{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:08:23Z","timestamp":1784333303172,"version":"3.55.0"},"reference-count":107,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T00:00:00Z","timestamp":1662768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["R01HD105301"],"award-info":[{"award-number":["R01HD105301"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["IOS2012106"],"award-info":[{"award-number":["IOS2012106"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"American College of Surgeons Clowe\u2019s Memorial Research Fund","award":["R01HD105301"],"award-info":[{"award-number":["R01HD105301"]}]},{"name":"American College of Surgeons Clowe\u2019s Memorial Research Fund","award":["IOS2012106"],"award-info":[{"award-number":["IOS2012106"]}]},{"name":"Gerber Foundation","award":["R01HD105301"],"award-info":[{"award-number":["R01HD105301"]}]},{"name":"Gerber Foundation","award":["IOS2012106"],"award-info":[{"award-number":["IOS2012106"]}]},{"name":"Riley Children\u2019s Foundation","award":["R01HD105301"],"award-info":[{"award-number":["R01HD105301"]}]},{"name":"Riley Children\u2019s Foundation","award":["IOS2012106"],"award-info":[{"award-number":["IOS2012106"]}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["R01HD105301"],"award-info":[{"award-number":["R01HD105301"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["IOS2012106"],"award-info":[{"award-number":["IOS2012106"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Indiana University Department of Surgery","award":["R01HD105301"],"award-info":[{"award-number":["R01HD105301"]}]},{"name":"Indiana University Department of Surgery","award":["IOS2012106"],"award-info":[{"award-number":["IOS2012106"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Hydrogen sulfide has been recently identified as the third biological gasotransmitter, along with the more well studied nitric oxide (NO) and carbon monoxide (CO). Intensive studies on its potential as a therapeutic agent for cardiovascular, inflammatory, infectious and neuropathological diseases have been undertaken. Here we review the possible direct targets of H2S in mammals. H2S directly interacts with reactive oxygen\/nitrogen species and is involved in redox signaling. H2S also reacts with hemeproteins and modulates metal-containing complexes. Once being oxidized, H2S can persulfidate proteins by adding -SSH to the amino acid cysteine. These direct modifications by H2S have significant impact on cell structure and many cellular functions, such as tight junctions, autophagy, apoptosis, vesicle trafficking, cell signaling, epigenetics and inflammasomes. Therefore, we conclude that H2S is involved in many important cellular and physiological processes. Compounds that donate H2S to biological systems can be developed as therapeutics for different diseases.<\/jats:p>","DOI":"10.3390\/antiox11091788","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T20:52:25Z","timestamp":1663015945000},"page":"1788","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Recent Development of the Molecular and Cellular Mechanisms of Hydrogen Sulfide Gasotransmitter"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6731-0375","authenticated-orcid":false,"given":"Jianyun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fikir M.","family":"Mesfin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea E.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0178-2203","authenticated-orcid":false,"given":"Kenneth R.","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Physiology, Indiana University School of Medicine\u2014South Bend, South Bend, IN 46617, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Christopher","family":"Shelley","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Brokaw","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3576-8584","authenticated-orcid":false,"given":"Krishna","family":"Manohar","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy A.","family":"Markel","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: A whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. 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