{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:37:13Z","timestamp":1789105033780,"version":"build-2803163510"},"reference-count":106,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades, Instituto de Salud Carlos III, co-financed by European Regional Development Fund (ERDF), \u201cA way of making Europe\u201d","award":["PI17\/01766 and  BA21\/00030"],"award-info":[{"award-number":["PI17\/01766 and  BA21\/00030"]}]},{"name":"CIBER de Salud Mental","award":["CB07\/09\/0031"],"award-info":[{"award-number":["CB07\/09\/0031"]}]},{"name":"Delegaci\u00f3n del Gobierno para el Plan Nacional sobre Drogas","award":["2017\/085"],"award-info":[{"award-number":["2017\/085"]}]},{"DOI":"10.13039\/100008062","name":"Fundaci\u00f3n Alicia Koplowitz","doi-asserted-by":"publisher","award":["FAK16\/01"],"award-info":[{"award-number":["FAK16\/01"]}],"id":[{"id":"10.13039\/100008062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Consejer\u00eda de Educaci\u00f3n e investigaci\u00f3n, Comunidad de Madrid, co-funded by the European Social Fund \u201cInvesting in your future","award":["PEJD-2018-PRE\/BMD-7899"],"award-info":[{"award-number":["PEJD-2018-PRE\/BMD-7899"]}]},{"name":"Instituto de investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, \u201cPrograma Intramural de Impulso a la I+D+I 2019","award":["2019\/01"],"award-info":[{"award-number":["2019\/01"]}]},{"name":"Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovaci\u00f3n (MCIN) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505)","award":["na"],"award-info":[{"award-number":["na"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Curcumin is a polyphenol extracted from the rhizome of the turmeric plant. Beyond its common use as a culinary spice in Eastern Asia, curcumin has been proposed as a therapeutic compound due to its antioxidant, anti-inflammatory and neuroprotective properties. Thus, its efficacy has been evaluated in various inflammatory-based psychiatric disorders, such as schizophrenia, depression, or autism. Our aim is to review those preclinical and clinical studies carried out in psychiatric disorders whose therapeutic approach has involved the use of curcumin and, therefore, to discern the possible positive effect of curcumin in these disorders. Preclinical studies and completed clinical trials of curcumin for psychiatric disorders published from January 2005 to October 2021 were identified through searching relevant databases until 31st October 2021. Sixty-five preclinical studies and 15 clinical trials and open-label studies were selected. Results showed a bias toward studies in depression and, to a lesser extent, schizophrenia. In all disorders, the results were positive in reducing psychiatric deficits. Despite the considerable number of beneficial outcomes reported, the small number of trials and the heterogeneity of protocols make it difficult to draw solid conclusions about the real potency of curcumin in psychiatric disorders.<\/jats:p>","DOI":"10.3390\/antiox11020353","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T02:37:46Z","timestamp":1644547066000},"page":"353","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["An Update on the Exploratory Use of Curcumin in Neuropsychiatric Disorders"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3450-566X","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"Lamanna-Rama","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"},{"name":"Departamento de Bioingenier\u00eda e Ingenier\u00eda Aeroespacial, Universidad Carlos III de Madrid, 28911 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8385-7936","authenticated-orcid":false,"given":"Diego","family":"Romero-Miguel","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"},{"name":"Departamento de Bioingenier\u00eda e Ingenier\u00eda Aeroespacial, Universidad Carlos III de Madrid, 28911 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0989-3231","authenticated-orcid":false,"given":"Manuel","family":"Desco","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"},{"name":"Departamento de Bioingenier\u00eda e Ingenier\u00eda Aeroespacial, Universidad Carlos III de Madrid, 28911 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), 28029 Madrid, Spain"},{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4350-4789","authenticated-orcid":false,"given":"Maria Luisa","family":"Soto-Montenegro","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), 28029 Madrid, Spain"},{"name":"High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut), Universidad Rey Juan Carlos, Alcorc\u00f3n, 28922 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1007\/s11010-021-04201-6","article-title":"Turmeric and its bioactive constituents trigger cell signaling mechanisms that protect against diabetes and cardiovascular diseases","volume":"476","author":"Zhang","year":"2021","journal-title":"Mol. 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