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11-01-17-008"]}],"id":[{"id":"10.13039\/100013360","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a progressive neurodegenerative disorder with unmet medical need. This investigation consisted of testing a range of ethanolic ethnomedicinal plant extracts (n = 18) traditionally used in the treatment of disorders such as anxiety, delirium, and memory loss. They were then screened for in vitro inhibitory activity against acetylcholinesterase (AChE), butylcholinesterase (BuChE), beta-secretase 1\/beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1), and antioxidant activities. Plants with potent activities were further characterised using a recently developed in vivo model of AD, Globodera pallida. The ability of phytoextracts to protect this organism against amyloid-beta A\u03b2 (1-42) exposure was assessed by measuring chemosensing, survival rate, production of reactive oxygen species (ROS), and antioxidant responses. Extracts (n = 5) from Juglans regia (leaves), Ellettaria cardamomum (seeds), Cinnamomum zeylanicum (bark), Salvia officinalis (leaves\/flowers), and Hypericum perforatum (flowers) exerted concentration-dependent inhibitory activities against AChE and BuChE. Three of these plant extracts (i.e., J. regia, E. cardamomum, and S. officinalis) possessed strong concentration-dependent inhibitory activity against BACE1. Furthermore, the five selected medicinal plant extracts not only enhanced significantly (p &lt; 0.05) the nematode\u2019s chemosensing, survival rate, and antioxidant responses (i.e., anti-ROS production, mitochondrial reductase activity, oxidized glutathione (GSSG) to reduced glutathione (GSH) ratio), but also greatly restored (p &lt; 0.05) in a concentration-dependent manner the A\u03b2 (1-42)-induced deleterious changes in these same parameters. In brief, this investigation highlights plant extracts with strong anti-AD activities which could be trialled as novel therapeutic supplements or undergo further biodiscovery research.<\/jats:p>","DOI":"10.3390\/antiox11101865","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T21:22:23Z","timestamp":1663795343000},"page":"1865","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ethnomedicinal Plants with Protective Effects against Beta-Amyloid Peptide (A\u03b2)1-42 Indicate Therapeutic Potential in a New In Vivo Model of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6893-5521","authenticated-orcid":false,"given":"Norah A.","family":"Althobaiti","sequence":"first","affiliation":[{"name":"Institute for Global Food Security, School of Biological Sciences, Queen\u2019s University Belfast, Biological Sciences Building, Chlorine Gardens, Belfast BT9 5DL, UK"},{"name":"Biology Department, College of Science and Humanities-Al Quwaiiyah, Shaqra University, Al Quwaiiyah 19257, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0258-7322","authenticated-orcid":false,"given":"Farid","family":"Menaa","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and Advanced Technologies, Fluorotronics-California Innovations Corporation, La Jolla, San Diego, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnathan J.","family":"Dalzell","sequence":"additional","affiliation":[{"name":"Department of Grassland and Plant Science, AgriFood and Biosciences Institute, Belfast BT9 5PX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7695-8691","authenticated-orcid":false,"given":"Aishah E.","family":"Albalawi","sequence":"additional","affiliation":[{"name":"Biology Department, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8008-4595","authenticated-orcid":false,"given":"Hammad","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, University of Gujrat, Gujrat 50700, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mousa A.","family":"Alghuthaymi","sequence":"additional","affiliation":[{"name":"Biology Department, College of Science and Humanities-Al Quwaiiyah, Shaqra University, Al Quwaiiyah 19257, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0749-9110","authenticated-orcid":false,"given":"Reem D.","family":"Aldawsari","sequence":"additional","affiliation":[{"name":"Biology Department, College of Science and Humanities-Al Quwaiiyah, Shaqra University, Al Quwaiiyah 19257, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haroon","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Institute for Global Food Security, School of Biological Sciences, Queen\u2019s University Belfast, Biological Sciences Building, Chlorine Gardens, Belfast BT9 5DL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"McAlinney","sequence":"additional","affiliation":[{"name":"Institute for Global Food Security, School of Biological Sciences, Queen\u2019s University Belfast, Biological Sciences Building, Chlorine Gardens, Belfast BT9 5DL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3331-0032","authenticated-orcid":false,"given":"Brian D.","family":"Green","sequence":"additional","affiliation":[{"name":"Institute for Global Food Security, School of Biological Sciences, Queen\u2019s University Belfast, Biological Sciences Building, Chlorine Gardens, Belfast BT9 5DL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.biotechadv.2016.12.005","article-title":"Natural products against Alzheimer\u2019s disease: Pharmaco-therapeutics and biotechnological interventions","volume":"35","author":"Dey","year":"2017","journal-title":"Biotechnol. 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