{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:32:50Z","timestamp":1787027570041,"version":"build-2736575974"},"reference-count":103,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Austrian Competence Centre for Feed and Food Quality, Safety and Innovation","award":["WP 146"],"award-info":[{"award-number":["WP 146"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Reports of the underlying mechanisms of dietary grape extract (GE) in overcoming weaning challenges in piglets have been partly inconsistent. Furthermore, evaluations of the effects of GE at weaning in comparison to those of widely used therapeutic antibiotics have been scarce. To explore the mode of action of GE in selected tissues and plasma, we evaluated gut morphology, antioxidant and inflammation indices. Accordingly, 180 weaning piglets were allocated to three treatment groups: negative control (NC), NC and antibiotic treatment for the first 5 days of the trial (positive control, PC), and NC and GE (entire trial). The villus surface was positively affected by GE and PC on day 27\/28 of the trial in the jejunum and on day 55\/56 of the trial in the ileum. In the colon, NC tended (p &lt; 0.10) to increase crypt parameters compared to PC on day 55\/56. The PC group tended (p &lt; 0.10) to increase catalase activity in the ileum and decrease Cu\/Zn-SOD activity in the jejunum, both compared to NC. There were no additional effects on antioxidant measurements of tissue and plasma, tissue gene expression, or plasma acute-phase proteins. In conclusion, GE supplementation beneficially affected the villus surface of the small intestine. However, these changes were not linked to the antioxidant and anti-inflammatory properties of GE.<\/jats:p>","DOI":"10.3390\/antiox11081428","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T12:53:45Z","timestamp":1658494425000},"page":"1428","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of a Dietary Grape Extract on Oxidative Status, Intestinal Morphology, Plasma Acute-Phase Proteins and Inflammation Parameters of Weaning Piglets at Various Points of Time"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1370-8345","authenticated-orcid":false,"given":"Emina","family":"Rajkovi\u0107","sequence":"first","affiliation":[{"name":"FFoQSI GmbH\u2014Austrian Competence Centre for Feed and Food Quality, Safety and Innovation, 3430 Tulln, Austria"},{"name":"Institute of Animal Nutrition, Livestock Products, and Nutrition Physiology (TTE), Department of Agrobiotechnology, IFA-Tulln, University of Natural Resources and Life Sciences, 1190 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4213-3608","authenticated-orcid":false,"given":"Christiane","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Livestock Products, and Nutrition Physiology (TTE), Department of Agrobiotechnology, IFA-Tulln, University of Natural Resources and Life Sciences, 1190 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan Bruno","family":"Kapsamer","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Livestock Products, and Nutrition Physiology (TTE), Department of Agrobiotechnology, IFA-Tulln, University of Natural Resources and Life Sciences, 1190 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8408-4015","authenticated-orcid":false,"given":"Karl","family":"Schedle","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Livestock Products, and Nutrition Physiology (TTE), Department of Agrobiotechnology, IFA-Tulln, University of Natural Resources and Life Sciences, 1190 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9207-452X","authenticated-orcid":false,"given":"Nicole","family":"Reisinger","sequence":"additional","affiliation":[{"name":"DSM\u2014BIOMIN Research Center, Technopark 1, 3430 Tulln, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Emsenhuber","sequence":"additional","affiliation":[{"name":"DSM\u2014BIOMIN Research Center, Technopark 1, 3430 Tulln, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimira","family":"Ocelova","sequence":"additional","affiliation":[{"name":"DSM\u2014BIOMIN Research Center, Technopark 1, 3430 Tulln, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliya","family":"Roth","sequence":"additional","affiliation":[{"name":"DSM\u2014BIOMIN Research Center, Technopark 1, 3430 Tulln, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00f6rte","family":"Frieten","sequence":"additional","affiliation":[{"name":"Animal Nutrition, Department Life Sciences, University of Applied Sciences Bingen, 55411 Bingen am Rhein, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Dusel","sequence":"additional","affiliation":[{"name":"Animal Nutrition, Department Life Sciences, University of Applied Sciences Bingen, 55411 Bingen am Rhein, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6909-0356","authenticated-orcid":false,"given":"Martin","family":"Gierus","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Livestock Products, and Nutrition Physiology (TTE), Department of Agrobiotechnology, IFA-Tulln, University of Natural Resources and Life Sciences, 1190 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1017\/S0029665107005484","article-title":"Nutritional management of gut health in pigs around weaning","volume":"66","author":"Bosi","year":"2007","journal-title":"Proc. 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