{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:35:30Z","timestamp":1791495330771,"version":"4.3.4"},"reference-count":54,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Pro-Rectory of the Federal University of Par\u00e1 (PROPESP, UFPA, Brazil)","award":["10\/2021.2-PROPESP"],"award-info":[{"award-number":["10\/2021.2-PROPESP"]}]},{"name":"Research Pro-Rectory of the Federal University of Par\u00e1 (PROPESP, UFPA, Brazil)","award":["02\/2022-PROPESP"],"award-info":[{"award-number":["02\/2022-PROPESP"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The present study aimed to investigate the antioxidant activity of Aniba canelilla (kunth) Mez (Lauraceae) essential oil (AcEO), exploring its potential for prevention and\/or treatment of oxidative stress and associated inflammatory process. With this aim, Wistar rats (n = 6\/group) were pre-treated intraperitoneally with saline (0.9%) or AcEO (2 or 5 mg\/kg) for 5 days. One hour after the last dose, inflammation and oxidative stress were induced by carrageenan (0.3 mg\/kg; ip.) administration. Total antioxidant capacity, reduced glutathione (GSH) and lipid peroxidation levels, protein concentration, and leukocyte migration were evaluated in peritoneal fluid. Lipid peroxidation was also evaluated in plasma. Carrageenan strongly reduced the peritoneal antioxidant capacity and GSH concentration, increasing peritoneal and plasma lipid peroxidation. It also promoted increased plasma leakage and leukocyte migration. Treatment with AcEO (2 and 5 mg\/kg), whose major constituent was 1-nitro-2-phenylethane (77.5%), increased the peritoneal antioxidant capacity and GSH concentrations, and reduced lipid peroxidation, both peritoneal and plasma, thus inhibiting the carrageenan-induced oxidative imbalance. AcEO also reduced the carrageenan-induced plasma leakage and leukocyte migration. These data demonstrate the AcEO antioxidant activity and its ability to modulate plasma leakage and leukocyte migration, confirming its potential for treating diseases associated with inflammation and oxidative stress.<\/jats:p>","DOI":"10.3390\/antiox11101903","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T05:20:58Z","timestamp":1664169658000},"page":"1903","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Aniba canelilla (Kunth) Mez (Lauraceae) Essential Oil: Effects on Oxidative Stress and Vascular Permeability"],"prefix":"10.3390","volume":"11","author":[{"given":"Eloise K. Serr\u00e3o","family":"Cardoso","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Behavior, Faculty of Pharmacy, Institute of Health Science, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Kubota","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Behavior, Faculty of Pharmacy, Institute of Health Science, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diandra Ara\u00fajo","family":"Luz","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Behavior, Faculty of Pharmacy, Institute of Health Science, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5495-0835","authenticated-orcid":false,"given":"Paulo Fernando S.","family":"Mendes","sequence":"additional","affiliation":[{"name":"Laboratory of Structural and Functional Biology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1365-3513","authenticated-orcid":false,"given":"Pablo Luis B.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Natural Products Chemistry Laboratory, State University of Par\u00e1, Bel\u00e9m 66050-540, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1486-4013","authenticated-orcid":false,"given":"Rafael Rodrigues","family":"Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Structural and Functional Biology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4493-7375","authenticated-orcid":false,"given":"Cristiane S. Ferraz","family":"Maia","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Behavior, Faculty of Pharmacy, Institute of Health Science, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6186-9581","authenticated-orcid":false,"given":"En\u00e9as Andrade","family":"Fontes-J\u00fanior","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Behavior, Faculty of Pharmacy, Institute of Health Science, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"C849","DOI":"10.1152\/ajpcell.00283.2008","article-title":"Radical-free biology of oxidative stress","volume":"295","author":"Jones","year":"2008","journal-title":"Am. 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