{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:29:31Z","timestamp":1790832571157,"version":"4.1.0"},"reference-count":87,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wesley Hospital","award":["Grant Ref. No. 2020-28"],"award-info":[{"award-number":["Grant Ref. No. 2020-28"]}]},{"name":"Medical Research Future Fund","award":["APP1200255"],"award-info":[{"award-number":["APP1200255"]}]},{"name":"Queensland Children\u2019s Hospital","award":["RM2018002270"],"award-info":[{"award-number":["RM2018002270"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The ataxia-telangiectasia mutated (ATM) protein kinase is, as the name implies, mutated in the human genetic disorder ataxia-telangiectasia (A-T). This protein has its \u201cfinger in many pies\u201d, being responsible for the phosphorylation of many thousands of proteins in different signaling pathways in its role in protecting the cell against a variety of different forms of stress that threaten to perturb cellular homeostasis. The classical role of ATM is the protection against DNA damage, but it is evident that it also plays a key role in maintaining cell homeostasis in the face of oxidative and other forms of non-DNA damaging stress. The presence of ATM is not only in the nucleus to cope with damage to DNA, but also in association with other organelles in the cytoplasm, which suggests a greater protective role. This review attempts to address this greater role of ATM in protecting the cell against both external and endogenous damage.<\/jats:p>","DOI":"10.3390\/antiox11040653","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T21:40:14Z","timestamp":1648590014000},"page":"653","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Metabolic Stress and Mitochondrial Dysfunction in Ataxia-Telangiectasia"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2835-8464","authenticated-orcid":false,"given":"Goutham Narayanan","family":"Subramanian","sequence":"first","affiliation":[{"name":"University of Queensland Centre for Clinical Research, University of Queensland, Brisbane, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abrey Jie","family":"Yeo","sequence":"additional","affiliation":[{"name":"University of Queensland Centre for Clinical Research, University of Queensland, Brisbane, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magtouf Hnaidi","family":"Gatei","sequence":"additional","affiliation":[{"name":"University of Queensland Centre for Clinical Research, University of Queensland, Brisbane, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6303-6471","authenticated-orcid":false,"given":"David John","family":"Coman","sequence":"additional","affiliation":[{"name":"Queensland Children\u2019s Hospital, Brisbane, QLD 4101, Australia"},{"name":"Faculty of Medicine, University of Queensland, Brisbane, QLD 4006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Francis","family":"Lavin","sequence":"additional","affiliation":[{"name":"University of Queensland Centre for Clinical Research, University of Queensland, Brisbane, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nrm2514","article-title":"Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signalling and cancer","volume":"9","author":"Lavin","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev-pathol-011811-132509","article-title":"ATM and the Molecular Pathogenesis of Ataxia Telangiectasia","volume":"7","author":"McKinnon","year":"2012","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1126\/science.7792600","article-title":"A single ataxia telangiectasia gene with a product similar to PI-3 kinase","volume":"268","author":"Savitsky","year":"1995","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/85798","article-title":"DNA double-strand breaks: Signaling, repair and the cancer connection","volume":"27","author":"Khanna","year":"2001","journal-title":"Nat. Genet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/258427a0","article-title":"Ataxia telangiectasia: A human mutation with abnormal radiation sensitivity","volume":"258","author":"Taylor","year":"1975","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/274484a0","article-title":"Identification of ataxia telangiectasia heterozygotes, a cancer prone population","volume":"274","author":"Chen","year":"1978","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrm3546","article-title":"The ATM protein kinase: Regulating the cellular response to genotoxic stress, and more","volume":"14","author":"Shiloh","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_8","first-page":"207","article-title":"DNA replication-dependent nuclear dynamics of the Mre11 complex","volume":"1","author":"Mirzoeva","year":"2003","journal-title":"Mol. Cancer Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.1093\/emboj\/cdg541","article-title":"Requirement of the MRN complex for ATM activation by DNA damage","volume":"22","author":"Uziel","year":"2003","journal-title":"EMBO J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nature01368","article-title":"DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation","volume":"421","author":"Bakkenist","year":"2003","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.3390\/biom5042877","article-title":"ATM-dependent phosphorylation of all three members of the MRN complex: From sensor to adaptor","volume":"5","author":"Lavin","year":"2015","journal-title":"Biomolecules"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1126\/science.1192912","article-title":"ATM activation by oxidative stress","volume":"330","author":"Guo","year":"2010","journal-title":"Science"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1007\/s00204-020-02712-7","article-title":"Quantitative phosphoproteomics to unravel the cellular response to chemical stressors with different modes of action","volume":"94","author":"Sampadi","year":"2020","journal-title":"Arch. Toxicol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1074\/mcp.M115.055723","article-title":"Reactive Oxygen Species (ROS)-activated ATM-dependent phosphorylation of cytoplasmic substrates identified by large-scale phosphoproteomics screen","volume":"15","author":"Kozlov","year":"2016","journal-title":"Mol. Cell. Proteom."},{"key":"ref_15","first-page":"e104400","article-title":"Phosphoproteomics reveals novel modes of function and inter-relationships among PIKKs in response to genotoxic stress","volume":"40","author":"Bensimon","year":"2020","journal-title":"EMBO J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bbabio.2006.04.029","article-title":"Mitochondrial ROS-induced ROS release: An update and review","volume":"1757","author":"Zorov","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"101354","DOI":"10.1016\/j.molmet.2021.101354","article-title":"An anaplerotic approach to correct the mitochondrial dysfunction in ataxia-telangiectasia (A-T)","volume":"54","author":"Yeo","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"eaaq0702","DOI":"10.1126\/scisignal.aaq0702","article-title":"Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity","volume":"11","author":"Zhang","year":"2018","journal-title":"Sci. Signal."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s12275-020-9520-x","article-title":"Functional interplay between the oxidative stress response and DNA damage checkpoint signaling for genome maintenance in aerobic organisms","volume":"58","author":"Choi","year":"2020","journal-title":"J. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"101972","DOI":"10.1016\/j.isci.2020.101972","article-title":"Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia","volume":"24","author":"Yeo","year":"2021","journal-title":"iScience"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/s41580-021-00394-2","article-title":"Cellular functions of the protein kinase ATM and their relevance to human disease","volume":"22","author":"Lee","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e1700933","DOI":"10.1126\/sciadv.1700933","article-title":"Structures of closed and open conformations of dimeric human ATM","volume":"3","author":"Pollard","year":"2017","journal-title":"Sci. Adv."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1038\/sj.onc.1201037","article-title":"Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms","volume":"14","author":"Watters","year":"1997","journal-title":"Oncogene"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"34277","DOI":"10.1074\/jbc.274.48.34277","article-title":"Localization of a Portion of Extranuclear ATM to Peroxisomes","volume":"274","author":"Watters","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"10146","DOI":"10.1073\/pnas.95.17.10146","article-title":"ATM binds to beta-adaptin in cytoplasmic vesicles","volume":"95","author":"Lim","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0304-3940(98)00576-X","article-title":"Expression of the ataxia-telangiectasia gene (ATM) product in human cerebellar neurons during development","volume":"252","author":"Oka","year":"1998","journal-title":"Neurosci. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1073\/pnas.97.2.871","article-title":"ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation","volume":"97","author":"Barlow","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s004270000077","article-title":"Expression and subcellular localization of X-ATM during early Xenopus development","volume":"210","author":"Hensey","year":"2000","journal-title":"Dev. Genes Evol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1182\/blood-2011-08-373639","article-title":"Mitochondrial dysfunction in ataxia-telangiectasia","volume":"119","author":"MacLean","year":"2012","journal-title":"Blood"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.bbrc.2013.12.139","article-title":"Mitochondria are required for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line Hep G2 cells","volume":"443","author":"Morita","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.1038\/s41598-019-41108-1","article-title":"Ataxia-Telangiectasia Mutated is located in cardiac mitochondria and impacts oxidative phosphorylation","volume":"9","author":"Blignaut","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1038\/ncb3230","article-title":"ATM functions at the peroxisome to induce pexophagy in response to ROS","volume":"17","author":"Zhang","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0014-4827(82)90169-0","article-title":"Colony-forming ability of ataxia-telangiectasia skin fibroblasts is an indicator of their early senescence and increased demand for growth factors","volume":"140","author":"Shiloh","year":"1982","journal-title":"Exp. Cell Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0090-1229(80)90021-5","article-title":"Mitogen receptor redistribution defects and concomitant absence of blastogenesis in ataxia-telangiectasia T lymphocytes","volume":"15","author":"Linthicum","year":"1980","journal-title":"Clin. Immunol. Immunopathol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1365-3083.1993.tb01692.x","article-title":"Defective calcium-dependent signal transduction in T lymphocytes of ataxia-telangiectasia","volume":"38","author":"Kondo","year":"1993","journal-title":"Scand. J. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"9489","DOI":"10.1074\/jbc.272.14.9489","article-title":"Defective Signaling through the B Cell Antigen Receptor in Epstein-Barr Virus-transformed Ataxia-Telangiectasia Cells","volume":"272","author":"Khanna","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"166667","DOI":"10.1016\/j.jmb.2020.10.002","article-title":"The alternate pathway for BCR signaling induced by IL-4 requires Lyn tyrosine kinase","volume":"433","author":"Khan","year":"2021","journal-title":"J. Mol. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1074\/jbc.M110109200","article-title":"Signal transduction through the B cell antigen receptor is normal int ataxia-telangiectasia B lymphocytes","volume":"277","author":"Speck","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1182\/blood-2007-04-085399","article-title":"ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells","volume":"111","author":"Stagni","year":"2008","journal-title":"Blood"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1073\/pnas.0237083100","article-title":"Nitric oxide-induced cellular stress and p53 activation in chronic inflammation","volume":"100","author":"Saito","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1600-065X.2012.01101.x","article-title":"Damage-dependent NF-\u03baB activation: NEMO turns nuclear signaling inside out","volume":"246","author":"McCool","year":"2012","journal-title":"Immunol. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Sabatel, H., Di Valentin, E., Gloire, G., Dequiedt, F., Piette, J., and Habraken, Y. (2012). Phosphorylation of p65(RelA) on Ser547 by ATM Represses NF-\u03baB-Dependent Transcription of Specific Genes after Genotoxic Stress. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038246"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1038\/s41598-019-38901-3","article-title":"Increased susceptibility of airway epithelial cells from ataxia-telangiectasia to S. pneumoniae infection due to oxidative damage and impaired innate immunity","volume":"9","author":"Yeo","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.immuni.2015.01.012","article-title":"DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity","volume":"42","author":"Hartlova","year":"2015","journal-title":"Immunity"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e13468","DOI":"10.1111\/acel.13468","article-title":"Inhibition of the cGAS-STING pathway ameliorates the premature senescence hallmarks of Ataxia-Telangiectasia brain organoids","volume":"20","author":"Aguado","year":"2021","journal-title":"Aging Cell"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"192","DOI":"10.18632\/aging.100546","article-title":"A novel diagnostic tool reveals mitochondrial pathology in human diseases and aging","volume":"5","author":"Canugovi","year":"2013","journal-title":"Aging"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1093\/hmg\/ddm166","article-title":"Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells","volume":"16","author":"Ambrose","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"24700","DOI":"10.1038\/srep24700","article-title":"ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts","volume":"6","author":"Qi","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.cmet.2016.09.004","article-title":"NAD+ replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair","volume":"24","author":"Fang","year":"2016","journal-title":"Cell Metab."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"8850708","DOI":"10.1155\/2021\/8850708","article-title":"Ataxia telangiectasia mutated protein kinase: A potential master puppeteer of oxidative stress-induced metabolic recycling","volume":"2021","author":"Blignaut","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"111296","DOI":"10.1016\/j.mad.2020.111296","article-title":"ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy","volume":"190","author":"Sunderland","year":"2020","journal-title":"Mech. Ageing Dev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1007\/s11010-021-04183-5","article-title":"Activation of ATM kinase by ROS generated during ionophore-induced mitophagy in human T and B cell malignancies","volume":"476","author":"Sarkar","year":"2021","journal-title":"Mol. Cell. Biochem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3324\/haematol.2019.234385","article-title":"Ataxia-telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma","volume":"106","author":"Sarkar","year":"2020","journal-title":"Haematologica"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.dnarep.2013.11.002","article-title":"Intrinsic mitochondrial DNA repair defects in Ataxia Telangiectasia","volume":"13","author":"Sharma","year":"2014","journal-title":"DNA Repair"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nature09773","article-title":"DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair","volume":"471","author":"Gao","year":"2011","journal-title":"Nature"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e103111","DOI":"10.15252\/embj.2019103111","article-title":"ATM-CHK 2-Beclin 1 axis promotes autophagy to maintain ROS homeostasis under oxidative stress","volume":"39","author":"Guo","year":"2020","journal-title":"EMBO J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/mt.2012.203","article-title":"Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia","volume":"21","author":"Parish","year":"2013","journal-title":"Mol. Ther."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.cmet.2006.10.002","article-title":"ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome","volume":"4","author":"Schneider","year":"2006","journal-title":"Cell Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3389\/fped.2020.00317","article-title":"Diabetes in patients With ataxia telangiectasia: A national cohort study","volume":"8","author":"Donath","year":"2020","journal-title":"Front. Pediatr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/j.cellsig.2008.04.011","article-title":"ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 translocation by insulin in muscle cells","volume":"20","author":"Halaby","year":"2008","journal-title":"Cell. Signal."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.1128\/MCB.00347-10","article-title":"Requirement of the ATM\/p53 tumor suppressor pathway for glucose homeostasis","volume":"30","author":"Armata","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3389\/fphys.2014.00175","article-title":"Mitochondria, endothelial cell function, and vascular diseases","volume":"5","author":"Tang","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/jcbfm.2012.35","article-title":"Updated energy budgets for neural computation in the neocortex and cerebellum","volume":"32","author":"Howarth","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1083\/jcb.201806197","article-title":"ATM is activated by ATP depletion and modulates mitochondrial function through NRF1","volume":"218","author":"Chow","year":"2019","journal-title":"J. Cell Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"767493","DOI":"10.3389\/fnagi.2021.767493","article-title":"The interplay of the unfolded protein response in neurodegenerative diseases: A therapeutic role of curcumin","volume":"13","author":"Mukherjee","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"740653","DOI":"10.3389\/fcell.2021.740653","article-title":"Endoplasmic reticulum quality control in immune cells","volume":"9","author":"Jiang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1593\/neo.07935","article-title":"Endoplasmic reticulum stress and unfolded protein response in atm-deficient thymocytes and thymic lymphoma cells are attributable to oxidative stress","volume":"10","author":"Yan","year":"2008","journal-title":"Neoplasia"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"10042","DOI":"10.1093\/nar\/gkx635","article-title":"Modulation of proteostasis counteracts oxidative stress and affects DNA base excision repair capacity in ATM-deficient cells","volume":"45","author":"Poletto","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"eaan5598","DOI":"10.1126\/scisignal.aan5598","article-title":"ATM directs DNA damage responses and proteostasis via genetically separable pathways","volume":"11","author":"Lee","year":"2018","journal-title":"Sci. Signal."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.molcel.2021.01.019","article-title":"Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency","volume":"81","author":"Lee","year":"2021","journal-title":"Mol. Cell"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1080\/09553000050111497","article-title":"Defective radiation signal transduction in ataxia-telangiectasia cells","volume":"76","author":"Yan","year":"2000","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.cell.2010.06.007","article-title":"Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria","volume":"142","author":"Miller","year":"2010","journal-title":"Cell"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.2147\/JMDH.S295486","article-title":"Multidisciplinary management of ataxia telangiectasia: Current perspectives","volume":"14","author":"Wright","year":"2021","journal-title":"J. Multidiscip. Healthc."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"De Oliveira, B.S.P., Putti, S., Naro, F., and Pellegrini, M. (2020). Bone marrow transplantation as therapy for ataxia-telangiectasia: A systematic review. Cancers, 12.","DOI":"10.3390\/cancers12113207"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0304-3835(90)90089-G","article-title":"Response of fibroblast cultures from ataxia-telangiectasia patients to oxidative stress","volume":"54","author":"Yi","year":"1990","journal-title":"Cancer Lett"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1164\/rccm.201611-2210LE","article-title":"Loss of ATM in airway epithelial cells is associated with susceptibility to oxidative stress","volume":"196","author":"Yeo","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13023-017-0689-y","article-title":"Is age a risk factor for liver disease and metabolic alterations in ataxia Telangiectasia patients?","volume":"12","author":"Paulino","year":"2017","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_78","first-page":"761250","article-title":"Nonalcoholic steatohepatitis in a patient with ataxia-telangiectasia","volume":"2014","author":"Caballero","year":"2014","journal-title":"Case Rep. Hepatol."},{"key":"ref_79","first-page":"204","article-title":"Antioxidant enzymes in red blood cells and lymphocytes of ataxia-telangiectasia patients","volume":"46","author":"Aksoy","year":"2004","journal-title":"Turk. J. Pediatr."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1046\/j.1365-2249.1999.01000.x","article-title":"Anti-oxidative capacity in patients with ataxia telangiectasia","volume":"117","author":"Reichenbach","year":"1999","journal-title":"Clin. Exp. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"11453","DOI":"10.1523\/JNEUROSCI.23-36-11453.2003","article-title":"Oxidative stress is responsible for deficient survival and dendritogenesis in purkinje neurons from ataxia-telangiectasia mutated mutant mice","volume":"23","author":"Chen","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1080\/15548627.2016.1257467","article-title":"NAD+: The convergence of DNA repair and mitophagy","volume":"13","author":"Fang","year":"2017","journal-title":"Autophagy"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/jimd.12199","article-title":"Therapeutic potential of triheptanoin in metabolic and neurodegenerative diseases","volume":"43","author":"Wehbe","year":"2020","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ymgme.2005.09.018","article-title":"Differentiation of long-chain fatty acid oxidation disorders using alternative precursors and acylcarnitine profiling in fibroblasts","volume":"87","author":"Roe","year":"2006","journal-title":"Mol. Genet. Metab."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1007\/s40265-020-01399-5","article-title":"Triheptanoin: First Approval","volume":"80","author":"Shirley","year":"2020","journal-title":"Drugs"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3233\/JAD-200594","article-title":"Triheptanoin mitigates brain ATP depletion and mitochondrial dysfunction in a mouse model of Alzheimer\u2019s disease","volume":"78","author":"Yuan","year":"2020","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"100814","DOI":"10.1016\/j.ymgmr.2021.100814","article-title":"Triheptanoin\u2013Novel therapeutic approach for the ultra-rare disease mitochondrial malate dehydrogenase deficiency","volume":"29","author":"Laemmle","year":"2021","journal-title":"Mol. Genet. Metab. 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