{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:38:51Z","timestamp":1785335931904,"version":"3.55.0"},"reference-count":81,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Epilobium hirsutum is extensively used as a traditional remedy in folk medicine, especially against prostate inflammation. Therefore, we evaluated the chemical profiles and biopharmaceutical potentials of different extracts of E. hirsutum aerial parts and roots. Metabolomic, antioxidant, and enzyme inhibitory profiles were investigated. Human prostate cancer PC3 cells were exposed to the extracts to evaluate antiproliferative effects. Gene expression and bioinformatics analyses were performed to investigate anti-inflammatory mechanisms. Oenothein B and myricetin were prominent compounds in the extracts. In scavenging\/reducing assays, the methanol, infusion, and methanol\/water extracts exhibited similar activities. We also observed the reduction of PC3 viability occurring following exposure to methanol and methanol\/water extracts. According to bioinformatics analysis, myricetin was predicted to interact with COX-2 and TNF\u03b1. The interaction between TNF\u03b1 and oxo-dihydroxy-octadecenoic acid was predicted as well. Intriguingly, the gene expression of COX-2 and TNF\u03b1 was reduced in PC3 cells after exposure to methanol and methanol\/water extracts. These effects were paralleled by the decreased gene expression of IL-8 and NFkB and the inhibition of PGE2 release. Therefore, the present findings suggest the potential use of E. hirsutum for the management of the burden of inflammation and oxidative stress occurring in lower urinary tract diseases, including prostatitis.<\/jats:p>","DOI":"10.3390\/antiox10091389","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T11:01:37Z","timestamp":1630321297000},"page":"1389","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Shedding Light into the Connection between Chemical Components and Biological Effects of Extracts from Epilobium hirsutum: Is It a Potent Source of Bioactive Agents from Natural Treasure?"],"prefix":"10.3390","volume":"10","author":[{"given":"Gunes","family":"Ak","sequence":"first","affiliation":[{"name":"Physiology and Biochemistry Research Laboratory, Department of Biology, Science Faculty, Selcuk University, 42250 Konya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Physiology and Biochemistry Research Laboratory, Department of Biology, Science Faculty, Selcuk University, 42250 Konya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3962-8666","authenticated-orcid":false,"given":"Mohamad Fawzi","family":"Mahomoodally","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, R\u00e9duit 80837, Mauritius"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0180-5172","authenticated-orcid":false,"given":"Eulogio","family":"Llorent-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Physical and Analytical Chemistry, Campus Las Lagunillas S\/N, University of Ja\u00e9n, E-23071 Ja\u00e9n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giustino","family":"Orlando","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Botanic Garden \u201cGiardino dei Semplici\u201d, Universit\u00e0 degli Studi \u201cGabriele d\u2019Annunzio\u201d, via dei Vestini 31, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Chiavaroli","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Botanic Garden \u201cGiardino dei Semplici\u201d, Universit\u00e0 degli Studi \u201cGabriele d\u2019Annunzio\u201d, via dei Vestini 31, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Botanic Garden \u201cGiardino dei Semplici\u201d, Universit\u00e0 degli Studi \u201cGabriele d\u2019Annunzio\u201d, 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Universit\u00e0 degli Studi \u201cGabriele d\u2019Annunzio\u201d, via dei Vestini 31, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7346-7395","authenticated-orcid":false,"given":"Luigi","family":"Menghini","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Botanic Garden \u201cGiardino dei Semplici\u201d, Universit\u00e0 degli Studi \u201cGabriele d\u2019Annunzio\u201d, via dei Vestini 31, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9431-9407","authenticated-orcid":false,"given":"Claudio","family":"Ferrante","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Botanic Garden \u201cGiardino dei Semplici\u201d, Universit\u00e0 degli Studi \u201cGabriele d\u2019Annunzio\u201d, via dei Vestini 31, 66100 Chieti, 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