{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:54:24Z","timestamp":1787698464540,"version":"build-2784847793"},"reference-count":40,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T00:00:00Z","timestamp":1653696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"General Directorate of Academic Personnel Affairs, National Autonomous University of Mexico (DGAPA and UNAM), the Secretariat of Science","award":["PAPIIT IN215821"],"award-info":[{"award-number":["PAPIIT IN215821"]}]},{"name":"General Directorate of Academic Personnel Affairs, National Autonomous University of Mexico (DGAPA and UNAM), the Secretariat of Science","award":["SECITI\/045\/2018"],"award-info":[{"award-number":["SECITI\/045\/2018"]}]},{"name":"Technology and Innovation Project of Mexico City (SECITI)","award":["PAPIIT IN215821"],"award-info":[{"award-number":["PAPIIT IN215821"]}]},{"name":"Technology and Innovation Project of Mexico City (SECITI)","award":["SECITI\/045\/2018"],"award-info":[{"award-number":["SECITI\/045\/2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Metabolic syndrome (MetS) has a high prevalence in older adults and is a risk factor for cardiovascular diseases and complications of old age. It has also been related to oxidative stress (OxS) and chronic inflammation (CI) and their consequent alterations. Therefore, it is important to propose therapeutic alternatives such as the consumption of Sechium edule (Chayote), since hypoglycemic, hypotensive, and lipogenesis inhibitor properties are attributed to it. We carried out a study in 81 older adults (OA) with MetS to determine the effect of consumption of chayote powder concentrate (500 mg, three times a day) for six months, with a baseline measurement, at three and six months in an experimental group (EG) (n = 41) and a placebo group (PG) (n = 40), all with a diagnosis of MetS according to the criteria of National Adult Treatment Panel of the National Cholesterol Program III (NCEP\/ATP III). Anthropometric, biochemical, OxS markers, and inflammation measurements were performed on all participants, basal, three, and six months after. A statistically significant decrease was found in the concentration of lipoperoxides (TBARS), 8-isoprostanes, 8-OHdG, oxidative stress score (OSS), HbA1c, blood pressure, and in the number of MetS diagnostic criteria, as well as an increase in total antioxidant status (TAS), antioxidant gap (GAP), superoxide dismutase (SOD), interleukin 10 (IL-10), and HDL-cholesterol in EG. The results suggest that the consumption of Sechium edule powder has a hypotensive, hypoglycemic, antioxidant, and anti-inflammatory effect in OA with MetS and reduced the percentage of patients with MetS.<\/jats:p>","DOI":"10.3390\/antiox11061076","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T08:50:51Z","timestamp":1653814251000},"page":"1076","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Antioxidant and Anti-Inflammatory Effect of the Consumption of Powdered Concentrate of Sechium edule var. nigrum spinosum in Mexican Older Adults with Metabolic Syndrome"],"prefix":"10.3390","volume":"11","author":[{"given":"Taide Laurita","family":"Arista-Ugalde","sequence":"first","affiliation":[{"name":"Research Unit on Gerontology, FES Zaragoza, National Autonomous University of Mexico, Mexico City 09230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4876-0688","authenticated-orcid":false,"given":"Edelmiro","family":"Santiago-Osorio","sequence":"additional","affiliation":[{"name":"Hematopoiesis and Leukemia Laboratory, Research Unit on Cell Differentiation and Cancer, FES Zaragoza, National Autonomous University of Mexico, Mexico City 09230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Monroy-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Immunology and Cancer Laboratory, Medical Research Unit in Oncological Diseases, CMN SXXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juana","family":"Rosado-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Research Unit on Gerontology, FES Zaragoza, National Autonomous University of Mexico, Mexico City 09230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1692-8287","authenticated-orcid":false,"given":"Itzen","family":"Agui\u00f1iga-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Postgraduate College, Campus San Luis Potos\u00ed, Iturbide No. 73 Street, Salinas de Hidalgo, San Luis Potos\u00ed 78600, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Cadena-I\u00f1iguez","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Medicine, FES Zaragoza, National Autonomous University of Mexico, Mexico City 09230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Gavia-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Research Unit on Gerontology, FES Zaragoza, National Autonomous University of Mexico, Mexico City 09230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9137-3405","authenticated-orcid":false,"given":"V\u00edctor Manuel","family":"Mendoza-N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Research Unit on Gerontology, FES Zaragoza, National Autonomous University of Mexico, Mexico City 09230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,28]]},"reference":[{"key":"ref_1","unstructured":"S\u00e1nchez-Rodr\u00edguez, M.A., and Mendoza-N\u00fa\u00f1ez, V. 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