{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:05:27Z","timestamp":1790787927990,"version":"4.1.0"},"reference-count":95,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Previous studies have indicated that curcumin supplementation may be beneficial for cardiometabolic health; however, current evidence regarding the effects of its nanorange formulations, popularly known as \u201cnano-curcumin\u201d, remains unclear. This systematic review and meta-analysis aimed to determine the impact of nano-curcumin supplementation on risk factors for cardiovascular disease. PubMed, Scopus, Embase, and ISI web of science were systematically searched up to May 2021 using relevant keywords. All randomized controlled trials (RCTs) investigating the effects of nano-curcumin supplementation on cardiovascular disease risk factors were included. Meta-analysis was performed using random-effects models, and subgroup analysis was performed to explore variations by dose and baseline risk profiles. According to the results of this study, nano-curcumin supplementation was associated with improvements in the glycemic profile by decreasing fasting blood glucose (FBG) (WMD: \u221218.14 mg\/dL; 95% CI: \u221229.31 to \u22126.97; p = 0.001), insulin (WMD: \u22121.21 mg\/dL; 95% CI: \u22121.43 to \u22121.00; p &lt; 0.001), and HOMA-IR (WMD: \u22120.28 mg\/dL; 95% CI: \u22120.33 to \u22120.23; p &lt; 0.001). Interestingly, nano-curcumin supplementation resulted in increases in high-density lipoprotein (HDL) (WMD: 5.77 mg\/dL; 95% CI: 2.90 to 8.64; p &lt; 0.001). In terms of other lipid profile markers (triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL)), subgroup analyses showed that nano-curcumin supplementation had more favorable effects on lipid profiles in individuals with dyslipidemia at baseline. Nano-curcumin supplementation also showed favorable anti-inflammatory effects by decreasing C-reactive protein (CRP) (WMD: \u22121.29 mg\/L; 95% CI: \u22122.15 to \u22120.44; p = 0.003) and interleukin-6 (IL-6) (WMD: \u22122.78 mg\/dL; 95% CI: \u22123.76 to \u22121.79; p &lt; 0.001). Moreover, our results showed the hypotensive effect of nano-curcumin, evidenced by a decrease in systolic blood pressure (SBP). In conclusion, our meta-analysis suggests that nano-curcumin supplementation may decline cardiovascular disease risk by improving glycemic and lipid profiles, inflammation, and SBP. Future large-scale investigations with longer durations are needed to expand on our findings.<\/jats:p>","DOI":"10.3390\/antiox10071015","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T11:01:38Z","timestamp":1624532498000},"page":"1015","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["The Effects of Nano-Curcumin Supplementation on Risk Factors for Cardiovascular Disease: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials"],"prefix":"10.3390","volume":"10","author":[{"given":"Damoon","family":"Ashtary-Larky","sequence":"first","affiliation":[{"name":"Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 6135715794, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnaz","family":"Rezaei Kelishadi","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan 8174673461, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, University of Isfahan, Isfahan 8174673441, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5990-1984","authenticated-orcid":false,"given":"Seyedeh Parisa","family":"Moosavian","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan 8174673461, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Health and Human Performance, Marymount University, Arlington, VA 22207, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed Hossein","family":"Davoodi","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1416753955, Iran"},{"name":"Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology, Research Institute, Shahid Beheshti University of Medical Sciences, Tehran 1416753955, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pardis","family":"Khalili","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology, Research Institute, Shahid Beheshti University of Medical Sciences, Tehran 1416753955, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1468-6029","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Dutheil","sequence":"additional","affiliation":[{"name":"CNRS, LaPSCo, Physiological and Psychosocial Stress, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, Preventive and Occupational Medicine, WittyFit, Universit\u00e9 Clermont Auvergne, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6572-5809","authenticated-orcid":false,"given":"Katsuhiko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Faculty of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa 359-1192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Asbaghi","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1416753955, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,24]]},"reference":[{"key":"ref_1","unstructured":"Wilkins, E., Wilson, L., Wickramasinghe, K., Bhatnagar, P., Leal, J., Luengo-Fernandez, R., Burns, R., Rayner, M., and Townsend, N. 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