{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:31:34Z","timestamp":1787027494512,"version":"build-2736575974"},"reference-count":67,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Laboratory on Human Reproduction","award":["RRF 2.3.1-21-2022-00012"],"award-info":[{"award-number":["RRF 2.3.1-21-2022-00012"]}]},{"name":"National Laboratory on Human Reproduction","award":["\u00daNKP-21-4-II-PTE-1241"],"award-info":[{"award-number":["\u00daNKP-21-4-II-PTE-1241"]}]},{"DOI":"10.13039\/501100015498","name":"Ministry for Innovation and Technology from the source of the National Research","doi-asserted-by":"publisher","award":["RRF 2.3.1-21-2022-00012"],"award-info":[{"award-number":["RRF 2.3.1-21-2022-00012"]}],"id":[{"id":"10.13039\/501100015498","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015498","name":"Ministry for Innovation and Technology from the source of the National Research","doi-asserted-by":"publisher","award":["\u00daNKP-21-4-II-PTE-1241"],"award-info":[{"award-number":["\u00daNKP-21-4-II-PTE-1241"]}],"id":[{"id":"10.13039\/501100015498","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>(1) Background: This study was designed to define whether pretreatment habitual physical activity (PA)-induced oxidative stress (OS) influences outcome measures by using 8-hydroxy-2\u2032-deoxyguanosine (8-OHdG) in saliva samples of patients undergoing in vitro fertilization (IVF). (2) Method: In this cohort study, samples were obtained from 26 patients (age: 34.6 \u00b1 5.5 years, BMI: 25.3 \u00b1 5.1, infertility: 51.0 \u00b1 28.7 months) before the treatment and a follow-up of outcome measures of IVF\/ICSI. The 8-OHdG was evaluated by Abcam\u2019s ELISA (ab201734), PA patterns by GPAQ-H and ActiGraph GT3X; (3) Results: The number of matured oocytes was positively influenced by the GPAQ-H recreation MET (R2 = 0.367, F = 10.994, p = 0.004; \u03b2 = 0.005, p = 0.004, B Constant = 4.604) and a positive significant relationship (R2 = 0.757, F = 17.692, p &lt; 0.001, B Constant = 1.342) was found with GPAQ-H recreational PA MET (\u03b2 = 0.004, p &lt; 0.001), and Grade 1 embryos and higher very vigorous activity (GT3X) were accompanied (R2 = 0.958, F = 408.479, p &lt; 0.001) by higher \u00df-hCG levels (\u03b2 = 63.703, p \u2264 0.001). Unanticipated positive correlation between 8-OHdG and \u00df-hCG level (R = 0.467, p = 0.028) was noticed, and there were significant differences in 8-OHdG in biochemical pregnancies (pregnant: 54.82 \u00b1 35.56 ng\/mL, non-pregnant: 30.06 \u00b1 10.40 ng\/mL, p = 0.022) as well. (4) Conclusions: Pretreatment PA could positively influence reproductive performance in IVF\/ICSI despite the induced OS. However, a more sensitive biomarker and the recommended amount of activity should be further investigated.<\/jats:p>","DOI":"10.3390\/antiox11081586","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T23:44:25Z","timestamp":1660693465000},"page":"1586","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pre-Treatment Physical Activity Could Positively Influence Pregnancy Rates in IVF despite the Induced Oxidative Stress: A Cohort Study on Salivary 8-Hydroxy-2\u2032-deoxyguanosine"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4059-104X","authenticated-orcid":false,"given":"Vikt\u00f3ria","family":"Pr\u00e9musz","sequence":"first","affiliation":[{"name":"ELKH-PTE Human Reproduction Scientific Research Group, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"Institute of Physiotherapy and Sport Sciences, Faculty of Health Sciences, University of P\u00e9cs, H-7621 P\u00e9cs, Hungary"},{"name":"National Laboratory on Human Reproduction, University of P\u00e9cs, H-7622 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1439-6627","authenticated-orcid":false,"given":"Dominika","family":"Lendvai-Emmert","sequence":"additional","affiliation":[{"name":"Doctoral School of Health Sciences, Faculty of Health Sciences, University of P\u00e9cs, H-7621 P\u00e9cs, Hungary"},{"name":"Department of Neurosurgery, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Makai","sequence":"additional","affiliation":[{"name":"Institute of Physiotherapy and Sport Sciences, Faculty of Health Sciences, University of P\u00e9cs, H-7621 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina","family":"Amrein","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"Neurotrauma Research Group, Szent\u00e1gothai Research Centre, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Doctoral School of Health Sciences, Faculty of Health Sciences, University of P\u00e9cs, H-7621 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef","family":"B\u00f3dis","sequence":"additional","affiliation":[{"name":"ELKH-PTE Human Reproduction Scientific Research Group, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"National Laboratory on Human Reproduction, University of P\u00e9cs, H-7622 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1lm\u00e1n Andr\u00e1s","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1kos","family":"V\u00e1rnagy","sequence":"additional","affiliation":[{"name":"ELKH-PTE Human Reproduction Scientific Research Group, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"National Laboratory on Human Reproduction, University of P\u00e9cs, H-7622 P\u00e9cs, Hungary"},{"name":"Department of Obstetrics and Gynaecology, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"ref_1","unstructured":"WHO (2018). Global Action Plan on Physical Activity 2018\u20132030: More Active People for a Healthier World, World Health Organization."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.eujim.2016.11.003","article-title":"Economic and public health benefits: The result of increased regular physical activity","volume":"8","author":"Stocker","year":"2016","journal-title":"Eur. J. Integr. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"8416763","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative Stress: Harms and Benefits for Human Health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.rbmo.2014.03.006","article-title":"Physical activity before IVF and ICSI cycles in infertile obese women: An observational cohort study","volume":"29","author":"Palomba","year":"2014","journal-title":"Reprod. Biomed. Online"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12958-018-0328-z","article-title":"Maternal physical activity before IVF\/ICSI cycles improves clinical pregnancy rate and live birth rate: A systematic review and meta-analysis","volume":"16","author":"Rao","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/00001648-200203000-00013","article-title":"Physical activity, body mass index, and ovulatory disorder infertility","volume":"13","author":"Spiegelman","year":"2002","journal-title":"Epidemiology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1097\/01.AOG.0000235704.45652.0b","article-title":"Effects of lifetime exercise on the outcome of In Vitro fertilization","volume":"108","author":"Morris","year":"2006","journal-title":"Obstet. Gynecol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Davison, G.W., and McClean, C. (2022). Oxidative Stress and Exercise. Antioxidants, 11.","DOI":"10.3390\/books978-3-0365-4202-7"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez Macarro, M., \u00c1vila-Gand\u00eda, V., P\u00e9rez-Pi\u00f1ero, S., C\u00e1novas, F., Garc\u00eda-Mu\u00f1oz, A.M., Abell\u00e1n-Ruiz, M.S., Victoria-Montesinos, D., Luque-Rubia, A.J., Climent, E., and Genov\u00e9s, S. (2021). Antioxidant Effect of a Probiotic Product on a Model of Oxidative Stress Induced by High-Intensity and Duration Physical Exercise. Antioxidants, 10.","DOI":"10.3390\/antiox10020323"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Tominaga, T., Ma, S., Sugama, K., Kanda, K., Omae, C., Choi, W., Hashimoto, S., Aoyama, K., Yoshikai, Y., and Suzuki, K. (2021). Changes in Urinary Biomarkers of Organ Damage, Inflammation, Oxidative Stress, and Bone Turnover Following a 3000-m Time Trial. Antioxidants, 10.","DOI":"10.3390\/antiox10010079"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"de Salazar, L., Contreras, C., Torregrosa-Garc\u00eda, A., Luque-Rubia, A.J., \u00c1vila-Gand\u00eda, V., Domingo, J.C., and L\u00f3pez-Rom\u00e1n, F.J. (2020). Oxidative Stress in Endurance Cycling Is Reduced Dose-Dependently after One Month of Re-Esterified DHA Supplementation. Antioxidants, 9.","DOI":"10.3390\/antiox9111145"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Kawamura, T., and Muraoka, I. (2018). Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint. Antioxidants, 7.","DOI":"10.3390\/antiox7090119"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1249\/00005768-199302000-00010","article-title":"Exercise-induced oxidative stress","volume":"25","author":"Alessio","year":"1993","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1249\/00005768-199302000-00011","article-title":"Antioxidant enzyme response to exercise and aging","volume":"25","author":"Ji","year":"1993","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1600-079X.2007.00524.x","article-title":"Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate","volume":"44","author":"Tamura","year":"2008","journal-title":"J. Pineal Res."},{"key":"ref_16","first-page":"235","article-title":"The effect of sperm DNA damage on assisted reproduction outcomes","volume":"56","author":"Agarwal","year":"2004","journal-title":"Minerva Ginecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1477-7827-10-49","article-title":"The effects of oxidative stress on female reproduction: A review","volume":"10","author":"Agarwal","year":"2012","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1089\/ars.2007.1964","article-title":"Redox considerations in female reproductive function and assisted reproduction: From molecular mechanisms to health implications","volume":"10","author":"Agarwal","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/S1472-6483(10)60038-7","article-title":"Could oxidative stress influence the in-vitro maturation of oocytes?","volume":"18","author":"Combelles","year":"2009","journal-title":"Reprod. Biomed. Online"},{"key":"ref_20","first-page":"61","article-title":"Review on the role of glutathione on oxidative stress and infertility","volume":"22","author":"Adeoye","year":"2018","journal-title":"JBRA Assist. Reprod."},{"key":"ref_21","first-page":"314","article-title":"The effect of follicular fluid reactive oxygen species on the outcome of In Vitro fertilization","volume":"45","author":"Attaran","year":"2000","journal-title":"Int. J. Fertil. Womens Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.fertnstert.2004.06.013","article-title":"Oxidative stress indices in follicular fluid as measured by the thermochemiluminescence assay correlate with outcome parameters in In Vitro fertilization","volume":"82","author":"Vardi","year":"2004","journal-title":"Fertil. Steril."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1093\/oxfordjournals.humrep.a019146","article-title":"Antioxidative capacity of preimplantation embryo culture medium declines following the incubation of poor quality embryos","volume":"11","author":"Paszkowski","year":"1996","journal-title":"Hum. Reprod."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/humrep\/13.4.998","article-title":"Detection of reactive oxygen species (ROS) and apoptosis in human fragmented embryos","volume":"13","author":"Yang","year":"1998","journal-title":"Hum. Reprod."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.reprotox.2010.04.002","article-title":"Upper control limit of reactive oxygen species in follicular fluid beyond which viable embryo formation is not favorable","volume":"29","author":"Jana","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1095\/biolreprod.112.100552","article-title":"Oxygen Regulates Amino Acid Turnover and Carbohydrate Uptake During the Preimplantation Period of Mouse Embryo Development","volume":"87","author":"Wale","year":"2012","journal-title":"Biol. Reprod."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/molehr\/gan065","article-title":"Metabolism of the viable mammalian embryo: Quietness revisited","volume":"14","author":"Leese","year":"2008","journal-title":"Mol. Hum. Reprod."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.fertnstert.2012.12.004","article-title":"Analysis of metabolism to select viable human embryos for transfer","volume":"99","author":"Gardner","year":"2013","journal-title":"Fertil. Steril."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2152\/jmi.69.112","article-title":"Follicular fluid 8-Hydroxy-2-Deoxyguanosine (8-OHdG) as biomarker for oxidative stress in intracytoplasmic sperm injection","volume":"69","author":"Mukheef","year":"2022","journal-title":"J. Med. Investig."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/mrd.20604","article-title":"The quiet embryo hypothesis: Molecular characteristics favoring viability","volume":"74","author":"Baumann","year":"2007","journal-title":"Mol. Reprod. Dev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/humrep\/13.4.991","article-title":"Amino acids and vitamins prevent culture-induced metabolic perturbations and associated loss of viability of mouse blastocysts","volume":"13","author":"Lane","year":"1998","journal-title":"Hum. Reprod."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.fertnstert.2012.06.040","article-title":"Time-dependent O2 consumption patterns determined optimal time ranges for selecting viable human embryos","volume":"98","author":"Tejera","year":"2012","journal-title":"Fertil. Steril."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/S0015-0282(02)03103-5","article-title":"Eight-hydroxy-2\u2032-deoxyguanosine in granulosa cells is correlated with the quality of oocytes and embryos in an In Vitro fertilization-embryo transfer program","volume":"77","author":"Seino","year":"2002","journal-title":"Fertil. Steril."},{"key":"ref_34","first-page":"200","article-title":"Levels of total antioxidant capacity and 8-hydroxy-2\u2032-deoxyguanosine of serum and follicular fluid in women undergoing In Vitro fertilization: Focusing on endometriosis","volume":"23","author":"Sulyok","year":"2018","journal-title":"Hum. Fertil."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s41021-018-0095-2","article-title":"Measurement of 8-hydroxyguanine as an oxidative stress biomarker in saliva by HPLC-ECD","volume":"40","author":"Kawai","year":"2018","journal-title":"Genes Environ."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.freeradbiomed.2015.04.005","article-title":"Salivary biomarkers of oxidative stress: A critical review","volume":"85","author":"Wang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.freeradbiomed.2009.02.017","article-title":"Urea, the most abundant component in urine, cross-reacts with a commercial 8-OH-dG ELISA kit and contributes to overestimation of urinary 8-OH-dG","volume":"47","author":"Song","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_38","unstructured":"Salimetrics, LLC, and SalivaBio, LLC (2015). Saliva Collection and Handling Advice, SalivaBio LLC."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000334412","article-title":"Children\u2032s morning and evening salivary cortisol: Pattern, instruction compliance and sampling confounders","volume":"77","author":"Michels","year":"2012","journal-title":"Horm. Res. Paediatr."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"ESHRE (2011). The Istanbul consensus workshop on embryo assessment: Proceedings of an expert meeting. Hum. Reprod., 26, 1270\u20131283.","DOI":"10.1093\/humrep\/der037"},{"key":"ref_41","first-page":"269","article-title":"Biochemical pregnancy during assisted conception: A little bit pregnant","volume":"5","author":"Annan","year":"2013","journal-title":"J. Clin. Med. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s10389-006-0024-x","article-title":"Development of the World Health Organization Global Physical Activity Questionnaire (GPAQ)","volume":"14","author":"Armstrong","year":"2006","journal-title":"J. Public Health"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1123\/jpah.6.6.790","article-title":"Global Physical Activity Questionnaire (GPAQ): Nine Country Reliability and Validity Study","volume":"6","author":"Bull","year":"2009","journal-title":"J. Phys. Act. Health"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Cleland, C.L., Hunter, R.F., Kee, F., Cupples, M.E., Sallis, J.F., and Tully, M.A. (2014). Validity of the Global Physical Activity Questionnaire (GPAQ) in assessing levels and change in moderate-vigorous physical activity and sedentary behaviour. BMC Public Health, 14.","DOI":"10.1186\/1471-2458-14-1255"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/1091367X.2013.805139","article-title":"Validity and Reliability of the Global Physical Activity Questionnaire (GPAQ)","volume":"17","author":"Herrmann","year":"2013","journal-title":"Meas. Phys. Educ. Exerc. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"\u00c1cs, P., Betlehem, J., Ol\u00e1h, A., Bergier, B., Morvay-Sey, K., Makai, A., and Pr\u00e9musz, V. (2020). Cross-cultural adaptation and validation of the Global Physical Activity Questionnaire among healthy Hungarian adults. BMC Public Health, 20.","DOI":"10.1186\/s12889-020-08477-z"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1097\/00005768-200212000-00020","article-title":"Correlates of adults\u2032 participation in physical activity: Review and update","volume":"34","author":"Trost","year":"2002","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/00005768-199805000-00021","article-title":"Calibration of the Computer Science and Applications, Inc. accelerometer","volume":"30","author":"Freedson","year":"1998","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1097\/00005768-200208000-00021","article-title":"Sources of variance in daily physical activity levels as measured by an accelerometer","volume":"34","author":"Matthews","year":"2002","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1123\/jpah.2011-0347","article-title":"Detection of physical activity types using triaxial accelerometers","volume":"11","author":"Skotte","year":"2014","journal-title":"J. Phys. Act. Health"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1093\/humrep\/dex264","article-title":"Assisted reproductive technology in Europe, 2013: Results generated from European registers by ESHRE","volume":"32","author":"Kupka","year":"2017","journal-title":"Hum. Reprod."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ogc.2012.09.001","article-title":"Infertility Evaluation","volume":"39","author":"McLaren","year":"2012","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"5","DOI":"10.31382\/eqol.191201","article-title":"Preliminary study on pre-treatment physical activity and quality of life in infertility","volume":"11","author":"Makai","year":"2019","journal-title":"Exerc. Qual. Life"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Pr\u00e9musz, V., Makai, A., Perj\u00e9s, B., M\u00e1t\u00e9, O., Hock, M., \u00c1cs, P., Kopp\u00e1n, M., B\u00f3dis, J., V\u00e1rnagy, \u00c1., and Lampek, K. (2021). Multicausal analysis on psychosocial and lifestyle factors among patients undergoing assisted reproductive therapy\u2014With special regard to self-reported and objective measures of pre-treatment habitual physical activity. BMC Public Health, 21.","DOI":"10.1186\/s12889-020-09522-7"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Halliwell, B., and Gutteridge, J.M. (2015). Free Radicals in Biology & Medicine, Oxford University Press.","DOI":"10.1093\/acprof:oso\/9780198717478.001.0001"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1152\/physrev.00031.2007","article-title":"Exercise-induced oxidative stress: Cellular mechanisms and impact on muscle force production","volume":"88","author":"Powers","year":"2008","journal-title":"Physiol. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"9697","DOI":"10.1073\/pnas.86.24.9697","article-title":"Urinary 8-hydroxy-2\u2032-deoxyguanosine as a biological marker of invivo oxidative DNA damage","volume":"86","author":"Shigenaga","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0009-8981(03)00191-8","article-title":"Urinary 8-hydroxydeoxyguano sine and its analogs as DNA marker of oxidative stress: Development of an ELISA and measurement in both bladder and prostate cancers","volume":"334","author":"Chiou","year":"2003","journal-title":"Clin. Chim. Acta"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0076-6879(99)00123-8","article-title":"8-hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage","volume":"300","author":"Helbock","year":"1999","journal-title":"Oxid. Antioxid."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/MCA.0b013e328344b615","article-title":"Association of serum 8-hydroxy-2\u2032-deoxyguanosine levels with the presence and severity of coronary artery disease","volume":"22","author":"Fei","year":"2011","journal-title":"Coron. Artery Dis."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Llorente-Cantarero, F.J., Aguilar-G\u00f3mez, F.J., Leis, R., Bueno, G., Rup\u00e9rez, A.I., Anguita-Ruiz, A., V\u00e1zquez-Cobela, R., Mesa, M.D., Moreno, L.A., and Gil, \u00c1. (2021). Relationship between Physical Activity, Oxidative Stress, and Total Plasma Antioxidant Capacity in Spanish Children from the GENOBOX Study. Antioxidants, 10.","DOI":"10.3390\/antiox10020320"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1080\/02640414.2015.1004637","article-title":"Effects of repeated bouts of long-duration endurance exercise on muscle and urinary levels of 8-hydroxy-2\u2032-deoxyguanosine in moderately trained cyclists","volume":"33","author":"Yasuda","year":"2015","journal-title":"J. Sports Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"9799","DOI":"10.1007\/s11357-015-9799-4","article-title":"Effects of combined physical exercise training on DNA damage and repair capacity: Role of oxidative stress changes","volume":"37","author":"Soares","year":"2015","journal-title":"AGE"},{"key":"ref_64","first-page":"60","article-title":"Effects of regular exercise on neutrophil functions, oxidative stress parameters and antibody responses against 4-hydroxy-2-nonenal adducts in middle aged humans","volume":"19","author":"Sasaki","year":"2013","journal-title":"Exerc. Immunol. Rev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3109\/19396368.2012.743197","article-title":"Oxidative status in granulosa cells of infertile women undergoing IVF","volume":"59","author":"Karuputhula","year":"2013","journal-title":"Syst. Biol. Reprod. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s004210000342","article-title":"Strenuous endurance training in humans reduces oxidative stress following exhausting exercise","volume":"84","author":"Miyazaki","year":"2001","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1093\/humrep\/dep337","article-title":"Physical activity and fertility in women: The North-Trondelag Health Study","volume":"24","author":"Gudmundsdottir","year":"2009","journal-title":"Hum. Reprod."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/11\/8\/1586\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:10:35Z","timestamp":1760141435000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/11\/8\/1586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":67,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["antiox11081586"],"URL":"https:\/\/doi.org\/10.3390\/antiox11081586","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,16]]}}}