{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:17:02Z","timestamp":1787775422325,"version":"build-2784847793"},"reference-count":42,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing Natural Science Foundation","award":["7224336"],"award-info":[{"award-number":["7224336"]}]},{"name":"Beijing Natural Science Foundation","award":["2021ZD0201100"],"award-info":[{"award-number":["2021ZD0201100"]}]},{"name":"Beijing Natural Science Foundation","award":["2021ZD0201101"],"award-info":[{"award-number":["2021ZD0201101"]}]},{"name":"Human brain bank and regional brain bank collaboration network platform","award":["7224336"],"award-info":[{"award-number":["7224336"]}]},{"name":"Human brain bank and regional brain bank collaboration network platform","award":["2021ZD0201100"],"award-info":[{"award-number":["2021ZD0201100"]}]},{"name":"Human brain bank and regional brain bank collaboration network platform","award":["2021ZD0201101"],"award-info":[{"award-number":["2021ZD0201101"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>High altitude (HA) has become one of the most challenging environments featuring hypobaric hypoxia, which seriously threatens public health, hence its gradual attraction of public attention over the past decade. The purpose of this study is to investigate the effect of HA hypoxia on iron levels, redox state, inflammation, and ferroptosis in adipose tissue. Here, 40 mice were randomly divided into two groups: the sea-level group and HA hypoxia group (altitude of 5000 m, treatment for 4 weeks). Total iron contents, ferrous iron contents, ROS generation, lipid peroxidation, the oxidative enzyme system, proinflammatory factor secretion, and ferroptosis-related biomarkers were examined, respectively. According to the results, HA exposure increases total iron and ferrous iron levels in both WAT and BAT. Meanwhile, ROS release, MDA, 4-HNE elevation, GSH depletion, as well as the decrease in SOD, CAT, and GSH-Px activities further evidenced a phenotype of redox imbalance in adipose tissue during HA exposure. Additionally, the secretion of inflammatory factors was also significantly enhanced in HA mice. Moreover, the remarkably changed expression of ferroptosis-related markers suggested that HA exposure increased ferroptosis sensitivity in adipose tissue. Overall, this study reveals that HA exposure is capable of inducing adipose tissue redox imbalance, inflammatory response, and ferroptosis, driven in part by changes in iron overload, which is expected to provide novel preventive targets for HA-related illness.<\/jats:p>","DOI":"10.3390\/antiox11122367","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T04:05:24Z","timestamp":1669781124000},"page":"2367","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["High-Altitude Hypoxia Exposure Induces Iron Overload and Ferroptosis in Adipose Tissue"],"prefix":"10.3390","volume":"11","author":[{"given":"Yanfei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Peking University School of Basic Medical Sciences, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyue","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences and Peking University Center for Obesity and Metabolic Disease Research, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiru","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Peking University School of Basic Medical Sciences, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3527-252X","authenticated-orcid":false,"given":"Quancheng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Peking University School of Basic Medical Sciences, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaicun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Peking University School of Basic Medical Sciences, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences and Peking University Center for Obesity and Metabolic Disease Research, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5055-4907","authenticated-orcid":false,"given":"Weiguang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Peking University School of Basic Medical Sciences, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1093\/jxb\/eraa483","article-title":"Coordinated homeostasis of essential mineral nutrients: A focus on iron","volume":"72","author":"Hanikenne","year":"2021","journal-title":"J. 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