{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:27:33Z","timestamp":1790782053335,"version":"4.1.0"},"reference-count":171,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Infertility is defined as a couple\u2019s inability to conceive after at least one year of regular unprotected intercourse. This condition has become a global health problem affecting approximately 187 million couples worldwide and about half of the cases are attributable to male factors. Oxidative stress is a common reason for several conditions associated with male infertility. High levels of reactive oxygen species (ROS) impair sperm quality by decreasing motility and increasing the oxidation of DNA, of protein and of lipids. Multi-antioxidant supplementation is considered effective for male fertility parameters due to the synergistic effects of antioxidants. Most of them act by decreasing ROS concentration, thus improving sperm quality. In addition, other natural molecules, myo-inositol (MI) and d-chiro\u2013inositol (DCI), ameliorate sperm quality. In sperm cells, MI is involved in many transduction mechanisms that regulate cytoplasmic calcium levels, capacitation and mitochondrial function. On the other hand, DCI is involved in the downregulation of steroidogenic enzyme aromatase, which produces testosterone. In this review, we analyze the processes involving oxidative stress in male fertility and the mechanisms of action of different molecules.<\/jats:p>","DOI":"10.3390\/antiox10081283","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T05:34:46Z","timestamp":1628832886000},"page":"1283","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Oxidative Stress and Male Fertility: Role of Antioxidants and Inositols"],"prefix":"10.3390","volume":"10","author":[{"given":"Maria Nunzia","family":"De Luca","sequence":"first","affiliation":[{"name":"The Experts Group on Inositol in Basic and Clinical Research (EGOI), 00161 Rome, Italy"},{"name":"System Biology Group Lab, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7522-7483","authenticated-orcid":false,"given":"Marisa","family":"Colone","sequence":"additional","affiliation":[{"name":"National Center for Drug Research and Evaluation, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Gambioli","sequence":"additional","affiliation":[{"name":"The Experts Group on Inositol in Basic and Clinical Research (EGOI), 00161 Rome, Italy"},{"name":"System Biology Group Lab, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0143-2978","authenticated-orcid":false,"given":"Annarita","family":"Stringaro","sequence":"additional","affiliation":[{"name":"National Center for Drug Research and Evaluation, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Unfer","sequence":"additional","affiliation":[{"name":"The Experts Group on Inositol in Basic and Clinical Research (EGOI), 00161 Rome, Italy"},{"name":"System Biology Group Lab, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"key":"ref_1","unstructured":"Comhaire, F.H., and World Health Organization (1987). Towards More Objectivity in Diagnosis and Management of Male Infertility, Blackwell Scientific."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"308","DOI":"10.5534\/wjmh.190068","article-title":"A schematic overview of the current status of male infertility practice","volume":"38","author":"Agarwal","year":"2020","journal-title":"World J. Men\u2019s Health"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0015-0282(16)54855-9","article-title":"Formation of reactive oxygen species in spermatozoa of infertile patients","volume":"57","author":"Iwasaki","year":"1992","journal-title":"Fertil. Steril."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/humupd\/dmn004","article-title":"Oxidative stress and male infertility\u2014A clinical perspective","volume":"14","author":"Tremellen","year":"2008","journal-title":"Hum. Reprod Update"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Wu, P.Y., Scarlata, E., and O\u2019Flaherty, C. (2020). Long-term adverse effects of oxidative stress on rat epididymis and spermatozoa. Antioxidants, 9.","DOI":"10.3390\/antiox9020170"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Ghaleno, L.R., Alizadeh, A., Drevet, J.R., Shahverdi, A., and Valojerdi, M.R. (2021). Oxidation of sperm DNA and male infertility. Antioxidants, 10.","DOI":"10.3390\/antiox10010097"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.aju.2017.12.004","article-title":"Lifestyle causes of male infertility","volume":"16","author":"Durairajanayagam","year":"2018","journal-title":"Arab. J. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2478\/v10034-012-0015-x","article-title":"Genetic causes of male infertility","volume":"15","author":"Noveski","year":"2012","journal-title":"Balk. J. Med. Genet."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Anifandis, G., Katsanaki, K., Lagodonti, G., Messini, C., Simopoulou, M., Dafopoulos, K., and Daponte, A. (2018). The effect of glyphosate on human sperm motility and sperm DNA fragmentation. Int. J. Environ. Res. Public Health, 15.","DOI":"10.3390\/ijerph15061117"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/humupd\/5.5.399","article-title":"Infections in the male gential tract and reactive oxygen species","volume":"5","author":"Ochsendorf","year":"1999","journal-title":"Hum. Reprod. Update"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s43032-020-00261-z","article-title":"SARS-CoV-2 and male infertility: Possible multifaced pathology","volume":"28","author":"Dutta","year":"2021","journal-title":"Reprod. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.4081\/aiua.2021.1.115","article-title":"COVID-19 and male fertility: Taking stock of one year after the outbreak began","volume":"93","author":"Fave","year":"2021","journal-title":"Arch. Ital. Urol. Androl."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Falahieh, F.M., Zarabadipour, M., Mirani, M., Abdiyan, M., Dinparvar, M., Alizadeh, H., Paktinat, S., and Hosseinirad, H. (2021). Effects of moderate COVID-19 infection on semen oxidative status and parameters 14 and 120 days after diagnosis. Reprod. Fertil. Dev.","DOI":"10.1071\/RD21153"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Arafa, M., Agarwal, A., Majzoub, A., Selvam, M.K.P., Baskaran, S., Henkel, R., and ElBardisi, H. (2020). Efficacy of antioxidant supplementation on conventional and advanced sperm function tests in patients with idiopathic male infertility. Antioxidants, 9.","DOI":"10.3390\/antiox9030219"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4650182","DOI":"10.1155\/2017\/4650182","article-title":"Conservative nonhormonal options for the treatment of male infertility: Antibiotics, anti-inflammatory drugs, and antioxidants","volume":"2017","author":"Calogero","year":"2017","journal-title":"BioMed Res. Int."},{"key":"ref_16","first-page":"2704","article-title":"Myo-inositol impact on sperm motility in vagina and evaluation of its effects on foetal development","volume":"24","author":"Oliva","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_17","first-page":"438","article-title":"The use of D-chiro-Inositol in clinical practice","volume":"25","author":"Gambioli","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"O\u2019Flaherty, C. (2020). Reactive oxygen species and male fertility. Antioxidants, 9.","DOI":"10.3390\/antiox9040287"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Martin-Hidalgo, D., Bragado, M.J., Batista, A.R., Oliveira, P.F., and Alves, M.G. (2019). Antioxidants and male fertility: From molecular studies to clinical evidence. Antioxidants, 8.","DOI":"10.3390\/antiox8040089"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e12783","DOI":"10.1111\/and.12783","article-title":"Oxidative stress and motility impairment in the semen of fertile males","volume":"49","author":"Dobrakowski","year":"2017","journal-title":"Andrologia"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1590\/S1677-55382007000500002","article-title":"Clinical relevance of oxidative stress and sperm chromatin damage in male infertility: An evidence based analysis","volume":"33","author":"Cocuzza","year":"2007","journal-title":"Int. Braz. J. Urol."},{"key":"ref_22","first-page":"461","article-title":"Oxidative stress and male infertility: A cross sectional study","volume":"70","author":"Rehman","year":"2020","journal-title":"J. Pakistan Med. Assoc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"60","DOI":"10.5173\/ceju.2013.01.art19","article-title":"The role of oxidative stress and antioxidants in male fertility","volume":"65","author":"Wolski","year":"2013","journal-title":"Central Eur. J. Urol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1095\/biolreprod64.2.674","article-title":"Failure of the expression of phospholipid hydroperoxide glutathione peroxidase in the spermatozoa of human infertile males1","volume":"64","author":"Imai","year":"2001","journal-title":"Biol. Reprod."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e13126","DOI":"10.1111\/and.13126","article-title":"Role of oxidative stress, infection and inflammation in male infertility","volume":"50","author":"Agarwal","year":"2018","journal-title":"Andrologia"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1477-7827-2-12","article-title":"Reactive oxygen species and sperm cells","volume":"2","author":"Sanocka","year":"2004","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/mgme.2000.3027","article-title":"Folic acid: Nutritional biochemistry, molecular biology, and role in disease processes","volume":"71","author":"Lucock","year":"2000","journal-title":"Mol. Genet. Metab."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/and.12067","article-title":"Effect of folic acid and zinc sulphate on endocrine parameters and seminal antioxidant level after varicocelectomy","volume":"46","author":"Azizollahi","year":"2014","journal-title":"Andrologia"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/S0891-5849(01)00543-3","article-title":"Free radical scavenging behavior of folic acid: Evi-dence for possible antioxidant activity","volume":"30","author":"Joshi","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/j100618a017","article-title":"Intermediates produced from the one-electron reduction of nitrogen heterocyclic compounds in solution","volume":"78","author":"Moorthy","year":"1974","journal-title":"J. Phys. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1021\/jo00871a028","article-title":"One-electron redox reactions of water soluble vitamins II. Pterin and folic acid","volume":"41","author":"Moorthy","year":"1976","journal-title":"J. Org. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/0006-291X(67)90309-9","article-title":"Reaction of Cu2+ and Fe3+ with tetrahydropteridines","volume":"28","author":"Vanderschitt","year":"1967","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_33","first-page":"335","article-title":"Free radicals of biological interest as studied by electron spin resonance","volume":"302","author":"Hemmerich","year":"1968","journal-title":"Proc. R. Soc. London. Ser. A Math. Phys. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/oxfordjournals.bmb.a011628","article-title":"p53 and apoptosis","volume":"53","author":"Bellamy","year":"1997","journal-title":"Br. Med. Bull."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0753-3322(01)00095-6","article-title":"Folate deficiency-induced oxidative stress and apoptosis are mediated via homocysteine-dependent overproduction of hydrogen peroxide and enhanced activation of NF-kappaB in human Hep G2 cells","volume":"55","author":"Chern","year":"2001","journal-title":"Biomed. Pharmacother."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0015-0282(16)56225-6","article-title":"Folinic acid in the treatment of human male infertility","volume":"60","author":"Bentivoglio","year":"1993","journal-title":"Fertil. Steril."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1210\/jcem.83.9.5121","article-title":"Serum inhibin B as a marker of spermatogenesis","volume":"83","author":"Pierik","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1053\/beem.2000.0086","article-title":"Inhibin B in the assessment of seminiferous tubular function","volume":"14","author":"Andersson","year":"2000","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1046\/j.1365-2605.2000.00229.x","article-title":"Regulation of inhibin production in the human male and its clinical applications","volume":"23","author":"Anderson","year":"2000","journal-title":"Int. J. Androl."},{"key":"ref_40","first-page":"4069","article-title":"The effect of folate and folate plus zinc supplementation on endocrine parameters and sperm characteristics in sub-fertile men: A systematic review and meta-analysis","volume":"14","author":"Irani","year":"2017","journal-title":"Urol. J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/humupd\/2.2.87","article-title":"Role of free L-carnitine and acetyl-L-carnitine in post-gonadal maturation of mammalian spermatozoa","volume":"2","author":"Jeulin","year":"1996","journal-title":"Hum. Reprod. Update"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev.pa.27.040187.001353","article-title":"Bressler, R. The pharmacology of carnitine","volume":"27","author":"Bahl","year":"1987","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev.nutr.18.1.179","article-title":"Generic disorders of carnitine metabolism and their nutritional management","volume":"18","author":"Kerner","year":"1998","journal-title":"Annu. Rev. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/iub.1646","article-title":"Signifi-cance of l-carnitine for human health","volume":"69","year":"2017","journal-title":"IUBMB Life"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/andr.12426","article-title":"Carnitine partially improves oxidative stress, acrosome integrity, and reproductive competence in doxorubicin-treated rats","volume":"6","author":"Cabral","year":"2018","journal-title":"Andrology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"155","DOI":"10.5653\/cerm.2019.03440","article-title":"Effect of L-carnitine on the expression of the apoptotic genes Bcl-2 and Bax","volume":"47","author":"Vardiyan","year":"2020","journal-title":"Clin. Exp. Reprod. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1093\/humrep\/16.11.2338","article-title":"Effects of treatment with carnitines in infertile patients with pros-tato-vesiculo-epididymitis","volume":"16","author":"Vicari","year":"2001","journal-title":"Hum. Reprod."},{"key":"ref_48","first-page":"15","article-title":"Antioxidant therapeutic effi-ciency after the use of carnitine in infertile patients with bacterial or non bacterial prostato-vesiculo-epididymitis","volume":"73","author":"Vicari","year":"2001","journal-title":"Arch. Ital. Urol Androl."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0015-0282(02)04350-9","article-title":"Antioxidant treatment with carnitines is effective in infertile patients with prostatovesiculoepididymitis and elevated seminal leukocyte concentrations after treatment with nonsteroidal anti-inflammatory compounds","volume":"78","author":"Vicari","year":"2002","journal-title":"Fertil. Steril."},{"key":"ref_50","first-page":"817","article-title":"Combination effect of Pentoxifylline and L-carnitine on idiopathic oligoasthenoteratozoospermia","volume":"12","author":"Mehni","year":"2014","journal-title":"Iran. J. Reprod. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0015-0282(02)04679-4","article-title":"Use of carnitine therapy in selected cases of male factor infertility: A double-blind crossover trial","volume":"79","author":"Lenzi","year":"2003","journal-title":"Fertil. Steril."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.fertnstert.2003.10.034","article-title":"A placebo controlled double-blind randomized trial of the use of combined l-carnitine and l-acetylcarnitine treatment in men with asthenozoospermia","volume":"81","author":"Lenzi","year":"2004","journal-title":"Fertil. Steril."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.fertnstert.2005.03.064","article-title":"Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and Lacetylcarnitine in men with idiopathic asthenozoospermia","volume":"84","author":"Balercia","year":"2005","journal-title":"Fertil. Steril."},{"key":"ref_54","first-page":"331","article-title":"Effects of L-carnitine on infertile men\u2019s spermogram; a randomised clinical trial","volume":"10","author":"Peivandi","year":"2010","journal-title":"J. Reprod. Infertil."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1439-0272.1994.tb00780.x","article-title":"Lcarnitine in idiopathic asthenozoospermia: A multi-center study. Italian study group on carnitine and male infertility","volume":"26","author":"Costa","year":"1994","journal-title":"Andrologia"},{"key":"ref_56","first-page":"221","article-title":"Effect of acetylcarnitine treatment in oligoasthenospermic patients","volume":"23","author":"Moncada","year":"1992","journal-title":"Acta Eur. Fertil."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.fertnstert.2004.10.010","article-title":"Oral carnitine supplementation in-creases sperm motility in asthenozoospermic men with normal sperm phospholipid hydroperoxide glutathione peroxidase levels","volume":"83","author":"Garolla","year":"2005","journal-title":"Fertil. Steril."},{"key":"ref_58","first-page":"383","article-title":"Effect of L-carnitine and\/or L-acetyl-carnitine in nutrition treatment for male infertility: A systematic review","volume":"16","author":"Zhou","year":"2007","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0015-0282(16)37384-8","article-title":"Effect of arginine on oligospermia","volume":"21","author":"Miroueh","year":"1970","journal-title":"Fertil. Steril."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Ong, A.S.H., and Packer, L. (1992). Lipid Soluble Antioxidants: Biochemistry and Clinical Applications, Birkhauser Verlag.","DOI":"10.1007\/978-3-0348-7432-8"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/333664a0","article-title":"Vascular endothelial cells synthesize nitric oxide from L-arginine","volume":"333","author":"Palmer","year":"1988","journal-title":"Nature"},{"key":"ref_62","first-page":"109","article-title":"Nitric oxide: Physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/j.1939-4640.1995.tb00558.x","article-title":"Low levels of nitric oxide promote human sperm capacitation in vitro","volume":"16","author":"Zini","year":"1995","journal-title":"J. Androl."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1242\/jcs.108.5.2017","article-title":"Redox regulation of tyrosine phosphorylation in human spermatozoa and its role in the control of human sperm function","volume":"108","author":"Aitken","year":"1995","journal-title":"J. Cell Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1095\/biolreprod.105.046896","article-title":"Mechanism of action of L-arginine on the vitality of spermatozoa is primarily through increased biosynthesis of nitric oxide","volume":"74","author":"Srivastava","year":"2006","journal-title":"Biol. Reprod."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1095\/biolreprod13.2.154","article-title":"L-arginine stimulation of human sperm motility in vitro","volume":"13","author":"Keller","year":"1975","journal-title":"Biol. Reprod."},{"key":"ref_67","first-page":"127","article-title":"Protective effect of L-arginine against lipid peroxidation in goat epi-didymal spermatozoa","volume":"32","author":"Srivastava","year":"2000","journal-title":"Physiol. Chem. Phys. Med. NMR"},{"key":"ref_68","first-page":"251","article-title":"Arginine and male infertility","volume":"46","author":"Scibona","year":"1994","journal-title":"Minerva Urol. Nefrol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/BF02551320","article-title":"The role of arginine indomethacin and kallikrein in the treatment of oligospermia","volume":"27","author":"Aydin","year":"1995","journal-title":"Int. Urol. Nephrol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/ptr.2592","article-title":"Improvement of seminal parameters with Prelox\u00ae: A randomized, double-blind, placebo-controlled, cross-over trial","volume":"23","author":"Stanislavov","year":"2009","journal-title":"Phytother. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1517\/14728220802517901","article-title":"N-acetylcysteine for antioxidant therapy: Pharmacology and clinical utility","volume":"8","author":"Dodd","year":"2008","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_72","first-page":"783","article-title":"In vitro comparative assessment of the antioxidant activity of nacystelyn against three reactive oxygen species","volume":"46","author":"Vanderbist","year":"1996","journal-title":"Arzneimittelforschung"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0014-5793(97)00922-8","article-title":"Peroxynitrite-induced hemolysis of human erythrocytes and its inhibition by antioxidants","volume":"413","author":"Kondo","year":"1997","journal-title":"FEBS Lett."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3164\/jcbn.13-53","article-title":"Scavenging rate constants of hydrophilic antioxidants against multiple reactive oxygen species","volume":"54","author":"Sueishi","year":"2014","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1080\/10715760801998638","article-title":"Antioxidant and free radical scavenging properties of N-acetylcysteine amide (NACA) and comparison with N-acetylcysteine (NAC)","volume":"42","author":"Ates","year":"2008","journal-title":"Free Radic. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/10715760290019354","article-title":"Antioxidant and pro-oxidant effect of the thiolic com-pounds N-acetyl-L-cysteine and glutathione against free radical-induced lipid peroxidation","volume":"36","author":"Sagrista","year":"2002","journal-title":"Free Radic. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1515\/CCLM.2002.002","article-title":"Growing significance of myeloperoxidase in non-infectious diseases","volume":"40","author":"Hoy","year":"2002","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1016\/j.bbagen.2012.09.018","article-title":"Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes","volume":"1830","author":"Deponte","year":"2013","journal-title":"Biochim. Biophys. Acta BBA Gen. Subj."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1089\/ars.2012.4973","article-title":"Kinetics and mechanisms of thiol\u2013disulfide exchange covering direct substitution and thiol oxidation-mediated pathways","volume":"18","author":"Nagy","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1080\/10715762.2018.1468564","article-title":"N-Acetylcysteine as an antioxidant and disulphide breaking agent: The reasons why","volume":"52","author":"Aldini","year":"2018","journal-title":"Free Radic. Res."},{"key":"ref_81","first-page":"249","article-title":"Histopathological effects of titanium dioxide nanoparticles and the possible protective role of n-acetylcysteine on the testes of male albino rats","volume":"12","author":"Elnagar","year":"2018","journal-title":"Int. J. Fertil. Steril."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"4257498","DOI":"10.1155\/2016\/4257498","article-title":"The coadministration of n-acetylcysteine ameliorates the effects of arsenic trioxide on the male mouse genital system","volume":"2016","author":"Missassi","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_83","first-page":"51","article-title":"Protective effect of n-acetyl cysteine on chlorpyrifos-induced testicular toxicity in mice","volume":"13","author":"Kheradmandi","year":"2019","journal-title":"Int. J. Fertil. Steril."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Sarafian, T.A., Montes, C., Imura, T., Qi, J., Coppola, G., Geschwind, D.H., and Sofroniew, M.V. (2010). Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0009532"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.bone.2011.04.020","article-title":"Osteo-blast\/osteocyte-specific inactivation of STAT3 decreases load-driven bone formation and accumulates reactive oxygen species","volume":"49","author":"Zhou","year":"2011","journal-title":"Bone"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/andr.12123","article-title":"The immobilization of human spermatozoa by STAT3 inhibitory compound V results from an excessive intracellular amount of reactive oxygen species","volume":"4","author":"Lachance","year":"2015","journal-title":"Andrology"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12958-019-0468-9","article-title":"Effects of N-acetyl-cysteine supplementation on sperm quality, chromatin integrity and level of oxidative stress in infertile men","volume":"17","author":"Jannatifar","year":"2019","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_88","first-page":"120","article-title":"A pre-liminary study: N-acetyl-L-cysteine improves semen quality following varicocelectomy","volume":"10","author":"Barekat","year":"2016","journal-title":"Int. J. Fertil. Steril."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.juro.2008.10.015","article-title":"Efficacy of selenium and\/or N-acetyl-cysteine for improving semen parameters in infertile men: A double-blind, placebo controlled, randomized study","volume":"181","author":"Safarinejad","year":"2009","journal-title":"J. Urol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.urology.2009.02.034","article-title":"Effects of N-acetylcysteine on semen parameters and oxidative\/antioxidant status","volume":"74","author":"Ciftci","year":"2009","journal-title":"Urology"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Wolfram, T., Schwarz, M., Reu\u00df, M., Lossow, K., Ost, M., Klaus, S., Schwerdtle, T., and Kipp, A.P. (2020). N-acetylcysteine as modulator of the essential trace elements copper and zinc. Antioxidants, 9.","DOI":"10.3390\/antiox9111117"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0024-3205(99)00410-5","article-title":"Biological effects of resveratrol","volume":"66","year":"2000","journal-title":"Life Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrd2060","article-title":"Therapeutic potential of resveratrol: The in vivo evidence","volume":"5","author":"Baur","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1161\/CIRCULATIONAHA.108.787440","article-title":"Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1","volume":"119","author":"Dolinsky","year":"2009","journal-title":"Circulation"},{"key":"ref_95","first-page":"111","article-title":"Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4)","volume":"60","author":"Spanier","year":"2009","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"8375","DOI":"10.1074\/jbc.M109.090266","article-title":"Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure","volume":"285","author":"Tanno","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1152\/ajpheart.01258.2006","article-title":"Resveratrol increases vascular oxidative stress resistance","volume":"292","author":"Ungvari","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3390\/nu6020489","article-title":"Protective effect of resveratrol on biomarkers of oxidative stress induced by iron\/ascorbate in mouse spermatozoa","volume":"6","year":"2014","journal-title":"Nutrients"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/mrd.22478","article-title":"Resveratrol attenuates inflammation and oxidative stress in epididymal white adipose tissue: Implications for its involvement in improving steroidogenesis in diet-induced obese mice","volume":"82","author":"Lv","year":"2015","journal-title":"Mol. Reprod. Dev."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Albuquerque, R.V., Malcher, N.S., Amado, L.L., Coleman, M.D., Dos Santos, D.C., and Borges, R.S. (2015). In vitro protective effect and antioxidant mechanism of resveratrol induced by Dapsone hydroxylamine in human cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0134768"},{"key":"ref_101","first-page":"87","article-title":"Effects of resveratrol on the rat brain respiratory chain","volume":"25","author":"Zini","year":"1999","journal-title":"Drugs Exp. Clin. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.atherosclerosis.2009.05.017","article-title":"A new insight into resveratrol as an atheroprotective compound: Inhibition of lipid peroxidation and enhancement of cholesterol efflux","volume":"207","author":"Berrougui","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/10408690390826509","article-title":"The study of phenolic compounds as natural antioxidants in wine","volume":"43","year":"2003","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.cell.2012.01.017","article-title":"Resveratrol ameliorates aging-related metabolicphenotypes by inhibiting cAMP phosphodiesterases","volume":"148","author":"Park","year":"2012","journal-title":"Cell"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1095\/biolreprod.102.012716","article-title":"Endogenous redox activity in mouse spermatozoa and its role in regulating the tyrosine phosphorylation events associated with sperm capacitation1","volume":"69","author":"Ecroyd","year":"2003","journal-title":"Biol. Reprod."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/andr.12306","article-title":"Protective features of resveratrol on human spermatozoa cryopreservation may be mediated through 5\u2032 AMP-activated protein kinase activation","volume":"5","author":"Nashtaei","year":"2017","journal-title":"Andrology"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1016\/j.fertnstert.2010.01.058","article-title":"Effects of resveratrol supplementation on cryopreservation medium of human semen","volume":"94","author":"Garcez","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.fct.2018.04.026","article-title":"Alleviative effect of resveratrol on polyvinyl chloride-induced reproductive toxicity in male Wistar rats","volume":"116","author":"Archana","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2016.05.004","article-title":"Chronic acrylamide exposure in male mice induces DNA damage to spermatozoa; potential for amelioration by resveratrol","volume":"63","author":"Katen","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.etp.2016.07.001","article-title":"Resveratrol prevents oxidative damage and loss of sperm motility induced by long-term treatment with valproic acid in Wistar rats","volume":"68","author":"Ourique","year":"2016","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/andr.12891","article-title":"Resveratrol improves sperm DNA quality and reproductive capacity in type 1 diabetes","volume":"9","author":"Simas","year":"2021","journal-title":"Andrology"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/0-387-27600-9_1","article-title":"Structure and nomenclature of inositol phosphates, phosphoinositides, and glycosylphosphatidylinositols","volume":"39","author":"Murthy","year":"2006","journal-title":"Subcell. Biochem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/febs.12575","article-title":"The enzymes of human diphosphoinositol polyphosphate metabolism","volume":"281","author":"Thomas","year":"2013","journal-title":"FEBS J."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/hlca.19420250410","article-title":"Recherches dans la serie des cyclites VI. Sut la configuration de la meso-inosite, de la scyllite et d\u2019un inosose obtenu par voie biochimique (scyllo-ms-inosose)","volume":"25","author":"Posternak","year":"1942","journal-title":"Helv. Chim. Acta"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1093\/ajcn\/33.9.1954","article-title":"Myo-inositol content of common foods: Development of a high myo-inositol diet","volume":"33","author":"Clements","year":"1980","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1158\/1055-9965.EPI-06-0128","article-title":"A phase i study of myo-inositol for lung cancer chemoprevention","volume":"15","author":"Lam","year":"2006","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Reddy, N.R., and Sathe, S.K. (2002). Food Phytates, CRC Press.","DOI":"10.1201\/9781420014419"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/biof.5520150105","article-title":"Absorption and excretion of orally ad-ministrered inositol hexaphosphate (IP (6) or phyteta) in humans","volume":"15","author":"Grases","year":"2001","journal-title":"Biofactors"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/andr.12718","article-title":"Myo-inositol in health and disease: Its impact on semen parameters and male fertility","volume":"8","year":"2020","journal-title":"Andrology"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1095\/biolreprod.103.022731","article-title":"Characterization of the expression and regulation of genes necessary for myo-inositol biosynthesis and transport in the seminiferous epithelium","volume":"70","author":"Chauvin","year":"2004","journal-title":"Biol. Reprod."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.2174\/1567201815666180509102641","article-title":"Alpha-lactalbumin effect on myo-inositol intestinal absorption: In vivo and in vitro","volume":"15","author":"Monastra","year":"2018","journal-title":"Curr. Drug Deliv."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"6297","DOI":"10.1016\/S0021-9258(18)42695-6","article-title":"Cloning of the cDNa for a Na+\/myo-inositol cotransporter, a hypertonicity stress protein","volume":"267","author":"Kwon","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3389\/fendo.2019.00305","article-title":"Molecular mechanisms of action of FSH","volume":"10","author":"Casarini","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/molehr\/7.10.923","article-title":"Co-localization of inositol triphosphate receptor and calreticulin in the equatorial segment and in membrabe bounded vesicles in the cutoplasmatic droplet of huma spermatozoa","volume":"7","author":"Wolkowicz","year":"2001","journal-title":"Mol. Hum. Reprod."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1439-0272.2010.01117.x","article-title":"Influence of mitochondrial membrane potential of spermatozoa on in vitro fertilisation outcome","volume":"44","author":"Marchetti","year":"2012","journal-title":"Andrologia"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.urology.2012.03.005","article-title":"Myoinositol: Does it improve sperm mitochondrial function and sperm motility?","volume":"79","author":"Condorelli","year":"2012","journal-title":"Urology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0070-2153(08)60562-1","article-title":"1 Sperm-egg recognition mechanisms in mammals","volume":"30","author":"Wassarman","year":"1995","journal-title":"Curr. Top. Dev. Biol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1093\/oxfordjournals.humrep.a137020","article-title":"Appropriate timing of the acrosome reaction is a major requirement for the fertilizing spermatozoa","volume":"4","author":"Tesarik","year":"1989","journal-title":"Hum. Reprod."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Condorelli, R.A., Barbagallo, F., Calogero, A.E., Cannarella, R., Crafa, A., and La Vignera, S. (2020). D-chiro-inositol improves sperm mitochondrial membrane potential: In vitro evidence. J. Clin. Med., 9.","DOI":"10.3390\/jcm9051373"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1476-5381.2009.00570.x","article-title":"Rimonabant (SR141716) induces metabolism and acquisition of fertilizing ability in human sperm","volume":"159","author":"Aquila","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1093\/humrep\/dem243","article-title":"Human sperm express a functional androgen receptor: Effects on PI3K\/AKT pathway","volume":"22","author":"Aquila","year":"2007","journal-title":"Hum. Reprod."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1242\/dev.121.4.1129","article-title":"Capacitation in mouse spermatozoa I. Correlation between the capacitation state and protein phosphorylation","volume":"121","author":"Visconti","year":"1995","journal-title":"Development"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1530\/REP-13-0542","article-title":"Human sperm anatomy and endocrinology in varicocele: Role of androgen receptor","volume":"147","author":"Guido","year":"2014","journal-title":"Reproduction"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/joa.12352","article-title":"Human sperm liver receptor homolog-1 (LRH-1) acts as a downstream target of the estrogen signaling pathway","volume":"227","author":"Montanaro","year":"2015","journal-title":"J. Anat."},{"key":"ref_135","first-page":"485","article-title":"Proliferation of sertoli cells in fetal and postnatal rats: A quantitative autoradiographic study","volume":"203","author":"Orth","year":"1982","journal-title":"Anat. Rec. Adv. Integr. Anat. Evol. Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1006\/scdb.1998.0203","article-title":"The central role of Sertoli cells in spermatogenesis","volume":"9","author":"Griswold","year":"1998","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/oxfordjournals.bmb.a071568","article-title":"Endocrinology of male infertility","volume":"35","year":"1979","journal-title":"Br. Med. Bull."},{"key":"ref_138","first-page":"286","article-title":"Inhibition of protein kinase C by staurosporine increases estrogen secretion by rat Sertoli cells","volume":"125","author":"Lambert","year":"1991","journal-title":"Acta Endocrinol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/BF02549588","article-title":"Gonadotropins, testosterone and prolactin in men with abnormal semen findings and an evaluation of the hormone profile","volume":"21","author":"Abramsson","year":"1989","journal-title":"Int. Urol. Nephrol."},{"key":"ref_140","first-page":"1321","article-title":"Inhibin-B: A likely candidate for the physiologically important form of inhibin in men","volume":"81","author":"Illingworth","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_141","first-page":"57","article-title":"A serum marker of spermatogenesis\u2013inhibin B","volume":"8","author":"Hu","year":"2002","journal-title":"Zhonghua Nan Ke Xue"},{"key":"ref_142","first-page":"891","article-title":"Inositol activity in oligoasthenoteratospermia--an in vitro study","volume":"14","author":"Colone","year":"2010","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_143","first-page":"129","article-title":"Effects of myoinositol on sperm mitochondrial function in-vitro","volume":"15","author":"Condorelli","year":"2011","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0015-0282(98)00146-0","article-title":"In vitro fertilization and pregnancy rates: The influence of sperm motility and morphology on IVF outcome","volume":"70","author":"Donnelly","year":"1998","journal-title":"Fertil. Steril."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1023\/A:1009420432234","article-title":"Relationships between sperm motility characteristics assessed by the computer-aided sperm analysis (CASA) and fertilization rates in vitro","volume":"18","author":"Hirano","year":"2001","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/humrep\/17.5.1257","article-title":"Study of mitochondrial membrane potential, reactive oxygen species, DNA fragmentation and cell viability by fow cytometry in human sperm","volume":"17","author":"Marchetti","year":"2002","journal-title":"Hum. Reprod."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s10815-014-0401-2","article-title":"Improving fertilization rate in ICSI cycles by adding myoinositol to the semen preparation procedures: A prospective, bicentric, randomized trial on sibling oocytes","volume":"32","author":"Rubino","year":"2015","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/09513590.2016.1254179","article-title":"In vitro effect of myo-inositol on sperm motility in normal and oligoasthenospermia patients undergoing in vitro fertilization","volume":"33","author":"Artini","year":"2016","journal-title":"Gynecol. Endocrinol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4081\/aiua.2016.4.279","article-title":"Analysis of MYO-Inositol effect on spermatozoa motility, in hyper viscous ejaculates and in patients with grades II and III varicocele","volume":"88","author":"Scarselli","year":"2016","journal-title":"Arch. Ital. Urol. Androl."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2839041","DOI":"10.1155\/2016\/2839041","article-title":"In vitroantioxidant treatment of semen samples in assisted reproductive technology: Effects of myo-inositol on nemaspermic parameters","volume":"2016","author":"Palmieri","year":"2016","journal-title":"Int. J. Endocrinol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s10561-018-9731-0","article-title":"Supplementation of sperm freezing medium with myoinositol improve human sperm parameters and protects it against DNA fragmentation and apoptosis","volume":"20","author":"Mohammadi","year":"2019","journal-title":"Cell Tissue Bank."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"177","DOI":"10.5653\/cerm.2018.45.4.177","article-title":"Increased cryo-survival rate in ejaculated human sperm from infertile men following pre-freeze in vitro myo-inositol supplementation","volume":"45","author":"Saleh","year":"2018","journal-title":"Clin. Exp. Reprod. Med."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Governini, L., Ponchia, R., Artini, P.G., Casarosa, E., Marzi, I., Capaldo, A., Luddi, A., and Piomboni, P. (2020). Respiratory mitochondrial efficiency and DNA oxidation in human sperm after in vitro myo-inositol treatment. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061638"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/andr.12025","article-title":"Myoinositol improves sperm parameters and serum reproductive hormones in patients with idiopathic infertility: A prospective double-blind randomized placebo-controlled study","volume":"3","author":"Calogero","year":"2015","journal-title":"Andrology"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3109\/09513590.2015.1080680","article-title":"Effect of treatment with myo-inositol on semen parameters of patients undergoing an IVF cycle: In vivo study","volume":"32","author":"Gulino","year":"2016","journal-title":"Gynecol. Endocrinol."},{"key":"ref_156","first-page":"1674950","article-title":"Effect of myoinositol and antioxidants on sperm quality in men with metabolic syndrome","volume":"2016","author":"Oliva","year":"2016","journal-title":"Int. J. Endocrinol."},{"key":"ref_157","first-page":"62","article-title":"Efficacy of myo-inositol in the clinical management of patients with asthenozoospermia","volume":"21","author":"Dinkova","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.tem.2020.04.003","article-title":"Breakthroughs in the use of inositols for assisted reproductive treatment (ART)","volume":"31","author":"Facchinetti","year":"2020","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.tem.2020.02.002","article-title":"Inositols in polycystic ovary syndrome: An overview on the advances","volume":"31","author":"Facchinetti","year":"2020","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1177\/1933719113518985","article-title":"Hyperinsulinemia alters myoinositol to d-chiroinositol ratio in the follicular fluid of patients with PCOS","volume":"21","author":"Unfer","year":"2014","journal-title":"Reprod. Sci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1507\/endocrj.EJ13-0423","article-title":"Decreased myo-inositol to chiro-inositol (M\/C) ratios and increased M\/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls","volume":"61","author":"Heimark","year":"2014","journal-title":"Endocr. J."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3109\/09513590.2015.1006616","article-title":"Results from the international consensus conference on myo-inositol and d-chiroinositol in obstetrics and gynecology\u2013assisted reproduction technology","volume":"31","author":"Bevilacqua","year":"2015","journal-title":"Gynecol. Endocrinol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1210\/endo.132.2.8425485","article-title":"Chiroinositol deficiency and insulin resistance. III. Acute glycogenic and hypoglycemic effects of two inositol phosphoglycan insulin mediators in normal and streptozotocin-diabetic rats in vivo","volume":"132","author":"Huang","year":"1993","journal-title":"Endocrinology"},{"key":"ref_164","first-page":"47","article-title":"D-chiro-inositol\u2014Its functional role in insulin action and its deficit in insulin resistance","volume":"3","author":"Larner","year":"2002","journal-title":"Int. J. Exp. Diabetes Res."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12958-016-0189-2","article-title":"Modulation of gonadotrophin induced steroidogenic enzymes in granulosa cells by d-chiroinositol","volume":"14","author":"Sacchi","year":"2016","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.steroids.2011.10.013","article-title":"Tissue physiology and pathology of aromatase","volume":"77","author":"Stocco","year":"2012","journal-title":"Steroids"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/17425255.2020.1785429","article-title":"New clinical targets of d-chiro-inositol: Rationale and potential applications","volume":"16","author":"Garzon","year":"2020","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1017\/S0967199414000781","article-title":"Treatment of aromatase (CYP19A1) inhibitor reduces fertility in porcine sperm","volume":"24","author":"Oh","year":"2015","journal-title":"Zygote"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1111\/jsm.12944","article-title":"A randomized prospective double-blind comparison trial of clomiphene citrate and anastrozole in raising testosterone in hypogonadal infertile men","volume":"12","author":"Helo","year":"2015","journal-title":"J. Sex. Med."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/j.1939-4640.1989.tb00094.x","article-title":"Treatment of men with idiopathic oligozoospermic infertility using the aromatase inhibitor, testolactone results of a double-blinded, randomized, placebo-controlled trial with crossover","volume":"10","author":"Clark","year":"1989","journal-title":"J. Androl."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.fertnstert.2016.11.021","article-title":"Outcomes of anastrozole in oligozoospermic hypoandrogenic subfertile men","volume":"107","author":"Shoshany","year":"2017","journal-title":"Fertil. 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