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We investigated the effect of NEM, an \u03b1,\u03b2-unsaturated carboxyl compound, on H2S signaling in in vitro- and ex vivo-dedifferentiated Schwann cells using global proteomics (LC-MS) and transcriptomics (whole-genome and small RNA-sequencing (RNA-seq)) methods. The multi-omics analyses identified several genes and proteins related to oxidative stress, such as Sod1, Gnao1, Stx4, Hmox2, Srxn1, and Edn1. The responses to oxidative stress were transcriptionally regulated by several transcription factors, such as Atf3, Fos, Rela, and Smad2. In a functional enrichment analysis, cell cycle, oxidative stress, and lipid\/cholesterol metabolism were enriched, implicating H2S signaling in Schwann cell dedifferentiation, proliferation, and myelination. NEM-induced changes in the H2S signaling pathway affect oxidative stress, lipid metabolism, and the cell cycle in Schwann cells. Therefore, regulation of the H2S signaling pathway by NEM during PND could prevent Schwann cell demyelination, dedifferentiation, and proliferation.<\/jats:p>","DOI":"10.3390\/antiox11081606","type":"journal-article","created":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T21:05:51Z","timestamp":1661115951000},"page":"1606","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Investigation of the Hydrogen Sulfide Signaling Pathway in Schwann Cells during Peripheral Nerve Degeneration: Multi-Omics Approaches"],"prefix":"10.3390","volume":"11","author":[{"given":"Yoo Lim","family":"Chun","sequence":"first","affiliation":[{"name":"Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea"},{"name":"Department of Biomedical Science, Graduation School, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea"},{"name":"Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, Seo-gu, Busan 49201, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Joon","family":"Eom","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea"},{"name":"Department of Biomedical Science, Graduation School, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Hyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Dalseong-gu, Daegu 42988, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thy N. C.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Dalseong-gu, Daegu 42988, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea"},{"name":"Department of Anesthesiology and Pain Medicine, College of Medicine, Kosin University, Seo-gu, Busan 49267, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung-Joo","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, College of Medicine, Kosin University, Seo-gu, Busan 49267, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, College of Medicine, Kosin University, Seo-gu, Busan 49267, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngbuhm","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea"},{"name":"Department of Biomedical Science, Graduation School, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5045-5060","authenticated-orcid":false,"given":"Sang Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8021-1024","authenticated-orcid":false,"given":"Seung Geun","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonseok","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Good Samsun Hospital, Sasang-gu, Busan, 47007, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geul","family":"Bang","sequence":"additional","affiliation":[{"name":"Research Center for Bioconvergence Analysis, Korea Basic Science Institute, Ochang 28119, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Center for Bioconvergence Analysis, Korea Basic Science Institute, Ochang 28119, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7317-5360","authenticated-orcid":false,"given":"Min-Sik","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Dalseong-gu, Daegu 42988, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na Young","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, Seo-gu, Busan 49201, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3946-5406","authenticated-orcid":false,"given":"Junyang","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea"},{"name":"Department of Biomedical Science, Graduation School, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"ref_1","first-page":"13","article-title":"The success and failure of the Schwann cell response to nerve injury","volume":"11","author":"Jessen","year":"2019","journal-title":"Front. 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