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Autophagy plays an important role under normal physiological conditions in multiple biological processes, but it is induced under cellular stress. Therefore, it needs to be tightly regulated to respond to different cellular stimuli. In this review, the regulation of autophagy by hydrogen sulfide is described in both animal and plant systems. The underlying mechanism of action of sulfide is deciphered as the persulfidation of specific targets, regulating the pro- or anti-autophagic role of sulfide with a cell survival outcome. This review aims to highlight the importance of sulfide and persulfidation in autophagy regulation comparing the knowledge available in mammals and plants.<\/jats:p>","DOI":"10.3390\/antiox11020327","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T01:03:40Z","timestamp":1644368620000},"page":"327","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Hydrogen Sulfide: A Key Role in Autophagy Regulation from Plants to Mammalians"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4915-170X","authenticated-orcid":false,"given":"Angeles","family":"Aroca","sequence":"first","affiliation":[{"name":"Institute of Plant Biochemistry and Photosynthesis, University of Seville and CSIC, 41092 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4272-7446","authenticated-orcid":false,"given":"Cecilia","family":"Gotor","sequence":"additional","affiliation":[{"name":"Institute of Plant Biochemistry and Photosynthesis, University of Seville and CSIC, 41092 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1083\/jcb.33.2.437","article-title":"Influence of glucagon, an inducer of cellular autophagy, on some physical properties of rat liver lysosomes","volume":"33","author":"Deter","year":"1967","journal-title":"J. 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