{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:48:54Z","timestamp":1792842534335,"version":"4.5.0"},"reference-count":183,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81971394"],"award-info":[{"award-number":["81971394"]}]},{"name":"National Natural Science Foundation of China","award":["81973119"],"award-info":[{"award-number":["81973119"]}]},{"name":"National Natural Science Foundation of China","award":["15PJ1400900"],"award-info":[{"award-number":["15PJ1400900"]}]},{"name":"Shanghai Pujiang Program","award":["81971394"],"award-info":[{"award-number":["81971394"]}]},{"name":"Shanghai Pujiang Program","award":["81973119"],"award-info":[{"award-number":["81973119"]}]},{"name":"Shanghai Pujiang Program","award":["15PJ1400900"],"award-info":[{"award-number":["15PJ1400900"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Iron is essential for cell survival, and iron deficiency is a known risk factor for many reproductive diseases. Paradoxically, such disorders are also more common in cases of iron overload. Here, we evaluated the role of ferroptosis in women\u2019s health, particularly focusing on pre-eclampsia (PE). PE is a multisystem disorder and is one of the leading causes of maternal and perinatal morbidity and mortality, especially when the condition is of early onset. Nevertheless, the exact etiological mechanism of PE remains unclear. Interestingly, ferroptosis, as a regulated iron-dependent cell death pathway, involves a lethal accumulation of lipid peroxides and shares some characteristics with PE pathophysiology. In this review, we comprehensively reviewed and summarized recent studies investigating the molecular mechanisms involved in the regulation and execution of ferroptosis, as well as ferroptosis mechanisms in the pathology of PE. We propose that ferroptosis not only plays an important role in PE, but may also become a novel therapeutic target for PE.<\/jats:p>","DOI":"10.3390\/antiox11071282","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T23:59:22Z","timestamp":1656460762000},"page":"1282","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Ferroptosis and Its Emerging Role in Pre-Eclampsia"],"prefix":"10.3390","volume":"11","author":[{"given":"Zhixian","family":"Chen","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China"},{"name":"Department of Obstetrics and Gynecology of Shanghai Medical School, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Gan","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China"},{"name":"Department of Obstetrics and Gynecology of Shanghai Medical School, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3021-9201","authenticated-orcid":false,"given":"Mo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China"},{"name":"Department of Obstetrics and Gynecology of Shanghai Medical School, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5413-7836","authenticated-orcid":false,"given":"Yan","family":"Du","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China"},{"name":"Department of Obstetrics and Gynecology of Shanghai Medical School, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China"},{"name":"Department of Obstetrics and Gynecology of Shanghai Medical School, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1097\/AOG.0b013e3181a45b25","article-title":"Hypertensive Disorders and Severe Obstetric Morbidity in the United States","volume":"113","author":"Kuklina","year":"2009","journal-title":"Obstet. 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