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Resveratrol (RES) efficiently exerts anti-inflammatory and antioxidant effects. However, the information regarding RES protecting against DON-induced oxidative stress and intestinal inflammation in piglets is limited. (2) Methods: A total of 64 weaned piglets (Duroc \u00d7 (Landrace \u00d7 Yorkshire), 21-d-old, barrow) were randomly allocated to four groups (eight replicate pens per group, each pen containing two piglets) for 28 d. The piglets were fed a control diet (CON) or the CON diet supplemented with 300 mg RES\/kg diet (RES group), 3.8 mg DON\/kg diet (DON) or both (DON+RES) in a 2 \u00d7 2 factorial design. (3) Compared with unsupplemented DON-challenged piglets, RES supplementation in DON-challenged piglets increased ileal villus height and the abundance of ileal SOD1, GCLC and PG1-5 transcripts and Muc2 protein (p &lt; 0.05), while decreasing the mRNA and proteins expression of ileal IL-1\u03b2, IL-6 and TNF-\u03b1, and malondialdehyde (MDA) levels in plasma and ileum in DON-challenged piglets (p &lt; 0.05). Moreover, the abundances of class Bacilli, order Lactobacillales, family Lactobacillaceae and species Lactobacillus\u00a0gasseri were increased in DON-challenged piglets fed a RES-supplemented diet compared with those in DON-challenged piglets(p \u2264 0.05). (4) Conclusions: our results indicated that RES supplementation in DON-challenged piglets efficiently attenuated intestinal inflammation and oxidative stress and improved gut microbiota, thereby alleviating DON-induced intestinal barrier injury.<\/jats:p>","DOI":"10.3390\/antiox11091775","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T07:05:56Z","timestamp":1662620756000},"page":"1775","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effect of Resveratrol Supplementation on Intestinal Oxidative Stress, Immunity and Gut Microbiota in Weaned Piglets Challenged with Deoxynivalenol"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6989-7026","authenticated-orcid":false,"given":"Yueqin","family":"Qiu","sequence":"first","affiliation":[{"name":"Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"},{"name":"State Key Laboratory of Livestock and Poultry Breeding, Guangzhou 510640, China"},{"name":"Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China"},{"name":"Guangdong Provincial Key Laboratory of Animal Breeding and Nutrition, Guangzhou 510640, China"},{"name":"Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhi","family":"Nie","sequence":"additional","affiliation":[{"name":"Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"},{"name":"State Key Laboratory of Livestock and Poultry Breeding, Guangzhou 510640, China"},{"name":"Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China"},{"name":"Guangdong Provincial Key Laboratory of Animal Breeding and Nutrition, Guangzhou 510640, China"},{"name":"Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"},{"name":"State Key Laboratory of Livestock and Poultry Breeding, Guangzhou 510640, China"},{"name":"Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China"},{"name":"Guangdong Provincial Key Laboratory of Animal Breeding and Nutrition, Guangzhou 510640, China"},{"name":"Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"},{"name":"State Key Laboratory of Livestock and Poultry Breeding, Guangzhou 510640, China"},{"name":"Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China"},{"name":"Guangdong Provincial Key Laboratory of Animal Breeding and Nutrition, Guangzhou 510640, China"},{"name":"Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering, Foshan University, Foshan 528225, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefen","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"},{"name":"State Key Laboratory of Livestock and Poultry 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