{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:35:09Z","timestamp":1785530109906,"version":"3.56.0"},"reference-count":31,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>We investigated whether standardized edible bird\u2019s nest extract (BNE-PK) can prevent ultraviolet B (UVB) irradiation-mediated oxidative stress and photoaging in the skin using in vitro and in vivo models. BNE-PK increased skin hydration by hyaluronic acid synthesis and activation of ceramide synthase in UVB-irradiated hairless mice and HaCaT cells. Furthermore, BNE-PK suppressed melanogenesis by down-regulation of the cAMP\/PKA\/CREB\/MITF\/TRP-1\/TRP-2\/tyrosinase pathway in UVB-irradiated hairless mice and 3-isobutyl-1-methylxanthine (IBMX)-treated B16F10 cells. In UVB-irradiated hairless mice, BNE-PK attenuated the wrinkle formation-related JNK\/c-FOS\/c-Jun\/MMP pathway and activated the TGF-\u03b2RI\/SMAD3\/pro-collagen type I pathway during UVB-mediated oxidative stress. Based on these findings, our data suggest that BNE-PK may potentially be used for the development of effective natural anti-photoaging functional foods for skin health.<\/jats:p>","DOI":"10.3390\/antiox10091452","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T21:37:12Z","timestamp":1631569032000},"page":"1452","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Standardized Edible Bird\u2019s Nest Extract Prevents UVB Irradiation-Mediated Oxidative Stress and Photoaging in the Skin"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-2571","authenticated-orcid":false,"given":"Ok-Kyung","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju 61186, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9619-5081","authenticated-orcid":false,"given":"Dakyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medical Nutrition, Kyung Hee University, Yongin 17104, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8820-4395","authenticated-orcid":false,"given":"Minhee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medical Nutrition, Kyung Hee University, Yongin 17104, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8808-6328","authenticated-orcid":false,"given":"Seong-Hoo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medical Nutrition, Kyung Hee University, Yongin 17104, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wakana","family":"Yamada","sequence":"additional","affiliation":[{"name":"Oryza Oil & Fat Chemical Co., Ltd., Ichinomiya 493-8001, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangwon","family":"Eun","sequence":"additional","affiliation":[{"name":"R&D Division, Daehan Chemtech Co. Ltd., Seoul 01811, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongmin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medical Nutrition, Kyung Hee University, Yongin 17104, Korea"},{"name":"Research Institute of Clinical Nutrition, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"key":"ref_1","first-page":"159","article-title":"What is the \u2019true\u2019 function of skin?","volume":"11","author":"Chuong","year":"2002","journal-title":"Exp. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1568-1637(02)00024-7","article-title":"UV-light-induced signal cascades and skin aging","volume":"1","author":"Fisher","year":"2002","journal-title":"Ageing Res. 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