{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:05:54Z","timestamp":1760551554912,"version":"build-2065373602"},"reference-count":65,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Unpredictable climate change might cause serious lack of food in the world. Therefore, in the present world, it is urgent to prepare countermeasures to solve problems in terms of human survival. In this research, quantitative trait loci (QTLs) were analyzed when rice attacked by white backed planthopper (WBPH) were analyzed using 120 Cheongcheong\/Nagdong double haploid lines. Moreover, from the detected QTLs, WBPH resistance-related genes were screened in large candidate genes. Among them, OsCM, a major gene in the synthesis of Cochlioquinone-9 (cq-9), was screened. OsCM has high homology with the sequence of chorismate mutase, and exists in various functional and structural forms in plants that produce aromatic amino acids. It also induces resistance to biotic stress through the synthesis of secondary metabolites in plants. The WBPH resistance was improved in rice overexpressed through map-based cloning of the WBPH resistance-related gene OsCM, which was finally detected by QTL mapping. In addition, cq-9 increased the survival rate of caecal ligation puncture (CLP)-surgery mice by 60%. Moreover, the aorta of rat treated with cq-9 was effective in vasodilation response and significantly reduced the aggregation of rat platelets induced by collagen treatment. A cq-9, which is strongly associated with resistance to WBPH in rice, is also associated with positive effect of CLP surgery mice survival rate, vasodilation, and significantly reduced rat platelet aggregation induced by collagen treatment. Therefore, cq-9 presents research possibilities as a substance in a new paradigm that can act on both Plant-Insect in response to the present unpredictable future.<\/jats:p>","DOI":"10.3390\/antiox10111691","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T23:49:52Z","timestamp":1635292192000},"page":"1691","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Quantitative Trait Loci Mapping of Rice Plant and the Components of Its Extract Confirmed the Anti-Inflammatory and Platelet Aggregation Effects In Vitro and In Vivo"],"prefix":"10.3390","volume":"10","author":[{"given":"Jae-Ryoung","family":"Park","sequence":"first","affiliation":[{"name":"Division of Plant Biosciences, School of Applied Biosciences, College of Agriculture & Life Science, Kyungpook National University, 80 Dahak-ro, Buk-gu, Daegu 41566, Korea"},{"name":"Costal Agriculture Research Institute, Kyungpook National University, 80 Dahak-ro, Buk-gu, Daegu 41566, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahmatullah","family":"Jan","sequence":"additional","affiliation":[{"name":"Division of Plant Biosciences, School of Applied Biosciences, College of Agriculture & Life Science, Kyungpook National University, 80 Dahak-ro, Buk-gu, Daegu 41566, Korea"},{"name":"Costal Agriculture Research Institute, Kyungpook National University, 80 Dahak-ro, Buk-gu, Daegu 41566, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seul-Gi","family":"Park","sequence":"additional","affiliation":[{"name":"National Institute of Crop Science, Rural Development Administration, Jeonju 54874, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tri","family":"Handoyo","sequence":"additional","affiliation":[{"name":"Department of Agronomy, Faculty of Agriculture, Jember University, Jl. Kalimantan 37, Jember 68121, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang-Seob","family":"Lee","sequence":"additional","affiliation":[{"name":"Biosafety Division, National Academy of Agricultural Science, Rural Development Administration, Jeonju 54874, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sopheap","family":"Yun","sequence":"additional","affiliation":[{"name":"Graduate School of Science, Royal University of Phnom Penh, Sangkat Teuk Laak 1, Russian Federation Boulevard, Toul Kork, Phnom Penh 12101, Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon-Hee","family":"Jang","sequence":"additional","affiliation":[{"name":"Division of Plant Biosciences, School of Applied Biosciences, College of Agriculture & Life Science, Kyungpook National University, 80 Dahak-ro, Buk-gu, Daegu 41566, Korea"},{"name":"Costal Agriculture Research Institute, Kyungpook National University, 80 Dahak-ro, Buk-gu, Daegu 41566, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0294-6740","authenticated-orcid":false,"given":"Xiao-Xuan","family":"Du","sequence":"additional","affiliation":[{"name":"Costal Agriculture Research Institute, Kyungpook National University, 80 Dahak-ro, Buk-gu, Daegu 41566, Korea"},{"name":"Biosafety Division, National Academy of Agricultural Science, Rural Development Administration, Jeonju 54874, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taeho","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Dahak-ro, Buk-gu, Daegu 41566, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Sham","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering, College of Natural Resources and Life Science, Dong-A University, Busan 49315, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5409-0027","authenticated-orcid":false,"given":"Doh Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering, College of Natural Resources and Life Science, Dong-A University, Busan 49315, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Mi","family":"Seok","sequence":"additional","affiliation":[{"name":"Department of Korean Medicine Development, National Institute for Korean Medicine Development, 94, Hwarang-ro, Gyeongsan-si 38540, Gyeongsangbuk-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5756-9367","authenticated-orcid":false,"given":"Jong-Sup","family":"Bae","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Dahak-ro, Buk-gu, Daegu 41566, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4812-6297","authenticated-orcid":false,"given":"Kyung-Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Plant Biosciences, School of Applied Biosciences, College of Agriculture & Life Science, Kyungpook National University, 80 Dahak-ro, Buk-gu, Daegu 41566, Korea"},{"name":"Costal Agriculture Research Institute, Kyungpook National University, 80 Dahak-ro, Buk-gu, Daegu 41566, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1007\/s00705-008-0209-4","article-title":"A black-streaked dwarf disease on rice in China is caused by a novel fijivirus","volume":"153","author":"Zhang","year":"2008","journal-title":"Arch. Virol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1094\/PDIS-07-10-0535","article-title":"An identification, characterization, and distribution of southern rice black-streaked dwarf virus in Vietnam","volume":"95","author":"Hoang","year":"2011","journal-title":"Plant Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1743-422X-2-64","article-title":"International committee on taxonomy of viruses and the 3,142 unassigned species","volume":"2","author":"Fauquet","year":"2005","journal-title":"Virol. J."},{"key":"ref_4","first-page":"1","article-title":"Introduction: Biochemistry, physiology and ecological functions of secondary metabolites","volume":"40","author":"Wink","year":"2010","journal-title":"Biochem. Plant Second. Metab. Second Ed."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1572-557X(06)03011-X","article-title":"Chapter 11 importance of plant secondary metabolites for protection against insects and microbial infections","volume":"3","author":"Wink","year":"2006","journal-title":"Adv. Phytomed."},{"key":"ref_6","first-page":"243","article-title":"The potential of secondary metabolites in plant material as deterents against insect pests: A review","volume":"4","author":"Adeyemi","year":"2010","journal-title":"Afr. J. Pure Appl. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fpls.2013.00287","article-title":"Promise for plant pest control: Root-associated pseudomonads with insecticidal activities","volume":"4","author":"Kupferschmied","year":"2013","journal-title":"Front. Plant Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ecolind.2018.04.038","article-title":"Use of botanical insecticides for sustainable agriculture: Future perspectives","volume":"105","author":"Campos","year":"2019","journal-title":"Ecol. Indic."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/ps.3438","article-title":"The repelling effect of plant secondary metabolites on water voles, Arvicola amphibius","volume":"69","author":"Fischer","year":"2013","journal-title":"Pest Manag. Sci."},{"key":"ref_10","first-page":"893","article-title":"Induced plant secondary metabolites for phytopatogenic fungi control: A review","volume":"12","author":"Ribera","year":"2012","journal-title":"J. Soil Sci. Plant Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Abdelhalim, A., and Hanrahan, J. (2021). Biologically Active Compounds from Lamiaceae Family: Central Nervous System Effects, Elsevier. [1st ed.].","DOI":"10.1016\/B978-0-12-819485-0.00017-7"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1104\/pp.20.00433","article-title":"Plant secondary metabolites as defenses, regulators, and primary metabolites: The blurred functional trichotomy","volume":"184","author":"Erb","year":"2020","journal-title":"Plant Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/nph.15656","article-title":"How to analyse plant phenotypic plasticity in response to a changing climate","volume":"222","author":"Arnold","year":"2019","journal-title":"New Phytol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/ppl.12540","article-title":"Plant adaptations to the combination of drought and high temperatures","volume":"162","author":"Zandalinas","year":"2018","journal-title":"Physiol. Plant"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.micpath.2018.08.034","article-title":"Role of secondary metabolites in plant defense against pathogens","volume":"124","author":"Zaynab","year":"2018","journal-title":"Microb. Pathog."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.tplants.2014.01.001","article-title":"Genotype \u00d7 environment interaction QTL mapping in plants: Lessons from Arabidopsis","volume":"19","author":"Malosetti","year":"2014","journal-title":"Trends Plant Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1007\/s00122-017-2963-8","article-title":"Development of 25 near-isogenic lines (NILs) with ten BPH resistance genes in rice (Oryza sativa L.): Production, resistance spectrum, and molecular analysis","volume":"130","author":"Jena","year":"2017","journal-title":"Theor. Appl. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Campos, F.F., Rosa, L.H., Cota, B.B., Caligiorne, R.B., Teles Rabello, A.L., Alves, T.M.A., Rosa, C.A., and Zani, C.L. (2008). Leishmanicidal metabolites from Cochliobolus sp., an endophytic fungus isolated from Piptadenia adiantoides (Fabaceae). PLoS Negl. Trop. Dis., 2.","DOI":"10.1371\/journal.pntd.0000348"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Borrelli, G.M., and Trono, D. (2016). Molecular approaches to genetically improve the accumulation of health-promoting secondary metabolites in staple crops-a case study: The lipoxygenase-b1 genes and regulation of the carotenoid content in pasta products. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17071177"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.mrfmmm.2010.10.007","article-title":"Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells","volume":"706","author":"Arafa","year":"2011","journal-title":"Mutat. Res. Fundam. Mol. Mech. Mutagen."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S1016-8478(23)15069-2","article-title":"Marker-assisted introgression of quantitative trait loci associated with plant regeneration ability in anther culture of rice (Oryza sativa L.)","volume":"14","author":"Kwon","year":"2002","journal-title":"Mol. Cells"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"844","DOI":"10.17957\/IJAB\/15.0181","article-title":"Optimum screening time for improved WBPH-associated QTL analysis in rice","volume":"18","author":"Yun","year":"2016","journal-title":"Int. J. Agric. Biol."},{"key":"ref_23","unstructured":"Wang, S., Basten, C.J., and Zeng, Z.B. (2012). Windows QTL Cartographer 2.Raleigh, Department of Statistics, North Carolina State University."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0076-6879(02)50954-X","article-title":"Getting started with yeast","volume":"350","author":"Fred","year":"2002","journal-title":"Methods Enzymol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/(SICI)1097-0061(199910)15:14<1541::AID-YEA476>3.0.CO;2-K","article-title":"Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae","volume":"15","author":"Goldstein","year":"1999","journal-title":"Yeast"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/275104a0","article-title":"Transformation of yeast by a replicating hybrid plasmid","volume":"275","author":"Beggs","year":"1978","journal-title":"Nature"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1567-1364.2011.00769.x","article-title":"Introduction and expression of genes for metabolic engineering applications in Saccharomyces cerevisiae","volume":"12","author":"Srikrishnan","year":"2012","journal-title":"FEMS Yeast Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF00331307","article-title":"Genetic engineering of Schizosaccharomyces pombe: A system for gene disruption and replacement using the ura4 gene as a selectable marker","volume":"215","author":"Grimm","year":"1988","journal-title":"MGG Mol. Gen. Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/yea.320110408","article-title":"Studies on the transformation of intact yeast cells by the LiAc\/SS-DNA\/PEG procedure","volume":"11","author":"Gietz","year":"1995","journal-title":"Yeast"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0734-9750(96)00033-X","article-title":"Plasmid stability in recombinant Saccharomyces cerevisiae","volume":"14","author":"Zhang","year":"1996","journal-title":"Biotechnol. Adv."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1006\/abbi.1993.1493","article-title":"Purification and enzymatic characterization of the geranylgeranyl pyrophosphate synthase from Erwinia uredovora after expression in Escherichia coli","volume":"306","author":"Wiedemann","year":"1993","journal-title":"Arch. Biochem. Biophys"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Lammli","year":"1970","journal-title":"Nature"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1046\/j.1432-1033.2002.03172.x","article-title":"Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of Arabidopsis thaliana","volume":"269","author":"Rippert","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/cbdv.201100049","article-title":"Synthesis and antidiabetic activity of 5,7-dihydroxyflavonoids and analogs","volume":"9","author":"Chang","year":"2012","journal-title":"Chem. Biodivers."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"577","DOI":"10.5483\/BMBRep.2015.48.10.044","article-title":"Antitcoagulant and antiplatelet activities of scolymoside","volume":"48","author":"Yoon","year":"2015","journal-title":"BMB Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1164\/rccm.201311-2033OC","article-title":"Transforming growth factor \u03b2-induced protein promotes severe vascular inflammatory responses","volume":"189","author":"Bae","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/nm1124","article-title":"Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis","volume":"10","author":"Wang","year":"2004","journal-title":"Nat. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"Rittirsch","year":"2009","journal-title":"Nat. Protoc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1161\/HYPERTENSIONAHA.110.160853","article-title":"Enhanced Ca2+-dependent activation of phosphoinositide 3-kinase class II\u03b1 isoform-Rho axis in blood vessels of spontaneously hypertensive rats","volume":"56","author":"Seok","year":"2010","journal-title":"Hypertension"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ryu, Y., Kee, H.J., Sun, S., Seok, Y.M., Choi, S.Y., Kim, G.R., Kee, S.J., Pflieger, M., Kurz, T., and Kim, H.S. (2019). Class I histone deacetylase inhibitor MS-275 attenuates vasoconstriction and inflammation in angiotensin II-induced hypertension. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0213186"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Jeong, D., Irfan, M., Lee, D.H., Hong, S.B., Oh, J.W., and Rhee, M.H. (2020). Rumex acetosa modulates platelet function and inhibits thrombus formation in rats. BMC Complement. Med. Ther., 20.","DOI":"10.1186\/s12906-020-02889-5"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s00122-002-1025-y","article-title":"QTL analysis of genotype \u00d7 environment interactions affecting cotton fiber quality","volume":"106","author":"Paterson","year":"2003","journal-title":"Theor. Appl. Genet."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1038\/emboj.2009.165","article-title":"Structure and function of a complex between chorismate mutase and DAHP synthase: Efficiency boost for the junior partner","volume":"28","author":"Sasso","year":"2009","journal-title":"EMBO J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"22275","DOI":"10.1074\/jbc.274.32.22275","article-title":"The aroC gene of Aspergillus nidulans codes for a monofunctional, allosterically regulated chorismate mutase","volume":"274","author":"Krappmann","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/mp\/ssp106","article-title":"Phenylpropanoid biosynthesis","volume":"3","author":"Vogt","year":"2010","journal-title":"Mol. Plant"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/417571a","article-title":"Isochorismate synthase is required to synthesize salicylic acid for plant defence","volume":"417","author":"Wildermuth","year":"2002","journal-title":"Nature"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1104\/pp.108.119420","article-title":"Characterization and biological function of the Isochorismate Synthase2 gene of Arabidopsis","volume":"147","author":"Garcion","year":"2008","journal-title":"Plant Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"17189","DOI":"10.1074\/jbc.M601754200","article-title":"A plant locus essential for phylloquinone (vitamin K1) biosynthesis originated from a fusion of four eubacterial genes","volume":"281","author":"Gross","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1365-313X.2008.03416.x","article-title":"The AAE14 gene encodes the Arabidopsis o-succinylbenzoyl-CoA ligase that is essential for phylloquinone synthesis and photosystem-I function","volume":"54","author":"Kim","year":"2008","journal-title":"Plant J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1039\/b820413f","article-title":"Meroterpenoids produced by fungi","volume":"26","author":"Geris","year":"2009","journal-title":"Nat. Prod. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Canonica, L., Ranzi, B.M., Rindone, B., Scala, A., and Scolastico, C. (1973). Biosynthesis of cochlioquniones. J. Chem. Soc. Chem. Commun., 213\u2013214.","DOI":"10.1039\/c39730000213"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1039\/b413068e","article-title":"Biotransformation of the sesquiterpene (+)-valencene by cytochrome P450cam and P450BM-3","volume":"3","author":"Sowden","year":"2005","journal-title":"Org. Biomol. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1002\/cbic.200600338","article-title":"A gene cluster for prenylated naphthoquinone and prenylated phenazine biosynthesis in Streptomyces cinnamonensis DSM","volume":"7","author":"Haaqen","year":"2006","journal-title":"ChemBioChem"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5532","DOI":"10.1016\/j.tetlet.2010.07.153","article-title":"The first total synthesis and structural determination of epi-cochlioquinone A","volume":"51","author":"Hosokawa","year":"2010","journal-title":"Tetrahedron Lett."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1104\/pp.113.214346","article-title":"Veratrole biosynthesis in white campion","volume":"162","author":"Akhtar","year":"2013","journal-title":"Plant Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"59","DOI":"10.7164\/antibiotics.57.59","article-title":"Cochlioquinones and Epi-cochlioquinones: Antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum","volume":"57","author":"Yoganathan","year":"2004","journal-title":"J. Antibiot."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1039\/c29710000164","article-title":"Structures of cochlioquinones A and B, new metabolites of Cochliobolus miyabeanus: Chemical and X-ray crystallographic determination","volume":"3","author":"Carruthers","year":"1971","journal-title":"J. Chem. Soc. D Chem. Commun."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4788","DOI":"10.1016\/j.tet.2015.05.044","article-title":"Isolation, ECD assisted structural analyses, biosynthetic discussions, and biological activities of epi-cochlioquinones D and its derivatives","volume":"71","author":"Arayama","year":"2015","journal-title":"Tetrahedron"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1016\/S0968-0896(03)00523-6","article-title":"Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola","volume":"11","author":"Jung","year":"2003","journal-title":"Bioorganic Med. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.fitote.2016.02.005","article-title":"Cytotoxic cochlioquinone derivatives from the endophytic fungus Bipolaris sorokiniana derived from Pogostemon cablin","volume":"110","author":"Wang","year":"2016","journal-title":"Fitoterapia"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s10600-015-1259-y","article-title":"Chemical constituents of the fungus Veronaea sp.","volume":"51","author":"Zhou","year":"2015","journal-title":"Chem. Nat. Compd."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Jang, Y.-H., Park, J.-R., and Kim, K.-M. (2020). Antimicrobial Activity of Chrysoeriol 7 and Chochlioquinone 9, White-Backed Planthopper-Resistant Compounds, Against Rice Pathogenic Strains. Biology, 9.","DOI":"10.3390\/biology9110382"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"58","DOI":"10.7831\/ras.8.0_58","article-title":"Common strategies to control pythium disease","volume":"8","author":"Wu","year":"2020","journal-title":"Rev. Agric. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1111\/jphp.12113","article-title":"GPER-1 agonist G1 induces vasorelaxation through activation of epidermal growth factor receptor-dependent signalling pathway","volume":"65","author":"Jang","year":"2013","journal-title":"J. Pharm. Pharmacol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/10\/11\/1691\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:24:16Z","timestamp":1760167456000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/10\/11\/1691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,26]]},"references-count":65,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["antiox10111691"],"URL":"https:\/\/doi.org\/10.3390\/antiox10111691","relation":{},"ISSN":["2076-3921"],"issn-type":[{"type":"electronic","value":"2076-3921"}],"subject":[],"published":{"date-parts":[[2021,10,26]]}}}