{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T07:33:32Z","timestamp":1782545612147,"version":"3.54.5"},"reference-count":20,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Phytotherapy has been promoted for the treatment of liver diseases in dogs. The interest in identifying the antioxidant\/hepatoprotective potential of various plants is increasing. Every 10 days for 30 days, forty dogs were subjected to blood sampling and hepatic ultrasound assessment. Clinically healthy dogs (group A) and dogs with liver enzyme and ultrasound hepatic aspects and sizes outside the physiological range (group B) were divided into two subgroups. Every day for 30 days, one subgroup received Epacare pet + pasta\u00ae and the other received a placebo. Differences due to groups were observed in dROM, SHp, AST and LDH serum concentrations. The administration of Epacarepet + pasta\u00ae for 30 days had an influence on the serum concentration of dROMs, SHp, AST, ALT, ALP, LDH, and urea. The application of paired Student\u2019s t-test showed a decrease in the longitudinal and transverse liver axis size. In conclusion, feed supplementation with Epacare pet + pasta\u00ae had a beneficial effect on the antioxidant status and liver enzymes in animals with liver enzymatic alterations and in healthy dogs.<\/jats:p>","DOI":"10.3390\/antiox11122339","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T04:01:33Z","timestamp":1669608093000},"page":"2339","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Antioxidant and Hepatoprotective Effect of a Nutritional Supplement with Silymarin Phytosome, Choline Chloride, l-Cystine, Artichoke, and Vitamin E in Dogs"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3049-1181","authenticated-orcid":false,"given":"Claudia","family":"Giannetto","sequence":"first","affiliation":[{"name":"Department of Veterinary Sciences, Polo Universitario dell\u2019Annunziata, University of Messina, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6139-2691","authenticated-orcid":false,"given":"Francesca","family":"Arfuso","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, Polo Universitario dell\u2019Annunziata, University of Messina, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Giudice","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, Polo Universitario dell\u2019Annunziata, University of Messina, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4343-8937","authenticated-orcid":false,"given":"Maria","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, Polo Universitario dell\u2019Annunziata, University of Messina, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4736-1087","authenticated-orcid":false,"given":"Giuseppe","family":"Piccione","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, Polo Universitario dell\u2019Annunziata, University of Messina, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9432-4588","authenticated-orcid":false,"given":"Kamel","family":"Mhalhel","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, Polo Universitario dell\u2019Annunziata, University of Messina, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Levanti","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, Polo Universitario dell\u2019Annunziata, University of Messina, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1177\/0148607108324584","article-title":"Inflammation and liver","volume":"32","author":"Dasarathy","year":"2008","journal-title":"J. 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