{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:28:02Z","timestamp":1783074482309,"version":"3.54.6"},"reference-count":80,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Coronavirus disease 2019 (COVID-19) involves a complex pathogenesis and with the evolving novel variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the long-term impacts of the unceasing COVID-19 pandemic are mostly uncertain. Evidence indicates deleterious impact of this disease upon male reproductive health. It is concerning that COVID-19 may contribute to the already global declining trend of male fertility. The adverse impacts of COVID-19 on male reproduction may primarily be attributed to the induction of systemic inflammatory responses and oxidative stress (OS), which operate as a vicious loop. Bringing the systemic inflammation to a halt is critical for \u2018putting out\u2019 the \u2018cytokine storm\u2019 induced by excessive reactive oxygen species (ROS) generation. The possibility of OS playing a prime role in COVID-19-mediated male reproductive dysfunctions has led to the advocacy of antioxidant therapy. An array of antioxidant defense medications has shown to be effective in experimental and clinical studies of COVID-19. The present review thus discusses the possibilities as to whether antioxidant drugs would contribute to combating the SARS-CoV-2 infection-induced male reproductive disruptions, thereby aiming at kindling research ideas that are needed for identification and treatment of COVID-19-mediated male reproductive impairments.<\/jats:p>","DOI":"10.3390\/antiox11030548","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T03:06:10Z","timestamp":1647313570000},"page":"548","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["COVID-19, Oxidative Stress and Male Reproduction: Possible Role of Antioxidants"],"prefix":"10.3390","volume":"11","author":[{"given":"Pallav","family":"Sengupta","sequence":"first","affiliation":[{"name":"Physiology Unit, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom 42610, Selangor, Malaysia"},{"name":"School of Medical Sciences, Bharath Institute of Higher Education and Research (BIHER), Chennai 600126, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulagna","family":"Dutta","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Bharath Institute of Higher Education and Research (BIHER), Chennai 600126, India"},{"name":"Department of Oral Biology and Biomedical Sciences, Faculty of Dentistry, MAHSA University, Jenjarom 42610, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4174-1852","authenticated-orcid":false,"given":"Shubhadeep","family":"Roychoudhury","sequence":"additional","affiliation":[{"name":"Department of Life Science and Bioinformatics, Assam University, Silchar 788011, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3624-4683","authenticated-orcid":false,"given":"Urban John Arnold","family":"D\u2019Souza","sequence":"additional","affiliation":[{"name":"Father Muller Medical College, Mangalore 575025, India"},{"name":"Father Muller College of Allied Health Sciences, Kankanady, Mangalore 575002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadirvel","family":"Govindasamy","sequence":"additional","affiliation":[{"name":"Animal Production Division, ICAR Research Complex for NEH Region, Indian Council of Agricultural Research, Umiam 793103, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Kolesarova","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, 94976 Nitra, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N. Eng. J. Med."},{"key":"ref_2","unstructured":"World Health Organization (2022, February 17). Naming the Coronavirus Disease (COVID-19) and the Virus that Causes It, Available online: https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/technical-guidance\/naming-the-coronavirus-disease-(COVID-2019)-and-the-virus-that-causes-it."},{"key":"ref_3","first-page":"368","article-title":"COVID-19: Risk factors for severe disease and death","volume":"26","author":"Jordan","year":"2020","journal-title":"BMJ"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s40618-021-01628-y","article-title":"COVID-19 autopsy cases: Detection of virus in endocrine tissues","volume":"45","author":"Poma","year":"2022","journal-title":"J. Endocrinol. Investig."},{"key":"ref_5","first-page":"08292","article-title":"Clinical characteristics and results of semen tests among men with coronavirus disease 2019","volume":"3","author":"Li","year":"2020","journal-title":"JAMA Net Open"},{"key":"ref_6","first-page":"4","article-title":"Detection of 2019 novel coronavirus in semen and testicular biopsy specimen of COVID-19 patients","volume":"103","author":"Song","year":"2020","journal-title":"MedRxiv"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Gong, J., Zeng, Q., Yu, D., and Duan, Y.G. (2020). T lymphocytes and testicular immunity: A new insight into immune regulation in testes. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010057"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"100604","DOI":"10.1016\/j.eclinm.2020.100604","article-title":"Impaired spermatogenesis in COVID-19 patients","volume":"28","author":"Li","year":"2020","journal-title":"EClinicalMedicine"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/jmv.26259","article-title":"Evaluation of sex-related hormones and semen characteristics in reproductive-aged male COVID-19 patients","volume":"93","author":"Ma","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1159\/000517276","article-title":"Does COVID-19 worsen the semen parameters? Early results of a tertiary healthcare center","volume":"105","year":"2021","journal-title":"Urol. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/andr.13081","article-title":"The relationship of serum testosterone levels with the clinical course and prognosis of COVID-19 disease in male patients: A prospective study","volume":"10","author":"Cinislioglu","year":"2022","journal-title":"Andrology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"13912","DOI":"10.1111\/and.13912","article-title":"Investigation of SARS-CoV-2 in semen samples and the effects of COVID-19 on male sexual health by using semen analysis and serum male hormone profile: A cross-sectional, pilot study","volume":"53","author":"Temiz","year":"2021","journal-title":"Andrologia"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1093\/humrep\/deab026","article-title":"Semen impairment and occurrence of SARS-CoV-2 virus in semen after recovery from COVID-19","volume":"36","author":"Gacci","year":"2021","journal-title":"Hum. Reprod."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.arcmed.2020.04.019","article-title":"Oxidative stress as key player in severe acute respiratory syndrome coronavirus (SARS-CoV) infection","volume":"51","author":"Mesta","year":"2020","journal-title":"Arch. Med. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nrurol.2017.69","article-title":"Oxidative stress and male infertility","volume":"14","author":"Bisht","year":"2017","journal-title":"Nat. Rev. Urol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"ref_17","unstructured":"Dutta, S., Sandhu, N., Sengupta, P., Alves, M.G., Henkel, R., and Agarwal, A. (2022, February 17). Somatic-Immune Cells Crosstalk in-the-Making of Testicular Immune Privilege. Available online: https:\/\/link.springer.com\/article\/10.1007\/s43032-021-00721-0."},{"key":"ref_18","first-page":"1","article-title":"Immune privilege and inflammation of the testis","volume":"Volume 88","author":"Schuppe","year":"2005","journal-title":"Immunology of Gametes and Embryo Implantation"},{"key":"ref_19","first-page":"73","article-title":"Reproductive inflammatory mediators and male infertility","volume":"7","author":"Dutta","year":"2020","journal-title":"Chem. Biol. Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"563893","DOI":"10.3389\/fmed.2020.563893","article-title":"Ace2 expression in kidney and testis may cause kidney and testis damage after 2019-ncov infection","volume":"7","author":"Fan","year":"2020","journal-title":"Front. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2164\/jandrol.111.012989","article-title":"Immunophysiology and pathology of inflammation in the testis and epididymis","volume":"32","author":"Hedger","year":"2011","journal-title":"J. Androl."},{"key":"ref_22","first-page":"113","article-title":"Role of toll-like receptors in the reproductive tract inflammation and male infertility","volume":"7","author":"Dutta","year":"2020","journal-title":"Chem. Biol. Lett."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1097\/CM9.0000000000000722","article-title":"Identification of a novel coronavirus causing severe pneumonia in human: A descriptive study","volume":"133","author":"Ren","year":"2020","journal-title":"Chin. Med. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41577-020-0331-4","article-title":"Pathological inflammation in patients with COVID-19: A key role for monocytes and macrophages","volume":"20","author":"Merad","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/2090598X.2019.1599624","article-title":"Oxidative stress and sperm function: A systematic review on evaluation and management","volume":"17","author":"Dutta","year":"2019","journal-title":"Arab. J. Urol."},{"key":"ref_26","first-page":"75","article-title":"Reproductive tract infection, inflammation and male infertility","volume":"7","author":"Sengupta","year":"2020","journal-title":"Chem. Biol. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Ma, L., Xie, W., Li, D., Shi, L., Mao, Y., Xiong, Y., Zhang, Y., and Zhang, M. (2020). Effect of SARS-CoV-2 infection upon male gonadal function: A single center-based study. MedRxiv.","DOI":"10.1101\/2020.03.21.20037267"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12958-018-0406-2","article-title":"Reactive oxygen species and male reproductive hormones","volume":"16","author":"Darbandi","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10495-021-01680-2","article-title":"COVID-19 disrupts spermatogenesis through the oxidative stress pathway following induction of apoptosis","volume":"26","author":"Moghimi","year":"2021","journal-title":"Apoptosis"},{"key":"ref_30","first-page":"156","article-title":"Antioxidants, anti-inflammatory drugs and antibiotics in the treatment of reproductive tract infections and their association with male infertility","volume":"7","author":"Izuka","year":"2020","journal-title":"Chem. Biol. Lett."},{"key":"ref_31","first-page":"7090534","article-title":"Role of nrf2 and its activators in respiratory diseases","volume":"2019","author":"Liu","year":"2019","journal-title":"Oxidat. Med. Cell. Longev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"52","DOI":"10.5492\/wjccm.v7.i5.52","article-title":"Vitamin C in the critically ill-indications and controversies","volume":"7","author":"Nabzdyk","year":"2018","journal-title":"World J. Crit. Care Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-018-2191-x","article-title":"Evidence is stronger than you think: A meta-analysis of vitamin c use in patients with sepsis","volume":"22","author":"Li","year":"2018","journal-title":"Crit. Care"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Patel, V., Dial, K., Wu, J., Gauthier, A.G., Wu, W., Lin, M., Espey, M.G., Thomas, D.D., Ashby, C.R., and Mantell, L.L. (2020). Dietary antioxidants significantly attenuate hyperoxia-induced acute inflammatory lung injury by enhancing macrophage function via reducing the accumulation of airway hmgb1. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21030977"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4067\/S0716-97602011000200009","article-title":"Vitamin C and oxidative stress in the seminiferous epithelium","volume":"44","author":"Angulo","year":"2011","journal-title":"Biol. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1016\/j.theriogenology.2004.10.003","article-title":"The effect of ascorbic acid supplementation on sperm quality, lipid peroxidation and testosterone levels of male wistar rats","volume":"63","year":"2005","journal-title":"Theriogenology"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Ayinde, O.C., Ogunnowo, S., and Ogedegbe, R.A. (2012). Influence of vitamin c and vitamin e on testicular zinc content and testicular toxicity in lead exposed albino rats. BMC Pharm. Toxicol, 13.","DOI":"10.1186\/2050-6511-13-17"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Behairy, A., El-Sharkawy, N.I., Saber, T.M., Soliman, M.M., Metwally, M.M.M., Abd El-Rahman, G.I., Abd-Elhakim, Y.M., and El Deib, M.M. (2020). The modulatory role of vitamin C in boldenone undecylenate induced testicular oxidative damage and androgen receptor dysregulation in adult male rats. Antioxidants, 9.","DOI":"10.3390\/antiox9111053"},{"key":"ref_39","unstructured":"National Cancer Institute (2022, February 17). High-Dose Vitamin C (pdq\u00ae)\u2013Health Professional Version, Available online: https:\/\/www.cancer.gov\/about-cancer\/treatment\/cam\/hp\/vitamin-c-pdq."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.pcad.2020.02.007","article-title":"Nutraceuticals have potential for boosting the type 1 interferon response to rna viruses including influenza and coronavirus","volume":"63","author":"McCarty","year":"2020","journal-title":"Prog. Card. Dis."},{"key":"ref_41","first-page":"19","article-title":"COVID-19, oxidative stress, and male reproductive dysfunctions: Is vitamin c a potential remedy?","volume":"71","author":"Sengupta","year":"2022","journal-title":"Physiol. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.bcp.2011.05.014","article-title":"N-acetyl-l-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type ii epithelial cells infected with influenza virus a and b and with respiratory syncytial virus (rsv)","volume":"82","author":"Mata","year":"2011","journal-title":"Biochem. Pharm."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1021\/acsinfecdis.0c00288","article-title":"Endogenous deficiency of glutathione as the most likely cause of serious manifestations and death in COVID-19 patients","volume":"6","author":"Polonikov","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Sengupta, P., and Dutta, S. (2021). COVID-19 and hypogonadism: Secondary immune responses rule-over endocrine mechanisms. Hum. Fertil., 1\u20136.","DOI":"10.1080\/14647273.2020.1867902"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000507376","article-title":"Remote treatment delivery in response to the COVID-19 pandemic","volume":"89","author":"Wright","year":"2020","journal-title":"Psychother. Psychosom."},{"key":"ref_46","first-page":"959","article-title":"N-acetylcysteine as a potential treatment for novel coronavirus disease 2019","volume":"15","year":"2020","journal-title":"Fut. Micobiol."},{"key":"ref_47","unstructured":"(2022, February 17). Memorial Sloan Kettering Cancer Center. A Study of N-Acetylcysteine in Patients with COVID-19 Infection; Clinical Trial Identifier: NCT04374461, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04374461."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12958-019-0468-9","article-title":"Effects of n-acetyl-cysteine supplementation on sperm quality, chromatin integrity and level of oxidative stress in infertile men","volume":"17","author":"Jannatifar","year":"2019","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1054\/plef.2000.0174","article-title":"The effects of combined conventional treatment, oral antioxidants and essential fatty acids on sperm biology in subfertile men","volume":"63","author":"Comhaire","year":"2000","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12985-019-1182-0","article-title":"Coronavirus envelope protein: Current knowledge","volume":"16","author":"Schoeman","year":"2019","journal-title":"Virol. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1080\/10715762.2018.1468564","article-title":"N-acetylcysteine as an antioxidant and disulphide breaking agent: The reasons why","volume":"52","author":"Aldini","year":"2018","journal-title":"Free Rad. Res."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Semenovich, D.S., Plotnikov, E.Y., Titko, O.V., Lukiyenko, E.P., and Kanunnikova, N.P. (2021). Effects of Panthenol and N-Acetylcysteine on Changes in the Redox State of Brain Mitochondria under Oxidative Stress In Vitro. Antioxidants., 10.","DOI":"10.3390\/antiox10111699"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"43","DOI":"10.32794\/mr11250047","article-title":"Treatment of ebola and other infectious diseases: Melatonin \u201cgoes viral\u201d","volume":"3","author":"Reiter","year":"2020","journal-title":"Melatonin Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"100765","DOI":"10.1016\/j.isci.2019.100765","article-title":"Ebola hemorrhagic shock syndrome-on-a-chip","volume":"23","author":"Junaid","year":"2020","journal-title":"IScience"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/rmv.1714","article-title":"Beneficial actions of melatonin in the management of viral infections: A new use for this \u201dmolecular handyman\u201d?","volume":"22","author":"Boga","year":"2012","journal-title":"Rev. Med. Virol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.7150\/ijms.48053","article-title":"COVID-19: Rational discovery of the therapeutic potential of melatonin as a SARS-CoV-2 main protease inhibitor","volume":"17","author":"Feitosa","year":"2020","journal-title":"Int. J. Med. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF01309858","article-title":"Protective effects of melatonin in mice infected with encephalitis viruses","volume":"140","author":"Maestroni","year":"1995","journal-title":"Arch. Virol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"173329","DOI":"10.1016\/j.ejphar.2020.173329","article-title":"Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of COVID-19","volume":"882","author":"Othman","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/08830185.2020.1756284","article-title":"Can melatonin reduce the severity of COVID-19 pandemic?","volume":"39","author":"Shneider","year":"2020","journal-title":"Int. Rev. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cca.2015.04.029","article-title":"Melatonin and male reproduction","volume":"446","author":"Li","year":"2015","journal-title":"Clin. Chim. Acta."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"110889","DOI":"10.1016\/j.mce.2020.110889","article-title":"Melatonin daily oral supplementation attenuates inflammation and oxidative stress in testes of men with altered spermatogenesis of unknown aetiology","volume":"515","author":"Riviere","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Deng, S.L., Zhang, B.L., Reiter, R.J., and Liu, Y.X. (2020). Melatonin ameliorates inflammation and oxidative stress by suppressing the p38mapk signaling pathway in lps-induced sheep orchitis. Antioxidants, 9.","DOI":"10.3390\/antiox9121277"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/ajcn\/nqaa095","article-title":"Association between regional selenium status and reported outcome of COVID-19 cases in china","volume":"111","author":"Zhang","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Alexander, J., Tinkov, A., Strand, T.A., Alehagen, U., Skalny, A., and Aaseth, J. (2020). Early nutritional interventions with zinc, selenium and vitamin d for raising anti-viral resistance against progressive COVID-19. Nutrients, 12.","DOI":"10.3390\/nu12082358"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.freeradbiomed.2020.06.032","article-title":"Potential therapeutic use of ebselen for COVID-19 and other respiratory viral infections","volume":"156","author":"Sies","year":"2020","journal-title":"Free Rad. Biol. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41586-020-2223-y","article-title":"Structure of mpro from SARS-CoV-2 and discovery of its inhibitors","volume":"582","author":"Jin","year":"2020","journal-title":"Nature"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2147\/IJGM.S16275","article-title":"Selenium-vitamin E supplementation in infertile men: Effects on semen parameters and pregnancy rate","volume":"4","author":"Moslemi","year":"2011","journal-title":"Int. J. Gen. Med."},{"key":"ref_68","first-page":"89","article-title":"Evaluation of gpx1 pro198leu polymorphism in idiopathic male infertility","volume":"50","author":"Mazjin","year":"2016","journal-title":"Molekul. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/ajcn\/nqaa177","article-title":"A role for selenium-dependent gpx1 in SARS-CoV-2 virulence","volume":"112","author":"Seale","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"134","DOI":"10.5455\/medarh.2020.74.134-138","article-title":"The nrf2 activator (dmf) and COVID-19: Is there a possible role?","volume":"74","author":"Hassan","year":"2020","journal-title":"Med. Arch."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"McCord, J.M., Hybertson, B.M., Cota-Gomez, A., Geraci, K.P., and Gao, B. (2020). Nrf2 activator pb125(\u00ae) as a potential therapeutic agent against COVID-19. Antioxidants, 9.","DOI":"10.1101\/2020.05.16.099788"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3389\/fcell.2020.00479","article-title":"The inhibitory effect of curcumin on virus-induced cytokine storm and its potential use in the associated severe pneumonia","volume":"8","author":"Liu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Menegazzi, M., Campagnari, R., Bertoldi, M., Crupi, R., Di Paola, R., and Cuzzocrea, S. (2020). Protective effect of epigallocatechin-3-gallate (egcg) in diseases with uncontrolled immune activation: Could such a scenario be helpful to counteract COVID-19?. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21145171"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Mendonca, P., and Soliman, K.F.A. (2020). Flavonoids activation of the transcription factor nrf2 as a hypothesis approach for the prevention and modulation of SARS-CoV-2 infection severity. Antioxidants, 9.","DOI":"10.3390\/antiox9080659"},{"key":"ref_75","first-page":"215","article-title":"Human sperm quality and metal toxicants: Protective effects of some flavonoids on male reproductive function","volume":"10","author":"Jamalan","year":"2016","journal-title":"Int. J. Fert. Steril."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s11481-020-09923-w","article-title":"Smooth or risky revisit of an old malaria drug for COVID-19?","volume":"15","author":"Pahan","year":"2020","journal-title":"J. Neuroimm. Pharmacol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"108544","DOI":"10.1016\/j.clim.2020.108544","article-title":"Therapeutic blockade of inflammation in severe COVID-19 infection with intravenous n-acetylcysteine","volume":"219","author":"Ibrahim","year":"2020","journal-title":"Clin. Immunol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1142\/S0192415X20500512","article-title":"Potential targets for treatment of coronavirus disease 2019 (COVID-19): A review of qing-fei-pai-du-tang and its major herbs","volume":"48","author":"Zhong","year":"2020","journal-title":"Am. J. Chin. Med."},{"key":"ref_79","first-page":"202080186","article-title":"Paracetamol use in COVID-19: Friend or enemy?","volume":"2020","author":"Sestili","year":"2020","journal-title":"Preprints"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"12874","DOI":"10.1111\/and.12874","article-title":"Effect of paracetamol on semen quality","volume":"50","author":"Banihani","year":"2018","journal-title":"Andrologia"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/11\/3\/548\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:36:22Z","timestamp":1760135782000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/11\/3\/548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,14]]},"references-count":80,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["antiox11030548"],"URL":"https:\/\/doi.org\/10.3390\/antiox11030548","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,14]]}}}