{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:56:24Z","timestamp":1788533784319,"version":"build-2803163510"},"reference-count":35,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Oceans and Fisheries, Korea","award":["M01201920150306"],"award-info":[{"award-number":["M01201920150306"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The present study evaluated the effects of (\u2013)-loliolide isolated from Sargassum horneri (S. horneri) against oxidative stress and inflammation, and its biological mechanism in interferon (IFN)-\u03b3\/tumor necrosis factor (TNF)-\u03b1-stimulated HaCaT keratinocytes. The results showed that (\u2013)-loliolide improved the cell viability by reducing the production of intracellular reactive oxygen species (ROS) in IFN-\u03b3\/TNF-\u03b1-stimulated HaCaT keratinocytes. In addition, (\u2013)-loliolide effectively decreased the expression of inflammatory cytokines (interleukin (IL)-4 IL-6, IL-13, IFN-\u03b3 and TNF-\u03b1) and chemokines (CCL11 (Eotaxin), macrophage-derived chemokine (MDC), regulated on activation, normal T cell expressed and secreted (RANTES), and thymus and activation-regulated chemokine (TARC)), by downregulating the expression of epidermal-derived initial cytokines (IL-25, IL-33 and thymic stromal lymphopoietin (TSLP)). Furthermore, (\u2013)-loliolide suppressed the activation of mitogen-activated protein kinase (MAPK) and nuclear factor-\u03baB (NF-\u03baB) signaling, whereas it activated nuclear factor erythroid 2-related factor 2 (Nrf2)\/heme oxygenase-1 (HO-1) signaling. Interestingly, the cytoprotective effects of (\u2013)-loliolide against IFN-\u03b3\/TNF-\u03b1 stimulation were significantly blocked upon inhibition of HO-1. Taken together, these results suggest that (\u2013)-loliolide effectively suppressed the oxidative stress and inflammation by activating the Nrf2\/HO-1 signaling in IFN-\u03b3\/TNF-\u03b1-stimulated HaCaT keratinocytes.<\/jats:p>","DOI":"10.3390\/antiox10060856","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T04:30:46Z","timestamp":1622089846000},"page":"856","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["(\u2013)-Loliolide Isolated from Sargassum horneri Suppressed Oxidative Stress and Inflammation by Activating Nrf2\/HO-1 Signaling in IFN-\u03b3\/TNF-\u03b1-Stimulated HaCaT Keratinocytes"],"prefix":"10.3390","volume":"10","author":[{"given":"Eui-Jeong","family":"Han","sequence":"first","affiliation":[{"name":"Research Center for Healthcare and Biomedical Engineering, Chonnam National University, Yeosu 59626, Korea"},{"name":"Department of Food Technology and Nutrition, Chonnam National University, Yeosu 59626, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilekuttige Priyan Shanura","family":"Fernando","sequence":"additional","affiliation":[{"name":"Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu 59626, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"National Marine Biodiversity Institute of Korea, 75, Jangsan-ro 101 gil, Janghang-eup, Seocheon 33662, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Sung","family":"Lee","sequence":"additional","affiliation":[{"name":"National Marine Biodiversity Institute of Korea, 75, Jangsan-ro 101 gil, Janghang-eup, Seocheon 33662, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areum","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Geon","family":"Je","sequence":"additional","affiliation":[{"name":"Department of Marine Life Science, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Jeong","family":"Seo","sequence":"additional","affiliation":[{"name":"Freshwater Biosources Utilization Bureau, Bioresources Industrialization Support Division, Nakdonggang National Institute of Biological Resources (NNIBR), Sangju 37242, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Heun","family":"Jee","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 63243, Korea"},{"name":"Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Jin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Marine Life Science, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Chuncheon Center, Korea Basic Science Institute, Chuncheon 24341, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginnae","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Food Technology and Nutrition, Chonnam National University, Yeosu 59626, Korea"},{"name":"Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu 59626, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.mrgentox.2008.09.013","article-title":"Environmental-induced oxidative stress in neurodegenerative disorders and aging","volume":"674","author":"Miglore","year":"2009","journal-title":"Res. 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