{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:57:17Z","timestamp":1791824237025,"version":"4.3.4"},"reference-count":68,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Thiazolidine compounds NJ20 {(E)-2-(2-(5-bromo-2-methoxybenzylidene)hydrazinyl)-4-(4-nitrophenyl)thiazole} and NW05 [(2-(benzo (d) (1,3) dioxol-4-ylmethylene)-N-(4-bromophenyl)-thiosemicarbazone] potentiated the effect of norfloxacin in resistant bacteria; however, there are no reports on their effects on Nauphoeta cinerea in the literature. The objective of this work was to evaluate the behavioral effects and oxidative markers of NW05 and NJ20 in lobster cockroach N. cinerea. To evaluate the behavioral study, a video tracking software was used to evaluate the locomotor points and the exploratory profile of cockroaches in the horizontal and vertical regions of a new environment. The total concentration of thiol and reduced glutathione (GSH), substances reactive to thiobarbituric acid (TBARS), free iron (II) content and mitochondrial viability were determined. The antioxidant potential was evaluated by the DPPH method. Both substances induced changes in the behavior of cockroaches, showing a significant reduction in the total distance covered and in the speed. In the cell viability test (MTT), there was a significant reduction for NJ20 (1 mM). NJ20 caused a significant increase in total levels of thiol and non-protein thiol (NPSH), although it also slightly increased the content of malondialdehyde (MDA). Both compounds (NW05 and NJ20) caused a significant reduction in the content of free iron at a concentration of 10 mM. In conclusion, the compound NJ20 caused moderate neurotoxicity (1 mM), but had good antioxidant action, while NW05 did not show toxicity or significant antioxidant activity in the model organism tested. It is desirable to carry out complementary tests related to the antioxidant prospection of these same compounds, evaluating them at different concentrations.<\/jats:p>","DOI":"10.3390\/antiox11020420","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T08:14:46Z","timestamp":1645431286000},"page":"420","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Neurolocomotor Behavior and Oxidative Stress Markers of Thiazole and Thiazolidinedione Derivatives against Nauphoeta cinerea"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0001-7238","authenticated-orcid":false,"given":"Pedro Silvino","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Antibiotics, Federal University of Pernambuco (UFPE), Prof. Artur de Sa Avenue, University City, Recife 54740-520, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrielle Rodrigues","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Regional University of Cariri (URCA), 1161 Cel. Antonio Luiz Avenue, Pimenta, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalyta Julyanne Silva","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Regional University of Cariri (URCA), 1161 Cel. Antonio Luiz Avenue, Pimenta, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2126-1464","authenticated-orcid":false,"given":"Carlos Vin\u00edcius Barros","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Regional University of Cariri (URCA), 1161 Cel. Antonio Luiz Avenue, Pimenta, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria do Carmo Alves","family":"de Lima","sequence":"additional","affiliation":[{"name":"Department of Antibiotics, Federal University of Pernambuco (UFPE), Prof. Artur de Sa Avenue, University City, Recife 54740-520, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamerson Ferreira","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences, Auroras Campus, University of International Integration of Afro-Brazilian Lusophony (UNILAB), 3 Abolition Avenue, Downtown, Reden\u00e7\u00e3o 62790-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8678-156X","authenticated-orcid":false,"given":"Bonglee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-4207","authenticated-orcid":false,"given":"Henrique D. M.","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Regional University of Cariri (URCA), 1161 Cel. Antonio Luiz Avenue, Pimenta, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia Eliene","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Regional University of Cariri (URCA), 1161 Cel. Antonio Luiz Avenue, Pimenta, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1730-8602","authenticated-orcid":false,"given":"Jean Paul","family":"Kamdem","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Regional University of Cariri (URCA), 1161 Cel. Antonio Luiz Avenue, Pimenta, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresinha Gon\u00e7alves","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Antibiotics, Federal University of Pernambuco (UFPE), Prof. Artur de Sa Avenue, University City, Recife 54740-520, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Conti, I., Morigi, R., Locatelli, A., Rambaldi, M., Bua, G., Gallinella, G., and Leoni, A. (2019). Synthesis of 3-(Imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one Derivatives and Study of Their Antiviral Activity against Parvovirus B19. 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