{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:04:08Z","timestamp":1791810248865,"version":"4.3.4"},"reference-count":121,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15\/00052 and PI18\/00252"],"award-info":[{"award-number":["PI15\/00052 and PI18\/00252"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Retinitis pigmentosa (RP) is a group of inherited retinal dystrophies characterized by progressive degeneration of photoreceptor cells. Ocular redox status is altered in RP suggesting oxidative stress could contribute to their progression. In this study, we investigated the effect of a mixture of nutraceuticals with antioxidant properties (NUT) on retinal degeneration in rd10 mice, a model of RP. NUT was orally administered to rd10 mice from postnatal day (PD) 9 to PD18. At PD18 retinal function and morphology were examined by electroretinography (ERG) and histology including TUNEL assay, immunolabeling of microglia, M\u00fcller cells, and poly ADP ribose polymers. Retinal redox status was determined by measuring the activity of antioxidant enzymes and some oxidative stress markers. Gene expression of the cytokines IL-6, TNF\u03b1, and IL-1\u03b2 was assessed by real-time PCR. NUT treatment delayed the loss of photoreceptors in rd10 mice partially preserving their electrical responses to light stimuli. Moreover, it ameliorated redox status and reduced inflammation including microglia activation, upregulation of cytokines, reactive gliosis, and PARP overactivation. NUT ameliorated retinal functionality and morphology at early stages of RP in rd10 mice. This formulation could be useful as a neuroprotective approach for patients with RP in the future.<\/jats:p>","DOI":"10.3390\/antiox10071033","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T22:24:57Z","timestamp":1624832697000},"page":"1033","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Nutraceutical Supplementation Ameliorates Visual Function, Retinal Degeneration, and Redox Status in rd10 Mice"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8180-1229","authenticated-orcid":false,"given":"Lorena","family":"Olivares-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Pathophysiology and Therapies for Vision Disorders, Principe Felipe Research Center (CIPF), Eduardo Primo Y\u00fafera 3, 46012 Valencia, Spain"},{"name":"Joint Research Unit on Rare Diseases CIPF-Health Research Institute Hospital La Fe (IIS-La Fe), 46012 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4242-7112","authenticated-orcid":false,"given":"Sheyla","family":"Velasco","sequence":"additional","affiliation":[{"name":"Pathophysiology and Therapies for Vision Disorders, Principe Felipe Research Center (CIPF), Eduardo Primo Y\u00fafera 3, 46012 Valencia, Spain"},{"name":"Joint Research Unit on Rare Diseases CIPF-Health Research Institute Hospital La Fe (IIS-La Fe), 46012 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Campillo","sequence":"additional","affiliation":[{"name":"Pathophysiology and Therapies for Vision Disorders, Principe Felipe Research Center (CIPF), Eduardo Primo Y\u00fafera 3, 46012 Valencia, Spain"},{"name":"Joint Research Unit on Rare Diseases CIPF-Health Research Institute Hospital La Fe (IIS-La Fe), 46012 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Salom","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Manises Hospital, Av. de la Generalitat Valenciana, 50, 46940 Manises, Spain"},{"name":"CIBER de Enfermedades Raras (CIBERER), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Gonz\u00e1lez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Manises Hospital, Av. de la Generalitat Valenciana, 50, 46940 Manises, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2846-1311","authenticated-orcid":false,"given":"Jos\u00e9 Miguel","family":"Soriano del Castillo","sequence":"additional","affiliation":[{"name":"Food & Health Laboratory, Institute of Materials Science, University of Valencia (UV), Catedr\u00e0tic Jos\u00e9 Beltr\u00e1n Mart\u00ednez, 2, 46980 Valencia, Spain"},{"name":"Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics UV-IIS La Fe, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5875-986X","authenticated-orcid":false,"given":"Regina","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Pathophysiology and Therapies for Vision Disorders, Principe Felipe Research Center (CIPF), Eduardo Primo Y\u00fafera 3, 46012 Valencia, Spain"},{"name":"Joint Research Unit on Rare Diseases CIPF-Health Research Institute Hospital La Fe (IIS-La Fe), 46012 Valencia, Spain"},{"name":"CIBER de Enfermedades Raras (CIBERER), 28029 Madrid, Spain"},{"name":"Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics UV-IIS La Fe, 46026 Valencia, Spain"},{"name":"Department of Physiology, University of Valencia (UV), Avda. Vicente Andr\u00e9s Estell\u00e9s, 50, Burjassot, 46100 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,26]]},"reference":[{"key":"ref_1","first-page":"1295","article-title":"Animal models and different therapies for treatment of retinitis pigmentosa","volume":"24","author":"Rivas","year":"2009","journal-title":"Histol. Histopathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.preteyeres.2017.08.004","article-title":"The mechanism of cone cell death in Retinitis Pigmentosa","volume":"62","author":"Campochiaro","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1113\/expphysiol.1997.sp004024","article-title":"Oxidative stress: Oxidants and antioxidants","volume":"82","author":"Sies","year":"1997","journal-title":"Exp. 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