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The DOCA-salt model presented higher blood pressure, which was significantly reduced by EWH. The impaired acetylcholine-induced relaxation and eNOS expression observed in MRA and aorta from DOCA-salt rats was ameliorated by EWH. This effect on vessels (MRA and aorta) was related to the antioxidant effect of EWH, since hydrolysate intake prevented the NF-\u03baB\/TNF\u03b1 inflammatory pathway and NADPH oxidase-induced reactive oxygen species (ROS) generation, as well as the mitochondrial source of ROS in MRA. At the plasma level, EWH blocked the higher ROS and MDA generation by DOCA-salt treatment, without altering the antioxidant marker. In conclusion, EWH demonstrated an antihypertensive effect in a model of severe hypertension. This effect could be related to its endothelium-dependent vasodilator properties mediated by an ameliorated vessel\u2019s redox imbalance and inflammatory state.<\/jats:p>","DOI":"10.3390\/antiox11091713","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T21:25:18Z","timestamp":1661894718000},"page":"1713","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["ROS Suppression by Egg White Hydrolysate in DOCA-Salt Rats\u2014An Alternative Tool against Vascular Dysfunction in Severe Hypertension"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0405-0027","authenticated-orcid":false,"given":"Edina da Luz","family":"Abreu","sequence":"first","affiliation":[{"name":"Cardiovascular Physiology Laboratory, Universidade Federal do Pampa, BR 472, Km 592, Uruguaiana 97501-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Rodrigues Moro","sequence":"additional","affiliation":[{"name":"Cardiovascular Physiology Laboratory, Universidade Federal do Pampa, BR 472, Km 592, Uruguaiana 97501-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5538-8549","authenticated-orcid":false,"given":"Samia","family":"Hassan Husein Kanaan","sequence":"additional","affiliation":[{"name":"Cardiovascular Physiology Laboratory, Universidade Federal do Pampa, BR 472, Km 592, Uruguaiana 97501-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Bernardino","family":"de Paula","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Science, University of S\u00e3o Paulo, Av. 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Marechal Campos, 1468, Vit\u00f3ria 29040-090, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0944-9483","authenticated-orcid":false,"given":"Luciana Venturini","family":"Rossoni","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Science, University of S\u00e3o Paulo, Av. ProfessorLineu Prestes, n\u00ba 2415, S\u00e3o Paulo 97501-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5525-1056","authenticated-orcid":false,"given":"Marta","family":"Miguel-Castro","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias de la Alimentaci\u00f3n (CIAL, CSIC-UAM.), C\/Nicol\u00e1s Cabrera, 9, Campus Universitario de Cantoblanco, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5401-828X","authenticated-orcid":false,"given":"Giulia Alessandra","family":"Wiggers","sequence":"additional","affiliation":[{"name":"Cardiovascular Physiology Laboratory, Universidade Federal do Pampa, BR 472, Km 592, Uruguaiana 97501-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.jacc.2021.01.014","article-title":"Systolic Blood Pressure Time in Target Range and Cardiovascular Outcomes in Patients with Hypertension","volume":"77","author":"Fatani","year":"2021","journal-title":"J. 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