{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:25:47Z","timestamp":1792016747979,"version":"4.4.0"},"reference-count":272,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>There is a growing body of scientific research showing the link between depression and dementia in Alzheimer\u2019s disease (AD). The chronic stress contributes to the formation of oxidative stress in the parts of the brain involved in the development of depression and AD. The scientific literature reports the significant role of antioxidants, which are highly effective in treating these diseases. In this review, we have summarized the relationship between chronic stress, oxidative stress, and the changes in the brain they cause occurring in the brain. Among all the compounds showing antioxidant properties, the most promising results in AD treatment were observed for Vitamin E, coenzyme Q10 (CoQ10), melatonin, polyphenols, curcumin, and selenium. In case of depression treatment, the greatest potential was observed in curcumin, zinc, selenium, vitamin E, and saffron.<\/jats:p>","DOI":"10.3390\/antiox10091439","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T12:20:37Z","timestamp":1631190037000},"page":"1439","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":203,"title":["Chronic Stress and Oxidative Stress as Common Factors of the Pathogenesis of Depression and Alzheimer\u2019s Disease: The Role of Antioxidants in Prevention and Treatment"],"prefix":"10.3390","volume":"10","author":[{"given":"Gabriela","family":"Juszczyk","sequence":"first","affiliation":[{"name":"Chair and Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 8bStreet, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4305-5410","authenticated-orcid":false,"given":"Joanna","family":"Mikulska","sequence":"additional","affiliation":[{"name":"Chair and Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 8bStreet, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Kasperek","sequence":"additional","affiliation":[{"name":"Chair and Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 8bStreet, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5060-534X","authenticated-orcid":false,"given":"Diana","family":"Pietrzak","sequence":"additional","affiliation":[{"name":"Chair and Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 8bStreet, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weronika","family":"Mrozek","sequence":"additional","affiliation":[{"name":"Chair and Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 8bStreet, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8975-8093","authenticated-orcid":false,"given":"Mariola","family":"Herbet","sequence":"additional","affiliation":[{"name":"Chair and Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 8bStreet, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2021, July 29). Depression. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/depression."},{"key":"ref_2","unstructured":"WHO (2021). Suicide Worldwide in 2019: Global Health Estimates, World Health Organization. Licence: CC BY-NC-SA 3.0 IGO."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.yfrne.2015.12.001","article-title":"Depression as a risk factor for Alzheimer\u2019s disease: Genes, steroids, cytokines and neurogenesis\u2014What do we need to know?","volume":"41","author":"Herbert","year":"2016","journal-title":"Front. Neuroendocrinol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1001\/jamapsychiatry.2017.0660","article-title":"Trajectories of depressive symptoms before diagnosis of dementia: A 28-year follow-up study","volume":"74","author":"Dugravot","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1016\/j.bbadis.2013.07.022","article-title":"Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: Implications for depression and Alzheimer\u2019s disease","volume":"1832","author":"Wuwongse","year":"2013","journal-title":"Biochim. Biophys Acta"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0924-9338(02)00678-8","article-title":"Depression in Alzheimer\u2019s disease: Is there a temporal relationship between the onset of depression and the onset of dementia?","volume":"17","author":"Heun","year":"2002","journal-title":"Eur. Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.archger.2012.10.008","article-title":"History of depression prior to Alzheimer\u2019s disease and vascular dementia verified post-mortem","volume":"56","author":"Passant","year":"2013","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0924-9338(03)00003-8","article-title":"Lifetime symptoms of depression in Alzheimer\u2019s disease","volume":"18","author":"Reinhard","year":"2003","journal-title":"Eur. Psychiatry"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.jagp.2019.05.010","article-title":"Commentary on: Mechanisms linking white matter lesions, tract integrity and depression in alzheimer\u2019s disease","volume":"27","author":"Paradise","year":"2019","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3389\/fphar.2019.00483","article-title":"Monoaminergic system modulation in depression and alzheimer\u2019s disease: A new standpoint?","volume":"10","author":"Morgese","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1111\/j.1460-9568.2004.03717.x","article-title":"The corticoid environment: A determining factor for neural progenitors\u2019 survival in the adult hippocampus","volume":"20","author":"Wong","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"ref_12","first-page":"25","article-title":"Understanding the pathophysiology of depression: From monoamines to the neurogenesis hypothesis model\u2014Are we there yet?","volume":"341","author":"Jesulola","year":"2017","journal-title":"Behav. Brain Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"586578","DOI":"10.3389\/fcell.2020.586578","article-title":"Oxidative damage and antioxidant defense in ferroptosis","volume":"8","author":"Kuang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/aje\/kwf074","article-title":"Risk factors for Alzheimer\u2019s disease: A prospective analysis from the canadian study of health and aging","volume":"156","author":"Lindsay","year":"2002","journal-title":"Am. J. Epidemiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.trci.2019.04.002","article-title":"A 24-week double-blind placebo-controlled study of the efficacy and safety of the AMPA modulator S47445 in patients with mild to moderate Alzheimer\u2019s disease and depressive symptoms","volume":"5","author":"Bernard","year":"2019","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jad.2017.07.008","article-title":"Trajectories of depressive symptoms and their relationship to the progression of dementia","volume":"222","author":"Barca","year":"2017","journal-title":"J. Affect. Disord."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/acps.12352","article-title":"Neurobiological correlates of depressive symptoms in people with subjective and mild cognitive impairment","volume":"131","author":"Auning","year":"2015","journal-title":"Acta Psychiatr. Scand"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"104067","DOI":"10.1016\/j.archger.2020.104067","article-title":"Depressive symptoms were a common risk factor for pre-frailty and frailty in patients with Alzheimer\u2019s disease","volume":"89","author":"Wu","year":"2020","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41398-020-0839-1","article-title":"Depression-an underrecognized target for prevention of dementia in Alzheimer\u2019s disease","volume":"10","author":"Dafsari","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.it.2005.11.006","article-title":"Cytokines sing the blues: Inflammation and the pathogenesis of depression","volume":"27","author":"Raison","year":"2006","journal-title":"Trends Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/S0140-6736(17)31363-6","article-title":"Dementia prevention, intervention, and care","volume":"390","author":"Livingston","year":"2017","journal-title":"Lancet."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.psc.2011.12.001","article-title":"Etiology of depression: Genetic and environmental factors","volume":"35","author":"Saveanu","year":"2012","journal-title":"Psychiatr. Clin. North. Am."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2008.06.006","article-title":"The HPA axis in major depression: Classical theories and new developments","volume":"31","author":"Pariante","year":"2008","journal-title":"Trends Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ynstr.2018.04.002","article-title":"The Relationship between Stress and Alzheimer\u2019s Disease","volume":"8","author":"Justice","year":"2018","journal-title":"Neurobiol. Stress"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1523\/JNEUROSCI.2797-06.2006","article-title":"Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer\u2019s disease","volume":"26","author":"Green","year":"2006","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1176\/ajp.140.5.586","article-title":"The dexamethasone suppression test in the clinical setting","volume":"140","author":"Evans","year":"1983","journal-title":"Am. J. Psychiatry"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.biopsych.2020.11.007","article-title":"How stress shapes neuroimmune function: Implications for the neurobiology of psychiatric disorders","volume":"90","author":"Koo","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"212","DOI":"10.2174\/1871523011009030212","article-title":"Inflammation and mood disorders: Proinflammatory cytokines and the pathogenesis of depression","volume":"9","author":"Currier","year":"2010","journal-title":"Anti-Inflamm. Anti-Allergy Agents Med. Chem."},{"key":"ref_29","first-page":"31","article-title":"COX-2 inhibitors as antidepressants and antipsychotics: Clinical evidence","volume":"11","year":"2010","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0893-133X(99)00134-7","article-title":"Cytokine production and treatment response in major depressive disorder","volume":"22","author":"Lanquillon","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.pnpbp.2004.11.003","article-title":"Cytokines and major depression","volume":"29","author":"Schiepers","year":"2005","journal-title":"Prog. Neuropsychopharm. Biol. Psychiatr."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Zou, W., Feng, R., and Yang, Y. (2018). Changes in the serum levels of inflammatory cytokines in antidepressant drug-na\u00efve patients with major depression. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0197267"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Joergensen, A., Broedbaek, K., Weimann, A., Semba, R.D., Ferrucci, L., Joergensen, M.B., and Poulsen, H.E. (2011). Association between urinary excretion of cortisol and markers of oxidatively damaged DNA and RNA in humans. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0020795"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1124\/pr.112.005892","article-title":"Unraveling the time domains of corticosteroid hormone influences on brain activity: Rapid, slow, and chronic modes","volume":"64","author":"Sarabdjitsingh","year":"2012","journal-title":"Pharmacol. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ejphar.2007.11.071","article-title":"Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators","volume":"583","author":"McEwen","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.neubiorev.2008.05.007","article-title":"Stress and glucocorticoid footprints in the brain-the path from depression to Alzheimer\u2019s disease","volume":"32","author":"Sotiropoulos","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3233\/JAD-2010-100663","article-title":"HPA axis dysregulation associated to apolipoprotein E4 genotype in Alzheimer\u2019s disease","volume":"22","author":"Aisa","year":"2010","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_38","first-page":"356","article-title":"Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology","volume":"74","author":"Medeiros","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev-biochem-061516-045037","article-title":"Oxidative stress","volume":"86","author":"Sies","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0026-0495(00)80077-3","article-title":"What is oxidative stress?","volume":"49","author":"Betteridge","year":"2000","journal-title":"Metabolism"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Wojsiat, J., Zoltowska, K.M., Laskowska-Kaszub, K., and Wojda, U. (2018). Oxidant\/antioxidant imbalance in alzheimer\u2019s disease: Therapeutic and diagnostic prospects. Oxid. Med. Cell Longev., 6435861.","DOI":"10.1155\/2018\/6435861"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"8416763","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative stress: Harms and benefits for human health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_43","first-page":"3","article-title":"Mitochondrial electron transport chain, ROS generation and uncoupling (Review)","volume":"44","author":"Zhao","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.redox.2017.01.021","article-title":"Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration","volume":"12","author":"Hambright","year":"2017","journal-title":"Redox Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e90777","DOI":"10.1172\/jci.insight.90777","article-title":"Inhibition of neuronal ferroptosis protects hemorrhagic brain","volume":"2","author":"Li","year":"2017","journal-title":"JCI Insight."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3389\/fneur.2018.00581","article-title":"Ultrastructural characteristics of neuronal death and white matter injury in mouse brain tissues after intracerebral hemorrhage: Coexistence of ferroptosis, autophagy, and necrosis","volume":"9","author":"Li","year":"2018","journal-title":"Front. Neurol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1007\/s12035-018-1403-3","article-title":"Ferroptosis and its role in diverse brain diseases","volume":"56","author":"Weiland","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1038\/onc.2017.146","article-title":"ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner","volume":"36","author":"Chen","year":"2017","journal-title":"Oncogene"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5080843","DOI":"10.1155\/2019\/5080843","article-title":"Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.exger.2010.03.014","article-title":"How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)","volume":"45","author":"Ristow","year":"2010","journal-title":"Exp. Gerontol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1055\/s-0033-1351132","article-title":"Perioperative stress-dose steroids","volume":"26","author":"Kelly","year":"2013","journal-title":"Clin. Colon. Rectal. Surg."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.psyneuen.2014.09.025","article-title":"Is depression associated with increased oxidative stress? A systematic review and meta-analysis","volume":"51","author":"Black","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"581976","DOI":"10.1155\/2015\/581976","article-title":"Clinical and biochemical manifestations of depression: Relation to the neurobiology of stress","volume":"2015","author":"Gold","year":"2015","journal-title":"Neural. Plast."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1080\/13547500500216546","article-title":"F2-isoprostanes as markers of oxidative stress in vivo: An overview","volume":"1","author":"Milne","year":"2005","journal-title":"Biomarkers"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/7210783","article-title":"\u03b1-Tocopherol ameliorates redox equilibrium and reduces inflammatory response caused by chronic variable stress","volume":"2018","author":"Herbet","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"113185","DOI":"10.1016\/j.bbr.2021.113185","article-title":"Beneficial effects of combined administration of fluoxetine and mitochondria-targeted antioxidant at in behavioural and molecular studies in mice model of depression","volume":"405","author":"Herbet","year":"2021","journal-title":"Behav. Brain Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"114689","DOI":"10.1016\/j.taap.2019.114689","article-title":"Edaravone presents antidepressant-like activity in corticosterone model of depression in mice with possible role of Fkbp5, Comt, Adora1 and Slc6a15 genes","volume":"380","author":"Herbet","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"7313090","DOI":"10.1155\/2017\/7313090","article-title":"Chronic variable stress is responsible for lipid and DNA oxidative disorders and activation of oxidative stress response genes in the brain of rats","volume":"2017","author":"Herbet","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.psyneuen.2013.02.004","article-title":"Good stress, bad stress and oxidative stress: Insights from anticipatory cortisol reactivity","volume":"38","author":"Aschbacher","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"616","DOI":"10.4306\/pi.2016.13.6.616","article-title":"The levels of cortisol and oxidative stress and DNA damage in child and adolescent victims of sexual abuse with or without post-traumatic stress disorder","volume":"13","author":"Kaplan","year":"2016","journal-title":"Psychiatry Investig."},{"key":"ref_61","first-page":"118","article-title":"Two faces of free oxygen radicals","volume":"62","author":"Zablocka","year":"2008","journal-title":"Postepy. Hig. Med. Dosw."},{"key":"ref_62","first-page":"898393","article-title":"Markers of oxidative stress and neuroprogression in depression disorder","volume":"2015","year":"2015","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/npp.2014.190","article-title":"Relationship of monoamine oxidase-A distribution volume to postpartum depression and postpartum crying","volume":"40","author":"Sacher","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.pnpbp.2010.05.004","article-title":"A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness","volume":"35","author":"Maes","year":"2011","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jad.2007.08.006","article-title":"The course of nitric oxide and superoxide dismutase during treatment of bipolar depressive episode","volume":"107","author":"Selek","year":"2008","journal-title":"J. Affect. Disord."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.mrfmmm.2006.06.003","article-title":"Malondialdehyde, a major endogenous lipid peroxidation product, sensitizes human cells to UV- and BPDE-induced killing and mutagenesis through inhibition of nucleotide excision repair","volume":"601","author":"Feng","year":"2006","journal-title":"Mutat. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/10253890400012685","article-title":"Oxidative stress in university students during examinations","volume":"7","year":"2004","journal-title":"Stress"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1179\/135100003225003393","article-title":"Oxidative damage and major depression: The potential antioxidant action of selective serotonin re-uptake inhibitors","volume":"8","author":"Khanzode","year":"2003","journal-title":"Redox Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/hup.1014","article-title":"Oxidative stress parameters after combined fluoxetine and acetylsalicylic acid therapy in depressive patients","volume":"24","author":"Szemraj","year":"2009","journal-title":"Hum. Psychopharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Trzeciak, P., and Herbet, M. (2021). Role of the intestinal microbiome, intestinal barrier and psychobiotics in depression. Nutrients, 13.","DOI":"10.3390\/nu13030927"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0006-3223(03)00181-1","article-title":"Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants","volume":"54","author":"Shimizu","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0006-3223(00)00950-1","article-title":"Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells","volume":"48","author":"Rajkowska","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1523\/JNEUROSCI.19-12-05034.1999","article-title":"Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression","volume":"19","author":"Sheline","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.redox.2018.01.008","article-title":"13 reasons why the brain is susceptible to oxidative stress","volume":"15","author":"Cobley","year":"2018","journal-title":"Redox Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neurobiolaging.2018.02.024","article-title":"Deuterated polyunsaturated fatty acids reduce brain lipid peroxidation and hippocampal amyloid \u03b2-peptide levels, without discernable behavioral effects in an APP\/PS1 mutant transgenic mouse model of Alzheimer\u2019s disease","volume":"66","author":"Raefsky","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"104795","DOI":"10.1016\/j.nbd.2020.104795","article-title":"Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer\u2019s disease","volume":"138","author":"Butterfield","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0169-328X(00)00268-0","article-title":"Impact of apoE deficiency on oxidative insults and antioxidants in the brain","volume":"86","author":"Ramassamy","year":"2001","journal-title":"Brain Res. Mol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2016.02.030","article-title":"Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer\u2019s disease pathology","volume":"42","author":"Scheff","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0891-5849(91)90192-6","article-title":"Chemistry and biochemistry of 4- hydroxynonenal, malonaldehyde and related aldehydes","volume":"11","author":"Esterbauer","year":"1991","journal-title":"Free Radic. Biol. Med."},{"key":"ref_80","first-page":"221","article-title":"Preclinical Alzheimer disease: Brain oxidative stress, Abeta peptide, and proteomics","volume":"39","author":"Aluise","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"32583","DOI":"10.1038\/srep32583","article-title":"Integration of transcriptomic and genomic data suggests candidate mechanisms for ApoE4-mediated pathogenic action in Alzheimer\u2019s disease","volume":"6","author":"Caberlotto","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"101162","DOI":"10.1016\/j.redox.2019.101162","article-title":"Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of Down syndrome","volume":"23","author":"Tramutola","year":"2019","journal-title":"Redox Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"18694","DOI":"10.1073\/pnas.0508254102","article-title":"Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity","volume":"102","author":"Chang","year":"2005","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/nbdi.1999.0273","article-title":"Oxidative insults are associated with apolipoprotein E genotype in Alzheimer\u2019s disease brain","volume":"7","author":"Ramassamy","year":"2000","journal-title":"Neurobiol. Dis."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neulet.2005.12.017","article-title":"Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment","volume":"397","author":"Butterfield","year":"2006","journal-title":"Neurosci. Lett."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mito.2019.07.013","article-title":"Activities of mitochondrial respiratory chain complexes in platelets of patients with Alzheimer\u2019s disease and depressive disorder","volume":"48","author":"Wenchich","year":"2019","journal-title":"Mitochondrion"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.freeradbiomed.2010.11.026","article-title":"Neuroprotective strategies involving ROS in Alzheimer disease","volume":"51","author":"Dumont","year":"2011","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s12035-010-8109-5","article-title":"Convergence of amyloid-beta and tau pathologies on mitochondria in vivo","volume":"41","author":"Eckert","year":"2010","journal-title":"Mol. Neurobiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"20057","DOI":"10.1073\/pnas.0905529106","article-title":"Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer\u2019s disease mice","volume":"106","author":"Rhein","year":"2009","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1089\/ars.2009.2585","article-title":"Small-molecule NOX inhibitors: ROS-generating NADPH oxidases as therapeutic targets","volume":"11","author":"Jaquet","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"106507","DOI":"10.1155\/2008\/106507","article-title":"Apocynin: Molecular aptitudes","volume":"2018","author":"Stefanska","year":"2008","journal-title":"Mediat. Inflamm."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1021\/acs.chemrev.5b00407","article-title":"Superoxide ion: Generation and chemical implications","volume":"116","author":"Hayyan","year":"2016","journal-title":"Chem. Rev."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.ejmech.2019.06.010","article-title":"Medicinal prospects of antioxidants: A review","volume":"178","author":"Neha","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Aguilar, T.A.F., Navarro, B.C.H., and P\u00e9rez, J.A.M. (2016). Endogenous Antioxidants: A Review of Their Role in Oxidative Stress, IntechOpen Limited.","DOI":"10.5772\/65715"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Liu, R., Xing, L., Fu, Q., Zhou, G.H., and Zhang, W.G. (2016). A review of antioxidant peptides derived from meat muscle and by-products. Antioxidants, 5.","DOI":"10.3390\/antiox5030032"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"6719534","DOI":"10.1155\/2016\/6719534","article-title":"Antioxidant intake and antitumor therapy: Toward nutritional recommendations for optimal results","volume":"2016","author":"Garrido","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jad.2018.05.079","article-title":"Depression and anxiety symptoms are associated with prooxidant-antioxidant balance: A population-based study","volume":"238","author":"Shafiee","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Chong, P.S., Fung, M.L., Wong, K.H., and Lim, L.W. (2019). Therapeutic Potential of Hericium erinaceus for depressive disorder. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010163"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1515\/BC.2006.049","article-title":"Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis","volume":"387","author":"Kawanishi","year":"2006","journal-title":"Biol. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"795","DOI":"10.33549\/physiolres.933776","article-title":"Quercetin protects against stress-induced anxiety- and depression-like behavior and improves memory in male mice","volume":"67","author":"Samad","year":"2018","journal-title":"Physiol. Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.bcp.2004.09.018","article-title":"Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: Investigation in primary rat mesencephalic cultures","volume":"69","author":"Mercer","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ejphar.2009.08.030","article-title":"Flavonoid quercetin protects against swimming stress-induced changes in oxidative biomarkers in the hypothalamus of rats","volume":"621","author":"Haleagrahara","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0163-7258(02)00298-X","article-title":"The biochemistry and medical significance of the flavonoids","volume":"96","author":"Havsteen","year":"2002","journal-title":"Pharmacol. Ther."},{"key":"ref_104","first-page":"24","article-title":"Behavioral and neurochemical profile of m-CPP following exposure to single restraint stress in rat","volume":"109","author":"Samad","year":"2009","journal-title":"Acta Neurol. Belg."},{"key":"ref_105","first-page":"636","article-title":"Inhibition of restraint-induced neuroendocrine and serotonergic responses by buspirone in rats","volume":"58","author":"Samad","year":"2006","journal-title":"Pharmacol. Rep."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"10270","DOI":"10.1021\/jf303055b","article-title":"Evaluation of the inhibitory effects ofquercetin-related flavonoids and tea catechins on the monoamine oxidase-A reaction in mouse brain mitochondria","volume":"60","author":"Bandaruk","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1055\/s-0030-1270714","article-title":"Antiproliferative constituents of the roots of conyza canadensis","volume":"77","author":"Forgo","year":"2011","journal-title":"Planta Med."},{"key":"ref_108","unstructured":"Gruenwald, J., Brendler, T., and Jaenicke, C. (2007). PDR for Herbal Medicines, Thomson Reuters."},{"key":"ref_109","unstructured":"Weiner, M.A. (1980). Earth Medicine-Earth Food: Plant Remedies, Drugs, and Natural Foods of the North American Indians, Macmillan."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"El-Akhal, J., Humulescu, I., Ionita, R., Postu, P.A., Ungureanu, E., Hancianu, M., Bencheikh, R., Robu, S., Cioanca, O., and Hritcu, L. (2021). Anxiolytic and antidepressant-like effects of conyza canadensis aqueous extract in the scopolamine rat model. Plants, 10.","DOI":"10.3390\/plants10040645"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Na\u00df, J., Kampf, C.J., and Efferth, T. (2021). Increased stress resistance and lifespan in chaenorhabditis elegans wildtype and knockout mutants\u2014Implications for depression treatment by medicinal herbs. Molecules, 26.","DOI":"10.3390\/molecules26071827"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Chauhan, A., and Chauhan, V. (2020). Beneficial effects of walnuts on cognition and brain health. Nutrients, 12.","DOI":"10.3390\/nu12020550"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.1096\/fj.15-275404","article-title":"Mitochondria-targeted antioxidants","volume":"29","author":"Chen","year":"2015","journal-title":"FASEB J."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.biopsych.2013.05.008","article-title":"Zinc in depression: A meta-analysis","volume":"74","author":"Swardfager","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.psychres.2017.02.006","article-title":"Dietary zinc and iron intake and risk of depression: A meta-analysis","volume":"251","author":"Li","year":"2017","journal-title":"Psychiatry Res."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Szopa, A., Bogatko, K., Herbet, M., Serefko, A., Ostrowska, M., Wo\u015bko, S., \u015awi\u0105der, K., Szewczyk, B., Wla\u017a, A., and Ska\u0142ecki, P. (2021). The interaction of selective A1 and A2A adenosine receptor antagonists with magnesium and zinc ions in mice: Behavioural, biochemical and molecular studies. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041840"},{"key":"ref_117","unstructured":"Yosaeea, S., Clark, C.C.T., Keshtkar, Z., Ashourpour, M., Keshanie, P., and Soltani, S. (2020). Zinc in depression: From development to treatment: A comparative\/ dose response meta-analysis of observational studies and randomized controlled trials. Gen. Hosp. Psychiatry, In Press."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.neubiorev.2013.03.018","article-title":"Potential roles of zinc in the pathophysiology and treatment of major depressive disorder","volume":"37","author":"Swardfager","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Wang, J., Um, P., Dickerman, B.A., and Liu, J. (2018). Zinc, Magnesium, selenium and depression: A review of the evidence, potential mechanisms and implications. Nutrients, 10.","DOI":"10.3390\/nu10050584"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1053\/j.jrn.2009.04.005","article-title":"Effects of zinc supplementation on serum zinc and C-reactive protein concentrations in hemodialysis patients","volume":"19","author":"Rashidi","year":"2009","journal-title":"J. Ren. Nutr."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.bbi.2017.02.020","article-title":"Association between Creactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression","volume":"62","author":"Tansey","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s12640-017-9835-5","article-title":"Lipid peroxidation and immune biomarkers are associated with major depression and its phenotypes, including treatment-resistant depression and melancholia","volume":"33","author":"Siwek","year":"2018","journal-title":"Neurotox. Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neuro.2014.02.003","article-title":"Selenium exposure and depressive symptoms: The coronary artery risk development in young adults trace element study","volume":"41","author":"Colangelo","year":"2014","journal-title":"Neurotoxicology"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3945\/jn.114.198010","article-title":"Optimal serum selenium concentrations are associated with lower depressive symptoms and negative mood among young adults","volume":"145","author":"Conner","year":"2014","journal-title":"J. Nutr."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Prystupa, A., Kici\u0144ski, P., Luchowska-Kocot, D., B\u0142a\u017cewicz, A., Niedzia\u0142ek, J., Mizerski, G., Jojczuk, M., Ochal, A., Sak, J.J., and Za\u0142uska, W. (2017). Association between serum selenium concentrations and levels of proinflammatory and profibrotic cytokines\u2014Interleukin-6 and growth differentiation factor-15, in patients with alcoholic liver cirrhosis. Int. J. Environ. Res. Public Health., 14.","DOI":"10.20944\/preprints201703.0204.v1"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1093\/bja\/aev073","article-title":"Low zinc and selenium concentrations in sepsis are associated with oxidative damage and inflammation","volume":"114","author":"Mertens","year":"2015","journal-title":"Br. J. Anaesth."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0891-5849(94)90007-8","article-title":"On the nature of selenium toxicity and carcinostatic activity","volume":"17","author":"Spallholz","year":"1994","journal-title":"Free Radic. Biol. Med."},{"key":"ref_128","first-page":"549","article-title":"Magnesium and ketamine in the treatment of depression","volume":"31","author":"Szarmach","year":"2019","journal-title":"Psychiatr. Danub."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"4179326","DOI":"10.1155\/2017\/4179326","article-title":"The importance of magne-sium in clinical healthcare","volume":"2017","author":"Schwalfenberg","year":"2017","journal-title":"Scientifica"},{"key":"ref_130","first-page":"112","article-title":"Magnesium and depression","volume":"29","author":"Serefko","year":"2016","journal-title":"Magn. Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3122\/jabfm.2015.02.140176","article-title":"Magnesium intake and depression in adults","volume":"28","author":"Tarleton","year":"2015","journal-title":"J. Am. Board Fam Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.pharep.2014.03.001","article-title":"Essential elements in depression and anxiety. Part I","volume":"66","author":"Davies","year":"2014","journal-title":"Pharmacol. Rep."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/ejcn.2014.7","article-title":"Dietary magnesium intake is inversely associated with serum Creactive protein levels: Meta-analysis and systematic review","volume":"68","author":"Dibaba","year":"2014","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"304","DOI":"10.2337\/dc09-1402","article-title":"Relations of dietary magnesium intake to biomarkers of inflammation and endothelial dysfunctions in an ethnically diverse cohort of postmenopausal women","volume":"33","author":"Chacko","year":"2010","journal-title":"Diabetes Care"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2174\/1567205012666150325182702","article-title":"Oxidant\/Antioxidant imbalance and the risk of Alzheimer\u2019s disease","volume":"12","author":"Moneim","year":"2015","journal-title":"Curr. Alzheimer. Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.3390\/molecules17033082","article-title":"Anti-acetylcholinesterase and antioxidant activity of essential oils from hedychium gardnerianum sheppard ex Ker-Gawl","volume":"17","author":"Arruda","year":"2012","journal-title":"Molecules"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.3390\/ijms13045074","article-title":"Rhinacanthus nasutus extracts prevent glutamate and amyloid-\u03b2 neurotoxicity in HT-22 mouse hippocampal cells: Possible active compounds include lupeol, stigmasterol and \u03b2-sitosterol","volume":"13","author":"Brimson","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"6322","DOI":"10.3390\/molecules16086322","article-title":"Rhinacanthus nasutus protects cultured neuronal cells against hypoxia induced cell death","volume":"16","author":"Brimson","year":"2011","journal-title":"Molecules"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"951","DOI":"10.3390\/molecules18010951","article-title":"Investigating the antioxidant and acetylcholinesterase inhibition activities of gossypium herbaceam","volume":"18","author":"Zhao","year":"2013","journal-title":"Molecules"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3233\/JAD-2008-14302","article-title":"Gossypium herbaceam extracts inhibited NF-kappaB activation to attenuate spatial memory impairment and hippocampal neurodegeneration induced by amyloid-beta in rats","volume":"14","author":"Ji","year":"2008","journal-title":"J. Alzheimers Dis."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"767","DOI":"10.3390\/molecules19010767","article-title":"Acetylcholinesterase inhibitory, antioxidant and phytochemical properties of selected medicinal plants of the lamiaceae family","volume":"19","author":"Kindl","year":"2014","journal-title":"Molecules"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"6821","DOI":"10.3892\/mmr.2015.4317","article-title":"Azorella compacta methanolic extract induces apoptosis via activation of mitogen-activated protein kinase","volume":"12","author":"Sung","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Faraone, I., Rai, D.K., Russo, D., Chiummiento, L., Fernandez, E., Choudhary, A., and Milella, L. (2019). Antioxidant, antidiabetic, and anticholinesterase activities and phytochemical profile of azorella glabra wedd. Plants, 8.","DOI":"10.3390\/plants8080265"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jep.2007.11.038","article-title":"Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica","volume":"116","author":"Wattanathorn","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1097\/00004714-200012000-00015","article-title":"A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects","volume":"20","author":"Bradwejn","year":"2000","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"347569","DOI":"10.4061\/2011\/347569","article-title":"Centella asiatica Attenuates D-galactose-induced cognitive impairment, oxidative and mitochondrial dysfunction in mice","volume":"2011","author":"Kumar","year":"2011","journal-title":"Int. J. Alzheimers Dis."},{"key":"ref_147","first-page":"1","article-title":"Centella asiatica (L.) urban: From traditional medicine to modern medicine with neuroprotective potential","volume":"2012","author":"Orhan","year":"2012","journal-title":"Evid. Based Complement Altern. Med."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.3390\/ijms10093713","article-title":"Antioxidant and cytotoxic activities of Centella asiatica (L.) Urb","volume":"10","author":"Pittella","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1556\/JPC.24.2011.1.16","article-title":"Identification and quantification of triterpenoid centelloids in Centella asiatica (L.) Urban by densitometric TLC","volume":"24","author":"James","year":"2011","journal-title":"JPC. Planar Chromatogr. Mod. TLC"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Hafiz, Z.Z., Amin, M.M., Johari James, R.M., Teh, L.K., Salleh, M.Z., and Adenan, M.I. (2020). Inhibitory effects of raw-extract centella asiatica (RECA) on acetylcholinesterase, inflammation, and oxidative stress activities via in vitro and in vivo. Molecules, 25.","DOI":"10.3390\/molecules25040892"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Matthews, D.G., Caruso, M., Murchison, C.F., Zhu, J.Y., Wright, K.M., Harris, C.J., Gray, N.E., Quinn, J.F., and Soumyanath, A. (2019). Centella asiatica improves memory and promotes antioxidative signaling in 5XFAD mice. Antioxidants, 8.","DOI":"10.3390\/antiox8120630"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/14786419.2012.666749","article-title":"Grewialin and optivanin new constituents from the stem bark of Grewia optiva Drummond ex Burret (Tiliaceae)","volume":"27","author":"Uddin","year":"2013","journal-title":"Nat. Prod. Res."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Ul Bari, W., Ur Rehman, N., Khan, A., Ahsan Halim, S., Yuan, Y., Blaskovich, M.A.T., Ziora, Z.M., Zahoor, M., Naz, S., and Ullah, R. (2021). Bio-Potency and molecular docking studies of isolated compounds from grewia optiva J.R. Drumm. ex Burret. Molecules, 26.","DOI":"10.3390\/molecules26072019"},{"key":"ref_154","first-page":"1243","article-title":"Pharmacological and phytochemical studies of genus zizyphus","volume":"21","author":"Kaleem","year":"2014","journal-title":"Middle-East. J. Sci. Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"4568401","DOI":"10.1155\/2019\/4568401","article-title":"Anticholinesterase and antioxidant potential of hydromethanolic extract of ziziphus mucronata (Rhamnaceae) leaves on scopolamine-induced memory and cognitive dysfunctions in mice","volume":"2019","author":"Foyet","year":"2019","journal-title":"Evid. Based Complement Altern. Med."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Badshah, S.L., Riaz, A., Muhammad, A., Tel \u00c7ayan, G., \u00c7ayan, F., Emin Duru, M., Ahmad, N., Emwas, A.-H., and Jaremko, M. (2021). Isolation, characterization, and medicinal potential of polysaccharides of Morchella esculenta. Molecules, 26.","DOI":"10.3390\/molecules26051459"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s11481-012-9363-2","article-title":"Neuroprotective effect of curcuminoids against inflammation-mediated dopaminergic neurodegeneration in the MPTP model of Parkinson\u2019s disease","volume":"7","author":"Ojha","year":"2012","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jtcme.2018.01.002","article-title":"Neuroprotective potency of some spice herbs, a literature review","volume":"9","author":"Khazdair","year":"2018","journal-title":"J. Tradit. Complementary Med."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/ptr.2578","article-title":"Kinetics of enzyme inhibition by active molluscicidal agents ferulic acid, umbelliferone, eugenol and limonene in the nervous tissue of snail Lymnaea acuminata","volume":"23","author":"Kumar","year":"2009","journal-title":"Phytother. Res."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.3390\/molecules14072373","article-title":"Steroidal lactones from withania somnifera, an ancient plant for novel medicine","volume":"14","author":"Mirjalili","year":"2009","journal-title":"Molecules"},{"key":"ref_161","first-page":"e1","article-title":"Chemistry and pharmacology of Withania somnifera: An update","volume":"5","author":"Kumar","year":"2015","journal-title":"Tang (Humanit. Med.)"},{"key":"ref_162","first-page":"127","article-title":"Studies on Withania-ashwagandha, Kaul. V. The effect of total alkaloids (ashwagandholine) on the central nervous system","volume":"9","author":"Malhotra","year":"1965","journal-title":"Indian J. Physiol. Pharmacol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1080\/19390211.2017.1284970","article-title":"Efficacy and safety of ashwagandha (Withania somnifera (L.) dunal) root extract in improving memory and cognitive functions","volume":"14","author":"Choudhary","year":"2017","journal-title":"J. Diet. Suppl."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Mehla, J., Gupta, P., Pahuja, M., Diwan, D., and Diksha, D. (2020). Indian medicinal herbs and formulations for alzheimer\u2019s disease, from traditional knowledge to scientific assessment. Brain Sci., 10.","DOI":"10.3390\/brainsci10120964"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/ptr.6552","article-title":"A systematic review of the clinical use of Withania somnifera (Ashwagandha) to ameliorate cognitive dysfunction","volume":"34","author":"Ng","year":"2019","journal-title":"Phytother. Res."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1365-277X.2008.00923.x","article-title":"Acute effect of nut consumption on plasma total polyphenols, antioxidant capacity and lipid peroxidation","volume":"22","author":"Torabian","year":"2009","journal-title":"Hum. Nutr. Diet."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Capatina, L., Todirascu-Ciornea, E., Napoli, E.M., Ruberto, G., Hritcu, L., and Dumitru, G. (2020). Thymus vulgaris essential oil protects zebrafish against cognitive dysfunction by regulating cholinergic and antioxidants systems. Antioxidants, 9.","DOI":"10.3390\/antiox9111083"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.3390\/nu7075246","article-title":"Ferulic acid: A hope for alzheimer\u2019s disease therapy from plants","volume":"7","author":"Sgarbossa","year":"2015","journal-title":"Nutrients"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.biopha.2018.12.151","article-title":"A review for the pharmacological effect of lycopene in central nervous system disorders","volume":"111","author":"Chen","year":"2019","journal-title":"Biomed. Pharmacother. Biomed. Pharmacother."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.neulet.2011.10.048","article-title":"Protective effects of lycopene against amyloid \u03b2-induced neurotoxicity in cultured rat corticalneurons","volume":"505","author":"Qi","year":"2011","journal-title":"Neurosci. Lett."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3233\/JAD-161216","article-title":"Dietary lycopene supplementation improves cognitive performances in Tau transgenic mice expressing P301L mutation via inhibiting oxidative stress and Tau hyperphosphorylation","volume":"57","author":"Yu","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.lfs.2008.05.013","article-title":"Lycopene attenuates diabetes-associated cognitive decline in rats","volume":"83","author":"Kuhad","year":"2008","journal-title":"Life Sci."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Hira, S., Saleem, U., Anwar, F., Sohail, M.F., Raza, Z., and Ahmad, B. (2019). \u03b2-carotene: A natural compound improves cognitive impairment and oxidative stress in a mouse model of streptozotocin-induced alzheimer\u2019s disease. Biomolecules, 9.","DOI":"10.3390\/biom9090441"},{"key":"ref_174","first-page":"369","article-title":"Anthocyanins and heart health","volume":"43","author":"Mazza","year":"2007","journal-title":"Ann. Ist. Super. Sanita"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Wallace, T.C., and Giusti, M.M. (2014). Anthocyanins in Health and Disease, CRC Press.","DOI":"10.1201\/b15554"},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Ullah, R., Khan, M., Shah, S.A., Saeed, K., and Kim, M.O. (2019). Natural antioxidant anthocyanins\u2014A hidden therapeutic candidate in metabolic disorders with major focus in neurodegeneration. Nutrients, 11.","DOI":"10.3390\/nu11061195"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.actatropica.2014.12.007","article-title":"Protective effects of melatonin against oxidative damage induced by Egyptian cobra (Naja haje) crude venom in rats","volume":"143","author":"Ortiz","year":"2015","journal-title":"Acta Trop."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"218","DOI":"10.2174\/157015910792246209","article-title":"Clinical aspects of melatonin intervention in Alzheimer\u2019s disease progression","volume":"8","author":"Cardinali","year":"2010","journal-title":"Curr. Neuropharmacol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1744-9081-2-15","article-title":"Melatonin in Alzheimer\u2019s disease and other neurodegenerative disorders","volume":"2","author":"Srinivasan","year":"2006","journal-title":"Behav. Brain Funct."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"PL271","DOI":"10.1016\/0024-3205(94)00666-0","article-title":"Melatonin: A peroxyl radical scavenger more effective than vitamin E","volume":"55","author":"Pieri","year":"1994","journal-title":"Life Sci."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yhbeh.2013.04.009","article-title":"A novel melatonin agonist Neu-P11 facilitates memory performance andimproves cognitive impairment in a rat model of Alzheimer\u2019 disease","volume":"64","author":"He","year":"2013","journal-title":"Horm. Behav."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1034\/j.1600-079X.2003.00057.x","article-title":"Orally administered melatonin reduces oxidative stress and proinflammatory cytokines induced by amyloid-beta peptide in rat brain: A comparative, in vivo study versus vitamin C and E","volume":"35","author":"Tan","year":"2003","journal-title":"J. Pineal. Res."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3390\/antiox3020245","article-title":"Melatonin therapy in patients with alzheimer\u2019s disease","volume":"3","author":"Cardinali","year":"2014","journal-title":"Antioxidants"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/1475-2891-12-142","article-title":"Effects of coenzyme Q10 supplementation (300 mg\/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: A randomized, placebo-controlled trial","volume":"12","author":"Lee","year":"2013","journal-title":"Nutr. J."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10571-015-0224-4","article-title":"Protective effects of coenzyme Q10 against hydrogen peroxide-induced oxidative stress in PC12 cell: The role of Nrf2 and antioxidant enzymes","volume":"36","author":"Li","year":"2016","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.brainresbull.2019.01.025","article-title":"Investigation of protective effects of coenzyme Q10 on impaired synaptic plasticity in a male rat model of Alzheimer\u2019s disease","volume":"147","author":"Komaki","year":"2019","journal-title":"Brain Res. Bull."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s11064-012-0755-8","article-title":"Elevated oxidative stress and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: Implications for neurodegeneration in Alzheimer\u2019s disease","volume":"37","author":"Venkateshappa","year":"2012","journal-title":"Neurochem. Res."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"13388","DOI":"10.3390\/ijms150813388","article-title":"Water-soluble coenzyme q10 inhibits nuclear translocation of apoptosis inducing factor and cell death caused by mitochondrial complex I inhibition","volume":"15","author":"Li","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"e22519","DOI":"10.1002\/jbt.22519","article-title":"Biotin, coenzyme Q10, and their combination ameliorate aluminium chloride-induced Alzheimer\u2019s disease via attenuating neuroinflammation and improving brain insulin signalling","volume":"34","author":"Attia","year":"2020","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Caruso, G., Godos, J., Castellano, S., Micek, A., Murabito, P., Galvano, F., Ferri, R., Grosso, G., and Caraci, F. (2021). The therapeutic potential of carnosine\/anserine supplementation against cognitive decline: A systematic review with meta-analysis. Biomedicines, 9.","DOI":"10.3390\/biomedicines9030253"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2014.03.035","article-title":"Natural forms of vitamin E: Metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy","volume":"72","author":"Jiang","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.mam.2007.01.002","article-title":"Absorption, transport, and tissue delivery of vitamin E","volume":"28","author":"Rigotti","year":"2007","journal-title":"Mol. Aspects Med."},{"key":"ref_193","unstructured":"IOM (2000). Dieatary Reference Intake for Vitamin C, Vitamin E, Selenium, and Carotenoids, National Academy Press."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.freeradbiomed.2016.09.017","article-title":"Vitamin E: Emerging aspects and new directions","volume":"102","author":"Galli","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_195","unstructured":"(2000). \u201cVitamins\u201d. Collective Work Edited by Prof. Jan Gaw\u0119cki, Library of the Nutrition Olympiad, Book 5, Department of Hygiene of Human Nutrition."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1136\/bmj.2.4219.709-a","article-title":"Vitamin-E therapy in neuromuscular disorders","volume":"2","author":"Bacharach","year":"1941","journal-title":"Br. Med. J."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/mnfr.200900575","article-title":"Dietary alpha-tocopherol and neuromuscular health: Search for optimal dose and molecular mechanisms continues","volume":"54","author":"Gohil","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/mnfr.200900460","article-title":"Vitamin E and neurological function","volume":"54","author":"Muller","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Teixeira, J.P., de Castro, A.A., Soares, F.V., da Cunha, E.F.F., and Ramalho, T.C. (2019). Future therapeutic perspectives into the Alzheimer\u2019s disease targeting the oxidative stress hypothesis. Molecules, 24.","DOI":"10.3390\/molecules24234410"},{"key":"ref_200","unstructured":"Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds (2000). Dietary reference intakes for Vitamin C, Vitamin E, selenium and carotenoids. J. Am. Diet. Assoc., 100, 637\u2013640."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3233\/ADR-200171","article-title":"Alzheimer\u2019s disease, inflammation, and the role of antioxidants","volume":"4","author":"Sinyor","year":"2020","journal-title":"J. Alzheimers Dis. Rep."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2016.07.005","article-title":"Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson\u2019s disease and Alzheimer\u2019s disease","volume":"147","author":"Jiang","year":"2016","journal-title":"Prog. Neurobiol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1001\/jama.287.24.3230","article-title":"Dietary intake of antioxidant nutrients and the risk of incident alzheimer disease in a biracial community study","volume":"287","author":"Morris","year":"2002","journal-title":"JAMA"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: Report of the NINCDS-ADRDA Work Group under the auspices of department of health and human services task force on alzheimer\u2019s disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"37","DOI":"10.7326\/0003-4819-142-1-200501040-00110","article-title":"Meta-analysis: High-dosage Vitamin E supplementation may increase all-cause mortality","volume":"142","author":"Miller","year":"2005","journal-title":"Ann. Intern. Med."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bbr.2004.04.012","article-title":"Beta-amyloid (1-42)-induced learning and memory deficits in mice: Involvement of oxidative burdens in the hippocampus and cerebral cortex","volume":"155","author":"Jhoo","year":"2004","journal-title":"Behav. Brain Res."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/npp.2012.247","article-title":"Increased amyloid-\u03b2 peptide-induced memory deficits in phospholipid transfer protein (PLTP) gene knockout mice","volume":"38","author":"Desrumaux","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Gugliandolo, A., Bramanti, P., and Mazzon, E. (2017). Role of Vitamin E in the treatment of alzheimer\u2019s disease: Evidence from animal models. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122504"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.freeradbiomed.2004.04.037","article-title":"Effects of \u03b1-tocopherol on an animal model of tauopathies","volume":"37","author":"Nakashima","year":"2004","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1753-4887.2012.00512.x","article-title":"Tocotrienol research: Past into present","volume":"70","author":"Wong","year":"2012","journal-title":"Nutr. Rev."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Meganathan, P., and Fu, J.Y. (2016). Biological properties of tocotrienols: Evidence in human studies. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17111682"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1126\/science.1083516","article-title":"Characterization of mammalian selenoproteomes","volume":"300","author":"Kryukov","year":"2003","journal-title":"Science"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0531-5565(00)00218-7","article-title":"Serum concentrations of zinc and selenium in elderly people: Results in healthy nonagenarians\/centenarians","volume":"6","author":"Savarino","year":"2001","journal-title":"Exp. Gerontol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1017\/S0007114509992832","article-title":"Nutritional status of selenium in Alzheimer\u2019s disease patients","volume":"103","author":"Cardoso","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3233\/JAD-131805","article-title":"Selenomethionine ameliorates cognitive decline, reduces tau hyperphosphorylation, and reverses synaptic deficit in the triple transgenic mouse model of Alzheimer\u2019s disease","volume":"41","author":"Song","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.brainres.2009.04.010","article-title":"Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer\u2019s type","volume":"1281","author":"Ishrat","year":"2009","journal-title":"Brain Res."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"13888","DOI":"10.1073\/pnas.1009038107","article-title":"Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer\u2019s disease models","volume":"107","author":"Ke","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/10408690590957188","article-title":"Astaxanthin: A review of its chemistry and applications","volume":"46","author":"Goycoolea","year":"2006","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Santonocito, D., Raciti, G., Campisi, A., Sposito, G., Panico, A., Siciliano, E.A., Sarpietro, M.G., Damiani, E., and Puglia, C. (2021). Astaxanthin-loaded stealth lipid nanoparticles (AST-SSLN) as potential carriers for the treatment of alzheimer\u2019s disease: Formulation development and optimization. Nanomaterials, 11.","DOI":"10.3390\/nano11020391"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1096\/fj.08-123281","article-title":"Astaxanthin reduces ischemic brain injury in adult rats","volume":"23","author":"Shen","year":"2009","journal-title":"FASEB J."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"3456783","DOI":"10.1155\/2016\/3456783","article-title":"Astaxanthin protects primary hippocampal neurons against noxious effects of a\u03b2-oligomers","volume":"2016","author":"Lobos","year":"2016","journal-title":"Neural Plast."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.molliq.2018.02.081","article-title":"Assessment of antioxidant, anticholinesterase and antiamyloidogenic effect of Terminalia chebula, Terminalia arjuna and its bioactive constituent 7-Methyl gallic acid\u2014An in vitro and in silico studies","volume":"257","author":"Pugazhendhi","year":"2018","journal-title":"J. Mol. Liq."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Prakashkumar, N., Sivamaruthi, B.S., Chaiyasut, C., and Suganthy, N. (2021). Decoding the neuroprotective potential of methyl gallate-loaded starch nanoparticles against beta amyloid-induced oxidative stress-mediated apoptosis: An in vitro study. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13030299"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0141-8130(98)00040-3","article-title":"Starch granules: Structure and biosynthesis","volume":"23","author":"Colonna","year":"1998","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1080\/87559129.2016.1261298","article-title":"Microencapsulation using starch as wall material: A review","volume":"34","author":"Garcia","year":"2018","journal-title":"Food Rev. Int."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/bph.13621","article-title":"Curcumin, the golden nutraceutical: Multitargeting for multiple chronic diseases","volume":"174","author":"Kunnumakkara","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_227","unstructured":"Surh, Y.J., Dong, Z., Cadenas, E., and Packer, L. (2009). Regulation of Inflammation, Redox, and Glucocorticoid Signaling by Dietary Polyphenols, CRC Press."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1080\/10408398.2019.1653260","article-title":"Curcumin for depression: A meta-analysis","volume":"60","author":"Vozza","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_229","first-page":"769","article-title":"Evaluation of antidepressant like activity of curcumin and its combination with fluoxetine and imipramine: An acute and chronic study","volume":"68","author":"Sanmukhani","year":"2011","journal-title":"Acta Pol. Pharm."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ejphar.2016.05.026","article-title":"Curcumin in depressive disorders: An overview of potential mechanisms, preclinical and clinical findings","volume":"784","author":"Kaufmann","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"12283","DOI":"10.1074\/jbc.AAC118.004745","article-title":"Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-\u03ba B and the serine\/threonine kinase akt and is independent of tubulin polymerization","volume":"293","author":"Bava","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_232","first-page":"211","article-title":"Effects of curcumin on brain-derived neurotrophic factor levels and oxidative damage in obesity and diabetes","volume":"39","author":"Segovia","year":"2013","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.12659\/MSM.906933","article-title":"Curcumin treatment is associated with increased expression of the N-Methyl-D-Aspartate Receptor (NMDAR) Subunit, NR2A, in a Rat PC12 cell line model of alzheimer\u2019s disease treated with the acetyl amyloid-\u03b2 Peptide, A\u03b2(25\u201335)","volume":"24","author":"Qian","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neulet.2016.10.050","article-title":"Curcumin attenuates paraquat-induced cell death in human neuroblastoma cells through modulating oxidative stress and autophagy","volume":"636","author":"Jaroonwitchawan","year":"2017","journal-title":"Neurosci. Lett."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuroscience.2019.09.032","article-title":"Curcumin-loaded nanocapsules reverses the depressant-like behavior and oxidative stress induced by beta-amyloid in mice","volume":"423","author":"Fidelis","year":"2019","journal-title":"Neuroscience"},{"key":"ref_236","first-page":"281","article-title":"Curcum\u0131n: Therapeut\u0131c appl\u0131cat\u0131ons in system\u0131c and oral health","volume":"6","author":"Deogade","year":"2015","journal-title":"Int. J. Biol. Pharm. Res."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1021\/cn200088r","article-title":"\u201cClicked\u201d sugar-curcumin conjugate: Modulator of amyloid-beta and tau peptide aggregation at ultralow concentrations","volume":"2","author":"Dolai","year":"2011","journal-title":"ACS Chem. Neurosci."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1080\/10408398.2015.1077195","article-title":"Curcumin, an active component of turmeric (Curcuma longa), and its effects on health","volume":"57","author":"Kocaadam","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Simeonova, R., Zheleva, D., Valkova, I., Stavrakov, G., Philipova, I., Atanasova, M., and Doytchinova, I. (2021). A novel galantamine-curcumin hybrid as a potential multi-target agent against neurodegenerative disorders. Molecules, 26.","DOI":"10.3390\/molecules26071865"},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"Stavrakov, G., Philipova, I., Lukarski, A., Atanasova, M., Zheleva, D., Zhivkova, Z.D., Ivanov, S., Atanasova, T., Konstantinov, S., and Doytchinova, I. (2020). Galantamine-curcumin hybrids as dual-site binding acetylcholinesterase inhibitors. Molecules, 25.","DOI":"10.3390\/molecules25153341"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neuro.2017.05.004","article-title":"Curcumin administration suppress acetylcholinesterase gene expression in cadmium treated rats","volume":"62","author":"Akinyemi","year":"2017","journal-title":"Neurotoxicology"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/HNP.0000000000000208","article-title":"Investigation of the anxiolytic and antidepressant effects of curcumin, a compound from turmeric (curcuma longa), in the adult male Sprague-Dawley rat","volume":"31","author":"Ceremuga","year":"2017","journal-title":"Holist. Nurs. Pract."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/hup.2434","article-title":"Saffron (Crocus sativus) for depression: A systematic review of clinical studies and examination of underlying antidepressant mechanisms of action","volume":"29","author":"Lopresti","year":"2014","journal-title":"Hum. Psychopharmacol. Clin. Exp."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.brainresbull.2018.08.021","article-title":"Crocin, a natural product attenuates lipopolysaccharide-induced anxiety and depressive-like behaviors through suppressing NF-kB and NLRP3 signaling pathway","volume":"142","author":"Zhang","year":"2018","journal-title":"Brain Res. Bull."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1365-2710.2009.01133.x","article-title":"Saffron in the treatment of patients with mild to moderate Alzheimer\u2019s disease: A 16-week, randomized and placebo-controlled trial","volume":"35","author":"Akhondzadeh","year":"2010","journal-title":"J. Clin. Pharm. Ther."},{"key":"ref_246","first-page":"1100","article-title":"Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders","volume":"23","author":"Hosseinzadeh","year":"2020","journal-title":"Iran. J. Basic Med Sci."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cofs.2015.02.002","article-title":"Preventive and protective properties of rosemary (Rosmarinus officinalis L.) in obesity and diabetes mellitus of metabolic disorders: A brief review","volume":"2","author":"Sedighi","year":"2015","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ejphar.2010.09.001","article-title":"Neuroprotective effects of chlorogenic acid on scopolamine- induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice","volume":"649","author":"Kwon","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"514","DOI":"10.2174\/1570159X1304150831120428","article-title":"Research on the pathological mechanism and drug treatment mechanism of depression","volume":"13","author":"Peng","year":"2015","journal-title":"Curr. Neuropharmacol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"4445","DOI":"10.1007\/s00018-015-2012-1","article-title":"Pharmacologic overview of Withania somnifera, the Indian Ginseng","volume":"72","author":"Dar","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.pnpbp.2009.03.004","article-title":"Antidepressant-like effect of the extract of rosmarinus officinalis in mice: Involvement of the monoaminergic system","volume":"33","author":"Machado","year":"2009","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.pbb.2012.08.016","article-title":"Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: Evidence for the involvement of the dopaminergic system","volume":"103","author":"Machado","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbr.2016.01.037","article-title":"Resveratrol exerts antidepressant properties in the chronic unpredictable mild stress model through the regulation of oxidative stress and mtor pathway in the rat hippocampus and prefrontal cortex","volume":"302","author":"Liu","year":"2016","journal-title":"Behav. Brain Res."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1021\/acschemneuro.5b00260","article-title":"Pomegranate\u2019s Neuroprotective effects against alzheimer\u2019s disease are mediated by urolithins, its ellagitannin-gut microbial derived metabolites","volume":"7","author":"Yuan","year":"2016","journal-title":"ACS Chem. Neurosci."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.biopsych.2010.06.012","article-title":"A meta-analysis of cytokines in Alzheimer\u2019s disease","volume":"68","author":"Swardfager","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/mp.2010.52","article-title":"Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression","volume":"16","author":"Shelton","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pbb.2013.10.028","article-title":"Antidepressant-like effect of resveratrol: Involvement of antioxidant effect and peripheral regulation on hpa axis","volume":"114\u2013115","author":"Ge","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/PSY.0000000000000009","article-title":"Depression and oxidative stress: Results from a meta-analysis of observational studies","volume":"76","author":"Palta","year":"2014","journal-title":"Psychosom. Med."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"12106","DOI":"10.1523\/JNEUROSCI.1269-16.2016","article-title":"Cross talk between brain innate immunity and serotonin signaling underlies depressive-like behavior induced by Alzheimer\u2019s amyloid-\u03b2 oligomers in mice","volume":"36","author":"Ledo","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_260","doi-asserted-by":"crossref","unstructured":"Kujawska, M., Jourdes, M., Kurpik, M., Szulc, M., Szaefer, H., Chmielarz, P., Kreiner, G., Krajka-Ku\u017aniak, V., Miko\u0142ajczak, P.\u0141., and Teissedre, P.-L. (2020). Neuroprotective effects of pomegranate juice against parkinson\u2019s disease and presence of ellagitannins-derived metabolite\u2014Urolithin A\u2014In the brain. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010202"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbr.2014.01.039","article-title":"Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and bdnf expression in rats","volume":"264","author":"Liu","year":"2014","journal-title":"Behav. Brain Res."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1111\/bph.13492","article-title":"Antioxidant effects of resveratrol in the cardiovascular system","volume":"174","author":"Xia","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"9568647","DOI":"10.1155\/2020\/9568647","article-title":"Antioxidant effects of salidroside in the cardiovascular system","volume":"2020","author":"Sun","year":"2020","journal-title":"Evid.-Based Complementary Altern. Med."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.vph.2015.03.005","article-title":"The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review)","volume":"71","author":"Siti","year":"2015","journal-title":"Vasc. Pharmacology."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1155\/2014\/904834","article-title":"Salidroside stimulates mitochondrial biogenesis and protects against H2O2-induced endothelial dysfunction","volume":"2014","author":"Xing","year":"2014","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_266","doi-asserted-by":"crossref","unstructured":"Essa, M.M., Subash, S., Akbar, M., Al-Adawi, S., and Guillemin, G.J. (2015). Long-term dietary supplementation of pomegranates, figs and dates alleviate neuroinflammation in a transgenic mouse model of Alzheimer\u2019s disease. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0120964"},{"key":"ref_267","first-page":"53","article-title":"Influence of salidroside from Rhodiola sachalinensis A. bor on some related indexes of free radical and energy metabolism after exercise in mice","volume":"28","author":"Li","year":"2012","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.pnpbp.2013.09.017","article-title":"A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers","volume":"48","author":"Lopresti","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.steroids.2015.05.010","article-title":"Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice","volume":"101","author":"Ali","year":"2015","journal-title":"Steroids"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fendo.2016.00044","article-title":"Resveratrol ameliorates the anxiety- and depression-like behavior of subclinical hypothyroidism rat: Possible involvement of the hpt axis, hpa axis, and wnt\/beta-catenin pathway","volume":"7","author":"Ge","year":"2016","journal-title":"Front Endocrinol."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.pbb.2013.10.007","article-title":"Antidepressant-like activity of resveratrol treatment in the forced swim test and tail suspension test in mice: The hpa axis, bdnf expression and phosphorylation of erk","volume":"112","author":"Wang","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_272","doi-asserted-by":"crossref","unstructured":"Lykkesfeldt, J., and Tveden-Nyborg, P. (2019). The pharmacokinetics of Vitamin C. Nutrients, 11.","DOI":"10.3390\/nu11102412"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/10\/9\/1439\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:59:39Z","timestamp":1760165979000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/10\/9\/1439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,9]]},"references-count":272,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["antiox10091439"],"URL":"https:\/\/doi.org\/10.3390\/antiox10091439","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,9]]}}}