{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:45:58Z","timestamp":1790394358838,"version":"4.1.0"},"reference-count":43,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Malnutrition has been reported in alcohol use disorder patients as having a possible influence on cognitive function. The aim of this study was to analyse the prevalence of ascorbic acid (AA) deficiency in inpatients admitted for alcohol detoxification and the associated factors, including cognitive impairment in the early period of abstinence. A retrospective chart review was conducted. The AA level was categorised into three groups: deficiency (AAD) (&lt;2 mg\/L), insufficiency (AAI) (2\u20135 mg\/L) and normal level. The cognitive impairment was screened using the Montreal Cognitive Assessment (MoCA). Ninety-six patients were included (74 men; mean age 49.1 years (\u00b111.5)). Twenty-seven AAD (28.1%) and twenty-two AAI (22.9%) were observed. In multivariate analysis, risk factors for AAD versus normal AA level were men (OR 17.8, 95%CI (1.63\u2013194)), compensated cirrhosis (OR 9.35, 95%CI (1.60\u201354.6)) and street homelessness (OR 5.76, 95%CI (1.24\u201326.8) versus personal housing). The MoCA score was available for 53 patients (mean MoCA score: 25.7 (\u00b13.3)). In multivariate analysis, the natural logarithm of AA (\u03b2 = 1.18, p = 0.037) and sedative use disorder (\u03b2 = \u22122.77, p = 0.046) were associated with the MoCA score. AAD and AAI are frequent in inpatients admitted for alcohol detoxification. A low level of AA was associated with cognitive impairment in the early period of abstinence.<\/jats:p>","DOI":"10.3390\/antiox10121892","type":"journal-article","created":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T22:19:16Z","timestamp":1638137956000},"page":"1892","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ascorbic Acid Deficiency Prevalence and Associated Cognitive Impairment in Alcohol Detoxification Inpatients: A Pilot Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2803-8249","authenticated-orcid":false,"given":"Virgile","family":"Clergue-Duval","sequence":"first","affiliation":[{"name":"APHP GHU Nord, Site Lariboisi\u00e8re Fernand-Widal, D\u00e9partement de Psychiatrie et de M\u00e9decine Addictologique, 75010 Paris, France"},{"name":"Inserm UMRS-1144 Optimisation Th\u00e9rapeutique en Neuropsychopharmacologie, Universit\u00e9 de Paris, 75006 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