{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T14:51:01Z","timestamp":1775487061084,"version":"3.50.1"},"reference-count":130,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Cyclophosphamide (CYP) is used to treat different malignancies and autoimmune disorders in men. This chemotherapy frequently reduces tumors, which is beneficial, but also causes infertility because of severe oxidative stress, inflammation, and apoptosis in the bladder and testes brought on by its metabolite, acrolein. The goal of this study was to assess the efficacy of a novel food, a\u00e7ai berry, in preventing CYP-induced damage in the bladder and testes. Methods: CYP was administered intraperitoneally once during the experiment at a dose of 200 mg\/kg body weight diluted in 10 mL\/kg b.w. of water. A\u00e7ai berry was administered orally at a dose of 500 mg\/kg. Results: The administration of a\u00e7ai berry was able to reduce inflammation, oxidative stress, lipid peroxidation, apoptosis, and histological changes in the bladder and testes after CYP injection. Conclusions: Our findings show for the first time that a\u00e7ai berry modulates physiological antioxidant defenses to protect the bladder and testes against CYP-induced changes.<\/jats:p>","DOI":"10.3390\/antiox11122355","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T08:13:09Z","timestamp":1669623189000},"page":"2355","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A\u00e7ai Berry Attenuates Cyclophosphamide-Induced Damage in Genitourinary Axis-Modulating Nrf-2\/HO-1 Pathways"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7868-2505","authenticated-orcid":false,"given":"Rosalba","family":"Siracusa","sequence":"first","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0389-3871","authenticated-orcid":false,"given":"Ramona","family":"D\u2019Amico","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0223-1403","authenticated-orcid":false,"given":"Roberta","family":"Fusco","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9492-3161","authenticated-orcid":false,"given":"Daniela","family":"Impellizzeri","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8545-990X","authenticated-orcid":false,"given":"Alessio Filippo","family":"Peritore","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6840-3154","authenticated-orcid":false,"given":"Enrico","family":"Gugliandolo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7629-3132","authenticated-orcid":false,"given":"Rosalia","family":"Crupi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia","family":"Interdonato","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3980-0043","authenticated-orcid":false,"given":"Marika","family":"Cordaro","sequence":"additional","affiliation":[{"name":"Department of Biomedical Dental and Morphological and Functional Imaging, University of Messina, Via Consolare Valeria, 98125 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6131-3690","authenticated-orcid":false,"given":"Salvatore","family":"Cuzzocrea","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D\u2019Alcontres 31, 98166 Messina, Italy"},{"name":"Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6725-8581","authenticated-orcid":false,"given":"Rosanna","family":"Di Paola","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nrc3397","article-title":"Future directions in cancer prevention","volume":"12","author":"Umar","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1182\/blood.V68.5.1114.1114","article-title":"Cyclophosphamide Cardiotoxicity\u2014An Analysis of Dosing as a Risk Factor","volume":"68","author":"Goldberg","year":"1986","journal-title":"Blood"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2165\/00003495-199142050-00005","article-title":"Cyclophosphamide Toxicity\u2014Characterizing and Avoiding the Problem","volume":"42","author":"Fraiser","year":"1991","journal-title":"Drugs"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s11033-011-0763-9","article-title":"The cyclophosphamide metabolite, acrolein, induces cytoskeletal changes and oxidative stress in Sertoli cells","volume":"39","author":"Liu","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.7326\/0003-4819-106-1-79","article-title":"NIH conference. Lupus nephritis","volume":"106","author":"Balow","year":"1987","journal-title":"Ann. Intern. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"122","DOI":"10.5152\/eurjrheum.2015.0043","article-title":"Updates in ANCA-associated vasculitis","volume":"3","author":"Pagnoux","year":"2016","journal-title":"Eur. J. Rheumatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.fct.2013.03.046","article-title":"Ellagic acid attenuates bleomycin and cyclophosphamide-induced pulmonary toxicity in Wistar rats","volume":"58","author":"Saba","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1080\/03602530500364023","article-title":"Metabolism and Transport of Oxazaphosphorines and the Clinical Implications","volume":"37","author":"Zhang","year":"2005","journal-title":"Drug Metab. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2165\/00003088-200038040-00001","article-title":"Metabolism and Pharmacokinetics of Oxazaphosphorines","volume":"38","author":"Boddy","year":"2000","journal-title":"Clin. Pharmacokinet."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Stork, C., and Schreffler, S. (2014). Cyclophosphamide. Encyclopedia of Toxicology, Elsevier.","DOI":"10.1016\/B978-0-12-386454-3.00720-X"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"871","DOI":"10.5114\/aoms.2016.59919","article-title":"Sulforaphane protects against acrolein-induced oxidative stress and inflammatory responses: Modulation of Nrf-2 and COX-2 expression","volume":"12","author":"Qin","year":"2016","journal-title":"Arch. Med. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"170309","DOI":"10.1155\/2015\/170309","article-title":"Enhancement of the Acrolein-Induced Production of Reactive Oxygen Species and Lung Injury by GADD","volume":"2015","author":"Sun","year":"2015","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0891-5849(91)90192-6","article-title":"Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes","volume":"11","author":"Esterbauer","year":"1991","journal-title":"Free Radic. Biol. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e13159","DOI":"10.1111\/and.13159","article-title":"Oxidative stress-induced alterations in seminal plasma antioxidants: Is there any association with keap1 gene methylation in human spermatozoa?","volume":"51","author":"Darbandi","year":"2019","journal-title":"Andrologia"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"488","DOI":"10.2164\/jandrol.108.005132","article-title":"Oxidative Stress: A Common Factor in Testicular Dysfunction","volume":"29","author":"Turner","year":"2008","journal-title":"J. Androl."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.mefs.2017.12.005","article-title":"A simple, rapid and economic manual method for human sperm DNA extraction in genetic and epigenetic studies","volume":"23","author":"Darbandi","year":"2018","journal-title":"Middle East Fertil. Soc. J."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Li, Y., and Tollefsbol, T.O. (2011). DNA Methylation Detection: Bisulfite Genomic Sequencing Analysis. Epigenetics Protocols, Springer.","DOI":"10.1007\/978-1-61779-316-5_2"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.freeradbiomed.2015.06.013","article-title":"Epigenetic regulation of Keap1-Nrf2 signaling","volume":"88","author":"Guo","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/0960327113489052","article-title":"Melatonin ameliorates oxidative stress and reproductive toxicity induced by cyclophosphamide in male mice","volume":"33","author":"Chabra","year":"2014","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"12149","DOI":"10.3390\/ijms150712149","article-title":"Nrf2-Mediated HO-1 Induction Coupled with the ERK Signaling Pathway Contributes to Indirect Antioxidant Capacity of Caffeic Acid Phenethyl Ester in HepG2 Cells","volume":"15","author":"Kim","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neulet.2006.06.052","article-title":"Heme oxygenase protects hippocampal neurons from ethanol-induced neurotoxicity","volume":"405","author":"Ku","year":"2006","journal-title":"Neurosci. Lett."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7382","DOI":"10.1074\/jbc.273.13.7382","article-title":"Disruption of the DT Diaphorase (NQO1) Gene in Mice Leads to Increased Menadione Toxicity","volume":"273","author":"Radjendirane","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1124\/jpet.116.237503","article-title":"Oxidative Stress and the Central Nervous System","volume":"360","author":"Salim","year":"2017","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cotox.2016.10.008","article-title":"Regulation of Keap1\u2013Nrf2 signaling: The role of epigenetics","volume":"1","author":"Cheng","year":"2016","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/andr.12074","article-title":"Differential expression of novel biomarkers (TLR-2, TLR-4, COX-2, and Nrf-2) of inflammation and oxidative stress in semen of leukocytospermia patients","volume":"3","author":"Hagan","year":"2015","journal-title":"Andrology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.fertnstert.2012.11.046","article-title":"Two-dimensional differential in-gel electrophoresis\u2013based proteomics of male gametes in relation to oxidative stress","volume":"99","author":"Hamada","year":"2013","journal-title":"Fertil. Steril."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"513196","DOI":"10.1155\/2015\/513196","article-title":"Variations in Antioxidant Genes and Male Infertility","volume":"2015","author":"Yu","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e23221","DOI":"10.1002\/ajp.23221","article-title":"Optional tool use: The case of wild bearded capuchins (Sapajus libidinosus) cracking cashew nuts by biting or by using percussors","volume":"83","author":"Visalberghi","year":"2021","journal-title":"Am. J. Primatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"106514","DOI":"10.1016\/j.dib.2020.106514","article-title":"Dataset on physical properties of raw and roasted cashew nuts","volume":"33","author":"Kilanko","year":"2020","journal-title":"Data Brief"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Cordaro, M., Fusco, R., D\u2019Amico, R., Siracusa, R., Peritore, A., Gugliandolo, E., Genovese, T., Crupi, R., Mandalari, G., and Cuzzocrea, S. (2020). Cashew (Anacardium occidentale L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein. Antioxidants, 9.","DOI":"10.3390\/antiox9100992"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Fusco, R., Cordaro, M., Siracusa, R., Peritore, A.F., Gugliandolo, E., Genovese, T., D\u2019Amico, R., Crupi, R., Smeriglio, A., and Mandalari, G. (2020). Consumption of Anacardium occidentale L. (Cashew Nuts) Inhibits Oxidative Stress through Modulation of the Nrf2\/HO\u22121 and NF-kB Pathways. Molecules, 25.","DOI":"10.3390\/molecules25194426"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Cordaro, M., Siracusa, R., Fusco, R., D\u2019Amico, R., Peritore, A., Gugliandolo, E., Genovese, T., Scuto, M., Crupi, R., and Mandalari, G. (2020). Cashew (Anacardium occidentale L.) Nuts Counteract Oxidative Stress and Inflammation in an Acute Experimental Model of Carrageenan-Induced Paw Edema. Antioxidants, 9.","DOI":"10.3390\/antiox9080660"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Fusco, R., Siracusa, R., Peritore, A.F., Gugliandolo, E., Genovese, T., D\u2019Amico, R., Cordaro, M., Crupi, R., Mandalari, G., and Impellizzeri, D. (2020). The Role of Cashew (Anacardium occidentale L.) Nuts on an Experimental Model of Painful Degenerative Joint Disease. Antioxidants, 9.","DOI":"10.3390\/antiox9060511"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Siracusa, R., Fusco, R., Peritore, A.F., Cordaro, M., D\u2019Amico, R., Genovese, T., Gugliandolo, E., Crupi, R., Smeriglio, A., and Mandalari, G. (2020). The Antioxidant and Anti-Inflammatory Properties of Anacardium occidentale L. Cashew Nuts in a Mouse Model of Colitis. Nutrients, 12.","DOI":"10.3390\/nu12030834"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5758191","DOI":"10.1155\/2018\/5758191","article-title":"Tribulus terrestris Protects against Male Reproductive Damage Induced by Cyclophosphamide in Mice","volume":"2018","author":"Pavin","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.redox.2017.11.007","article-title":"Resveratrol attenuates testicular apoptosis in type 1 diabetic mice: Role of Akt-mediated Nrf2 activation and p62-dependent Keap1 degradation","volume":"14","author":"Zhao","year":"2018","journal-title":"Redox Biol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Ram\u00edrez-Tortose, M.D.C., Pulido-Mor\u00e1n, M., Granados, S., Gaforio, J.J., and Quiles, J.L. (2015). Hydroxytyrosol as a Component of the Mediterranean Diet and Its Role in Disease Prevention. The Mediterranean Diet, Elsevier.","DOI":"10.1016\/B978-0-12-407849-9.00020-8"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1002\/bbb.2222","article-title":"Sustainable development in the Legal Amazon: Energy recovery from a\u00e7a\u00ed seeds","volume":"15","author":"Buller","year":"2021","journal-title":"Biofuels Bioprod. Biorefining"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e05214","DOI":"10.1016\/j.heliyon.2020.e05214","article-title":"Simulated gastrointestinal digestion of Brazilian a\u00e7a\u00ed seeds affects the content of flavan-3-ol derivatives, and their antioxidant and anti-inflammatory activities","volume":"6","author":"Melo","year":"2020","journal-title":"Heliyon"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"113204","DOI":"10.1016\/j.indcrop.2020.113204","article-title":"A\u00e7a\u00ed seeds: An unexplored agro-industrial residue as a potential source of lipids, fibers, and antioxidant phenolic compounds","volume":"161","author":"Melo","year":"2021","journal-title":"Ind. Crops Prod."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1021\/jf058169p","article-title":"Total Oxidant Scavenging Capacity of Euterpe oleracea Mart. (A\u00e7a\u00ed) Seeds and Identification of Their Polyphenolic Compounds","volume":"54","author":"Rodrigues","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.fct.2010.12.007","article-title":"Addition of a\u00e7a\u00ed (Euterpe oleracea) to cigarettes has a protective effect against emphysema in mice","volume":"49","author":"Pires","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"48","DOI":"10.15430\/JCP.2016.21.1.48","article-title":"Anti-inflammatory and Anti-tumorigenic Effects of A\u00e7ai Berry in Helicobacter felis-infected mice","volume":"21","author":"Lee","year":"2016","journal-title":"J. Cancer Prev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.phymed.2011.11.004","article-title":"Effects of Euterpe oleracea Mart. (A\u00c7A\u00cd) extract in acute lung inflammation induced by cigarette smoke in the mouse","volume":"19","author":"Ferreira","year":"2012","journal-title":"Phytomedicine"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1021\/jf203989k","article-title":"Anthocyanin-rich A\u00e7ai (Euterpe oleracea Mart.) Fruit Pulp Fractions Attenuate Inflammatory Stress Signaling in Mouse Brain BV-2 Microglial Cells","volume":"60","author":"Poulose","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.nutres.2020.05.006","article-title":"A\u00e7a\u00ed seed extract prevents the renin-angiotensin system activation, oxidative stress and inflammation in white adipose tissue of high-fat diet\u2013fed mice","volume":"79","author":"Santos","year":"2020","journal-title":"Nutr. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"166","DOI":"10.34172\/jhp.2022.21","article-title":"Neuroprotective activities of acai berries (Euterpe sp.): A review","volume":"11","author":"Alnasser","year":"2022","journal-title":"J. Herbmed Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"D\u2019Amico, R., Fusco, R., Cordaro, M., Siracusa, R., Peritore, A.F., Gugliandolo, E., Crupi, R., Scuto, M., Cuzzocrea, S., and Di Paola, R. (2020). Modulation of NLRP3 Inflammasome through Formyl Peptide Receptor 1 (Fpr-1) Pathway as a New Therapeutic Target in Bronchiolitis Obliterans Syndrome. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21062144"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.nbd.2019.01.007","article-title":"N-Palmitoylethanolamine-oxazoline (PEA-OXA): A new therapeutic strategy to reduce neuroinflammation, oxidative stress associated to vascular dementia in an experimental model of repeated bilateral common carotid arteries occlusion","volume":"125","author":"Impellizzeri","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1007\/s12035-017-0496-4","article-title":"Neuroprotective Effects of Temsirolimus in Animal Models of Parkinson\u2019s Disease","volume":"55","author":"Siracusa","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ejphar.2016.03.033","article-title":"A new co-micronized composite containing palmitoylethanolamide and polydatin shows superior oral efficacy compared to their association in a rat paw model of carrageenan-induced inflammation","volume":"782","author":"Esposito","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bcp.2018.06.029","article-title":"Therapeutic potential of dinitrobenzene sulfonic acid (DNBS)-induced colitis in mice by targeting IL-1\u03b2 and IL-18","volume":"155","author":"Impellizzeri","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Cordaro, M., Cuzzocrea, S., and Crupi, R. (2020). An Update of Palmitoylethanolamide and Luteolin Effects in Preclinical and Clinical Studies of Neuroinflammatory Events. Antioxidants, 9.","DOI":"10.3390\/antiox9030216"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.foodchem.2010.03.020","article-title":"Anti-oxidant capacities of flavonoid compounds isolated from acai pulp (Euterpe oleracea Mart.)","volume":"122","author":"Kang","year":"2010","journal-title":"Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"109721","DOI":"10.1016\/j.cbi.2021.109721","article-title":"A\u00e7a\u00ed seed extract (ASE) rich in proanthocyanidins improves cardiovascular remodeling by increasing antioxidant response in obese high-fat diet-fed mice","volume":"351","author":"Arnoso","year":"2022","journal-title":"Chem. Interact."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"108667","DOI":"10.1016\/j.meatsci.2021.108667","article-title":"A\u00e7a\u00ed extract powder as natural antioxidant on pork patties during the refrigerated storage","volume":"184","author":"Bellucci","year":"2022","journal-title":"Meat Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1007\/s10695-021-01010-y","article-title":"Dietary Euterpe oleracea Mart. attenuates seizures and damage to lipids in the brain of Colossoma macropomum","volume":"47","author":"Torres","year":"2021","journal-title":"Fish Physiol. Biochem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e13848","DOI":"10.1111\/jfbc.13848","article-title":"Acai berry extract as a regulator of intestinal inflammation pathways in a Caco-2 and RAW 264.7 co-culture model","volume":"45","author":"Kim","year":"2021","journal-title":"J. Food Biochem."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Silva, M., Costa, J., Pacheco-Fill, T., Ruiz, A., Vidal, F., Borges, K., Guimar\u00e3es, S., Azevedo-Santos, A., Buglio, K., and Foglio, M. (2021). A\u00e7ai (Euterpe oleracea Mart.) Seed Extract Induces ROS Production and Cell Death in MCF-7 Breast Cancer Cell Line. Molecules, 26.","DOI":"10.3390\/molecules26123546"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Martins, G.R., Guedes, D., de Paula, U.L.M., de Oliveira, M.D.S.P., Lutterbach, M.T.S., Reznik, L.Y., S\u00e9rvulo, E.F.C., Alviano, C.S., da Silva, A.J.R., and Alviano, D.S. (2021). A\u00e7a\u00ed (Euterpe oleracea Mart.) Seed Extracts from Different Varieties: A Source of Proanthocyanidins and Eco-Friendly Corrosion Inhibition Activity. Molecules, 26.","DOI":"10.3390\/molecules26113433"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1139\/apnm-2020-0099","article-title":"Anxiolytic and antioxidant effects of Euterpe oleracea Mart. (a\u00e7a\u00ed) seed extract in adult rat offspring submitted to periodic maternal separation","volume":"45","author":"Okinga","year":"2020","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Remigante, A., Spinelli, S., Straface, E., Gambardella, L., Caruso, D., Falliti, G., Dossena, S., Marino, A., and Morabito, R. (2022). A\u00e7a\u00ec (Euterpe oleracea) Extract Protects Human Erythrocytes from Age-Related Oxidative Stress. Cells, 11.","DOI":"10.3390\/cells11152391"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4103\/ijpvm.IJPVM_184_18","article-title":"Cerium oxide nanoparticles protect cyclophosphamide-induced testicular toxicity in mice","volume":"10","author":"Amiri","year":"2019","journal-title":"Int. J. Prev. Med."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Fusco, R., Salinaro, A., Siracusa, R., D\u2019Amico, R., Impellizzeri, D., Scuto, M., Ontario, M., Crea, R., Cordaro, M., and Cuzzocrea, S. (2021). Hidrox\u00ae Counteracts Cyclophosphamide-Induced Male Infertility through NRF2 Pathways in a Mouse Model. Antioxidants, 10.","DOI":"10.3390\/antiox10050778"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Impellizzeri, D., D\u2019Amico, R., Fusco, R., Genovese, T., Peritore, A.F., Gugliandolo, E., Crupi, R., Interdonato, L., Di Paola, D., and Di Paola, R. (2022). A\u00e7ai Berry Mitigates Vascular Dementia-Induced Neuropathological Alterations Modulating Nrf-2\/Beclin1 Pathways. Cells, 11.","DOI":"10.3390\/cells11162616"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"6519","DOI":"10.1007\/s12035-022-02982-5","article-title":"A\u00e7ai Berry Mitigates Parkinson\u2019s Disease Progression Showing Dopaminergic Neuroprotection via Nrf2-HO1 Pathways","volume":"59","author":"Impellizzeri","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.33594\/000000529","article-title":"A\u00e7a\u00ed (Euterpe oleraceae Mart.) Seeds Regulate NF-\u03baB and Nrf2\/ARE Pathways Protecting Lung against Acute and Chronic Inflammation","volume":"56","author":"Genovese","year":"2022","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e12593","DOI":"10.1111\/and.12593","article-title":"Rutin ameliorates cisplatin-induced reproductive damage via suppression of oxidative stress and apoptosis in adult male rats","volume":"49","author":"Aksu","year":"2017","journal-title":"Andrologia"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1007\/s12035-016-9827-0","article-title":"KU0063794, a Dual mTORC1 and mTORC2 Inhibitor, Reduces Neural Tissue Damage and Locomotor Impairment After Spinal Cord Injury in Mice","volume":"54","author":"Cordaro","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3389\/fneur.2017.00233","article-title":"Anti-Inflammatory and Neuroprotective Effects of Co-UltraPEALut in a Mouse Model of Vascular Dementia","volume":"8","author":"Siracusa","year":"2017","journal-title":"Front. Neurol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Di Paola, D., Iaria, C., Capparucci, F., Cordaro, M., Crupi, R., Siracusa, R., D\u2019Amico, R., Fusco, R., Impellizzeri, D., and Cuzzocrea, S. (2021). Aflatoxin B1 Toxicity in Zebrafish Larva (Danio rerio): Protective Role of Hericium erinaceus. Toxins, 13.","DOI":"10.3390\/toxins13100710"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Di Paola, D., Natale, S., Gugliandolo, E., Cordaro, M., Crupi, R., Siracusa, R., D\u2019Amico, R., Fusco, R., Impellizzeri, D., and Cuzzocrea, S. (2022). Assessment of 2-Pentadecyl-2-oxazoline Role on Lipopolysaccharide-Induced Inflammation on Early Stage Development of Zebrafish (Danio rerio). Life, 12.","DOI":"10.3390\/life12010128"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Di Paola, D., Capparucci, F., Natale, S., Crupi, R., Cuzzocrea, S., Span\u00f2, N., Gugliandolo, E., and Peritore, A.F. (2022). Combined Effects of Potassium Perchlorate and a Neonicotinoid on Zebrafish Larvae (Danio rerio). Toxics, 10.","DOI":"10.3390\/toxics10050203"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Di Paola, D., Capparucci, F., Lanteri, G., Cordaro, M., Crupi, R., Siracusa, R., D\u2019Amico, R., Fusco, R., Impellizzeri, D., and Cuzzocrea, S. (2021). Combined Toxicity of Xenobiotics Bisphenol A and Heavy Metals on Zebrafish Embryos (Danio rerio). Toxics, 9.","DOI":"10.3390\/toxics9120344"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Di Paola, D., Natale, S., Iaria, C., Crupi, R., Cuzzocrea, S., Span\u00f2, N., Gugliandolo, E., and Peritore, A.F. (2022). Environmental Co-Exposure to Potassium Perchlorate and Cd Caused Toxicity and Thyroid Endocrine Disruption in Zebrafish Embryos and Larvae (Danio rerio). Toxics, 10.","DOI":"10.3390\/toxics10040198"},{"key":"ref_76","first-page":"138","article-title":"Protective Effect of Ghrelin on Oxidative Stress and Tissue Damages of Mice Testes Followed by Chemotherapy with Cyclophosphamide","volume":"5","author":"Salimnejad","year":"2018","journal-title":"Crescent J. Med. Biol. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"D\u2019Amico, R., Salinaro, A.T., Cordaro, M., Fusco, R., Impellizzeri, D., Interdonato, L., Scuto, M., Ontario, M., Crea, R., and Siracusa, R. (2021). Hidrox\u00ae and Chronic Cystitis: Biochemical Evaluation of Inflammation, Oxidative Stress, and Pain. Antioxidants, 10.","DOI":"10.3390\/antiox10071046"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Di Paola, D., Abbate, J.M., Iaria, C., Cordaro, M., Crupi, R., Siracusa, R., D\u2019Amico, R., Fusco, R., Impellizzeri, D., and Cuzzocrea, S. (2022). Environmental Risk Assessment of Dexamethasone Sodium Phosphate and Tocilizumab Mixture in Zebrafish Early Life Stage (Danio rerio). Toxics, 10.","DOI":"10.3390\/toxics10060279"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1745-4522.2002.tb00208.x","article-title":"Antioxidant Role of Chitosan in a Cooked Cod (Gadus morhua) Model System","volume":"9","author":"Shahidi","year":"2002","journal-title":"J. Food Lipids"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/0003-9861(72)90080-X","article-title":"Human erythrocyte catalase: An improved method of isolation and a reevaluation of reported properties","volume":"150","author":"Bonaventura","year":"1972","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Di Paola, D., Capparucci, F., Abbate, J.M., Cordaro, M., Crupi, R., Siracusa, R., D\u2019Amico, R., Fusco, R., Genovese, T., and Impellizzeri, D. (2022). Environmental Risk Assessment of Oxaliplatin Exposure on Early Life Stages of Zebrafish (Danio rerio). Toxics, 10.","DOI":"10.3390\/toxics10020081"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Di Paola, D., Capparucci, F., Lanteri, G., Crupi, R., Marino, Y., Franco, G.A., Cuzzocrea, S., Span\u00f2, N., Gugliandolo, E., and Peritore, A.F. (2022). Environmental Toxicity Assessment of Sodium Fluoride and Platinum-Derived Drugs Co-Exposure on Aquatic Organisms. Toxics, 10.","DOI":"10.3390\/toxics10050272"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Di Paola, D., Natale, S., Iaria, C., Cordaro, M., Crupi, R., Siracusa, R., D\u2019Amico, R., Fusco, R., Impellizzeri, D., and Cuzzocrea, S. (2022). Intestinal Disorder in Zebrafish Larvae (Danio rerio): The Protective Action of N-Palmitoylethanolamide-oxazoline. Life, 12.","DOI":"10.3390\/life12010125"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Genovese, T., Impellizzeri, D., D\u2019Amico, R., Fusco, R., Peritore, A.F., Di Paola, D., Interdonato, L., Gugliandolo, E., Crupi, R., and Di Paola, R. (2022). Role of Bevacizumab on Vascular Endothelial Growth Factor in Apolipoprotein E Deficient Mice after Traumatic Brain Injury. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23084162"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Cordaro, M., Siracusa, R., D\u2019Amico, R., Genovese, T., Franco, G., Marino, Y., Di Paola, D., Cuzzocrea, S., Impellizzeri, D., and Di Paola, R. (2022). Role of Etanercept and Infliximab on Nociceptive Changes Induced by the Experimental Model of Fibromyalgia. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23116139"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"D\u2019Amico, R., Gugliandolo, E., Cordaro, M., Fusco, R., Genovese, T., Peritore, A.F., Crupi, R., Interdonato, L., Di Paola, D., and Cuzzocrea, S. (2022). Toxic Effects of Endocrine Disruptor Exposure on Collagen-Induced Arthritis. Biomolecules, 12.","DOI":"10.3390\/biom12040564"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"D\u2019Amico, R., Gugliandolo, E., Siracusa, R., Cordaro, M., Genovese, T., Peritore, A.F., Crupi, R., Interdonato, L., Di Paola, D., and Cuzzocrea, S. (2022). Toxic Exposure to Endocrine Disruptors Worsens Parkinson\u2019s Disease Progression through NRF2\/HO-1 Alteration. Biomedicines, 10.","DOI":"10.3390\/biomedicines10051073"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"9251","DOI":"10.1007\/s12035-018-1064-2","article-title":"2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease","volume":"55","author":"Cordaro","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.phrs.2016.04.007","article-title":"2-pentadecyl-2-oxazoline: Identification in coffee, synthesis and activity in a rat model of carrageenan-induced hindpaw inflammation","volume":"108","author":"Impellizzeri","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1186\/s13075-016-1189-5","article-title":"Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats","volume":"18","author":"Fusco","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Fusco, R., Cordaro, M., Genovese, T., Impellizzeri, D., Siracusa, R., Gugliandolo, E., Peritore, A., D\u2019Amico, R., Crupi, R., and Cuzzocrea, S. (2020). Adelmidrol: A New Promising Antioxidant and Anti-Inflammatory Therapeutic Tool in Pulmonary Fibrosis. Antioxidants, 9.","DOI":"10.3390\/antiox9070601"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Fusco, R., Cordaro, M., Siracusa, R., D\u2019Amico, R., Genovese, T., Gugliandolo, E., Peritore, A.F., Crupi, R., Impellizzeri, D., and Cuzzocrea, S. (2020). Biochemical Evaluation of the Antioxidant Effects of Hydroxytyrosol on Pancreatitis-Associated Gut Injury. Antioxidants, 9.","DOI":"10.3390\/antiox9090781"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Fusco, R., Gugliandolo, E., Siracusa, R., Scuto, M., Cordaro, M., D\u2019Amico, R., Evangelista, M., Peli, A., Peritore, A., and Impellizzeri, D. (2020). Formyl Peptide Receptor 1 Signaling in Acute Inflammation and Neural Differentiation Induced by Traumatic Brain Injury. Biology, 9.","DOI":"10.3390\/biology9090238"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1055\/s-0028-1114243","article-title":"Effect of a cyclic nitrogen mustard-phosphamidester on experimentally induced tumors in rats; chemotherapeutic effect and pharmacological properties of B 518 ASTA","volume":"83","author":"Brock","year":"1958","journal-title":"DMW Dtsch. Med. Wochenschr."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.tox.2008.03.015","article-title":"Astaxanthin inhibits cytotoxic and genotoxic effects of cyclophosphamide in mice germ cells","volume":"248","author":"Tripathi","year":"2008","journal-title":"Toxicology"},{"key":"ref_98","first-page":"105","article-title":"Colchicine, cyclophosphamide and prednisone in the treatment of mild-moderate idiopathic pulmonary fibrosis: Comparison of three currently available therapeutic regimens","volume":"12","author":"Fiorucci","year":"2008","journal-title":"Eur. Rev. Med Pharmacol. Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.cbi.2009.03.017","article-title":"Intervention of astaxanthin against cyclophosphamide-induced oxidative stress and DNA damage: A study in mice","volume":"180","author":"Tripathi","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/1097-0142(196410)17:10<1348::AID-CNCR2820171017>3.0.CO;2-0","article-title":"Cytological study of the effect of cyclophosphamide on the epithelium of the urinary bladder in man","volume":"17","author":"Forni","year":"1964","journal-title":"Cancer"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0022-5347(17)56306-5","article-title":"The Incidence of Bladder Cancer after Cyclophosphamide Therapy","volume":"122","author":"Fairchild","year":"1979","journal-title":"J. Urol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1445-5994.1985.tb02753.x","article-title":"Carcinoma of the urinary bladder in patients receiving cyclophosphamide","volume":"15","author":"Christophidis","year":"1985","journal-title":"Aust. N. Z. J. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1177\/0960327108102046","article-title":"Protection of cyclophosphamide-induced toxicity in reproductive tract histology, sperm characteristics, and DNA damage by an herbal source; evidence for role of free-radical toxic stress","volume":"27","author":"Rezvanfar","year":"2008","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4103\/0971-6580.97224","article-title":"Rutin ameliorates cyclophosphamide-induced reproductive toxicity in male rats","volume":"19","author":"Abarikwu","year":"2012","journal-title":"Toxicol. Int."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.etap.2014.12.014","article-title":"Zn(II)\u2013curcumin protects against oxidative stress, deleterious changes in sperm parameters and histological alterations in a male mouse model of cyclophosphamide-induced reproductive damage","volume":"39","author":"Lu","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1182\/blood-2002-06-1860","article-title":"Cyclophosphamide metabolism, liver toxicity, and mortality following hematopoietic stem cell transplantation","volume":"101","author":"McDonald","year":"2003","journal-title":"Blood"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"470425","DOI":"10.1155\/2014\/470425","article-title":"Prophylactic Efficacy of Melatonin on Cyclophosphamide-Induced Liver Toxicity in Mice","volume":"2014","author":"Shokrzadeh","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_108","first-page":"655","article-title":"Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles","volume":"27","author":"Roy","year":"1999","journal-title":"Drug. Metab. Dispos."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10565-006-0078-0","article-title":"Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation","volume":"23","author":"Korkmaz","year":"2007","journal-title":"Cell Biol. Toxicol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0027-5107(96)00019-X","article-title":"The clinical use of mutagenic anticancer drugs","volume":"355","author":"Ferguson","year":"1996","journal-title":"Mutat. Res. Mol. Mech. Mutagen."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Silva, A.F.R., Resende, D., Monteiro, M., Coimbra, M.A., Silva, A.M.S., and Cardoso, S.M. (2020). Application of Hydroxytyrosol in the Functional Foods Field: From Ingredient to Dietary Supplements. Antioxidants, 9.","DOI":"10.3390\/antiox9121246"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.3892\/mmr.2016.4948","article-title":"Role of neuroinflammation in neurodegenerative diseases (Review)","volume":"13","author":"Chen","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Magalh\u00e3es, T.S.S.D.A., Macedo, P.C.D.O., Converti, A., and De Lima, A.N. (2020). The Use of Euterpe oleracea Mart. As a New Perspective for Disease Treatment and Prevention. Biomolecules, 10.","DOI":"10.3390\/biom10060813"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.phrs.2015.11.019","article-title":"Modulation of mitochondrial dysfunction in neurodegenerative diseases via activation of nuclear factor erythroid-2-related factor 2 by food-derived compounds","volume":"103","author":"Denzer","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Kovacs, G.G. (2016). Molecular Pathological Classification of Neurodegenerative Diseases: Turning towards Precision Medicine. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17020189"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3389\/fnins.2015.00469","article-title":"Chronic Glutamate Toxicity in Neurodegenerative Diseases\u2014What is the Evidence?","volume":"9","author":"Lewerenz","year":"2015","journal-title":"Front. Neurosci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"8940850","DOI":"10.1155\/2016\/8940850","article-title":"Neuroprotective Effects of A\u00e7a\u00ed (Euterpe oleracea Mart.) against Rotenone In Vitro Exposure","volume":"2016","author":"Machado","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.foodchem.2016.12.006","article-title":"Hydroethanolic extracts from different genotypes of a\u00e7a\u00ed (Euterpe oleracea) presented antioxidant potential and protected human neuron-like cells (SH-SY5Y)","volume":"222","author":"Torma","year":"2017","journal-title":"Food Chem."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.jnutbio.2011.06.013","article-title":"The a\u00e7a\u00ed flavonoid velutin is a potent anti-inflammatory agent: Blockade of LPS-mediated TNF-\u03b1 and IL-6 production through inhibiting NF-\u03baB activation and MAPK pathway","volume":"23","author":"Xie","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.phrs.2018.05.013","article-title":"Adelmidrol + sodium hyaluronate in IC\/BPS or conditions associated to chronic urothelial inflammation. A translational study","volume":"134","author":"Ostardo","year":"2018","journal-title":"Pharmacol. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tox.2006.01.027","article-title":"Cyclophosphamide treatment causes impairment of sperm and its fertilizing ability in mice","volume":"222","author":"Elangovan","year":"2006","journal-title":"Toxicology"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.fertnstert.2008.07.1758","article-title":"Potential chemoprotective effect of melatonin in cyclophosphamide- and cisplatin-induced testicular damage in rats","volume":"92","author":"Ilbey","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1080\/1071576021000016472","article-title":"Protective Role of \u03b1-tocopherol-succinate (Provitamin-E) in Cyclophosphamide Induced Testicular Gametogenic and Steroidogenic Disorders: A Correlative Approach to Oxidative Stress","volume":"36","author":"Ghosh","year":"2002","journal-title":"Free Radic. Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0300-483X(00)00306-1","article-title":"Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology","volume":"153","year":"2000","journal-title":"Toxicology"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fendo.2014.00056","article-title":"Roles of Reactive Oxygen Species in the Spermatogenesis Regulation","volume":"5","author":"Guerriero","year":"2014","journal-title":"Front. Endocrinol."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Leri, M., Scuto, M., Ontario, M.L., Calabrese, V., Calabrese, E.J., Bucciantini, M., and Stefani, M. (2020). Healthy Effects of Plant Polyphenols: Molecular Mechanisms. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21041250"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jnutbio.2018.03.014","article-title":"Peracetylated hydroxytyrosol, a new hydroxytyrosol derivate, attenuates LPS-induced inflammatory response in murine peritoneal macrophages via regulation of non-canonical inflammasome, Nrf2\/HO1 and JAK\/STAT signaling pathways","volume":"57","author":"Montoya","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.bbrc.2014.02.055","article-title":"Zinc protects cyclophosphamide-induced testicular damage in rat: Involvement of metallothionein, tesmin and Nrf","volume":"445","author":"Maremanda","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.theriogenology.2006.10.013","article-title":"Lycopene protects against cyclosporine A-induced testicular toxicity in rats","volume":"67","author":"Ceribasi","year":"2007","journal-title":"Theriogenology"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1742-7843.2010.00571.x","article-title":"Toxic Effect of Cyclophosphamide on Sperm Morphology, Testicular Histology and Blood Oxidant-Antioxidant Balance, and Protective Roles of Lycopene and Ellagic Acid","volume":"107","author":"Ceribasi","year":"2010","journal-title":"Basic Clin. Pharmacol. Toxicol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/11\/12\/2355\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:28:31Z","timestamp":1760146111000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/11\/12\/2355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,28]]},"references-count":130,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["antiox11122355"],"URL":"https:\/\/doi.org\/10.3390\/antiox11122355","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,28]]}}}