{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:59:46Z","timestamp":1788850786399,"version":"build-2803163510"},"reference-count":65,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Science and Technology of Zhejiang Province","award":["the Key R&D Program of Zhejiang Province (No. 2022C02015)"],"award-info":[{"award-number":["the Key R&D Program of Zhejiang Province (No. 2022C02015)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Studies have shown that Periplaneta americana extract (PAE) has good therapeutic effects in inflammatory disorders such as ulcerative colitis, alcoholic hepatitis, and gastric ulcers. However, whether or not PAE has good pre-protective effects has not been widely and deeply studied. In this study, we investigated the effects of PAE pretreatment for 7 days on oxidative stress and inflammation triggered by oxidative stress by using diquat-induced C57BL\/6 mice as an oxidative stress model. The results showed that PAE pretreatment could significantly reduce oxidative stress in the intestine and liver by reducing the production of MDA, and improved antioxidant systems (SOD, CAT, GSH, and T-AOC). By primarily activating the anti-inflammatory cytokine (IL-10) mediated JAK1\/STAT3 signaling pathway, PAE also effectively reduced oxidative stress-induced liver inflammation while also reducing liver damage, as evidenced by the reductions in serum AST and ALT. PAE pretreatment also had a significant effect on maintaining the intestinal barrier function, which was manifested by inhibiting a decrease in the expression of tight junction proteins (ZO-1 and occludin), and reducing the increased intestinal permeability (serum DAO and D-Lac) caused by diquat. The 16S rRNA sequencing analysis revealed that diquat decreased the gut microbiota diversity index and increased the abundance of pathogenic bacteria (e.g., Allobaculum, Providencia and Escherichia-Shigella), while PAE pretreatment responded to diquat-induced damage by greatly increasing the abundance of Akkermansia muciniphila. These findings elucidate potential pre-protective mechanisms of PAE in alleviating oxidative stress and inflammation, while providing a direction for the treatment of metabolic diseases by utilizing PAE to enhance the abundance of gut A. muciniphila.<\/jats:p>","DOI":"10.3390\/antiox11091806","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T21:06:52Z","timestamp":1663103212000},"page":"1806","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Periplaneta americana Extract Pretreatment Alleviates Oxidative Stress and Inflammation and Increases the Abundance of Gut Akkermansia muciniphila in Diquat-Induced Mice"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5521-3009","authenticated-orcid":false,"given":"Shiyi","family":"Lu","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Nutrition & Feed, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition & Feed, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition & Feed, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Deng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition & Feed, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition & Feed, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.33549\/physiolres.931844","article-title":"Some current insights into oxidative stress","volume":"59","author":"Durackova","year":"2010","journal-title":"Physiol. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"31S","DOI":"10.1016\/0002-9343(91)90281-2","article-title":"Oxidative stress: From basic research to clinical application","volume":"91","author":"Sies","year":"1991","journal-title":"Am. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.freeradbiomed.2007.11.014","article-title":"Reactive oxygen species and oocyte aging: Role of superoxide, hydrogen peroxide, and hypochlorous acid","volume":"44","author":"Goud","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1089\/ars.2013.5258","article-title":"The cooperative roles of inflammation and oxidative stress in the pathogenesis of hypertension","volume":"20","author":"Crowley","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"7092151","DOI":"10.1155\/2019\/7092151","article-title":"Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease","volume":"2019","author":"Steven","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.2174\/13816128113196660748","article-title":"eNOS uncoupling in cardiovascular diseases\u2014the role of oxidative stress and inflammation","volume":"20","author":"Karbach","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s13105-012-0154-2","article-title":"Oxidative stress and inflammation interactions in human obesity","volume":"68","author":"Ryan","year":"2012","journal-title":"J. Physiol. Biochem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1096\/fj.11-181149","article-title":"MicroRNAs regulating oxidative stress and inflammation in relation to obesity and atherosclerosis","volume":"25","author":"Hulsmans","year":"2011","journal-title":"FASEB J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000447252","article-title":"Increased Intestinal Permeability and Decreased Barrier Function: Does It Really Influence the Risk of Inflammation?","volume":"1","author":"Fukui","year":"2016","journal-title":"Inflamm. Intest. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Bischoff, S.C., Barbara, G., Buurman, W., Ockhuizen, T., Schulzke, J.-D., Serino, M., Tilg, H., Watson, A., and Wells, J.M. (2014). Intestinal permeability\u2014A new target for disease prevention and therapy. BMC Gastroenterol., 14.","DOI":"10.1186\/s12876-014-0189-7"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Rose, E.C., Odle, J., Blikslager, A.T., and Ziegler, A.L. (2021). Probiotics, Prebiotics and Epithelial Tight Junctions: A Promising Approach to Modulate Intestinal Barrier Function. Int. J. Mol., 22.","DOI":"10.3390\/ijms22136729"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1136\/gutjnl-2015-309990","article-title":"The gut microbiota and host health: A new clinical frontier","volume":"65","author":"Marchesi","year":"2016","journal-title":"Gut"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev-immunol-051116-052415","article-title":"Immune Responses in the Liver","volume":"36","author":"Kubes","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.2147\/TCRM.S115902","article-title":"Intestinal permeability in a patient with liver cirrhosis","volume":"12","author":"Valadez","year":"2016","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S0168-8278(94)80241-6","article-title":"Translocation of gut bacteria in rats with cirrhosis to mesenteric lymph nodes partially explains the pathogenesis of spontaneous bacterial peritonitis","volume":"21","author":"Runyon","year":"1994","journal-title":"J. Hepatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"237ra66","DOI":"10.1126\/scitranslmed.3008618","article-title":"The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiota","volume":"6","author":"Balmer","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1136\/gutjnl-2021-326789","article-title":"Gut microbiome and health: Mechanistic insights","volume":"71","author":"Tilg","year":"2022","journal-title":"Gut"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1136\/gutjnl-2016-312729","article-title":"Gut microbiome and liver diseases","volume":"65","author":"Tilg","year":"2016","journal-title":"Gut"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1093\/jme\/tjz081","article-title":"The Role of Periplaneta americana (Blattodea: Blattidae) in Modern Versus Traditional Chinese Medicine","volume":"56","author":"Zeng","year":"2019","journal-title":"J. Med. Entomol."},{"key":"ref_21","first-page":"1507","article-title":"Research status of Periplaneta americana with analyses and prospects of key issues","volume":"43","author":"Qijuan","year":"2018","journal-title":"China J. Tradit. Chin. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/psc.3046","article-title":"The American cockroach peptide periplanetasin-4 inhibits Clostridium difficile toxin A-induced cell toxicities and inflammatory responses in the mouse gut","volume":"23","author":"Yoon","year":"2017","journal-title":"J. Pept. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"109753","DOI":"10.1016\/j.biopha.2019.109753","article-title":"Antipyretic, anti-inflammatory and analgesic activities of Periplaneta americana extract and underlying mechanisms","volume":"123","author":"Nguyen","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"798421","DOI":"10.3389\/fphar.2021.798421","article-title":"Gastroprotective Effects of Periplaneta americana L. Extract Against Ethanol-Induced Gastric Ulcer in Mice by Suppressing Apoptosis-Related Pathways","volume":"12","author":"Fu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.3109\/13880209.2016.1170862","article-title":"Protective effect of Periplaneta americana extract in ulcerative colitis rats induced by dinitrochlorobenzene and acetic acid","volume":"54","author":"Li","year":"2016","journal-title":"Pharm. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e202001002","DOI":"10.1590\/s0102-865020200100000002","article-title":"Periplaneta americana extract promotes intestinal mucosa repair of ulcerative colitis in rat","volume":"35","author":"Xue","year":"2020","journal-title":"Acta Cir. Bras."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1081\/CLT-100100926","article-title":"Mechanisms of toxicity, clinical features, and management of diquat poisoning: A review","volume":"38","author":"Jones","year":"2000","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.pharmthera.2017.10.013","article-title":"Hormesis as a mechanistic approach to understanding herbal treatments in traditional Chinese medicine","volume":"184","author":"Wang","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.phrs.2015.12.021","article-title":"Preconditioning is hormesis part I: Documentation, dose-response features and mechanistic foundations","volume":"110","author":"Calabrese","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1089\/ars.2011.3892","article-title":"Epithelial barriers in intestinal inflammation","volume":"15","author":"John","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"119846","DOI":"10.1016\/j.ijpharm.2020.119846","article-title":"Temperature-sensitive hydrogel for rectal perfusion improved the therapeutic effect of Kangfuxin liquid on DSS-induced ulcerative colitis mice: The inflammation alleviation and the colonic mucosal barriers repair","volume":"589","author":"Xue","year":"2020","journal-title":"Int. J. Pharm."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s10787-022-00955-7","article-title":"Periplaneta americana extract ameliorates dextran sulfate sodium-induced ulcerative colitis via immunoregulatory and PI3K\/AKT\/NF-kappaB signaling pathways","volume":"30","author":"Ni","year":"2022","journal-title":"Inflammopharmacology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"944","DOI":"10.3389\/fphar.2018.00944","article-title":"Periplaneta americanaAmeliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Rats by Keap1\/Nrf-2 Activation, Intestinal Barrier Function, and Gut Microbiota Regulation","volume":"9","author":"Ma","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF01535953","article-title":"Clinical use of serum enzymes in liver disease","volume":"33","author":"Reichling","year":"1988","journal-title":"Dig. Dis. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-kappaB pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3892\/ijmm.2017.3040","article-title":"JAK\/STAT3 and Smad3 activities are required for the wound healing properties of Periplaneta americana extracts","volume":"40","author":"Song","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3390\/microorganisms3040759","article-title":"Gut Microbiota and Host Reaction in Liver Diseases","volume":"3","author":"Fukui","year":"2015","journal-title":"Microorganisms"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"6451","DOI":"10.1128\/AEM.00692-09","article-title":"Response of gut microbiota to fasting and hibernation in Syrian hamsters","volume":"75","author":"Sonoyama","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.1007\/s00253-021-11362-3","article-title":"The interaction of Akkermansia muciniphila with host-derived substances, bacteria and diets","volume":"105","author":"Hagi","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/1751-7915.13410","article-title":"Akkermansia muciniphila is a promising probiotic","volume":"12","author":"Zhang","year":"2019","journal-title":"Microb. Biotechnol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nrgastro.2017.54","article-title":"Gut microbiota-at the intersection of everything?","volume":"14","author":"Cani","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4161\/gmic.1.4.12778","article-title":"Mucin-bacterial interactions in the human oral cavity and digestive tract","volume":"1","author":"Derrien","year":"2010","journal-title":"Gut Microbes"},{"key":"ref_43","first-page":"25","article-title":"Safety of probiotic bacteria","volume":"5","author":"Donohue","year":"1996","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3920\/BM2016.0009","article-title":"Akkermansia muciniphila: A novel functional microbe with probiotic properties","volume":"7","author":"Pohl","year":"2016","journal-title":"Benef. Microbes"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1128\/AEM.01226-07","article-title":"The Mucin degrader Akkermansia muciniphila is an abundant resident of the human intestinal tract","volume":"74","author":"Derrien","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijantimicag.2012.10.012","article-title":"High-level colonisation of the human gut by Verrucomicrobia following broad-spectrum antibiotic treatment","volume":"41","author":"Dubourg","year":"2013","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"698914","DOI":"10.3389\/fcimb.2021.698914","article-title":"Akkermansia muciniphila Exerts Strain-Specific Effects on DSS-Induced Ulcerative Colitis in Mice","volume":"11","author":"Liu","year":"2021","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.3389\/fmicb.2019.02259","article-title":"Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice","volume":"10","author":"Bian","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1161\/CIRCULATIONAHA.115.019645","article-title":"Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe-\/- Mice","volume":"133","author":"Li","year":"2016","journal-title":"Circulation"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1136\/gutjnl-2016-313432","article-title":"Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease","volume":"67","author":"Grander","year":"2018","journal-title":"Gut"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1136\/gutjnl-2019-320105","article-title":"A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8(+) T cells in mice","volume":"69","author":"Wang","year":"2020","journal-title":"Gut"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1128\/AEM.04050-14","article-title":"Akkermansia muciniphila Adheres to Enterocytes and Strengthens the Integrity of the Epithelial Cell Layer","volume":"81","author":"Reunanen","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e450","DOI":"10.1038\/emm.2017.282","article-title":"Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e1900732","DOI":"10.1002\/mnfr.201900732","article-title":"Akkermansia muciniphila Exerts Lipid-Lowering and Immunomodulatory Effects without Affecting Neointima Formation in Hyperlipidemic APOE*3-Leiden.CETP Mice","volume":"64","author":"Katiraei","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"586476","DOI":"10.3389\/fmicb.2020.586476","article-title":"Akkermansia muciniphila Improves Host Defense Against Influenza Virus Infection","volume":"11","author":"Hu","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"10184","DOI":"10.1039\/D1FO02172A","article-title":"Akkermansia muciniphila and its outer protein Amuc_1100 regulates tryptophan metabolism in colitis","volume":"12","author":"Gu","year":"2021","journal-title":"Food Funct."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/jcpe.13214","article-title":"Akkermansia muciniphila reduces Porphyromonas gingivalis-induced inflammation and periodontal bone destruction","volume":"47","author":"Huck","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Yang, W., Yanping, W., Yuanyuan, W., Han, X., Xiaoqiang, M., Dongyou, Y., Yibing, W., and Weifen, L. (2017). Antioxidant Properties of Probiotic Bacteria. Nutrients, 9.","DOI":"10.3390\/nu9050521"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Endo, H., Niioka, M., Kobayashi, N., Tanaka, M., and Watanabe, T. (2013). Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: New insight into the probiotics for the gut-liver axis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0063388"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000444066","article-title":"Physiological Role of Gut Microbiota for Maintaining Human Health","volume":"93","author":"Andoh","year":"2016","journal-title":"Digestion"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1055\/s-2004-828657","article-title":"Artificial nutrition: Principles and practice of enteral feeding","volume":"17","author":"Lloyd","year":"2004","journal-title":"Clin. Colon Rectal Surg."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1016\/j.bbmt.2018.07.030","article-title":"Antibiotic Exposure and Reduced Short Chain Fatty Acid Production after Hematopoietic Stem Cell Transplant","volume":"24","author":"Haslam","year":"2018","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12934-017-0691-z","article-title":"Beneficial effects on host energy metabolism of short-chain fatty acids and vitamins produced by commensal and probiotic bacteria","volume":"16","author":"LeBlanc","year":"2017","journal-title":"Microb. Cell Fact."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s40168-021-01115-9","article-title":"Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis","volume":"9","author":"Wu","year":"2021","journal-title":"Microbiome"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s42000-019-00093-w","article-title":"Metformin and gut microbiota: Their interactions and their impact on diabetes","volume":"18","author":"Vallianou","year":"2019","journal-title":"Hormones"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/11\/9\/1806\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:30:50Z","timestamp":1760142650000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/11\/9\/1806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,13]]},"references-count":65,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["antiox11091806"],"URL":"https:\/\/doi.org\/10.3390\/antiox11091806","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,13]]}}}