{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:11:20Z","timestamp":1789067480310,"version":"build-2803163510"},"reference-count":45,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T00:00:00Z","timestamp":1653091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Pelvis as a Mother Foundation","award":["UPB 20821141004"],"award-info":[{"award-number":["UPB 20821141004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Advanced maternal age impairs reproductive performance, influencing the quantity and the quality of oocytes. Mitochondria dysfunction seems to play a decisive role in conditioning the quality of the female gamete. Different in vitro and in vivo studies, demonstrated the antioxidant and anti-inflammatory activities of Resveratrol and its ability to improve mitochondria function even if the exact mechanism of action has not yet been demonstrated in human oocytes. In this paper, by retrospective analysis, we evaluated follicular fluid (FF) miRNome modification in aged women with a poor ovarian reserve receiving a resveratrol-based supplement the three months before the in vitro Fertilization (IVF) cycle. We found 13 differentially expressed microRNAs (miRNAs) in women treated with resveratrol and specifically miR-125b-5p, miR-132-3p, miR-19a-3p, miR-30a-5p and miR-660-5p, regulating mitochondrial proteins, are able to control metabolism and mitochondrial biogenesis. MiRNA expression differences, observed after resveratrol treatment in FF from women with a poor prognosis for IVF, demonstrated that resveratrol may act on mitomiRNAs to improve follicular microenvironment by transcriptomic and proteomic modifications in granulosa cells.<\/jats:p>","DOI":"10.3390\/antiox11051019","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T09:18:08Z","timestamp":1653124688000},"page":"1019","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Resveratrol Treatment Induces Mito-miRNome Modification in Follicular Fluid from Aged Women with a Poor Prognosis for In Vitro Fertilization Cycles"],"prefix":"10.3390","volume":"11","author":[{"given":"Rosalia","family":"Battaglia","sequence":"first","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, Section of Biology and Genetics \u201cGiovanni Sichel\u201d, University of Catania, 95123 Catania, CT, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Caponnetto","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, Section of Biology and Genetics \u201cGiovanni Sichel\u201d, University of Catania, 95123 Catania, CT, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Caringella","sequence":"additional","affiliation":[{"name":"Asl Bari, Reproductive and IVF Unit, PTA \u201cF Jaia\u201d, 70014 Conversano, BA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Cortone","sequence":"additional","affiliation":[{"name":"Asl Bari, Reproductive and IVF Unit, PTA \u201cF Jaia\u201d, 70014 Conversano, BA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Ferrara","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, Section of Biology and Genetics \u201cGiovanni Sichel\u201d, University of Catania, 95123 Catania, CT, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Smirni","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, Section of Biology and Genetics \u201cGiovanni Sichel\u201d, University of Catania, 95123 Catania, CT, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossana","family":"Iannitti","sequence":"additional","affiliation":[{"name":"S&R Farmaceutici S.p.A, 06083 Bastia Umbra, PG, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8873-3660","authenticated-orcid":false,"given":"Michele","family":"Purrello","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, Section of Biology and Genetics \u201cGiovanni Sichel\u201d, University of Catania, 95123 Catania, CT, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"D\u2019Amato","sequence":"additional","affiliation":[{"name":"Asl Bari, Reproductive and IVF Unit, PTA \u201cF Jaia\u201d, 70014 Conversano, BA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Fioretti","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnologies, University of Perugia, 06123 Perugia, PG, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6036-4469","authenticated-orcid":false,"given":"Cinzia","family":"Di Pietro","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, Section of Biology and Genetics \u201cGiovanni Sichel\u201d, University of Catania, 95123 Catania, CT, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16873","DOI":"10.18632\/aging.203206","article-title":"Searching for female reproductive aging and longevity biomarkers","volume":"13","author":"Yureneva","year":"2021","journal-title":"Aging"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.5935\/1518-0557.20160024","article-title":"Age and Fertility: A Study on Patient Awareness","volume":"20","author":"Deatsman","year":"2016","journal-title":"JBRA Assist. 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