{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:31:46Z","timestamp":1781109106468,"version":"3.54.1"},"reference-count":42,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council","award":["109-2320-B-182-025-MY3, 109-2320-B-182-029-MY3, and 109-2622-B-182-002"],"award-info":[{"award-number":["109-2320-B-182-025-MY3, 109-2320-B-182-029-MY3, and 109-2622-B-182-002"]}]},{"name":"National Science and Technology Council","award":["CMRPD1K0361, CMRPD1L0321, and CMRPD1M0491-2"],"award-info":[{"award-number":["CMRPD1K0361, CMRPD1L0321, and CMRPD1M0491-2"]}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["109-2320-B-182-025-MY3, 109-2320-B-182-029-MY3, and 109-2622-B-182-002"],"award-info":[{"award-number":["109-2320-B-182-025-MY3, 109-2320-B-182-029-MY3, and 109-2622-B-182-002"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPD1K0361, CMRPD1L0321, and CMRPD1M0491-2"],"award-info":[{"award-number":["CMRPD1K0361, CMRPD1L0321, and CMRPD1M0491-2"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Gastric ulcers are commonly seen in the upper gastrointestinal tract and may be related to the Helicobacter pylori infection and the use of aspirin, a nonsteroidal anti-inflammatory drug (NSAID). Typically, proton-pump inhibitors (PPIs) are used to treat gastric ulcers; however, adverse effects have emerged following long-term treatment. Natural medicines are used as alternative therapeutic agents in the treatment of gastric ulcers, with few side effects. Despite various reports on the anti-H. pylori and anti-gastric cancer activities of Anisomeles indica, its gastroprotective effect on ulcers remains undetermined. This study investigated the protective effect of A. indica on aspirin-induced gastric ulcers in murine models. Our results show that three fractions of ethanol-extracted A. indica inhibited aspirin-induced gastric injury. Among these, A. indica Fraction 1 was observed to enrich ovatodiolide, which effectively diminished gastric acidity and alleviated aspirin-induced inflammation in the stomach. Our results provide evidence that A. indica could be developed as an effective therapeutic agent for gastroprotective purposes.<\/jats:p>","DOI":"10.3390\/antiox11122327","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T02:29:23Z","timestamp":1669343363000},"page":"2327","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Gastroprotective Effect of Anisomeles indica on Aspirin-Induced Gastric Ulcer in Mice"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5466-7674","authenticated-orcid":false,"given":"Hsiu-Man","family":"Lien","sequence":"first","affiliation":[{"name":"Research Institute of Biotechnology, Hungkuang University, Taichung 433304, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Yen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Zi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Lu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, National Chung Hsing University, Taichung 40227, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"Animal Technology Research Center, Agricultural Technology Research Institute, Hsinchu 300110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9923-4656","authenticated-orcid":false,"given":"Shao-Wen","family":"Hung","sequence":"additional","affiliation":[{"name":"Animal Technology Research Center, Agricultural Technology Research Institute, Hsinchu 300110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Chang","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Management, Feng Chia University, Taichung 407102, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Hsun","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan"},{"name":"Molecular Infectious Disease Research Center, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou 33305, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7145-784X","authenticated-orcid":false,"given":"Chih-Ho","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan"},{"name":"Molecular Infectious Disease Research Center, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou 33305, Taiwan"},{"name":"Department of Nursing, Asia University, Taichung 413305, Taiwan"},{"name":"Department of Medical Research, School of Medicine, China Medical University and Hospital, Taichung 404333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.cgh.2014.11.007","article-title":"Risk of upper and lower gastrointestinal bleeding in patients taking nonsteroidal anti-inflammatory drugs, antiplatelet agents, or anticoagulants","volume":"13","author":"Lanas","year":"2015","journal-title":"Clin. 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