{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:26:18Z","timestamp":1789611978951,"version":"build-2803163510"},"reference-count":59,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chinese Natural Science Foundation Project","award":["32102588"],"award-info":[{"award-number":["32102588"]}]},{"name":"Top-notch Young Talent Supporting Program","award":["LHS"],"award-info":[{"award-number":["LHS"]}]},{"name":"A research grant from Adisseo France S.A.S.","award":["LHS"],"award-info":[{"award-number":["LHS"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>This study has determined whether hydroxy-selenomethionine (OH-SeMet) exerts a better protective action on broilers against environmental stress than sodium selenite (SS) or seleno-yeast (SY). Day-old male Cobb 500 broilers (12 cages\/diet, 9 broilers\/cage) were fed a selenium (Se)-deficient diet (0.047 mg\/kg) supplemented with SS, SY or OH-SeMet at 0.3 mg Se\/kg under a high stocking density and heat stress condition for six weeks. OH-SeMet improved the FCR and Se concentration in the tissues than SS and SY. SY and OH-SeMet both reduced the serum cortisol, T3, IL-6, IgA, IgM and LPS, more than SS, while only OH-SeMet further increased IL-10 and IgG. SY and OH-SeMet improved the intestinal morphology and increased the T-AOC, TXRND, SELENON and OCCLUDIN activities but decreased CLAUDIN2 in the jejunum than SS, while OH-SeMet further improved these values than SY. SY and OH-SeMet both increased SELENOS and TXNRD2 in the muscles than SS, and OH-SeMet further raised T-AOC, GPX4, SELENOP, SELENOW and TXNRD1, and reduced malondialdehyde and protein carbonyl in the muscles than SS and SY. OH-SeMet showed a better ability to maintain the performance and the redox and immune status of broilers under a high stocking density and heat stress challenge than SS and SY.<\/jats:p>","DOI":"10.3390\/antiox10101542","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T12:29:14Z","timestamp":1632832154000},"page":"1542","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Hydroxy-Selenomethionine Improves the Selenium Status and Helps to Maintain Broiler Performances under a High Stocking Density and Heat Stress Conditions through a Better Redox and Immune Response"],"prefix":"10.3390","volume":"10","author":[{"given":"Hua","family":"Sun","sequence":"first","affiliation":[{"name":"Hubei Hongshan Laboratory, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hubei Hongshan Laboratory, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"Hubei Hongshan Laboratory, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"De Marco","sequence":"additional","affiliation":[{"name":"Adisseo France S.A.S., 10, Place du G\u00e9n\u00e9ral de Gaulle, 92160 Antony, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9685-2739","authenticated-orcid":false,"given":"Mickael","family":"Briens","sequence":"additional","affiliation":[{"name":"Adisseo France S.A.S., 10, Place du G\u00e9n\u00e9ral de Gaulle, 92160 Antony, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Hua","family":"Yan","sequence":"additional","affiliation":[{"name":"Hubei Hongshan Laboratory, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lv-Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"Hubei Hongshan Laboratory, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.3382\/ps.2013-03081","article-title":"The effects of Forsythia suspensa extract and berberine on growth performance, immunity, antioxidant activities, and intestinal microbiota in broilers under high stocking density","volume":"92","author":"Zhang","year":"2013","journal-title":"Poult. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Goo, D., Kim, J.H., Park, G.H., Delos-Reyes, J.B., and Kil, D.Y. (2019). Effect of Heat Stress and Stocking Density on Growth Performance, Breast Meat Quality and Intestinal Barrier Function in Broiler Chickens. Animals, 9.","DOI":"10.3390\/ani9030107"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3390\/ani3020356","article-title":"Impact of Heat Stress on Poultry Production","volume":"3","author":"Lara","year":"2013","journal-title":"Animals"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S1471-4906(03)00173-X","article-title":"How stress influences the immune response","volume":"24","author":"Padgett","year":"2003","journal-title":"Trends Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.3382\/ps.2009-00220","article-title":"Effects of different levels of vitamin E on growth performance and immune responses of broilers under heat stress","volume":"88","author":"Niu","year":"2009","journal-title":"Poult. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.freeradbiomed.2013.04.003","article-title":"Epidemiology of selenium and type 2 diabetes: Can we make sense of it?","volume":"65","author":"Rayman","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00039.2013","article-title":"Selenoproteins: Molecular pathways and physiological roles","volume":"94","author":"Labunskyy","year":"2014","journal-title":"Physiol Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s12011-012-9517-3","article-title":"Effects of selenium source and level on growth performance, tissue selenium concentrations, antioxidation, and immune functions of heat-stressed broilers","volume":"150","author":"Liao","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12011-015-0275-x","article-title":"Selenium as a feed supplement for heat-stressed poultry: A review","volume":"165","author":"Habibian","year":"2015","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Shakeri, M., Oskoueian, E., Le, H.H., and Shakeri, M. (2020). Strategies to Combat Heat Stress in Broiler Chickens: Unveiling the Roles of Selenium, Vitamin E and Vitamin C. Vet. Sci., 7.","DOI":"10.3390\/vetsci7020071"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s12011-016-0899-5","article-title":"Nanoselenium Supplementation of Heat-Stressed Broilers: Effects on Performance, Carcass Characteristics, Blood Metabolites, Immune Response, Antioxidant Status, and Jejunal Morphology","volume":"178","author":"Perai","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2141\/jpsa.0170132","article-title":"Selenium in Poultry Nutrition: From Sodium Selenite to Organic Selenium Sources","volume":"55","author":"Surai","year":"2018","journal-title":"J. Poult. Sci."},{"key":"ref_13","unstructured":"EFSA (2009). Scientific Opinion of the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) on a request from the European Commission on the safety and efficacy of SELSAF (Selenium enriched yeast from Saccharomyces cerevisiae CNCM I-3399) as feed additive for all species. EFSA J., 9, 2279."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"EFSA (2013). Scientific opinion on safety and efficacy of hydroxyanalogue of selenomethionine as feed additive for all species. EFSA J., 11, 3046.","DOI":"10.2903\/j.efsa.2013.3046"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"EFSA (2019). Assessment of the application for renewal of authorisation of selenomethionine produced by Saccharomyces cerevisiae NCYC R397 for all animal species. EFSA J., 17, e05539.","DOI":"10.2903\/j.efsa.2019.5539"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"EFSA (2018). Assessment of the application for renewal of authorisation of selenomethionine produced by Saccharomyces cerevisiae CNCM I-3060 (selenised yeast inactivated) for all animal species. EFSA J., 16, e05386.","DOI":"10.2903\/j.efsa.2018.5386"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.3382\/ps\/pey406","article-title":"Nutritional modulation of the antioxidant capacities in poultry: The case of selenium","volume":"98","author":"Surai","year":"2019","journal-title":"Poult. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"9602","DOI":"10.3168\/jds.2017-12610","article-title":"Hydroxy-selenomethionine: A novel organic selenium source that improves antioxidant status and selenium concentrations in milk and plasma of mid-lactation dairy cows","volume":"100","author":"Sun","year":"2017","journal-title":"J. Dairy Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7000","DOI":"10.3168\/jds.2018-16065","article-title":"Bioefficacy of hydroxy-selenomethionine as a selenium supplement in pregnant dairy heifers and on the selenium status of their calves","volume":"102","author":"Juniper","year":"2019","journal-title":"J. Dairy Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"182","DOI":"10.2527\/jas.2013-6783","article-title":"Evaluation of the efficacy of 2-hydroxy-4-methylselenobutanoic acid on growth performance and tissue selenium retention in growing pigs","volume":"92","author":"Jlali","year":"2014","journal-title":"J. Anim. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s12011-019-01754-y","article-title":"Impact of Maternal Selenium Supplementation from Late Gestation and Lactation on Piglet Immune Function","volume":"194","author":"Li","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.2527\/jas.2012-5825","article-title":"Effect of 2-hydroxy-4-methylselenobutanoic acid as a dietary selenium supplement to improve the selenium concentration of table eggs","volume":"91","author":"Jlali","year":"2013","journal-title":"J. Anim. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s12011-015-0548-4","article-title":"2-Hydroxy-4-Methylselenobutanoic Acid as New Organic Selenium Dietary Supplement to Produce Selenium-Enriched Eggs","volume":"171","author":"Tufarelli","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3382\/ps.2013-03182","article-title":"2-Hydroxy-4-methylselenobutanoic acid induces additional tissue selenium enrichment in broiler chickens compared with other selenium sources","volume":"93","author":"Briens","year":"2014","journal-title":"Poult. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1080\/1828051X.2021.1894994","article-title":"Bio-efficacy of organic selenium compounds in broiler chickens","volume":"20","author":"Conjat","year":"2021","journal-title":"Ital. J. Anim. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"789","DOI":"10.3945\/jn.116.247338","article-title":"A Novel Organic Selenium Compound Exerts Unique Regulation of Selenium Speciation, Selenogenome, and Selenoproteins in Broiler Chicks","volume":"147","author":"Zhao","year":"2017","journal-title":"J. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.3382\/ps\/pey408","article-title":"Avian selenogenome: Response to dietary Se and vitamin E deficiency and supplementation","volume":"98","author":"Sun","year":"2019","journal-title":"Poult. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3945\/jn.115.224626","article-title":"Prevention of Aflatoxin B1 Hepatoxicity by Dietary Selenium Is Associated with Inhibition of Cytochrome P450 Isozymes and Up-Regulation of 6 Selenoprotein Genes in Chick Liver","volume":"146","author":"Sun","year":"2015","journal-title":"J. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"8852","DOI":"10.1073\/pnas.0308096101","article-title":"Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase","volume":"101","author":"McClung","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"108025","DOI":"10.1016\/j.meatsci.2019.108025","article-title":"Effects of heat stress on animal physiology, metabolism, and meat quality: A review","volume":"162","author":"Chauhan","year":"2020","journal-title":"Meat Sci."},{"key":"ref_31","unstructured":"Melaku, W., and Mengistu, U. (2015). Performance of Cobb 500 and Hubbard Broilers on Different Treatment, LAP LAMBERT Academic Publishing."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1071\/AN20133","article-title":"Effect of selenium supplementation on productive performance and antioxidant status of broilers under heat stress: A meta-analysis and a meta-regression","volume":"61","year":"2021","journal-title":"Anim. Prod. Sci."},{"key":"ref_33","unstructured":"Michiels, J., Majdeddin, M., Pincemail, J., De-Marco, M., Liu, Y.G., and Briens, M. (2019, January 17\u201320). Dietary hydroxy-selenomethionine helps finishing broilers to cope with heat stress. Proceedings of the 30th Annual Australian Poultry Science Symposium 2019, Sydney, Australia."},{"key":"ref_34","unstructured":"Juzaitis-Boelter, C.P., Davis, A.J., De Marco, M., Brackenridge, J.K., and Shirley, R.B. (2019, January 17\u201320). Hydroxy-selenomethionine sustains egg production and improves egg selenium deposition in aged laying hens under heat stress. Proceedings of the 30th Annual Australian Poultry Science Symposium 2019, Sydney, Australia."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3168\/jds.2018-14974","article-title":"Effects of source on bioavailability of selenium, antioxidant status, and performance in lactating dairy cows during oxidative stress-inducing conditions","volume":"102","author":"Sun","year":"2019","journal-title":"J. Dairy Sci."},{"key":"ref_36","first-page":"s431","article-title":"Review: Adaptation of animals to heat stress","volume":"12","author":"Sejian","year":"2018","journal-title":"Animals"},{"key":"ref_37","first-page":"195","article-title":"Metabolic and endocrine changes induced by chronic heat exposure in broiler chickens: Growth performance, body composition and energy retention","volume":"75","author":"Geraert","year":"1996","journal-title":"Br. J. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"256","DOI":"10.5713\/ajas.2011.11217","article-title":"Immune response of broiler chickens fed diets supplemented with different level of chromium methionine under heat stress conditions","volume":"25","author":"Ebrahimzadeh","year":"2012","journal-title":"Asian-Austral. J. Anim."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"176","DOI":"10.51791\/njap.v48i4.3008","article-title":"The role of selenium in ameliorating the impact of heat stress on growth, hormones, minerals and tibia measurements of broiler chickens","volume":"48","author":"Ndubuisi","year":"2021","journal-title":"Nigerian J. Anim. Prod."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.3382\/ps.2010-00751","article-title":"Alleviation of cyclic heat stress in broilers by dietary supplementation of mannan-oligosaccharide and Lactobacillus-based probiotic: Dynamics of cortisol, thyroid hormones, cholesterol, C-reactive protein, and humoral immunity","volume":"89","author":"Sohail","year":"2010","journal-title":"Poult. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/00071668.2017.1380296","article-title":"Effects of different dietary sources and levels of selenium supplements on growth performance, antioxidant status and immune parameters in Ross 308 broiler chickens","volume":"59","author":"Bakhshalinejad","year":"2018","journal-title":"Br. Poult. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1023\/A:1013204612762","article-title":"Physical and psychological stress in rats enhances colonic epithelial permeability via peripheral CRH","volume":"47","author":"Saunders","year":"2002","journal-title":"Digest. Dis. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jtherbio.2017.10.015","article-title":"The effect of heat stress on intestinal integrity and Salmonella invasion in broiler birds","volume":"70","author":"Alhenaky","year":"2017","journal-title":"J. Therm. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/labinvest.2008.78","article-title":"Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation","volume":"88","author":"Weber","year":"2008","journal-title":"Lab. Investig."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1017\/S0007114519001910","article-title":"The protective effect of selenium from heat stress-induced porcine small intestinal epithelial cell line (IPEC-J2) injury is associated with regulation expression of selenoproteins","volume":"122","author":"Tang","year":"2019","journal-title":"Br. J. Ntr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1071\/AN15725","article-title":"New biomarkers for intestinal permeability induced by lipopolysaccharide in chickens","volume":"56","author":"Gilani","year":"2016","journal-title":"Anim. Prod. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1146\/annurev-immunol-031210-101317","article-title":"Immunoglobulin Responses at the Mucosal Interface","volume":"29","author":"Cerutti","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bej.2018.01.031","article-title":"Intracellular response of CHO cells to oxidative stress and its influence on metabolism and antibody production","volume":"133","author":"Handlogten","year":"2018","journal-title":"Biochem. Eng. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/10409238.2019.1659227","article-title":"Current insights into the mechanism of mammalian immunoglobulin class switch recombination","volume":"54","author":"Yu","year":"2019","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1158\/2326-6066.CIR-14-0029","article-title":"Affinity enhancement of antibodies: How low-affinity antibodies produced early in immune responses are followed by high-affinity antibodies later and in memory B-cell responses","volume":"2","author":"Eisen","year":"2014","journal-title":"Cancer Immunol. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3109\/03009739909178961","article-title":"Chicken Antibodies","volume":"104","author":"Carlander","year":"1999","journal-title":"Upsala J. Med. Sci."},{"key":"ref_52","first-page":"145","article-title":"Effect of vitamin E and selenium on the immune response of chickens against living Newcastle disease vaccine","volume":"38","author":"Bassiouni","year":"1990","journal-title":"Vet. Med. J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/17450390802611610","article-title":"Effects of different levels of selenium on growth performance and immunocompetence of broilers under heat stress","volume":"63","author":"Niu","year":"2009","journal-title":"Arch. Anim. Nutr."},{"key":"ref_54","first-page":"69","article-title":"Effect of selenium-containing supplements on the indices of specific immunity and nonspecific resistance in chicken","volume":"54","author":"Kovalenko","year":"2008","journal-title":"Fiziol. Zh."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"732203","DOI":"10.3389\/fvets.2021.732203","article-title":"Impact of Climate Change on Immune Responses in Agricultural Animals","volume":"8","author":"Caroprese","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jdermsci.2018.11.008","article-title":"Regulatory and effector B cells: Friends or foes?","volume":"93","author":"Matsushita","year":"2019","journal-title":"J. Dermatol. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Nettford, S.K., and Prabhu, K.S. (2018). Selenium and Selenoproteins in Gut Inflammation\u2014A Review. Antioxidants, 7.","DOI":"10.3390\/antiox7030036"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Taylor, R.M., and Sunde, R.A. (2016). Selenoprotein Transcript Level and Enzyme Activity as Biomarkers for Selenium Status and Selenium Requirements of Chickens (Gallus gallus). PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0151665"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1261\/rna.043463.113","article-title":"Nonsense-mediated decay factors are involved in the regulation of selenoprotein mRNA levels during selenium deficiency","volume":"20","author":"Seyedali","year":"2014","journal-title":"RNA"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/10\/10\/1542\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:06:36Z","timestamp":1760166396000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/10\/10\/1542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,28]]},"references-count":59,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["antiox10101542"],"URL":"https:\/\/doi.org\/10.3390\/antiox10101542","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,28]]}}}