{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:59:46Z","timestamp":1788893986722,"version":"build-2803163510"},"reference-count":161,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Cancer cachexia is the progressive muscle wasting and weakness experienced by many cancer patients. It can compromise the response to gold standard cancer therapies, impair functional capacity and reduce overall quality of life. Cancer cachexia accounts for nearly one-third of all cancer-related deaths and has no effective treatment. The pathogenesis of cancer cachexia and its progression is multifactorial and includes increased oxidative stress derived from both the tumor and the host immune response. Antioxidants have therapeutic potential to attenuate cancer-related muscle loss, with polyphenols, a group of plant-derived antioxidants, being the most widely investigated. This review describes the potential of these plant-derived antioxidants for treating cancer cachexia.<\/jats:p>","DOI":"10.3390\/antiox11020183","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T22:46:32Z","timestamp":1642545992000},"page":"183","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Role for Plant-Derived Antioxidants in Attenuating Cancer Cachexia"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0281-9370","authenticated-orcid":false,"given":"Wenlan","family":"Li","sequence":"first","affiliation":[{"name":"Centre for Muscle Research, Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"Swiderski","sequence":"additional","affiliation":[{"name":"Centre for Muscle Research, Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1993-4367","authenticated-orcid":false,"given":"Kate T.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Centre for Muscle Research, Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9220-9810","authenticated-orcid":false,"given":"Gordon S.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Centre for Muscle Research, Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: An international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1093\/ajcn\/83.6.1345","article-title":"Definition of cancer cachexia: Effect of weight loss, reduced food intake, and systemic inflammation on functional status and prognosis","volume":"83","author":"Fearon","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.critrevonc.2018.05.006","article-title":"Cancer cachexia: Diagnosis, assessment, and treatment","volume":"127","author":"Sadeghi","year":"2018","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1158\/1078-0432.CCR-06-2307","article-title":"Cancer cachexia signaling pathways continue to emerge yet much still points to the proteasome","volume":"13","author":"Acharyya","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: Mediators, signaling, and metabolic pathways","volume":"16","author":"Fearon","year":"2012","journal-title":"Cell Metab."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.biocel.2004.10.003","article-title":"Molecular mechanisms involved in muscle wasting in cancer and ageing: Cachexia versus sarcopenia","volume":"37","author":"Argiles","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4251\/wjgo.v7.i4.17","article-title":"Cancer cachexia, mechanism and treatment","volume":"7","author":"Aoyagi","year":"2015","journal-title":"World J. Gastrointest. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00520-009-0722-3","article-title":"Cancer cachexia: Medical management","volume":"18","author":"Mantovani","year":"2010","journal-title":"Support Care Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrclinonc.2012.209","article-title":"Understanding the mechanisms and treatment options in cancer cachexia","volume":"10","author":"Fearon","year":"2013","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1249\/MSS.0000000000000975","article-title":"Disease-Induced Skeletal Muscle Atrophy and Fatigue","volume":"48","author":"Powers","year":"2016","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7087","DOI":"10.1074\/jbc.M610378200","article-title":"Skeletal muscle atrophy, a link between depression of protein synthesis and increase in degradation","volume":"282","author":"Eley","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_12","first-page":"1226","article-title":"Contribution of elevated protein turnover and anorexia to cachexia in patients with hepatocellular carcinoma","volume":"50","author":"Ogden","year":"1990","journal-title":"Cancer Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ccr.2005.10.004","article-title":"Dystrophin glycoprotein complex dysfunction: A regulatory link between muscular dystrophy and cancer cachexia","volume":"8","author":"Acharyya","year":"2005","journal-title":"Cancer Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7590","DOI":"10.4081\/ejtm.2018.7590","article-title":"Chemotherapy-induced muscle wasting: Association with NF-kappaB and cancer cachexia","volume":"28","author":"Damrauer","year":"2018","journal-title":"Eur. J. Transl. Myol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2063179","DOI":"10.1155\/2018\/2063179","article-title":"Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia","volume":"2018","author":"Abrigo","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/j.febslet.2005.02.017","article-title":"Both oxidative and nitrosative stress are associated with muscle wasting in tumour-bearing rats","volume":"579","author":"Barreiro","year":"2005","journal-title":"FEBS Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0304-3835(02)00006-X","article-title":"Induction of protein catabolism and the ubiquitin-proteasome pathway by mild oxidative stress","volume":"180","author":"Tisdale","year":"2002","journal-title":"Cancer Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2044-5040-2-14","article-title":"IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin\/+ mouse","volume":"2","author":"White","year":"2012","journal-title":"Skelet. Muscle"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1152\/physrev.00014.2008","article-title":"Positive and negative regulation of insulin signaling by reactive oxygen and nitrogen species","volume":"89","author":"Bashan","year":"2009","journal-title":"Physiol. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"26991","DOI":"10.1038\/srep26991","article-title":"Aerobic Exercise and Pharmacological Treatments Counteract Cachexia by Modulating Autophagy in Colon Cancer","volume":"6","author":"Pigna","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_21","first-page":"R659","article-title":"Cachectin\/TNF or IL-1 alpha induces cachexia with redistribution of body proteins","volume":"256","author":"Fong","year":"1989","journal-title":"Am. J. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1172\/JCI115767","article-title":"Evidence for the involvement of interleukin 6 in experimental cancer cachexia","volume":"89","author":"Strassmann","year":"1992","journal-title":"J. Clin. Investig."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.21037\/apm.2018.07.06","article-title":"Anti-cytokines in the treatment of cancer cachexia","volume":"8","author":"Prado","year":"2019","journal-title":"Ann. Palliat. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1016\/S0021-9258(18)42768-8","article-title":"Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation","volume":"267","author":"Bakker","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1158\/1055-9965.EPI-05-0538","article-title":"A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia\/cachexia and oxidative stress","volume":"15","author":"Mantovani","year":"2006","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.freeradbiomed.2014.11.006","article-title":"Oxidative stress, redox signaling pathways, and autophagy in cachectic muscles of male patients with advanced COPD and lung cancer","volume":"79","author":"Rodriguez","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/s00109-003-0476-1","article-title":"Antioxidant agents are effective in inducing lymphocyte progression through cell cycle in advanced cancer patients: Assessment of the most important laboratory indexes of cachexia and oxidative stress","volume":"81","author":"Mantovani","year":"2003","journal-title":"J. Mol. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1017\/S0007114509345250","article-title":"Attenuation of proteolysis and muscle wasting by curcumin c3 complex in MAC16 colon tumour-bearing mice","volume":"102","author":"Siddiqui","year":"2009","journal-title":"Br. J. Nutr."},{"key":"ref_29","first-page":"871","article-title":"Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response.e.e to tumor necrosis factor alpha","volume":"12","author":"Li","year":"1998","journal-title":"FASEB J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","article-title":"The NF-kappa B and I kappa B proteins: New discoveries and insights","volume":"14","author":"Baldwin","year":"1996","journal-title":"Annu. Rev. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1172\/JCI11991","article-title":"Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB","volume":"107","author":"Baldwin","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"915","DOI":"10.3389\/fphar.2017.00915","article-title":"Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis","volume":"8","author":"Miao","year":"2017","journal-title":"Front. Pharm."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1038\/sj.bjc.6602165","article-title":"Induction of proteasome expression in skeletal muscle is attenuated by inhibitors of NF-kappaB activation","volume":"91","author":"Wyke","year":"2004","journal-title":"Br. J. Cancer"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.canlet.2011.02.023","article-title":"Epigallocatechin-3-gallate effectively attenuates skeletal muscle atrophy caused by cancer cachexia","volume":"305","author":"Wang","year":"2011","journal-title":"Cancer Lett."},{"key":"ref_35","first-page":"1839","article-title":"Reasons for low incidence of peptic ulcer in pregnancy","volume":"72","author":"Schmid","year":"1950","journal-title":"Zent. Gynakol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.jnutbio.2015.08.001","article-title":"The complexity of the Nrf2 pathway: Beyond the antioxidant response","volume":"26","author":"Huang","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/128_2012_339","article-title":"Keap1-nrf2 signaling: A target for cancer prevention by sulforaphane","volume":"329","author":"Kensler","year":"2013","journal-title":"Top. Curr. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1080\/10408398.2016.1259983","article-title":"Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment","volume":"58","author":"Russo","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.yexcr.2018.02.013","article-title":"Deregulation of Nrf2\/ARE signaling pathway causes susceptibility of dystrophin-deficient myotubes to menadione-induced oxidative stress","volume":"364","author":"Choi","year":"2018","journal-title":"Exp. Cell Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.biopha.2017.09.002","article-title":"Sulforaphane prevents dexamethasone-induced muscle atrophy via regulation of the Akt\/Foxo1 axis in C2C12 myotubes","volume":"95","author":"Son","year":"2017","journal-title":"Biomed. Pharm."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejphar.2010.05.009","article-title":"The natural antioxidant alpha-lipoic acid induces p27(Kip1)-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells","volume":"641","author":"Dozio","year":"2010","journal-title":"Eur. J. Pharm."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"8137","DOI":"10.1128\/MCB.23.22.8137-8151.2003","article-title":"Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress","volume":"23","author":"Zhang","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1152\/japplphysiol.00721.2015","article-title":"Sulforaphane mitigates muscle fibrosis in mdx mice via Nrf2-mediated inhibition of TGF-beta\/Smad signaling","volume":"120","author":"Sun","year":"2016","journal-title":"J. Appl. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1080\/09637486.2018.1439901","article-title":"Broccoli and human health: Immunomodulatory effect of sulforaphane in a model of colon cancer","volume":"69","author":"Bessler","year":"2018","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nrc3278","article-title":"NRF2 and cancer: The good, the bad and the importance of context","volume":"12","author":"Sporn","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.freeradbiomed.2014.11.009","article-title":"Dual roles of NRF2 in tumor prevention and progression: Possible implications in cancer treatment","volume":"79","author":"Moon","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1053\/j.gastro.2008.06.082","article-title":"Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer","volume":"135","author":"Shibata","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1089\/ars.2010.3219","article-title":"Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance","volume":"13","author":"Singh","year":"2010","journal-title":"Antioxid. Redox. Signal."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1158\/0008-5472.CAN-12-4499","article-title":"Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis","volume":"73","author":"Satoh","year":"2013","journal-title":"Cancer Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.nutres.2019.11.004","article-title":"Polyphenols and their potential role in preventing skeletal muscle atrophy","volume":"74","author":"Salucci","year":"2020","journal-title":"Nutr. Res."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Zheng, J., Li, Y., Xu, D.-P., Li, S., Chen, Y.-M., and Li, H.-B. (2016). Natural Polyphenols for Prevention and Treatment of Cancer. Nutrients, 8.","DOI":"10.3390\/nu8080515"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1080\/01635581.2010.509536","article-title":"Green tea and cancer prevention","volume":"62","author":"Yang","year":"2010","journal-title":"Nutr. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/mc.20228","article-title":"Molecular targets for the cancer preventive activity of tea polyphenols","volume":"45","author":"Yang","year":"2006","journal-title":"Mol. Carcinog."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1006\/bbrc.1998.9916","article-title":"Resveratrol, a natural product present in wine, decreases tumour growth in a rat tumour model","volume":"254","author":"Carbo","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.phymed.2015.12.020","article-title":"Resveratrol improves the anticancer effects of doxorubicin in vitro and in vivo models: A mechanistic insight","volume":"23","author":"Rai","year":"2016","journal-title":"Phytomedicine"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1080\/01635581.2011.563032","article-title":"Oral resveratrol therapy inhibits cancer-induced skeletal muscle and cardiac atrophy in vivo","volume":"63","author":"Shadfar","year":"2011","journal-title":"Nutr. Cancer"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.clnu.2006.12.001","article-title":"Resveratrol does not ameliorate muscle wasting in different types of cancer cachexia models","volume":"26","author":"Busquets","year":"2007","journal-title":"Clin. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Penedo-V\u00e1zquez, A., Duran, X., Mateu, J., L\u00f3pez-Postigo, A., and Barreiro, E. (2021). Curcumin and Resveratrol Improve Muscle Function and Structure through Attenuation of Proteolytic Markers in Experimental Cancer-Induced Cachexia. Molecules, 26.","DOI":"10.3390\/molecules26164904"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0304-3835(01)00456-6","article-title":"Curcumin, a natural product present in turmeric, decreases tumor growth but does not behave as an anticachectic compound in a rat model","volume":"167","author":"Busquets","year":"2001","journal-title":"Cancer Lett."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/jcsm.12710","article-title":"Carnosol and its analogues attenuate muscle atrophy and fat lipolysis induced by cancer cachexia","volume":"12","author":"Lu","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"868","DOI":"10.3945\/jn.113.188367","article-title":"Quercetin Supplementation Attenuates the Progression of Cancer Cachexia in ApcMin\/+Mice","volume":"144","author":"Enos","year":"2014","journal-title":"J. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3233\/NHA-200084","article-title":"Quercetin supplementation attenuates muscle wasting in cancer-associated cachexia in mice","volume":"6","author":"Levolger","year":"2021","journal-title":"Nutr. Healthy Aging"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.lfs.2016.10.031","article-title":"HPV16 induces a wasting syndrome in transgenic mice: Amelioration by dietary polyphenols via NF-\u03baB inhibition","volume":"169","author":"Moutinho","year":"2017","journal-title":"Life Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3177\/jnsv.62.178","article-title":"Dietary Supplementation with Isoflavones Prevents Muscle Wasting in Tumor-Bearing Mice","volume":"62","author":"Hirasaka","year":"2016","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.bbrc.2018.10.184","article-title":"Morin suppresses cachexia-induced muscle wasti.ing by binding to ribosomal protein S10 in carcinoma cells","volume":"506","author":"Yoshimura","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.intimp.2014.02.002","article-title":"Resveratrol prevents TNF-alpha-induced muscle atrophy via regulation of Akt\/mTOR\/FoxO1 signaling in C2C12 myotubes","volume":"19","author":"Wang","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"6968","DOI":"10.1074\/jbc.M112.431155","article-title":"Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis","volume":"288","author":"Menzies","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1007\/s00018-013-1513-z","article-title":"FoxO transcription factors: Their roles in the maintenance of skeletal muscle homeostasis","volume":"71","author":"Sanchez","year":"2014","journal-title":"Cell Mol. Life Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"11766","DOI":"10.1039\/C4RA14128H","article-title":"NMR-based metabolomics reveals distinct pathways mediated by curcumin in cachexia mice bearing CT26 tumor","volume":"5","author":"Jun","year":"2015","journal-title":"RSC Adv."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1158\/1078-0432.CCR-08-0024","article-title":"Phase II trial of curcumin in patients with advanced pancreatic cancer","volume":"14","author":"Dhillon","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"6847","DOI":"10.1158\/1078-0432.CCR-04-0744","article-title":"Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance","volume":"10","author":"Sharma","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/ardp.200900319","article-title":"Curcumin in cancer chemoprevention: Molecular targets, pharmacokinetics, bioavailability, and clinical trials","volume":"343","author":"Shehzad","year":"2010","journal-title":"Arch. Pharm."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2147\/JIR.S110873","article-title":"Curcumin prevents muscle damage by regulating NF-kappaB and Nrf2 pathways and improves performance: An in vivo model","volume":"9","author":"Sahin","year":"2016","journal-title":"J. Inflamm. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.biochi.2018.10.012","article-title":"High altitude mediated skeletal muscle atrophy: Protective role of curcumin","volume":"156","author":"Chaudhary","year":"2019","journal-title":"Biochimie"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"9579868","DOI":"10.1155\/2016\/9579868","article-title":"The Janus-Faced Role of Antioxidants in Cancer Cachexia: New Insights on the Established Concepts","volume":"2016","author":"Assi","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1104\/pp.17.01183","article-title":"Carnosic Acid and Carnosol, Two Major Antioxidants of Rosemary, Act through Different Mechanisms","volume":"175","author":"Loussouarn","year":"2017","journal-title":"Plant. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/carcin\/23.6.983","article-title":"Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages","volume":"23","author":"Lo","year":"2002","journal-title":"Carcinogenesis"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1038\/s41598-018-22029-x","article-title":"The Mechanisms of Carnosol in Chemoprevention of Ultraviolet B-Light-Induced Non-Melanoma Skin Cancer Formation","volume":"8","author":"Tong","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1158\/0008-5472.1097.65.3","article-title":"Carnosol inhibits \u03b2-catenin tyrosine phosphorylation and prevents adenoma formation in the C57BL\/6J\/Min\/+(Min\/+) mouse","volume":"65","author":"Moran","year":"2005","journal-title":"Cancer Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3389\/fonc.2019.00743","article-title":"Carnosol, a Natural Polyphenol, Inhibits Migration, Metastasis, and Tumor Growth of Breast Cancer via a RO.OS-Dependent Proteasome Degradation of STAT3","volume":"9","author":"Alsamri","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"130233","DOI":"10.1016\/j.snb.2021.130233","article-title":"Evaluate the inhibition of cytochrome P450 1A1 for enhancing breast cancer chemotherapy with a turn-on fluorescent probe","volume":"344","author":"Huang","year":"2021","journal-title":"Sens. Actuators B Chem."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"(2018). Quercetin Reduces Tumor Necrosis Factor Alpha-Induced Muscle Atrophy by Upregulation of Heme Oxygenase-1. J. Med. Food, 21, 551\u2013559.","DOI":"10.1089\/jmf.2017.4108"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.bbrc.2011.02.111","article-title":"Inhibition of tumor growth by quercetin with increase of survival and prevention of cachexia in Walker 256 tumor-bearing rats","volume":"406","author":"Camargo","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Reyes-Farias, M., and Carrasco-Pozo, C. (2019). The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133177"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Farag, M.R., Moselhy, A.A.A., El-Mleeh, A., Aljuaydi, S.H., Ismail, T.A., Di Cerbo, A., Crescenzo, G., and Abou-Zeid, S.M. (2021). Quercetin Alleviates the Immunotoxic Impact Mediated by Oxidative Stress and Inflammation Induced by Doxorubicin Exposure in Rats. Antioxidants, 10.","DOI":"10.3390\/antiox10121906"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0014-5793(97)00467-5","article-title":"Bioavailability of rutin and quercetin in rats","volume":"409","author":"Manach","year":"1997","journal-title":"FEBS Lett."},{"key":"ref_87","first-page":"1461","article-title":"Curcumin and Rutin Down-regulate Cyclooxygenase-2 and Reduce Tumor-associated Inflammation in HPV16-Transgenic Mice","volume":"38","author":"Moutinho","year":"2018","journal-title":"Anticancer Res."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Satari, A., Ghasemi, S., Habtemariam, S., Asgharian, S., and Lorigooini, Z. (2021). Rutin: A Flavonoid as an Effective Sensitizer for Anticancer Therapy; Insights into Multifaceted Mechanisms and Applicability for Combination Therapy. Evid. -Based Complementary Altern. Med., 2021.","DOI":"10.1155\/2021\/9913179"},{"key":"ref_89","first-page":"625","article-title":"Genistein modulates the anti-tumor activity of cisplatin in MCF-7 breast and HT-29 colon cancer cells","volume":"88","author":"Hu","year":"2014","journal-title":"Arch. Toxicol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1007\/s00394-018-1853-4","article-title":"Soy and isoflavones consumption and breast cancer survival and recurrence: A systematic review and meta-analysis","volume":"58","author":"Qiu","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.toxlet.2021.11.013","article-title":"Genistein interferes with antitumor effects of cisplatin in an ovariectomized breast cancer xenograft tumor model","volume":"355","author":"Ma","year":"2022","journal-title":"Toxicol. Lett."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"101655","DOI":"10.1016\/j.jksus.2021.101655","article-title":"Ameliorative effects of morin on cisplatin-induced toxicity in renal mitochondria isolated from rats","volume":"33","author":"Ijaz","year":"2021","journal-title":"J. King Saud Univ. Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.bcp.2013.03.006","article-title":"Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies","volume":"85","author":"Shanmugam","year":"2013","journal-title":"Biochem. Pharm."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"651","DOI":"10.4196\/kjpp.2017.21.6.651","article-title":"Ursolic acid supplementation decreases markers of skeletal muscle damage during resistance training in resistance-trained men: A pilot study","volume":"21","author":"Bang","year":"2017","journal-title":"Korean J. Physiol. Pharm."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00109-011-0746-2","article-title":"Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice","volume":"89","author":"Shanmugam","year":"2011","journal-title":"J. Mol. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.3892\/ijo.2013.2101","article-title":"Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways","volume":"43","author":"Lin","year":"2013","journal-title":"Int. J. Oncol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.cmet.2011.03.020","article-title":"mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass","volume":"13","author":"Kunkel","year":"2011","journal-title":"Cell Metab."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/iub.2435","article-title":"Ursolic acid ameliorates hypobaric hypoxia-induced skeletal muscle protein loss via upregulating Akt pathway: An experimental study using rat model","volume":"73","author":"Rathor","year":"2021","journal-title":"IUBMB Life"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Kunkel, S.D., Elmore, C.J., Bongers, K.S., Ebert, S.M., Fox, D.K., Dyle, M.C., Bullard, S.A., and Adams, C.M. (2012). Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039332"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"E760","DOI":"10.1152\/ajpendo.00302.2013","article-title":"Ursolic acid stimulates mTORC1 signaling after resistance exercise in rat skeletal muscle","volume":"305","author":"Ogasawara","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.biopha.2016.01.010","article-title":"Short-term ursolic acid promotes skeletal muscle rejuvenation through enhancing of SIRT1 expression and satellite cells proliferation","volume":"78","author":"Bakhtiari","year":"2016","journal-title":"Biomed. Pharm."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mehy.2015.02.014","article-title":"Ursolic acid ameliorates aging-metabolic phenotype through promoting of skeletal muscle rejuvenation","volume":"85","author":"Bakhtiari","year":"2015","journal-title":"Med. Hypotheses"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1073\/pnas.89.6.2399","article-title":"A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure","volume":"89","author":"Zhang","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"10367","DOI":"10.1073\/pnas.94.19.10367","article-title":"Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens","volume":"94","author":"Fahey","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.etp.2010.11.005","article-title":"Protective effect of sulforaphane against oxidative stress: Recent advances","volume":"64","author":"Chirino","year":"2012","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1017\/S0007114507824093","article-title":"Absolute bioavailability and dose-dependent pharmacokinetic behaviour of dietary doses of the chemopreventive isothiocyanate sulforaphane in rat","volume":"99","author":"Hanlon","year":"2008","journal-title":"Br. J. Nutr."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2716870","DOI":"10.1155\/2019\/2716870","article-title":"Sulforaphane: Its \u201cComing of Age\u201d as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease","volume":"2019","author":"Houghton","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_108","first-page":"5196","article-title":"Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray","volume":"62","author":"Thimmulappa","year":"2002","journal-title":"Cancer Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1152\/japplphysiol.00744.2014","article-title":"Sulforaphane alleviates muscular dystrophy in mdx mice by activation of Nrf2","volume":"118","author":"Sun","year":"2015","journal-title":"J. Appl. Physiol."},{"key":"ref_110","first-page":"603","article-title":"Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice","volume":"26","author":"Kanematsu","year":"2011","journal-title":"Oncol. Rep."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/aps.2016.122","article-title":"Sulforaphane suppresses EMT and metastasis in human lung cancer through miR-616-5p-mediated GSK3beta\/beta-catenin signaling pathways","volume":"38","author":"Wang","year":"2017","journal-title":"Acta Pharm. Sin."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.bcp.2013.02.010","article-title":"Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation","volume":"85","author":"Zhang","year":"2013","journal-title":"Biochem. Pharm."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1002\/ijc.24106","article-title":"Gamma-tocopherol-enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice","volume":"124","author":"Barve","year":"2009","journal-title":"Int. J. Cancer"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/ajcn\/nqz012","article-title":"Transcriptional changes in prostate of men on active surveillance after a 12-mo glucoraphanin-rich broccoli intervention-results from the Effect of Sulforaphane on prostate CAncer PrEvention (ESCAPE) randomized controlled trial","volume":"109","author":"Traka","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.4161\/epi.22609","article-title":"Sulforaphane causes a major epigenetic repression of myostatin in porcine satellite cells","volume":"7","author":"Fan","year":"2012","journal-title":"Epigenetics"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1002\/cbin.11377","article-title":"Sulforaphane ameliorates serum starvation-induced muscle atrophy via activation of the Nrf2 pathway in cultured C2C12 cells","volume":"44","author":"Moon","year":"2020","journal-title":"Cell Biol. Int."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/j.yexcr.2013.07.015","article-title":"Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy","volume":"319","author":"Whitman","year":"2013","journal-title":"Exp. Cell Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"7971","DOI":"10.1007\/s11033-020-05875-9","article-title":"Sulforaphane modulates CX3CL1\/CX3CR1 axis and inflammation in palmitic acid-induced cell injury in C2C12 skeletal muscle cells","volume":"47","author":"Faridvand","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"17784","DOI":"10.1074\/jbc.M115.655019","article-title":"Sulforaphane Attenuates Muscle Inflammation in Dystrophin-deficient mdx Mice via NF-E2-related Factor 2 (Nrf2)-mediated Inhibition of NF-kappaB Signaling Pathway","volume":"290","author":"Sun","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"12902","DOI":"10.1038\/s41598-017-12926-y","article-title":"Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles","volume":"7","author":"Oh","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1152\/japplphysiol.00293.2009","article-title":"Sulforaphane treatment protects skeletal muscle against damage induced by exhaustive exercise in rats","volume":"107","author":"Malaguti","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"e13261","DOI":"10.1111\/acel.13261","article-title":"Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling","volume":"19","author":"Bose","year":"2020","journal-title":"Aging Cell"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"117823","DOI":"10.1016\/j.lfs.2020.117823","article-title":"Sulforaphane protects against skeletal muscle dysfunction in spontaneous type 2 diabetic db\/db mice","volume":"255","author":"Wang","year":"2020","journal-title":"Life Sci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1021\/np800494e","article-title":"Phenolic constituents from the stem bark of Magnolia officinalis","volume":"72","author":"Shen","year":"2009","journal-title":"J. Nat. Prod."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1142\/S0192415X09007247","article-title":"Protective effect of magnolol against hydrogen peroxide-induced oxidative stress in human lens epithelial cells","volume":"37","author":"Yao","year":"2009","journal-title":"Am. J. Chin. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1055\/s-2005-864100","article-title":"Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-kappaB activation signaling","volume":"71","author":"Lee","year":"2005","journal-title":"Planta Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1021\/jf904207m","article-title":"Anti-inflammatory bioactivities of honokiol through inhibition of protein kinase C, mitogen-activated protein kinase, and the NF-kappaB pathway to reduce LPS-induced TNFalpha and NO expression","volume":"58","author":"Chao","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.fct.2007.09.097","article-title":"Anti-clastogenic effect of magnolol on benzo(a)pyrene-induced clastogenicity in mice","volume":"46","author":"Saito","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.pharmthera.2011.01.010","article-title":"Therapeutic applications of compounds in the Magnolia family","volume":"130","author":"Lee","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ejphar.2009.03.035","article-title":"Honokiol protects rats against eccentric exercise-induced skeletal muscle damage by inhibiting NF-kappaB induced oxidative stress and inflammation","volume":"610","author":"Chiang","year":"2009","journal-title":"Eur. J. Pharm."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s11418-020-01428-3","article-title":"Magnolol inhibits myotube atrophy induced by cancer cachexia through myostatin signaling pathway in vitro","volume":"74","author":"Ge","year":"2020","journal-title":"J. Nat. Med."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Chen, M.C., Chen, Y.L., Lee, C.F., Hung, C.H., and Chou, T.C. (2015). Supplementation of Magnolol Attenuates Skeletal Muscle Atrophy in Bladder Cancer-Bearing Mice Undergoing Chemotherapy via Suppression of FoxO3 Activation and Induction of IGF-1. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0143594"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1158\/1535-7163.MCT-08-0136","article-title":"Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanism","volume":"7","author":"Rettig","year":"2008","journal-title":"Mol. Cancer"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1080\/01635580903285064","article-title":"Cancer Chemoprevention by Pomegranate: Laboratory and Clinical Evidence","volume":"61","author":"Adhami","year":"2009","journal-title":"Nutr. Cancer"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1007\/s10068-015-0247-0","article-title":"Effect of pomegranate peel polyphenols on human prostate cancer PC-3 cells in vivo","volume":"24","author":"Ma","year":"2015","journal-title":"Food Sci. Biotechnol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1211\/jpp.60.2.0001","article-title":"Ellagic acid, pomegranate and prostate cancer\u2014A mini review","volume":"60","author":"Bell","year":"2008","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/mc.21995","article-title":"Antiproliferative effects of pomegranate extract in MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double strand breaks","volume":"53","author":"Shirode","year":"2014","journal-title":"Mol. Carcinog."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/pcan.2012.20","article-title":"A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer","volume":"16","author":"Paller","year":"2013","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1600169","DOI":"10.1002\/mnfr.201600169","article-title":"Pomegranate extract prevents skeletal muscle of mice against wasting induced by acute TNF-\u03b1 injection","volume":"61","author":"Rodriguez","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1519\/JSC.0b013e318220d992","article-title":"The effect of pomegranate juice supplementation on strength and soreness after eccentric exercise","volume":"25","author":"Trombold","year":"2011","journal-title":"J. Strength Cond. Res."},{"key":"ref_141","first-page":"29","article-title":"The impact of supplementation with Pomegranate fruit (Punica Granatum L.) on sport performance","volume":"13","author":"Rosa","year":"2020","journal-title":"Sport Sci."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Rapa, S.F., Magliocca, G., Pepe, G., Amodio, G., Autore, G., Campiglia, P., and Marzocco, S. (2021). Protective Effect of Pomegranate on Oxidative Stress and Inflammatory Response Induced by 5-Fluorouracil in Human Keratinocytes. Antioxidants, 10.","DOI":"10.3390\/antiox10020203"},{"key":"ref_143","first-page":"92","article-title":"Research progress on the anticarcinogenic actions and mechanisms of ellagic acid","volume":"11","author":"Zhang","year":"2014","journal-title":"Cancer Biol. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1080\/14756366.2016.1220378","article-title":"A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia\/reperfusion injury","volume":"31","author":"Soslu","year":"2016","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1007\/s11033-020-05340-7","article-title":"The effect of ellagic acid on caspase-3\/bcl-2\/Nrf-2\/NF-kB\/TNF-\u03b1 \/COX-2 gene expression product apoptosis pathway: A new approach for muscle damage therapy","volume":"47","author":"Aslan","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"5571","DOI":"10.1021\/jf050384i","article-title":"Identification of urolithin a as a metabolite produced by human colon microflora from ellagic acid and related compounds","volume":"53","author":"Periago","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/jcsm.12190","article-title":"Urolithin B, a newly identified regulator of skeletal muscle mass","volume":"8","author":"Rodriguez","year":"2017","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"382001","DOI":"10.1088\/1361-6528\/ab912c","article-title":"Strategies to improve ellagic acid bioavailability: From natural or semisynthetic derivatives to nanotechnological approaches based on innovative carriers","volume":"31","author":"Ceci","year":"2020","journal-title":"Nanotechnology"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"647582","DOI":"10.3389\/fnut.2021.647582","article-title":"Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review","volume":"8","author":"Abdulrahman","year":"2021","journal-title":"Front. Nutr."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"eabb0319","DOI":"10.1126\/scitranslmed.abb0319","article-title":"Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy","volume":"13","author":"Luan","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"152887","DOI":"10.1016\/j.phymed.2019.152887","article-title":"Therapeutic potential of hesperidin and its aglycone hesperetin: Cell cycle regulation and apoptosis induction in cancer models","volume":"73","author":"Santos","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"9267","DOI":"10.1007\/s13277-015-3655-0","article-title":"Effect of hesperidin on mice bearing Ehrlich solid carcinoma maintained on doxorubicin","volume":"36","author":"Khedr","year":"2015","journal-title":"Tumor Biol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s10495-016-1258-x","article-title":"SIRT1 activation by pterostilbene attenuates the skeletal muscle oxidative stress injury and mitochondrial dysfunction induced by ischemia reperfusion injury","volume":"21","author":"Cheng","year":"2016","journal-title":"Apoptosis"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Obrador, E., Salvador-Palmer, R., Jihad-Jebbar, A., L\u00f3pez-Blanch, R., Dellinger, T.H., Dellinger, R.W., and Estrela, J.M. (2021). Pterostilbene in Cancer Therapy. Antioxidants, 10.","DOI":"10.3390\/antiox10030492"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1002\/mnfr.201000067","article-title":"Pterostilbene induces autophagy and apoptosis in sensitive and chemoresistant human bladder cancer cells","volume":"54","author":"Chen","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Zheng, J., Liu, W., Zhu, X., Ran, L., Lang, H., Yi, L., Mi, M., and Zhu, J. (2020). Pterostilbene Enhances Endurance Capacity via Promoting Skeletal Muscle Adaptations to Exercise Training in Rats. Molecules, 25.","DOI":"10.3390\/molecules25010186"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"997","DOI":"10.3389\/fcell.2020.580933","article-title":"The Polyphenol Pterostilbene Ameliorates the Myopathic Phenotype of Collagen VI Deficient Mice via Autophagy Induction","volume":"8","author":"Metti","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.freeradbiomed.2015.12.019","article-title":"Antioxidant supplementation accelerates cachexia development by promoting tumor growth in C26 tumor-bearing mice","volume":"91","author":"Assi","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr. Biol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.ccr.2008.11.003","article-title":"Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis","volume":"14","author":"Nogueira","year":"2008","journal-title":"Cancer Cell"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.2174\/138161212803216889","article-title":"Cachexia and oxidative stress in cancer: An innovative therapeutic management","volume":"18","author":"Mantovani","year":"2012","journal-title":"Curr. Pharm. 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