{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:24:16Z","timestamp":1787066656812,"version":"build-2736575974"},"reference-count":60,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Arachidonic acid (ARA) is a major component of lipid bilayers as well as the key substrate for the eicosanoid cascades. ARA is readily oxidized, and its non-enzymatic and enzymatic oxidation products induce inflammatory responses in nearly all tissues, including lung tissues. Deuteration at bis-allylic positions substantially decreases the overall rate of ARA oxidation when hydrogen abstraction is an initiating event. To compare the effects of dosing of arachidonic acid (H-ARA) and its bis-allylic hexadeuterated form (D-ARA) on lungs in conventionally healthy mice and in an acute lung injury model, mice were dosed with H-ARA or D-ARA for six weeks through dietary supplementation and then challenged with intranasal lipopolysaccharide (LPS) for subsequent analysis of bronchoalveolar lavage fluid and lung tissue. Dosing on D-ARA resulted in successful incorporation of D-ARA into various tissues. D-ARA significantly reduced LPS-induced adverse effects on alveolar septal thickness and the bronchoalveolar area. Oral deuterated ARA is taken up efficiently and protects against adverse LPS-induced pathology. This suggests novel therapeutic avenues for reducing lung damage during severe infections and other pathological conditions with inflammation in the pulmonary system and other inflammatory diseases.<\/jats:p>","DOI":"10.3390\/antiox11040681","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:33:03Z","timestamp":1648762383000},"page":"681","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Deuterated Arachidonic Acid Ameliorates Lipopolysaccharide-Induced Lung Damage in Mice"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5053-6602","authenticated-orcid":false,"given":"Alla Y.","family":"Molchanova","sequence":"first","affiliation":[{"name":"Institute of Physiology, National Academy of Sciences of Belarus, Academicheskaya 28, 220072 Minsk, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana N.","family":"Rjabceva","sequence":"additional","affiliation":[{"name":"Institute of Physiology, National Academy of Sciences of Belarus, Academicheskaya 28, 220072 Minsk, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tigran B.","family":"Melik-Kasumov","sequence":"additional","affiliation":[{"name":"Institute of Physiology, National Academy of Sciences of Belarus, Academicheskaya 28, 220072 Minsk, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay B.","family":"Pestov","sequence":"additional","affiliation":[{"name":"Laboratory of Tick-Borne Encephalitis and Other Viral Encephalitides, Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Poselok Instituta Poliomielita 8 bd 17, Poselenie Moskovsky, 108819 Moscow, Russia"},{"name":"Group of Cross-Linking Enzymes, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16\/10, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Plamena R.","family":"Angelova","sequence":"additional","affiliation":[{"name":"Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1775-8101","authenticated-orcid":false,"given":"Vadim V.","family":"Shmanai","sequence":"additional","affiliation":[{"name":"Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Surganova 13, 220072 Minsk, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga L.","family":"Sharko","sequence":"additional","affiliation":[{"name":"Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Surganova 13, 220072 Minsk, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei V.","family":"Bekish","sequence":"additional","affiliation":[{"name":"Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Surganova 13, 220072 Minsk, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve","family":"James","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, of Chemistry, and of Nutrition, Dell Pediatric Research Institute, University of Texas at Austin, 1400 Barbara Jordan Blvd, Austin, TX 78723, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui Gyu","family":"Park","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, of Chemistry, and of Nutrition, Dell Pediatric Research Institute, University of Texas at Austin, 1400 Barbara Jordan Blvd, Austin, TX 78723, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina A.","family":"Udalova","sequence":"additional","affiliation":[{"name":"The Kennedy Institute of Rheumatology, University of Oxford, Oxford OX1 2JD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9494-4245","authenticated-orcid":false,"given":"J. 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