{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:57:56Z","timestamp":1782856676073,"version":"3.54.5"},"reference-count":53,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the earmarked fund from the National Natural Science Foundation of China","award":["31972577, 30501963"],"award-info":[{"award-number":["31972577, 30501963"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Our previous studies revealed that L-arginine supplementation had beneficial effects on intestinal barrier functions of low-birth-weight (LBW) piglets, which were associated with the enhanced antioxidant capacity. Moreover, mitochondrial functions are closely related to the redox state. This study was to explore potential mechanisms of L-arginine-induced beneficial effects against intestinal dysfunction by regulating mitochondrial function of LBW piglets. Twenty 4-day-old normal birth weight (NBW) piglets (BW: 2.08 \u00b1 0.09 kg) and 20 LBW siblings (BW: 1.16 \u00b1 0.07 kg) were artificially fed either a basal diet or a basal diet supplemented with 1.0% L-arginine for 21 d, respectively. Growth performance, intestinal morphology, redox status, mitochondrial morphology, and mitochondrial functions were examined. Data were subjected to two-way analysis of variance. LBW piglets presented lower (p &lt; 0.05) ADG, shorter (p &lt; 0.05) intestinal villus height, lower (p &lt; 0.05) jejunal adenosine triphosphate (ATP) content and higher (p &lt; 0.05) concentrations of Ca2+ and 8-OH-dG in jejunal mitochondria, compared with NBW piglets. Supplementation with 1.0% L-arginine significantly increased (p &lt; 0.05) ADG, the activities of CAT, SOD, and GPx, intestinal villus height and mRNA abundances of ZO-1 (2-fold) in the jejunum of LBW piglets, but not in NBW piglets. Furthermore, the concentrations of ATP and the transcription of COX IV, COX V genes were up-regulated (p &lt; 0.05) and the concentration of Ca2+ and 8-OH-dG were decreased (p &lt; 0.05) in arginine-treated LBW piglets. The results suggest that mitochondrial morphology is affected, and mitochondrial functions are impaired in the jejunum of LBW piglets. While supplementation with 1.0% L-arginine relieved intestinal dysfunction through enhancing antioxidant capacity and improving mitochondrial functions via repairing mitochondrial morphology, normalizing mitochondrial calcium, and increasing ATP concentration in the jejunum of LBW piglets. However, supplementation with L-arginine has no significant beneficial effects on intestinal health in NBW piglets.<\/jats:p>","DOI":"10.3390\/antiox10121995","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T09:02:19Z","timestamp":1639558939000},"page":"1995","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dietary Arginine Supplementation Improves Intestinal Mitochondrial Functions in Low-Birth-Weight Piglets but Not in Normal-Birth-Weight Piglets"],"prefix":"10.3390","volume":"10","author":[{"given":"Hao","family":"Zhang","sequence":"first","affiliation":[{"name":"Animal Nutrition Insititute, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zheng","sequence":"additional","affiliation":[{"name":"Animal Nutrition Insititute, Sichuan Agricultural University, Chengdu 611130, China"},{"name":"Key Laboratory for Animal Disease-Resistance Nutrition, China Ministry of Education, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiwen","family":"Chen","sequence":"additional","affiliation":[{"name":"Animal Nutrition Insititute, Sichuan Agricultural University, Chengdu 611130, China"},{"name":"Key Laboratory for Animal Disease-Resistance Nutrition, China Ministry of Education, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6605-6742","authenticated-orcid":false,"given":"Bing","family":"Yu","sequence":"additional","affiliation":[{"name":"Animal Nutrition Insititute, Sichuan Agricultural University, Chengdu 611130, China"},{"name":"Key Laboratory for Animal Disease-Resistance Nutrition, China Ministry of Education, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1963-9766","authenticated-orcid":false,"given":"Jun","family":"He","sequence":"additional","affiliation":[{"name":"Animal Nutrition Insititute, Sichuan Agricultural University, Chengdu 611130, China"},{"name":"Key Laboratory for Animal Disease-Resistance Nutrition, China Ministry of Education, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6292-7747","authenticated-orcid":false,"given":"Xiangbing","family":"Mao","sequence":"additional","affiliation":[{"name":"Animal Nutrition Insititute, Sichuan Agricultural University, Chengdu 611130, China"},{"name":"Key Laboratory for Animal Disease-Resistance Nutrition, China Ministry of Education, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[{"name":"Animal Nutrition Insititute, Sichuan Agricultural University, Chengdu 611130, China"},{"name":"Key Laboratory for Animal Disease-Resistance Nutrition, China Ministry of Education, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Animal Nutrition Insititute, Sichuan Agricultural University, Chengdu 611130, China"},{"name":"Key Laboratory for Animal Disease-Resistance Nutrition, China Ministry of Education, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1024-1866","authenticated-orcid":false,"given":"Junqiu","family":"Luo","sequence":"additional","affiliation":[{"name":"Animal Nutrition Insititute, Sichuan Agricultural University, Chengdu 611130, China"},{"name":"Key Laboratory for Animal Disease-Resistance Nutrition, China Ministry of Education, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-9297","authenticated-orcid":false,"given":"Zhiqing","family":"Huang","sequence":"additional","affiliation":[{"name":"Animal Nutrition Insititute, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yan","sequence":"additional","affiliation":[{"name":"Animal Nutrition Insititute, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1152\/physrev.00053.2003","article-title":"Developmental origins of the metabolic syndrome: Prediction, plasticity, and programming","volume":"85","author":"McMillen","year":"2005","journal-title":"Physiol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.2527\/jas.2006-156","article-title":"Intrauterine growth retardation: Implications for the animal sciences","volume":"84","author":"Wu","year":"2006","journal-title":"J. Anim. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/1745039X.2012.710084","article-title":"Effects of intrauterine growth retardation and maternal folic acid supplementation on hepatic mitochondrial function and gene expression in piglets","volume":"66","author":"Liu","year":"2012","journal-title":"Arch. Anim. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1203\/00006450-199001000-00017","article-title":"Intrauterine growth retardation: Altered hepatic energy and redox states in the fetal rat","volume":"27","author":"Ogata","year":"1990","journal-title":"Pediatr. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1093\/jn\/nxy198","article-title":"Dietary arginine supplementation affects intestinal function by enhancing antioxidant capacity of a nitric oxide-independent pathway in Low-Birth-Weight piglets","volume":"148","author":"Zheng","year":"2018","journal-title":"J. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/jcp.25402","article-title":"Metabolic adaptation of the small intestine to short-and medium-term high-fat diet exposure","volume":"232","author":"Clara","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1017\/S0007114512000670","article-title":"Maturation of digestive function is retarded and plasma antioxidant capacity lowered in fully weaned low birth weight piglets","volume":"109","author":"Michiels","year":"2012","journal-title":"Br. J. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1096\/fj.15-274779","article-title":"Intrauterine growth restriction in neonatal piglets affects small intestinal mucosal permeability and mRNA expression of redox-sensitive genes","volume":"30","author":"Wang","year":"2015","journal-title":"FASEB J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/MCO.0000000000000051","article-title":"Impact of intrauterine growth restriction on long-term health","volume":"17","author":"Salam","year":"2014","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1089\/ars.2012.4729","article-title":"Mitochondria as a source of reactive oxygen and nitrogen species: From molecular mechanisms to human health","volume":"18","author":"Figueira","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s00424-013-1339-4","article-title":"Nutritional models of foetal programming and nutrigenomic and epigenomic dysregulations of fatty acid metabolism in the liver and heart","volume":"466","author":"Elakoum","year":"2014","journal-title":"Pfl\u00fcgers Arch.-Eur. J. Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.biocel.2004.09.010","article-title":"Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress","volume":"37","author":"Lee","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1093\/jn\/133.10.3085","article-title":"Fetal and early postnatal protein malnutrition cause long-term changes in rat liver and muscle mitochondria","volume":"133","author":"Park","year":"2003","journal-title":"J. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"28785","DOI":"10.1074\/jbc.M505695200","article-title":"Progressive accumulation of mitochondrial DNA mutations and decline in mitochondrial function lead to \u03b2-cell failure","volume":"280","author":"Simmons","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_15","first-page":"2190","article-title":"Antenatal taurine reduces cerebral cell apoptosis in fetal rats with intrauterine growth restriction","volume":"8","author":"Liu","year":"2012","journal-title":"Neural. Regen. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.theriogenology.2016.11.030","article-title":"Effects of intrauterine growth restriction during late pregnancy on the cell apoptosis and related gene expression in ovine fetal liver","volume":"90","author":"Liu","year":"2017","journal-title":"Theriogenology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s10495-007-0756-2","article-title":"Mitochondria, oxidative stress and cell death","volume":"12","author":"Ott","year":"2007","journal-title":"Apoptosis"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nri1668","article-title":"Regulation of immune responses by L-arginine metabolism","volume":"5","author":"Bronte","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0753-3322(02)00273-1","article-title":"The metabolic basis of arginine nutrition and pharmacotherapy","volume":"56","author":"Flynn","year":"2002","journal-title":"Biomed. Pharmacother."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1017\/S0007114512004321","article-title":"Protective effects of dietary arginine supplementation against oxidative stress in weaned piglets","volume":"109","author":"Zheng","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.aninu.2017.06.009","article-title":"Feed supplementation with arginine and zinc on antioxidant status and inflammatory response in challenged weanling piglets","volume":"3","author":"Bergeron","year":"2017","journal-title":"Anim. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00726-008-0213-8","article-title":"Dietary arginine supplementation enhances antioxidative capacity and improves meat quality of finishing pigs","volume":"38","author":"Ma","year":"2010","journal-title":"Amino Acids"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/jn\/134.3.625","article-title":"Dietary arginine supplementation enhances the growth of milk-fed young pigs","volume":"134","author":"Kim","year":"2004","journal-title":"J. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1017\/S0007114511006763","article-title":"Dietary L-arginine supplementation improves the intestinal development through increasing mucosal Akt and mammalian target of rapamycin signals in intra-uterine growth retarded piglets","volume":"108","author":"Wang","year":"2012","journal-title":"Br. J. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00726-008-0155-1","article-title":"Dietary L-arginine supplementation enhances the immune status in early-weaned piglets","volume":"37","author":"Tan","year":"2009","journal-title":"Amino Acids"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1093\/jn\/138.7.1304","article-title":"Dietary arginine supplementation affects microvascular development in the small intestine of early-weaned pigs","volume":"138","author":"Zhan","year":"2008","journal-title":"J. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"16507","DOI":"10.1073\/pnas.0405432101","article-title":"Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals","volume":"101","author":"Nisoli","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ymgme.2012.06.018","article-title":"Citrulline and arginine utility in treating nitric oxide deficiency in mitochondrial disorders","volume":"107","author":"Emrick","year":"2012","journal-title":"Mol. Genet. Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.repbio.2014.01.005","article-title":"Intrauterine growth retarded piglet as a model for humans\u2013Studies on the perinatal development of the gut structure and function","volume":"14","author":"Ferenc","year":"2014","journal-title":"Reprod. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1017\/S0007114517001519","article-title":"Arginine metabolism and its protective effects on intestinal health and functions in weaned piglets under oxidative stress induced by diquat","volume":"117","author":"Zheng","year":"2017","journal-title":"Br. J. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1017\/S0007114518000375","article-title":"Innate differences and colostrum-induced alterations of jejunal mucosal proteins in piglets with intra-uterine growth restriction","volume":"119","author":"Wang","year":"2018","journal-title":"Br. J. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1080\/15548627.2017.1320634","article-title":"Thermoresponsive nanocomposite gel for local drug delivery to suppress the growth of glioma by inducing autophagy","volume":"13","author":"Ding","year":"2017","journal-title":"Autophagy"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"A1076","DOI":"10.1096\/fasebj.21.6.A1076-c","article-title":"Postnatal jejunal expression patterns of four major house-keeping genes in pigs are measured by the real time RT-PCR","volume":"21","author":"Yang","year":"2007","journal-title":"FASEB J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_35","unstructured":"NRC (2012). Nutrient Requirements of Swine, Eleventh Revised Edition."},{"key":"ref_36","first-page":"284","article-title":"First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid","volume":"54","author":"Ighodaro","year":"2017","journal-title":"Alex. J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.fct.2018.03.029","article-title":"L-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway","volume":"115","author":"Liang","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000106488","article-title":"Role of oxidative stress in intrauterine growth restriction","volume":"64","author":"Biri","year":"2007","journal-title":"Gynecol. Obstet. Investig."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Gupta, P., Narang, M., Banerjee, B.D., and Basu, S. (2004). Oxidative stress in term small for gestational age neonates born to undernourished mothers: A case control study. BMC. Pediatrics, 4.","DOI":"10.1186\/1471-2431-4-14"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e849","DOI":"10.1111\/jpn.12845","article-title":"Effect of gut stress induced by oxidized wheat gluten on the growth performance, gut morphology and oxidative states of broilers","volume":"102","author":"Liao","year":"2018","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0014-5793(01)02316-X","article-title":"Mitochondrial permeability transition and oxidative stress","volume":"495","author":"Kowaltowski","year":"2001","journal-title":"FEBS Lett."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/mrd.10254","article-title":"Glutathione and adenosine triphosphate content of in vivo and in vitro matured porcine oocytes","volume":"64","author":"Brad","year":"2003","journal-title":"Mol. Reprod. Dev. Inc. Gamete Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1152\/physrev.1997.77.3.731","article-title":"Cellular energy utilization and molecular origin of standard metabolic rate in mammals","volume":"77","author":"Rolfe","year":"1997","journal-title":"Physiol. Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1128\/MCB.25.4.1354-1366.2005","article-title":"Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators","volume":"25","author":"Gleyzer","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.mito.2013.03.008","article-title":"Mitochondrial respiratory chain complexes I and IV are impaired by \u03b2-amyloid via direct interaction and through Complex I-dependent ROS production, respectively","volume":"13","author":"Bobba","year":"2013","journal-title":"Mitochondrion"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF00744680","article-title":"Inhibition of electron transfer in the cytochromeb-c 1 segment of the mitochondrial respiratory chain by a synthetic analogue of ubiquinone","volume":"12","author":"Trumpower","year":"1980","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1083\/jcb.201308006","article-title":"The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission","volume":"204","author":"Anand","year":"2014","journal-title":"J. Cell Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev.cellbio.22.010305.104638","article-title":"Mitochondrial fusion and fission in mammals","volume":"22","author":"Chan","year":"2006","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.yjmcc.2009.02.021","article-title":"What is the mitochondrial permeability transition pore?","volume":"46","author":"Halestrap","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/cncr.22417","article-title":"8-Hydroxy-2\u2019-deoxyguanosine (8-OH-dG) as a potential survival biomarker in patients with nonsmall-cell lung cancer","volume":"109","author":"Shen","year":"2007","journal-title":"Cancer"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/BF02256052","article-title":"Oxidative-stress-related changes in the livers of bile-duct-ligated rats","volume":"10","author":"Huang","year":"2003","journal-title":"J. Biomed. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1007\/s11064-013-1172-3","article-title":"Mitochondrial dysfunction in brain cortex mitochondria of stz-diabetic rats: Effect of l-arginine","volume":"38","author":"Ortiz","year":"2013","journal-title":"Neurochem. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.intimp.2010.08.025","article-title":"L-Arginine reduces mitochondrial dysfunction and airway injury in murine allergic airway inflammation","volume":"10","author":"Mabalirajan","year":"2010","journal-title":"Int. Immunopharmacol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/10\/12\/1995\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:48:31Z","timestamp":1760168911000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/10\/12\/1995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,15]]},"references-count":53,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["antiox10121995"],"URL":"https:\/\/doi.org\/10.3390\/antiox10121995","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,15]]}}}