{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:34:28Z","timestamp":1793986468814,"version":"4.8.0"},"reference-count":35,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T00:00:00Z","timestamp":1636329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministry of Economy and Competitiveness","doi-asserted-by":"publisher","award":["PS17173. NUTRADAF,ITC-20161265"],"award-info":[{"award-number":["PS17173. NUTRADAF,ITC-20161265"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg\/kg\/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67\u201373%), calculated creatinine clearance was significantly increased (26\u201338%), and the glomerular volume and glomerulosclerosis index were decreased (20\u201330%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg\/kg\/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production.<\/jats:p>","DOI":"10.3390\/antiox10111783","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T08:05:16Z","timestamp":1636358716000},"page":"1783","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect"],"prefix":"10.3390","volume":"10","author":[{"given":"Mar\u00eda Dolores","family":"Rodr\u00edguez-P\u00e9rez","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Biomedical Research Institute (IBIMA), University of Malaga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"L\u00f3pez-Villodres","sequence":"additional","affiliation":[{"name":"Area of Human Histology, Faculty of Medicine, University of Malaga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4843-0718","authenticated-orcid":false,"given":"Mar\u00eda Monsalud","family":"Arrebola","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Clinical Management Unit, Hospital Axarqu\u00eda, AGSEMA, 29740 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Mart\u00edn-Aurioles","sequence":"additional","affiliation":[{"name":"Clinical Management Unit La Roca, Distrito Sanitario, AGSEMA, 29740 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8292-3081","authenticated-orcid":false,"given":"\u00c1frica","family":"Fern\u00e1ndez-Prior","sequence":"additional","affiliation":[{"name":"Department of Food Phytochemistry, Instituto de la Grasa (Spanish National Research Council, CSIC), 41013 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3632-3595","authenticated-orcid":false,"given":"Alejandra","family":"Berm\u00fadez-Oria","sequence":"additional","affiliation":[{"name":"Department of Food Phytochemistry, Instituto de la Grasa (Spanish National Research Council, CSIC), 41013 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Carmen","family":"R\u00edos","sequence":"additional","affiliation":[{"name":"Area of Human Histology, Faculty of Medicine, University of Malaga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9613-6660","authenticated-orcid":false,"given":"Jos\u00e9 Pedro","family":"De La Cruz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Biomedical Research Institute (IBIMA), University of Malaga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Gonz\u00e1lez-Correa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Biomedical Research Institute (IBIMA), University of Malaga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,8]]},"reference":[{"key":"ref_1","unstructured":"NCD Risk Factor Collaboration (NCD-RisC) (2016). 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