{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:44:18Z","timestamp":1768322658541,"version":"3.49.0"},"reference-count":71,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15\/02218 and PI18\/01803"],"award-info":[{"award-number":["PI15\/02218 and PI18\/01803"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundaci\u00f3n Eugenio Rodr\u00edguez Pascual","award":["PI15\/02218 and PI18\/01803"],"award-info":[{"award-number":["PI15\/02218 and PI18\/01803"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Recent studies have related mitochondrial impairment with peritoneal membrane damage during peritoneal dialysis (PD) therapy. Here, we assessed the involvement of mitochondrial dysfunction in the inflammatory response in human mesothelial cells, a hallmark in the pathogenesis of PD-related peritoneal membrane damage. Our ex vivo studies showed that IL-1\u03b2 causes a drop in the mitochondrial membrane potential in cells from peritoneal effluent. Moreover, when mitochondrial damage was induced by inhibitors of mitochondrial function, a low-grade inflammatory response was generated. Interestingly, mitochondrial damage sensitized mesothelial cells, causing a significant increase in the inflammatory response induced by cytokines, in which ROS generation and NF-\u03baB activation appear to be involved, since inflammation was counteracted by both mitoTEMPO (mitochondrial ROS scavenger) and BAY-117085 (NF-\u03baB inhibitor). Furthermore, the natural anti-inflammatory antioxidant resveratrol significantly attenuated the inflammatory response, by reversing the decline in mitochondrial membrane potential and decreasing the expression of IL-8, COX-2 and PGE2 caused by IL-1\u03b2. These findings suggest that IL-1\u03b2 regulates mitochondrial function in mesothelial cells and that mitochondrial dysfunction could induce an inflammatory scenario that sensitizes these cells, causing significant amplification of the inflammatory response induced by cytokines. Resveratrol may represent a promising strategy in controlling the mesothelial inflammatory response to PD.<\/jats:p>","DOI":"10.3390\/antiox11112184","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T02:43:51Z","timestamp":1667789031000},"page":"2184","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Involvement of Mitochondrial Dysfunction in the Inflammatory Response in Human Mesothelial Cells from Peritoneal Dialysis Effluent"],"prefix":"10.3390","volume":"11","author":[{"given":"Olalla","family":"Ramil-G\u00f3mez","sequence":"first","affiliation":[{"name":"Aging and Inflammation Research Laboratory, Institute for Biomedical Research of A Coru\u00f1a (INIBIC), 15006 A Coru\u00f1a, Spain"},{"name":"Endocrine, Nutritional and Metabolic Diseases Group, Faculty of Health Sciences, A Coru\u00f1a, INIBIC, 15006 A Coru\u00f1a, Spain"},{"name":"Nephrology & Infectious Diseases Group, Institute of Research and Innovation in Health (i3s), 4200-135 Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirian","family":"L\u00f3pez-Pardo","sequence":"additional","affiliation":[{"name":"Aging and Inflammation Research Laboratory, Institute for Biomedical Research of A Coru\u00f1a (INIBIC), 15006 A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer Adriana","family":"Fern\u00e1ndez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Aging and Inflammation Research Laboratory, Institute for Biomedical Research of A Coru\u00f1a (INIBIC), 15006 A Coru\u00f1a, Spain"},{"name":"Congenital and Structural Heart Disease, INIBIC, 15006 A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Rodr\u00edguez-Carmona","sequence":"additional","affiliation":[{"name":"Aging and Inflammation Research Laboratory, Institute for Biomedical Research of A Coru\u00f1a (INIBIC), 15006 A Coru\u00f1a, Spain"},{"name":"Division of Nephrology, University Hospital A Coru\u00f1a (CHUAC), 15006 A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"P\u00e9rez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University Hospital A Coru\u00f1a (CHUAC), 15006 A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8658-5502","authenticated-orcid":false,"given":"Carlos","family":"Vaamonde-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Rheumatology Research Group, INIBIC, CHUAC, 15006 A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"P\u00e9rez-Font\u00e1n","sequence":"additional","affiliation":[{"name":"Endocrine, Nutritional and Metabolic Diseases Group, Faculty of Health Sciences, A Coru\u00f1a, INIBIC, 15006 A Coru\u00f1a, Spain"},{"name":"Division of Nephrology, University Hospital A Coru\u00f1a (CHUAC), 15006 A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5325-6251","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"L\u00f3pez-Armada","sequence":"additional","affiliation":[{"name":"Aging and Inflammation Research Laboratory, Institute for Biomedical Research of A Coru\u00f1a (INIBIC), 15006 A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrneph.2016.181","article-title":"Changes in the worldwide epidemiology of peritoneal dialysis","volume":"13","author":"Li","year":"2016","journal-title":"Nat. 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