{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T17:41:27Z","timestamp":1781804487393,"version":"3.54.5"},"reference-count":71,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cluster of Excellence and Deutsche Forschungsgemeinschaft Research Center Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB)","award":["456368804"],"award-info":[{"award-number":["456368804"]}]},{"name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","award":["456368804"],"award-info":[{"award-number":["456368804"]}]},{"name":"Umberto Veronesi Foundation","award":["456368804"],"award-info":[{"award-number":["456368804"]}]},{"name":"Georg-August-Universit\u00e4t G\u00f6ttingen","award":["456368804"],"award-info":[{"award-number":["456368804"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Rett syndrome (RTT) is a severe neurodevelopmental disorder that typically arises from spontaneous germline mutations in the X-chromosomal methyl-CpG binding protein 2 (MECP2) gene. For the first 6\u201318 months of life, the development of the mostly female patients appears normal. Subsequently, cognitive impairment, motor disturbances, hand stereotypies, epilepsy, and irregular breathing manifest, with previously learned skills being lost. Early mitochondrial impairment and a systemic oxidative burden are part of the complex pathogenesis, and contribute to disease progression. Accordingly, partial therapeutic merits of redox-stabilizing and antioxidant (AO) treatments were reported in RTT patients and Mecp2-mutant mice. Pursuing these findings, we conducted a full preclinical trial on male and female mice to define the therapeutic value of an orally administered AO cocktail composed of vitamin E, N-acetylcysteine, and \u03b1-lipoic acid. AO treatment ameliorated some of the microcephaly-related aspects. Moreover, the reduced growth, lowered blood glucose levels, and the hippocampal synaptic plasticity of Mecp2\u2212\/y mice improved. However, the first-time detected intensified oxidative DNA damage in Mecp2-mutant cortex persisted. The behavioral performance, breathing regularity, and life expectancy of Mecp2-mutant mice did not improve upon AO treatment. Long-term-treated Mecp2+\/\u2212 mice eventually became obese. In conclusion, the AO cocktail ameliorated a subset of symptoms of the complex RTT-related phenotype, thereby further confirming the potential merits of AO-based pharmacotherapies. Yet, it also became evident that long-term AO treatment may lose efficacy and even aggravate the metabolic disturbances in RTT. This emphasizes the importance of a constantly well-balanced redox balance for systemic well-being.<\/jats:p>","DOI":"10.3390\/antiox11071406","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T11:22:24Z","timestamp":1658316144000},"page":"1406","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Oral Feeding of an Antioxidant Cocktail as a Therapeutic Strategy in a Mouse Model of Rett Syndrome: Merits and Limitations of Long-Term Treatment"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6739-2860","authenticated-orcid":false,"given":"Laura","family":"Baroncelli","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Neuro- und Sinnesphysiologie, Universit\u00e4tsmedizin G\u00f6ttingen, Georg-August-Universit\u00e4t G\u00f6ttingen, Humboldtallee 23, D-37073 G\u00f6ttingen, Germany"},{"name":"Institute of Neuroscience, National Research Council (CNR), via Giuseppe Moruzzi 1, I-56124 Pisa, Italy"},{"name":"Department of Developmental Neuroscience, IRCCS Stella Maris Foundation, Viale del Tirreno 331, I-56128 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Auel","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Neuro- und Sinnesphysiologie, Universit\u00e4tsmedizin G\u00f6ttingen, Georg-August-Universit\u00e4t G\u00f6ttingen, Humboldtallee 23, D-37073 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Rinne","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Neuro- und Sinnesphysiologie, Universit\u00e4tsmedizin G\u00f6ttingen, Georg-August-Universit\u00e4t G\u00f6ttingen, Humboldtallee 23, D-37073 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Kathrin","family":"Schuster","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Neuro- und Sinnesphysiologie, Universit\u00e4tsmedizin G\u00f6ttingen, Georg-August-Universit\u00e4t G\u00f6ttingen, Humboldtallee 23, D-37073 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Brand","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Neuro- und Sinnesphysiologie, Universit\u00e4tsmedizin G\u00f6ttingen, Georg-August-Universit\u00e4t G\u00f6ttingen, Humboldtallee 23, D-37073 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Kempkes","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Neuro- und Sinnesphysiologie, Universit\u00e4tsmedizin G\u00f6ttingen, Georg-August-Universit\u00e4t G\u00f6ttingen, Humboldtallee 23, D-37073 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Neuro- und Sinnesphysiologie, Universit\u00e4tsmedizin G\u00f6ttingen, Georg-August-Universit\u00e4t G\u00f6ttingen, Humboldtallee 23, D-37073 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Neuro- und Sinnesphysiologie, Universit\u00e4tsmedizin G\u00f6ttingen, Georg-August-Universit\u00e4t G\u00f6ttingen, Humboldtallee 23, D-37073 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1651-2227.1985.tb10993.x","article-title":"Rett\u2019s syndrome: Prevalence and impact on progressive severe mental retardation in girls","volume":"74","author":"Hagberg","year":"1985","journal-title":"Acta Paediatr. 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