{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T10:31:31Z","timestamp":1768645891446,"version":"3.49.0"},"reference-count":62,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T00:00:00Z","timestamp":1661644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>This study aimed to evaluate the concentration of reactive oxidative metabolites, the antioxidant barrier, thiol groups of plasma compounds, and high-mobility group box 1 in shelter dogs naturally infected with helminths. In addition, the correlation between clinical signs and oxidative stress was investigated. Sixty-six (41 male and 25 female) adult mixed-breed dogs housed in a shelter with the diagnosis of gastrointestinal nematodes (i.e., Ancylostoma spp., Uncinaria stenocephala, Toxocara canis, Toxascaris leonina, or Trichuris vulpis) were enrolled in Group 1 (G1) and twenty healthy adult dogs were included in Group 2 (G2), which served as the control. A clinical assessment was performed using a physician-based scoring system. Oxidative stress variables and high-mobility group box 1 were assessed and compared by the means of unpaired t-tests (p &lt; 0.05). Spearman\u2019s rank correlation was performed to calculate the correlation between oxidative stress variables, high-mobility group box 1, hematological parameters, and clinical signs. The results showed statistically significant values for reactive oxidative metabolites, thiol groups of plasma compounds, and high-mobility group box 1 in G1. Negative correlations between thiol groups and the number of red cells and hemoglobin were recorded. These preliminary results support the potential role of oxidative stress and HGMB-1 in the pathogenesis of gastrointestinal helminthiasis in dogs.<\/jats:p>","DOI":"10.3390\/antiox11091679","type":"journal-article","created":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T21:22:56Z","timestamp":1661721776000},"page":"1679","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oxidative Stress and High-Mobility Group Box 1 Assay in Dogs with Gastrointestinal Parasites"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0440-5457","authenticated-orcid":false,"given":"Michela","family":"Pugliese","sequence":"first","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, Via Giovanni Palatucci, 98168 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ettore","family":"Napoli","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, Via Giovanni Palatucci, 98168 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Monti","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, Via Giovanni Palatucci, 98168 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8717-1966","authenticated-orcid":false,"given":"Vito","family":"Biondi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, Via Giovanni Palatucci, 98168 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Zema","sequence":"additional","affiliation":[{"name":"Veterinary Practitioner, Via Caserta Crocevia, 25, 89124 Reggio Calabria, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1701-3636","authenticated-orcid":false,"given":"Annamaria","family":"Passantino","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, Via Giovanni Palatucci, 98168 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,28]]},"reference":[{"key":"ref_1","first-page":"100452","article-title":"Epidemiological aspects of Ancylostoma spp. infection in naturally infected dogs from S\u00e3o Paulo state, Brazil","volume":"22","author":"Mora","year":"2020","journal-title":"Vet. 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