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Aging and\/or metabolic stress directly impact the cardiovascular system. Over the last few years, the contributions of altered nicotinamide adenine dinucleotide (NAD+) metabolism to aging and other pathological conditions closely related to cardiovascular diseases have been intensively investigated. NAD+ bioavailability decreases with age and cardiometabolic conditions in several mammalian tissues. Compelling data suggest that declining tissue NAD+ is commonly related to mitochondrial dysfunction and might be considered as a therapeutic target. Thus, NAD+ replenishment by either genetic or natural dietary NAD+-increasing strategies has been recently demonstrated to be effective for improving the pathophysiology of cardiac and vascular health in different experimental models, as well as human health, to a lesser extent. Here, we review and discuss recent experimental evidence illustrating that increasing NAD+ bioavailability, particularly by the use of natural NAD+ precursors, may offer hope for new therapeutic strategies to prevent and treat cardiovascular diseases.<\/jats:p>","DOI":"10.3390\/antiox10121939","type":"journal-article","created":{"date-parts":[[2021,12,5]],"date-time":"2021-12-05T20:59:33Z","timestamp":1638737973000},"page":"1939","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Therapeutic Potential of Emerging NAD+-Increasing Strategies for Cardiovascular Diseases"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0587-8045","authenticated-orcid":false,"given":"Noemi","family":"Rotllan","sequence":"first","affiliation":[{"name":"Institut de Recerca i d\u2019Investigaci\u00f3 Biom\u00e8dica de l\u2019Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, 08041 Barcelona, Spain"},{"name":"Department of Biochemistry and Molecular Biology, Universitat Aut\u00f2noma de Barcelona, 08193 Barcelona, Spain"},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas, CIBERDEM, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5970-3294","authenticated-orcid":false,"given":"Mercedes","family":"Camacho","sequence":"additional","affiliation":[{"name":"Institut de Recerca i d\u2019Investigaci\u00f3 Biom\u00e8dica de l\u2019Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, 08041 Barcelona, Spain"},{"name":"CIBER de Enfermedades Cardiovasculares, CIBERCV, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0301-9984","authenticated-orcid":false,"given":"Mireia","family":"Tondo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Universitat Aut\u00f2noma de Barcelona, 08193 Barcelona, Spain"},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas, CIBERDEM, 28029 Madrid, Spain"},{"name":"Department of Biochemistry, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena M. G.","family":"Diarte-A\u00f1azco","sequence":"additional","affiliation":[{"name":"Institut de Recerca i d\u2019Investigaci\u00f3 Biom\u00e8dica de l\u2019Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0278-5337","authenticated-orcid":false,"given":"Marina","family":"Canyelles","sequence":"additional","affiliation":[{"name":"Institut de Recerca i d\u2019Investigaci\u00f3 Biom\u00e8dica de l\u2019Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, 08041 Barcelona, Spain"},{"name":"Department of Biochemistry and Molecular Biology, Universitat Aut\u00f2noma de Barcelona, 08193 Barcelona, Spain"},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas, CIBERDEM, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8372-2310","authenticated-orcid":false,"given":"Karen Alejandra","family":"M\u00e9ndez-Lara","sequence":"additional","affiliation":[{"name":"Institut de Recerca i d\u2019Investigaci\u00f3 Biom\u00e8dica de l\u2019Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Benitez","sequence":"additional","affiliation":[{"name":"Institut de Recerca i d\u2019Investigaci\u00f3 Biom\u00e8dica de l\u2019Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Alonso","sequence":"additional","affiliation":[{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas, CIBERDEM, 28029 Madrid, Spain"},{"name":"Department of Endocrinology & Nutrition, Hospital Universitari Germans Trias i Pujol, 08916 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2868-0250","authenticated-orcid":false,"given":"Didac","family":"Mauricio","sequence":"additional","affiliation":[{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas, CIBERDEM, 28029 Madrid, Spain"},{"name":"Department of Endocrinology & Nutrition, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9021-2485","authenticated-orcid":false,"given":"Joan Carles","family":"Escol\u00e0-Gil","sequence":"additional","affiliation":[{"name":"Institut de Recerca i d\u2019Investigaci\u00f3 Biom\u00e8dica de l\u2019Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, 08041 Barcelona, Spain"},{"name":"Department of Biochemistry and Molecular Biology, Universitat Aut\u00f2noma de Barcelona, 08193 Barcelona, Spain"},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas, CIBERDEM, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7380-5385","authenticated-orcid":false,"given":"Francisco","family":"Blanco-Vaca","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Universitat Aut\u00f2noma de Barcelona, 08193 Barcelona, Spain"},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas, CIBERDEM, 28029 Madrid, Spain"},{"name":"Department of Biochemistry, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6531-2246","authenticated-orcid":false,"given":"Josep","family":"Julve","sequence":"additional","affiliation":[{"name":"Institut de Recerca i d\u2019Investigaci\u00f3 Biom\u00e8dica de l\u2019Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, 08041 Barcelona, Spain"},{"name":"Department of Biochemistry and Molecular Biology, Universitat Aut\u00f2noma de Barcelona, 08193 Barcelona, Spain"},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas, CIBERDEM, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7156435","DOI":"10.1155\/2018\/7156435","article-title":"Aging-Induced Biological Changes and Cardiovascular Diseases","volume":"2018","author":"Fajemiroye","year":"2018","journal-title":"Biomed. 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