"given":"Greg","family":"Hutchings","sequence":"first","affiliation":[{"name":"The School of Medicine, Medical Sciences and Nutrition, Aberdeen University, Aberdeen AB25 2ZD, UK"},{"name":"Department of Anatomy, Poznan University of Medical Sciences, 60-781 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5205-5765","authenticated-orcid":false,"given":"\u0141ukasz","family":"Kruszyna","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Angiology and Phlebology, Poznan University of Medical Sciences, 60-848 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3753-755X","authenticated-orcid":false,"given":"Mariusz J.","family":"Nawrocki","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Poznan University of Medical Sciences, 60-781 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8275-3126","authenticated-orcid":false,"given":"Ewa","family":"Strauss","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Angiology and Phlebology, Poznan University of Medical 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Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Jemielity","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, 61-848 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1575-3123","authenticated-orcid":false,"given":"Paul","family":"Mozdziak","sequence":"additional","affiliation":[{"name":"Physiology Graduate Program, North Carolina State University, Raleigh, NC 27695, USA"},{"name":"Prestage Department of Poultry Science, North Carolina State University, Raleigh, NC 27695, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartosz","family":"Kempisty","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Poznan University of Medical Sciences, 60-781 Poznan, Poland"},{"name":"Prestage Department of Poultry Science, North Carolina State University, Raleigh, NC 27695, 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Wound Care"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/74651","article-title":"Mechanisms of angiogenesis and lymphangiogenesis","volume":"6","author":"Carmeliet","year":"2000","journal-title":"Nat. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/mic.10.1.83.97","article-title":"Arteriogenesis: The development and growth of collateral arteries","volume":"10","author":"Helisch","year":"2003","journal-title":"Microcirculation"},{"key":"ref_4","first-page":"15","article-title":"Angiogenesis versus arteriogenesis","volume":"58","author":"Rizzi","year":"2017","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0140-6736(13)61249-0","article-title":"Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: A systematic review and analysis","volume":"382","author":"Fowkes","year":"2013","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.ejvs.2018.01.019","article-title":"Ten Year Mortality in Different Peripheral Arterial Disease Stages: A Population Based Observational Study on Outcome","volume":"55","author":"Sartipy","year":"2018","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/eurheartj\/ehx095","article-title":"2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS)","volume":"39","author":"Aboyans","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/j.jvs.2006.12.037","article-title":"Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)","volume":"45","author":"Norgren","year":"2007","journal-title":"J. Vasc. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1161\/STROKEAHA.108.532218","article-title":"Prevalence of asymptomatic carotid artery stenosis according to age and sex systematic review and metaregression analysis","volume":"40","author":"Greving","year":"2009","journal-title":"Stroke"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1161\/CIRCRESAHA.116.303849","article-title":"Epidemiology of Peripheral Artery Disease","volume":"116","author":"Criqui","year":"2015","journal-title":"Circ. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.2337\/diacare.24.8.1433","article-title":"Peripheral arterial disease in diabetic and nondiabetic patients: A comparison of severity and outcome","volume":"24","author":"Jude","year":"2001","journal-title":"Diabetes Care"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1161\/CIRCULATIONAHA.105.608679","article-title":"Risk factors for progression of peripheral arterial disease in large and small vessels","volume":"113","author":"Aboyans","year":"2006","journal-title":"Circulation"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1053\/j.semvascsurg.2015.01.009","article-title":"Inflammatory biomarkers in peripheral arterial disease","volume":"27","author":"Stone","year":"2014","journal-title":"Semin. Vasc. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Signorelli, S.S., Marino, E., Scuto, S., and Di Raimondo, D. (2020). Pathophysiology of peripheral arterial disease (Pad): A review on oxidative disorders. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124393"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kishimoto, Y., Ibe, S., Saita, E., Sasaki, K., Niki, H., Miura, K., Ikegami, Y., Ohmori, R., Kondo, K., and Momiyama, Y. (2018). Plasma Heme Oxygenase-1 Levels in Patients with Coronary and Peripheral Artery Diseases. Dis. Markers, 2018.","DOI":"10.1155\/2018\/6138124"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.atherosclerosis.2015.12.029","article-title":"Vasoactive enzymes and blood flow responses to passive and active exercise in peripheral arterial disease","volume":"246","author":"Walker","year":"2016","journal-title":"Atherosclerosis"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/j.bbadis.2014.07.008","article-title":"Vascular wall extracellular matrix proteins and vascular diseases","volume":"1842","author":"Xu","year":"2014","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.freeradbiomed.2017.01.025","article-title":"Vascular remodeling: A redox-modulated mechanism of vessel caliber regulation","volume":"109","author":"Tanaka","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.jvs.2017.12.071","article-title":"Assessment of extracellular matrix-related biomarkers in patients with lower extremity artery disease","volume":"68","author":"Nielsen","year":"2018","journal-title":"J. Vasc. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1161\/CIRCRESAHA.114.302721","article-title":"Mechanisms of Plaque Formation and Rupture","volume":"114","author":"Bentzon","year":"2014","journal-title":"Circ. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1161\/01.RES.0000126921.29919.51","article-title":"Proteoglycans in atherosclerosis and restenosis: Key roles for versican","volume":"94","author":"Wight","year":"2004","journal-title":"Circ. Res."},{"key":"ref_22","first-page":"1","article-title":"Atherofibrosis\u2014A unique and common process of the disease pathogenesis of atherosclerosis and fibrosis\u2014Lessons for biomarker development","volume":"5","author":"Vassiliadis","year":"2013","journal-title":"Am. J. Transl. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1161\/01.CIR.0000058700.41738.12","article-title":"Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease","volume":"107","author":"Blankenberg","year":"2003","journal-title":"Circulation"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Yan, H., Chang, Z., and Liu, Z. (2020). The risk factors for calcification vary among the different sections of the lower extremity artery in patients with symptomatic peripheral arterial disease. BMC Cardiovasc. Disord., 20.","DOI":"10.1186\/s12872-020-01615-w"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1161\/ATVBAHA.113.302070","article-title":"Inflammatory, metabolic, and genetic mechanisms of vascular calcification","volume":"34","author":"Demer","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Chistiakov, D.A., Myasoedova, V.A., Melnichenko, A.A., Grechko, A.V., and Orekhov, A.N. (2017). Calcifying Matrix Vesicles and Atherosclerosis. BioMed Res. Int., 2017.","DOI":"10.1155\/2017\/7463590"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1161\/CIRCGENETICS.113.000003","article-title":"Common genetic variants of MGP are associated with calcification on the arterial wall but not with calcification present in the atherosclerotic plaques","volume":"6","author":"Wang","year":"2013","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1093\/eurheartj\/ehu163","article-title":"Medial vascular calcification revisited: Review and perspectives","volume":"35","author":"Lanzer","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1161\/CIRCRESAHA.116.303518","article-title":"The Genetic Basis of Peripheral Arterial Disease: Current Knowledge, Challenges, and Future Directions","volume":"116","author":"Kullo","year":"2015","journal-title":"Circ. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1053\/ejvs.2002.1711","article-title":"The -174 G\/C polymorphism of the interleukin-6 gene promoter is associated with peripheral artery occlusive disease","volume":"24","author":"Flex","year":"2002","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0021-9150(00)00582-7","article-title":"Interaction of the glutathione S-transferase genes and cigarette smoking on risk of lower extremity arterial disease: The Atherosclerosis Risk in Communities (ARIC) study","volume":"154","author":"Li","year":"2001","journal-title":"Atherosclerosis"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.2174\/138161207782794103","article-title":"Nitric Oxide-Dependent Neovascularization Role in the Lower Extremity Disease","volume":"13","author":"Robles","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Vogel, J., Niederer, D., Jung, G., and Troidl, K. (2020). Exercise-Induced Vascular Adaptations under Artificially Versus Pathologically Reduced Blood Flow: A Focus Review with Special Emphasis on Arteriogenesis. Cells, 9.","DOI":"10.3390\/cells9020333"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.yjmcc.2010.03.014","article-title":"Formation and maturation of the native cerebral collateral circulation","volume":"49","author":"Chalothorn","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0925-4773(00)00522-0","article-title":"Postnatal vasculogenesis","volume":"100","author":"Ribatti","year":"2001","journal-title":"Mech. Dev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1161\/CIRCRESAHA.116.302953","article-title":"Molecular controls of arterial morphogenesis","volume":"116","author":"Simons","year":"2015","journal-title":"Circ. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm0603-677","article-title":"Regulation of angiogenesis by hypoxia: Role of the HIF system","volume":"9","author":"Pugh","year":"2003","journal-title":"Nat. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1172\/JCI6870","article-title":"Matrix metalloproteinases in angiogenesis: A moving target for therapeutic intervention","volume":"103","year":"1999","journal-title":"J. Clin. Investig."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1161\/ATVBAHA.114.303929","article-title":"A brief etymology of the collateral circulation","volume":"34","author":"Faber","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Lasch, M., Caballero Martinez, A., Kumaraswami, K., Ishikawa-Ankerhold, H., Meister, S., and Deindl, E. (2020). Contribution of the Potassium Channels KV1.3 and KCa3.1 to Smooth Muscle Cell Proliferation in Growing Collateral Arteries. Cells, 9.","DOI":"10.3390\/cells9040913"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ricard, N., Zhang, J., Zhuang, Z.W., and Simons, M. (2019). Isoform-Specific Roles of ERK1 and ERK2 in Arteriogenesis. Cells, 9.","DOI":"10.3390\/cells9010038"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1161\/CIRCRESAHA.114.302931","article-title":"Congenic fine-mapping identifies a major causal locus for variation in the native collateral circulation and ischemic injury in brain and lower extremity","volume":"114","author":"Sealock","year":"2014","journal-title":"Circ. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/713773592","article-title":"Microvascular remodeling: A complex continuum spanning angiogenesis to arteriogenesis","volume":"10","author":"Peirce","year":"2003","journal-title":"Microcirculation"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/FJC.0b013e3181c9556f","article-title":"Effects of endogenous nitric oxide and of deta nonoate in arteriogenesis","volume":"55","author":"Troidl","year":"2010","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1242\/dev.045351","article-title":"Pulsatile shear and Gja5 modulate arterial identity and remodeling events during flow-driven arteriogenesis","volume":"137","author":"Buschmann","year":"2010","journal-title":"Development"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Tronc, F., Mallat, Z., Lehoux, S., Wassef, M., Esposito, B., and Tedgui, A. (2000). Role of Matrix Metalloproteinases in Blood Flow\u2013Induced Arterial Enlargement. Arterioscler. Thromb. Vasc. Biol., 20.","DOI":"10.1161\/01.ATV.20.12.e120"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1007\/s10439-011-0309-2","article-title":"Fluid flow mechanotransduction in vascular smooth muscle cells and fibroblasts","volume":"39","author":"Shi","year":"2011","journal-title":"Ann. Biomed. Eng."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1152\/physiol.00007.2016","article-title":"Ion channels in endothelial responses to fluid shear stress","volume":"31","author":"Gerhold","year":"2016","journal-title":"Physiology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ejvs.2010.02.014","article-title":"Exercise linked to transient increase in expression and activity of cation channels in newly formed hind-limb collaterals","volume":"40","author":"Sayed","year":"2010","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1111\/j.1582-4934.2008.00579.x","article-title":"Trpv4 induces collateral vessel growth during regeneration of the arterial circulation","volume":"13","author":"Troidl","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.yjmcc.2012.05.011","article-title":"Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells","volume":"53","author":"Pfenniger","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1161\/CIRCRESAHA.110.229955","article-title":"Role of PECAM-1 in arteriogenesis and specification of preexisting collaterals","volume":"107","author":"Chen","year":"2010","journal-title":"Circ. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/nature10507","article-title":"Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis","volume":"479","author":"Takeda","year":"2011","journal-title":"Nature"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.trsl.2009.02.002","article-title":"Dual gene transfer of fibroblast growth factor-2 and platelet derived growth factor-BB using plasmid deoxyribonucleic acid promotes effective angiogenesis and arteriogenesis in a rodent model of hindlimb ischemia","volume":"153","author":"Arruda","year":"2009","journal-title":"Transl. Res."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Troidl, K., Schubert, C., Vlacil, A.K., Chennupati, R., Koch, S., Sch\u00fctt, J., Oberoi, R., Schaper, W., Schmitz-Rixen, T., and Schieffer, B. (2020). The Lipopeptide MALP-2 Promotes Collateral Growth. Cells, 9.","DOI":"10.3390\/cells9040997"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/hh2101.098613","article-title":"Role of ischemia and of hypoxia-inducible genes in arteriogenesis after femoral artery occlusion in the rabbit","volume":"89","author":"Deindl","year":"2001","journal-title":"Circ. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1161\/CIRCRESAHA.113.301340","article-title":"Endothelial cell-dependent regulation of arteriogenesis","volume":"113","author":"Moraes","year":"2013","journal-title":"Circ. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1161\/CIRCULATIONAHA.114.009683","article-title":"PTP1b is a physiologic regulator of vascular endothelial growth factor signaling in endothelial cells","volume":"130","author":"Lanahan","year":"2014","journal-title":"Circulation"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.devcel.2013.03.019","article-title":"The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis","volume":"25","author":"Lanahan","year":"2013","journal-title":"Dev. Cell"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0008-6363(00)00206-6","article-title":"Stimulation of arteriogenesis; a new concept for the treatment of arterial occlusive disease","volume":"49","author":"Piek","year":"2001","journal-title":"Cardiovasc. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"A48","DOI":"10.1016\/j.jvs.2007.02.030","article-title":"The chemokine system in arteriogenesis and hind limb ischemia","volume":"45","author":"Shireman","year":"2007","journal-title":"J. Vasc. Surg."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1161\/CIRCULATIONAHA.105.576702","article-title":"CD8+ T lymphocytes regulate the arteriogenic response to ischemia by infiltrating the site of collateral vessel development and recruiting CD4+ mononuclear cells through the expression of interleukin-16","volume":"113","author":"Stabile","year":"2006","journal-title":"Circulation"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-017-00953-2","article-title":"Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia","volume":"8","author":"Krishnasamy","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mvr.2018.02.008","article-title":"A new role of mast cells in arteriogenesis","volume":"118","author":"Ribatti","year":"2018","journal-title":"Microvasc. Res."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Heil, M., Ziegelhoeffer, T., Pipp, F., Kostin, S., Martin, S., Clauss, M., and Schaper, W. (2002). Blood monocyte concentration is critical for enhancement of collateral artery growth. Am. J. Physiol. Hear. Circ. Physiol., 283.","DOI":"10.1152\/ajpheart.01098.2001"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1084\/jem.20132130","article-title":"Chemokine-coupled \u03b22 integrin-induced macrophage Rac2-myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis","volume":"211","author":"Morrison","year":"2014","journal-title":"J. Exp. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/j.celrep.2016.07.040","article-title":"Perivascular Mast Cells Govern Shear Stress-Induced Arteriogenesis by Orchestrating Leukocyte Function","volume":"16","author":"Chillo","year":"2016","journal-title":"Cell Rep."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Bot, I., van der Velden, D., Bouwman, M., Kr\u00f6ner, M.J., Kuiper, J., Quax, P.H.A., and de Vries, M.R. (2020). Local Mast Cell Activation Promotes Neovascularization. Cells, 9.","DOI":"10.3390\/cells9030701"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1177\/2047487316665231","article-title":"Supervised exercise training in peripheral arterial disease increases vascular shear stress and profunda femoral artery diameter","volume":"24","author":"Dopheide","year":"2017","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1519\/JSC.0b013e3182874721","article-title":"Exercise and blood flow restriction","volume":"27","author":"Pope","year":"2013","journal-title":"J. Strength Cond. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-0029-1239499","article-title":"A mechanistic approach to blood flow occlusion","volume":"31","author":"Loenneke","year":"2010","journal-title":"Int. J. Sports Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1113\/jphysiol.2009.180489","article-title":"Nitric oxide contributes to the augmented vasodilatation during hypoxic exercise","volume":"588","author":"Casey","year":"2010","journal-title":"J. Physiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.critrevonc.2005.12.003","article-title":"Regulation of angiogenesis by hypoxia-inducible factor 1","volume":"59","author":"Hirota","year":"2006","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_74","first-page":"71","article-title":"Hypoxia and Cancer Metastasis","volume":"1136","author":"Hatfield","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.yjmcc.2003.10.002","article-title":"Re-evaluating therapeutic neovascularization","volume":"36","author":"Simons","year":"2004","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Ribatti, D. (2017). Inflammation and angiogenesis. Inflamm. Angiogenes., 1\u2013111.","DOI":"10.1007\/978-3-319-68448-2_1"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1172\/JCI93025","article-title":"CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis","volume":"128","author":"Guo","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1182\/blood-2013-09-512749","article-title":"Oxidative stress in angiogenesis and vascular disease","volume":"123","author":"Kim","year":"2014","journal-title":"Blood"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Cholan, P.M., Cartland, S.P., and Kavurma, M.M. (2017). NADPH oxidases, angiogenesis, and peripheral artery disease. Antioxidants, 6.","DOI":"10.3390\/antiox6030056"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1161\/01.CIR.0000164261.62586.14","article-title":"Role of gp91phox (Nox2)-containing NAD(P)H oxidase in angiogenesis in response to hindlimb ischemia","volume":"111","author":"Tojo","year":"2005","journal-title":"Circulation"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"719","DOI":"10.2353\/ajpath.2006.060042","article-title":"NADPH oxidase-derived overproduction of reactive oxygen species impairs postischemic neovascularization in mice with type 1 diabetes","volume":"169","author":"Ebrahimian","year":"2006","journal-title":"Am. J. Pathol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3892\/etm.2020.9366","article-title":"MicroRNA-210 improves perfusion recovery following hindlimb ischemia via suppressing reactive oxygen species","volume":"20","author":"Zhang","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1159\/000477402","article-title":"Pro-Angiogenesis Therapy and Aging: A Mini-Review","volume":"63","author":"Ambrose","year":"2017","journal-title":"Gerontology"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/ncb3555","article-title":"Dll4 and Notch signalling couples sprouting angiogenesis and artery formation","volume":"19","author":"Pitulescu","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Papetti, M., and Herman, I.M. (2002). Mechanisms of normal and tumor-derived angiogenesis. Am. J. Physiol. Cell Physiol., 282.","DOI":"10.1152\/ajpcell.00389.2001"},{"key":"ref_86","first-page":"409","article-title":"Molecular and cellular mechanisms of taste","volume":"35","author":"Kolesnikov","year":"2018","journal-title":"Biol. Membr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3109\/08977194.2012.703664","article-title":"Impact of VEGF polymorphisms on the severity of peripheral artery disease in diabetic patients","volume":"30","author":"Bleda","year":"2012","journal-title":"Growth Factors"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1161\/01.CIR.0000061911.47710.8A","article-title":"The VIVA trial: Vascular endothelial growth factor in ischemia for vascular angiogenesis","volume":"107","author":"Henry","year":"2003","journal-title":"Circulation"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1159\/000479869","article-title":"VEGF and IGF Delivered from Alginate Hydrogels Promote Stable Perfusion Recovery in Ischemic Hind Limbs of Aged Mice and Young Rabbits","volume":"54","author":"Anderson","year":"2017","journal-title":"J. Vasc. Res."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Pontes-Quero, S., Fern\u00e1ndez-Chac\u00f3n, M., Luo, W., Lunella, F.F., Casquero-Garcia, V., Garcia-Gonzalez, I., Hermoso, A., Rocha, S.F., Bansal, M., and Benedito, R. (2019). High mitogenic stimulation arrests angiogenesis. Nat. Commun., 10.","DOI":"10.1038\/s41467-019-09875-7"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0165-6147(00)01676-X","article-title":"FGF and VEGF function in angiogenesis: Signalling pathways, biological responses and therapeutic inhibition","volume":"22","author":"Cross","year":"2001","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1016\/j.ajpath.2016.08.015","article-title":"Basic Fibroblast Growth Factor Induces Angiogenic Properties of Fibrocytes to Stimulate Vascular Formation during Wound Healing","volume":"186","author":"Nakamichi","year":"2016","journal-title":"Am. J. Pathol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00441-010-1024-2","article-title":"Hormone-like (endocrine) Fgfs: Their evolutionary history and roles in development, metabolism, and disease","volume":"342","author":"Itoh","year":"2010","journal-title":"Cell Tissue Res."},{"key":"ref_94","first-page":"439","article-title":"Significant roles of anti-aging protein klotho and fibroblast growth factor23 in cardiovascular disease","volume":"12","author":"Ding","year":"2015","journal-title":"J. Geriatr. Cardiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/BF03344160","article-title":"Relationship between polymorphisms G395A in promoter and C1818T in exon 4 of the KLOTHO gene with glucose metabolism and cardiovascular risk factors in Korean women","volume":"29","author":"Rhee","year":"2006","journal-title":"J. Endocrinol. Investig."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1536\/ihj.50.23","article-title":"KLOTHO gene polymorphism is associated with coronary artery stenosis but not with coronary calcification in a Korean population","volume":"50","author":"Jo","year":"2009","journal-title":"Int. Heart J."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1161\/hc0802.104407","article-title":"Pharmacological treatment of coronary artery disease with recombinant fibroblast growth factor-2: Double-blind, randomized, controlled clinical trial","volume":"105","author":"Simons","year":"2002","journal-title":"Circulation"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00109-018-1729-3","article-title":"Approaches to therapeutic angiogenesis for ischemic heart disease","volume":"97","author":"Johnson","year":"2019","journal-title":"J. Mol. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/S0140-6736(11)60394-2","article-title":"Effect of fibroblast growth factor NV1FGF on amputation and death: A randomised placebo-controlled trial of gene therapy in critical limb ischaemia","volume":"377","author":"Belch","year":"2011","journal-title":"Lancet"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Sanada, F., Taniyama, Y., Muratsu, J., Otsu, R., Shimizu, H., Rakugi, H., and Morishita, R. (2018). Gene-Therapeutic Strategies Targeting Angiogenesis in Peripheral Artery Disease. Medicines, 5.","DOI":"10.3389\/fcvm.2018.00012"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/wrr.12205","article-title":"Clinical Application of Growth Factors and Cytokines in Wound Healing","volume":"22","author":"Barrientos","year":"2016","journal-title":"Wound Repair Regen."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Gaonac\u2019h-Lovejoy, V., Boscher, C., Delisle, C., and Gratton, J.-P. (2020). Rap1 Is Involved in Angiopoietin-1-Induced Cell-Cell Junction Stabilization and Endothelial Cell Sprouting. Cells, 9.","DOI":"10.3390\/cells9010155"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1126\/science.286.5449.2511","article-title":"Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1","volume":"286","author":"Thurston","year":"1999","journal-title":"Science"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1096\/fj.03-1466com","article-title":"Biological characterization of angiopoietin-3 and angiopoietin-4","volume":"18","author":"Lee","year":"2004","journal-title":"FASEB J."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1093\/nar\/gkw116","article-title":"Distribution of miRNA expression across human tissues","volume":"44","author":"Ludwig","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1182\/blood-2006-01-012369","article-title":"MicroRNAs modulate the angiogenic properties of HUVECs","volume":"108","author":"Poliseno","year":"2006","journal-title":"Blood"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.devcel.2008.07.002","article-title":"The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis","volume":"15","author":"Wang","year":"2008","journal-title":"Dev. Cell"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuroscience.2018.11.041","article-title":"MiRNA-27b Regulates Angiogenesis by Targeting AMPK in Mouse Ischemic Stroke Model","volume":"398","author":"Yuan","year":"2019","journal-title":"Neuroscience"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1093\/cvr\/cvr299","article-title":"MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling","volume":"93","author":"McDonald","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.coph.2018.04.001","article-title":"Peripheral artery disease: A micro-RNA-related condition?","volume":"39","author":"Vogiatzi","year":"2018","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_111","unstructured":"Mussbacher, M., Kral-pointner, J.B., and Salzmann, M. (2019). Fundamentals of Vascular Biology, Springer Nature Switzerland."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1182\/blood-2008-12-196840","article-title":"Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-\u03baB and Prox1","volume":"115","author":"Flister","year":"2010","journal-title":"Blood"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0092-8674(00)81511-1","article-title":"Prox1 function is required for the development of the murine lymphatic system","volume":"98","author":"Wigle","year":"1999","journal-title":"Cell"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"5356","DOI":"10.1091\/mbc.e05-07-0626","article-title":"Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes","volume":"16","author":"Theos","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"ref_115","first-page":"13","article-title":"Arteriogenesis versus angiogenesis in peripheral artery disease","volume":"32","author":"Troidl","year":"2012","journal-title":"Diabetes. Metab. Res. Rev."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ebiom.2017.11.020","article-title":"Midkine Controls Arteriogenesis by Regulating the Bioavailability of Vascular Endothelial Growth Factor A and the Expression of Nitric Oxide Synthase 1 and 3","volume":"27","author":"Lautz","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1161\/CIRCRESAHA.111.258673","article-title":"Novel biological functions of high-density lipoprotein cholesterol","volume":"111","author":"Mineo","year":"2012","journal-title":"Circ. Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1073\/pnas.96.6.2811","article-title":"Angiostatin binds ATP synthase on the surface of human endothelial cells","volume":"96","author":"Moser","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.bbabio.2008.08.003","article-title":"Structural and functional characterization of FoF1-ATP synthase on the extracellular surface of rat hepatocytes","volume":"1777","author":"Mangiullo","year":"2008","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.yexmp.2017.12.006","article-title":"Systematic review of plasma-membrane ecto-ATP synthase: A new player in health and disease","volume":"104","author":"Taurino","year":"2018","journal-title":"Exp. Mol. Pathol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"36992","DOI":"10.1038\/srep36992","article-title":"Effects of endothelial cell proliferation and migration rates in a computational model of sprouting angiogenesis","volume":"6","author":"Norton","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13287-017-0578-2","article-title":"Therapeutic angiogenesis of adipose-derived stem cells for ischemic diseases","volume":"8","author":"Zhao","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Maacha, S., Sidahmed, H., Jacob, S., Gentilcore, G., Calzone, R., Grivel, J.C., and Cugno, C. (2020). Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis. Stem Cells Int., 2020.","DOI":"10.1155\/2020\/4356359"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/sctm.17-0051","article-title":"Mesenchymal stem cells: Time to change the name!","volume":"6","author":"Caplan","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jconrel.2017.08.022","article-title":"Extracellular vesicles from mesenchymal stem cells activates VEGF receptors and accelerates recovery of hindlimb ischemia","volume":"264","author":"Gangadaran","year":"2017","journal-title":"J. Control. Release"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1161\/ATVBAHA.108.178962","article-title":"Cell therapy based on adipose tissue-derived stromal cells promotes physiological and pathological wound healing","volume":"29","author":"Ebrahimian","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jcyt.2013.11.011","article-title":"Phase I trial: The use of autologous cultured adipose-derived stroma\/stem cells to treat patients with non-revascularizable critical limb ischemia","volume":"16","author":"Bura","year":"2014","journal-title":"Cytotherapy"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/ccd.26601","article-title":"The Athena trials: Autologous adipose-derived regenerative cells for refractory chronic myocardial ischemia with left ventricular dysfunction","volume":"89","author":"Henry","year":"2017","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s11626-014-9828-0","article-title":"Static magnetic field enhances synthesis and secretion of membrane-derived microvesicles (MVs) rich in VEGF and BMP-2 in equine adipose-derived stromal cells (EqASCs)\u2014A new approach in veterinary regenerative medicine","volume":"51","author":"Marycz","year":"2015","journal-title":"Vitr. Cell. Dev. Biol. Anim."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"440","DOI":"10.5966\/sctm.2015-0177","article-title":"Adipose-Derived Stem Cells Induce Angiogenesis via Microvesicle Transport of miRNA-31","volume":"5","author":"Kang","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Aung, P.P., Maxwell, H.G., Jepson, R.G., Price, J.F., and Leng, G.C. (2007). Lipid-lowering for peripheral arterial disease of the lower limb. Cochrane Database Syst. Rev., 2007.","DOI":"10.1002\/14651858.CD000123.pub2"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.jacc.2013.09.073","article-title":"Association between statin medications and mortality, major adverse cardiovascular event, and amputation-free survival in patients with critical limb ischemia","volume":"63","author":"Westin","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ejvs.2009.06.002","article-title":"Drug Therapy for Improving Walking Distance in Intermittent Claudication: A Systematic Review and Meta-analysis of Robust Randomised Controlled Studies","volume":"38","author":"Momsen","year":"2009","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Robertson, L., and Andras, A. (2013). Prostanoids for intermittent claudication. Cochrane Database Syst. Rev., 2013.","DOI":"10.1002\/14651858.CD000986.pub3"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1002\/bjs.8895","article-title":"Systematic review of the efficacy of cilostazol, naftidrofuryl oxalate and pentoxifylline for the treatment of intermittent claudication","volume":"99","author":"Stevens","year":"2012","journal-title":"Br. J. Surg."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Moazzami, K., Majdzadeh, R., and Nedjat, S. (2011). Local intramuscular transplantation of autologous mononuclear cells for critical lower limb ischaemia. Cochrane Database of Systematic Reviews, John Wiley & Sons, Ltd.","DOI":"10.1002\/14651858.CD008347.pub2"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.ejvs.2015.08.018","article-title":"Bone Marrow derived Cell Therapy in Critical Limb Ischemia: A Meta-analysis of Randomized Placebo Controlled Trials","volume":"50","author":"Teraa","year":"2015","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.ahj.2007.01.038","article-title":"Results from a phase II multicenter, double-blind placebo-controlled study of Del-1 (VLTS-589) for intermittent claudication in subjects with peripheral arterial disease","volume":"153","author":"Grossman","year":"2007","journal-title":"Am. Heart J."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/mt.2008.33","article-title":"Therapeutic Angiogenesis with Intramuscular NV1FGF Improves Amputation-free Survival in Patients With Critical Limb Ischemia","volume":"16","author":"Nikol","year":"2008","journal-title":"Mol. 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