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ISCIII"],"award-info":[{"award-number":["MS19\/00092; ISCIII"]}]},{"name":"Gobierno de Arag\u00f3n fellowship","award":["CUS\/581\/2020"],"award-info":[{"award-number":["CUS\/581\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Osteoarthritis is a prevalent degenerative condition that is closely related to the destruction and inflammation of cartilage. The high prevalence of this pathology exhorts researchers to search for novel therapeutic approaches. Vegetable\u2013fruit wastes have emerged as a promising origin of anti-inflammatory and antioxidant compounds that, in some cases, may also exert chondroprotective effects. This study aims to decipher the potential of onion waste products in the inhibition of molecular events involved in osteoarthritis. Onion extracts showed a high content of phenolic compounds and antioxidant properties. Cytocompatibility was demonstrated in the chondrogenic cell line ATDC-5, exerting viability percentages higher than 90% and a slight increase in the S phase cycle cell. The induction of inflammation mediated by the lipopolysaccharide and onion extracts\u2019 treatment substantially inhibited molecular markers related to inflammation and cartilage degradation, highlighting the promising application of onion extracts in biomedical approaches. The in silico analyses suggested that the results could be attributed to protocatechuic, ellagic, and vanillic acids\u2019 greater cell membrane permeability. Our work provides distinctive information about the possible application of waste onion extracts as functional components with anti-inflammatory and chondroprotective characteristics in osteoarthritis.<\/jats:p>","DOI":"10.3390\/antiox11122381","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T03:32:25Z","timestamp":1669865545000},"page":"2381","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Anti-Inflammatory and Chondroprotective Effects Induced by Phenolic Compounds from Onion Waste Extracts in ATDC-5 Chondrogenic Cell Line"],"prefix":"10.3390","volume":"11","author":[{"given":"M\u00f3nica","family":"Paesa","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, University of Zaragoza, Campus R\u00edo Ebro-Edificio I+D, C\/ Poeta Mariano Esquillor S\/N, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Anc\u00edn-Azpilicueta","sequence":"additional","affiliation":[{"name":"Department of Sciences, Institute for Advanced Materials (INAMAT2), Navarra Public University, Campus Arrosad\u00eda s\/n, 31006 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5031-8402","authenticated-orcid":false,"given":"Gustavo","family":"Velderrain-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Alianza Latinoamericana De Nutricion Responsable, Inc., 400 E Randolph St Suite 2305, Chicago, IL 60611, USA"},{"name":"Department of Food Technology, University of Lleida\u2014Agrotecnio Center, Av. Alcalde Rovira Roure 191, 25198 Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7027-6972","authenticated-orcid":false,"given":"Olga","family":"Martin-Belloso","sequence":"additional","affiliation":[{"name":"Department of Food Technology, University of Lleida\u2014Agrotecnio Center, Av. Alcalde Rovira Roure 191, 25198 Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7154-1328","authenticated-orcid":false,"given":"Oreste","family":"Gualillo","sequence":"additional","affiliation":[{"name":"SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela), NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Research Laboratory 9, Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-8457","authenticated-orcid":false,"given":"Jes\u00fas","family":"Osada","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Cell Biology, Veterinary Faculty, Health Research Institute of Aragon-University of Zaragoza, 50009 Zaragoza, Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n, Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Instituto Agroalimentario de Arag\u00f3n, CITA-Universidad de Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3595-7668","authenticated-orcid":false,"given":"Maria Jes\u00fas","family":"Rodr\u00edguez-Yoldi","sequence":"additional","affiliation":[{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n, Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Instituto Agroalimentario de Arag\u00f3n, CITA-Universidad de Zaragoza, 50009 Zaragoza, Spain"},{"name":"Department of Pharmacology and Physiology, Forensic and Legal Medicine, Veterinary Faculty, Health Research Institute of Aragon-University of Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2293-363X","authenticated-orcid":false,"given":"Gracia","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology, Forensic and Legal Medicine, Veterinary Faculty, Health Research Institute of Aragon-University of Zaragoza, 50009 Zaragoza, Spain"},{"name":"Aragon Health Research Institute (IIS Aragon), 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12891-022-05091-5","article-title":"Projected Number of Osteoarthritis Patients in Austria for the next Decades\u2013Quantifying the Necessity of Treatment and Prevention Strategies in Europe","volume":"23","author":"Hitzl","year":"2022","journal-title":"BMC Musculoskelet. 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