{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:45:13Z","timestamp":1782254713711,"version":"3.54.5"},"reference-count":56,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T00:00:00Z","timestamp":1661644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003712","name":"Korea Food Research Institute (KFRI)","doi-asserted-by":"publisher","award":["E0210202-02"],"award-info":[{"award-number":["E0210202-02"]}],"id":[{"id":"10.13039\/501100003712","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Cigarette smoke (CS) is the major factor in the development of chronic obstructive pulmonary disease (COPD), the third leading cause of death worldwide. Furthermore, although Camellia sinensis (CN) has been known as an anti-inflammatory material, the effect of CN has not yet been known on pulmonary inflammation in COPD. Thus, we investigated the protective effects of Camellia sinensis L. extract (CLE) against pulmonary inflammation in porcine pancreas elastase (PPE) and a cigarette smoke extract (CSE)-induced COPD mouse model. Oral administration of CLE suppressed the symptoms such as infiltration of immune cells, cytokines\/chemokines secretion, mucus hypersecretion, and injuries of the lung parenchyma. Increased inflammatory responses in COPD are mediated by various immune cells such as airway epithelial cells, neutrophils, and alveolar macrophages. Thus, we investigated the effect and mechanisms of CLE in H292, HL-60, and MH-S cells. The CLE inhibited the expression of IL-6, IL-8, MUC5AC and MUC5B on CSE\/LPS-stimulated H292 cells and also suppressed the formation of neutrophil extracellular traps and secretion of neutrophil elastase by inhibiting reactive oxygen species in PMA-induced HL-60 cells. In particular, the CLE suppressed the release of cytokines and chemokines caused by activating the nuclear factor kappa-light-chain-enhancer of activated B via the activation of nuclear factor erythroid-2-related factor 2 and the heme oxygenase-1 pathway in CSE\/LPS-stimulated MH-S cells. Therefore, we suggest that the CLE administration be the effective approach for treating or preventing chronic pulmonary diseases such as COPD induced by CS.<\/jats:p>","DOI":"10.3390\/antiox11091683","type":"journal-article","created":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T21:22:56Z","timestamp":1661721776000},"page":"1683","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Camellia sinensis L. Alleviates Pulmonary Inflammation Induced by Porcine Pancreas Elastase and Cigarette Smoke Extract"],"prefix":"10.3390","volume":"11","author":[{"given":"Dong-Uk","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Food Biotechnology, Korea University of Science and Technology (UST), Daejeon 34113, Korea"},{"name":"Division of Food Functionality Research, Korea Food Research Institute (KFRI), Wanju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Eun","family":"Eom","sequence":"additional","affiliation":[{"name":"Food Function Infrastructure Team, Korea Food Research Institute (KFRI), Wanju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon-Ji","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Food Functionality Research, Korea Food Research Institute (KFRI), Wanju 55365, Korea"},{"name":"Department of Food Science and Technology, Jeonbuk National University, Jeonju 54896, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Young","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Food Biotechnology, Korea University of Science and Technology (UST), Daejeon 34113, Korea"},{"name":"Division of Food Functionality Research, Korea Food Research Institute (KFRI), Wanju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Van","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Institute of Medical Science, Jeonbuk National University Medical School, Jeonju 54907, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Min","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Food Biotechnology, Korea University of Science and Technology (UST), Daejeon 34113, Korea"},{"name":"Division of Food Functionality Research, Korea Food Research Institute (KFRI), Wanju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2889-9743","authenticated-orcid":false,"given":"Ok Hee","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Institute of Medical Science, Jeonbuk National University Medical School, Jeonju 54907, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Applied Life Science (BK21 Four), Department of Food Science and Technology, Institute of Agriculture and Life Science, Gyeongsang National University, 501 Jinjudaero, Jinju 52828, Korea"},{"name":"EZmass. Co., Ltd., 501 Jinjudaero, Jinju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gun-Dong","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Food Functionality Research, Korea Food Research Institute (KFRI), Wanju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0942-7161","authenticated-orcid":false,"given":"Hee Soon","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Food Biotechnology, Korea University of Science and Technology (UST), Daejeon 34113, Korea"},{"name":"Division of Food Functionality Research, Korea Food Research Institute (KFRI), Wanju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food Biotechnology, Korea University of Science and Technology (UST), Daejeon 34113, Korea"},{"name":"Division of Food Functionality Research, Korea Food Research Institute (KFRI), Wanju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wang, H.-H., and Cheng, S.-L. 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