{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:23:28Z","timestamp":1782919408916,"version":"3.54.5"},"reference-count":44,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund (FWF)","doi-asserted-by":"publisher","award":["DOC 31-B26"],"award-info":[{"award-number":["DOC 31-B26"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund (FWF)","doi-asserted-by":"publisher","award":["242187"],"award-info":[{"award-number":["242187"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund (FWF)","doi-asserted-by":"publisher","award":["200310013"],"award-info":[{"award-number":["200310013"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund (FWF)","doi-asserted-by":"publisher","award":["2203\/7. PR\/2011\/2"],"award-info":[{"award-number":["2203\/7. PR\/2011\/2"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical University","award":["DOC 31-B26"],"award-info":[{"award-number":["DOC 31-B26"]}]},{"name":"Medical University","award":["242187"],"award-info":[{"award-number":["242187"]}]},{"name":"Medical University","award":["200310013"],"award-info":[{"award-number":["200310013"]}]},{"name":"Medical University","award":["2203\/7. PR\/2011\/2"],"award-info":[{"award-number":["2203\/7. PR\/2011\/2"]}]},{"name":"European Community\u2019s 7th Framework Program","award":["DOC 31-B26"],"award-info":[{"award-number":["DOC 31-B26"]}]},{"name":"European Community\u2019s 7th Framework Program","award":["242187"],"award-info":[{"award-number":["242187"]}]},{"name":"European Community\u2019s 7th Framework Program","award":["200310013"],"award-info":[{"award-number":["200310013"]}]},{"name":"European Community\u2019s 7th Framework Program","award":["2203\/7. PR\/2011\/2"],"award-info":[{"award-number":["2203\/7. PR\/2011\/2"]}]},{"name":"Netherlands Organization for Health Research and Development (ZonMw)","award":["DOC 31-B26"],"award-info":[{"award-number":["DOC 31-B26"]}]},{"name":"Netherlands Organization for Health Research and Development (ZonMw)","award":["242187"],"award-info":[{"award-number":["242187"]}]},{"name":"Netherlands Organization for Health Research and Development (ZonMw)","award":["200310013"],"award-info":[{"award-number":["200310013"]}]},{"name":"Netherlands Organization for Health Research and Development (ZonMw)","award":["2203\/7. PR\/2011\/2"],"award-info":[{"award-number":["2203\/7. PR\/2011\/2"]}]},{"name":"Polish Ministry of Science","award":["DOC 31-B26"],"award-info":[{"award-number":["DOC 31-B26"]}]},{"name":"Polish Ministry of Science","award":["242187"],"award-info":[{"award-number":["242187"]}]},{"name":"Polish Ministry of Science","award":["200310013"],"award-info":[{"award-number":["200310013"]}]},{"name":"Polish Ministry of Science","award":["2203\/7. PR\/2011\/2"],"award-info":[{"award-number":["2203\/7. PR\/2011\/2"]}]},{"name":"Odense University Free Research Fund","award":["DOC 31-B26"],"award-info":[{"award-number":["DOC 31-B26"]}]},{"name":"Odense University Free Research Fund","award":["242187"],"award-info":[{"award-number":["242187"]}]},{"name":"Odense University Free Research Fund","award":["200310013"],"award-info":[{"award-number":["200310013"]}]},{"name":"Odense University Free Research Fund","award":["2203\/7. PR\/2011\/2"],"award-info":[{"award-number":["2203\/7. PR\/2011\/2"]}]},{"name":"NIHR Clinical Research Network: Eastern","award":["DOC 31-B26"],"award-info":[{"award-number":["DOC 31-B26"]}]},{"name":"NIHR Clinical Research Network: Eastern","award":["242187"],"award-info":[{"award-number":["242187"]}]},{"name":"NIHR Clinical Research Network: Eastern","award":["200310013"],"award-info":[{"award-number":["200310013"]}]},{"name":"NIHR Clinical Research Network: Eastern","award":["2203\/7. PR\/2011\/2"],"award-info":[{"award-number":["2203\/7. PR\/2011\/2"]}]},{"name":"CAIBER 1527-B-226","award":["DOC 31-B26"],"award-info":[{"award-number":["DOC 31-B26"]}]},{"name":"CAIBER 1527-B-226","award":["242187"],"award-info":[{"award-number":["242187"]}]},{"name":"CAIBER 1527-B-226","award":["200310013"],"award-info":[{"award-number":["200310013"]}]},{"name":"CAIBER 1527-B-226","award":["2203\/7. PR\/2011\/2"],"award-info":[{"award-number":["2203\/7. PR\/2011\/2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Gestational hypertension (GHTN) is associated with an increased cardiovascular risk for mothers and their offspring later in life. High-density lipoproteins (HDL) are anti-atherogenic by promoting efflux of cholesterol from macrophages and suppression of endothelial cell activation. Functional impairment of HDL in GHTN-complicated pregnancies may affect long-term health of both mothers and offspring. We studied functional parameters of maternal and neonatal HDL in 192 obese women (pre-pregnancy BMI \u2265 29), who were at high risk for GHTN. Maternal blood samples were collected longitudinally at &lt;20 weeks, at 24\u201328 and 35\u201337 weeks of gestation. Venous cord blood was collected immediately after birth. Maternal and cord blood were used to determine functional parameters of HDL, such as HDL cholesterol efflux capacity, activity of the vaso-protective HDL-associated enzyme paraoxonase-1, and levels of the HDL-associated anti-inflammatory apolipoprotein (apo)M. In addition, we determined serum anti-oxidative capacity. Thirteen percent of the women were diagnosed with GHTN. While we found no changes in measures of HDL function in mothers with GHTN, we observed impaired HDL cholesterol efflux capacity and paraoxonase-1 activity in cord blood, while serum antioxidant capacity was increased. Of particular interest, increased maternal paraoxonase-1 activity and apoM levels in early pregnancy were associated with the risk of developing GHTN. GHTN significantly impairs HDL cholesterol efflux capacity as well as HDL PON1 activity in cord blood and could affect vascular health in offspring. Maternal paraoxonase-1 activity and apoM levels in early pregnancy associate with the risk of developing GHTN.<\/jats:p>","DOI":"10.3390\/antiox12010068","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T02:59:01Z","timestamp":1672282741000},"page":"68","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Gestational Hypertension and High-Density Lipoprotein Function: An Explorative Study in Overweight\/Obese Women of the DALI Cohort"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1156-631X","authenticated-orcid":false,"given":"Julia T.","family":"Stadler","sequence":"first","affiliation":[{"name":"Division of Pharmacology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Universit\u00e4tsplatz 4, 8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5694-4324","authenticated-orcid":false,"given":"M. N. M.","family":"van Poppel","sequence":"additional","affiliation":[{"name":"Institute of Human Movement Science, Sport and Health, University of Graz, 8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Christoffersen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, University of Copenhagen, 2200 Copenhagen, Denmark"},{"name":"Department of Biochemistry, Rigshospitalet, University Hospital of Copenhagen, 2200 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2490-5678","authenticated-orcid":false,"given":"David","family":"Hill","sequence":"additional","affiliation":[{"name":"Lawson Health Research Institute, London, ON N6C 2R5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5589-8642","authenticated-orcid":false,"given":"Christian","family":"Wadsack","sequence":"additional","affiliation":[{"name":"Research Unit, Department of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, Austria"},{"name":"BioTechMed-Graz, 8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-0761","authenticated-orcid":false,"given":"David","family":"Simmons","sequence":"additional","affiliation":[{"name":"Macarthur Clinical School, Western Sydney University, Sydney, NSW 2560, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5715-3230","authenticated-orcid":false,"given":"Gernot","family":"Desoye","sequence":"additional","affiliation":[{"name":"Research Unit, Department of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2422-5381","authenticated-orcid":false,"given":"Gunther","family":"Marsche","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Universit\u00e4tsplatz 4, 8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"DALI Core Investigator Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"ref_1","first-page":"59","article-title":"Metabolic Adaptations in Pregnancy: A Review","volume":"70","author":"Zeng","year":"2017","journal-title":"ANM"},{"key":"ref_2","unstructured":"World Health Organization (2011). WHO Recommendations for Prevention and Treatment of Pre-Eclampsia and Eclampsia, World Health Organization."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1046\/j.1471-0528.2003.00034.x-i1","article-title":"MOMS Group Maternal Mortality as an Indicator of Obstetric Care in Europe","volume":"111","author":"Wildman","year":"2004","journal-title":"BJOG"},{"key":"ref_4","first-page":"486","article-title":"Maternal Obesity and Energy Intake as Risk Factors of Pregnancy-Induced Hypertension among Iranian Women","volume":"32","author":"Kazemian","year":"2014","journal-title":"J. Health Popul. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Simmons, D. (2017). Epidemiology of Diabetes in Pregnancy. A Practical Manual of Diabetes in Pregnancy, John Wiley & Sons, Ltd.","DOI":"10.1002\/9781119043805.ch1"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/emph\/eox004","article-title":"Time from Pre-Eclampsia Diagnosis to Delivery Affects Future Health Prospects of Children","volume":"2017","author":"Hollegaard","year":"2017","journal-title":"Evol. Med. Public Health"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1136\/bmj.39335.385301.BE","article-title":"Pre-Eclampsia and Risk of Cardiovascular Disease and Cancer in Later Life: Systematic Review and Meta-Analysis","volume":"335","author":"Bellamy","year":"2007","journal-title":"BMJ"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e003497","DOI":"10.1161\/CIRCOUTCOMES.116.003497","article-title":"Preeclampsia and Future Cardiovascular Health: A Systematic Review and Meta-Analysis","volume":"10","author":"Wu","year":"2017","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1056\/NEJMoa1409065","article-title":"HDL Cholesterol Efflux Capacity and Incident Cardiovascular Events","volume":"371","author":"Rohatgi","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Trakaki, A., and Marsche, G. (2021). Current Understanding of the Immunomodulatory Activities of High-Density Lipoproteins. Biomedicines, 9.","DOI":"10.3390\/biomedicines9060587"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1161\/01.RES.0000146094.59640.13","article-title":"Antiinflammatory Properties of HDL","volume":"95","author":"Barter","year":"2004","journal-title":"Circ. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/MOL.0b013e32833bcdc1","article-title":"Antiatherogenic Function of HDL Particle Subpopulations: Focus on Antioxidative Activities","volume":"21","author":"Kontush","year":"2010","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-1-60761-350-3_14","article-title":"Paraoxonase 1 Interactions with HDL, Antioxidants and Macrophages Regulate Atherogenesis\u2014A Protective Role for HDL Phospholipids","volume":"660","author":"Efrat","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e021261","DOI":"10.1161\/JAHA.121.021261","article-title":"Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine-1-Phosphate","volume":"10","author":"Rubinelli","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"9613","DOI":"10.1073\/pnas.1103187108","article-title":"Endothelium-Protective Sphingosine-1-Phosphate Provided by HDL-Associated Apolipoprotein M","volume":"108","author":"Christoffersen","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1172\/JCI42946","article-title":"Mechanisms Underlying Adverse Effects of HDL on ENOS-Activating Pathways in Patients with Coronary Artery Disease","volume":"121","author":"Besler","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1161\/ATVBAHA.117.310222","article-title":"HDL Function in Cardiovascular Disease and Diabetes","volume":"38","author":"He","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s10557-018-06846-w","article-title":"High-Density Lipoprotein Function and Dysfunction in Health and Disease","volume":"33","author":"Chiesa","year":"2019","journal-title":"Cardiovasc. Drugs"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Stadler, J.T., and Marsche, G. (2020). Obesity-Related Changes in High-Density Lipoprotein Metabolism and Function. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21238985"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Marsche, G., Heine, G.H., Stadler, J.T., and Holzer, M. (2020). Current Understanding of the Relationship of HDL Composition, Structure and Function to Their Cardioprotective Properties in Chronic Kidney Disease. Biomolecules, 10.","DOI":"10.3390\/biom10091348"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/00006250-199102000-00002","article-title":"C-Reactive Protein in Normal Pregnancy","volume":"77","author":"Watts","year":"1991","journal-title":"Obs. Gynecol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"100107","DOI":"10.1016\/j.jlr.2021.100107","article-title":"Pregnancy Is Accompanied by Larger High Density Lipoprotein Particles and Compositionally Distinct Subspecies","volume":"62","author":"Melchior","year":"2021","journal-title":"J. Lipid Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"523","DOI":"10.4103\/1947-2714.103310","article-title":"Antioxidant and Anti-Inflammatory Role of Paraoxonase 1: Implication in Arteriosclerosis Diseases","volume":"4","author":"Litvinov","year":"2012","journal-title":"N. Am. J. Med. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.atherosclerosis.2021.08.039","article-title":"Apolipoprotein M and Its Impact on Endothelial Dysfunction and Inflammation in the Cardiovascular System","volume":"334","author":"Christoffersen","year":"2021","journal-title":"Atherosclerosis"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Jelsma, J.G.M., van Poppel, M.N.M., Galjaard, S., Desoye, G., Corcoy, R., Devlieger, R., van Assche, A., Timmerman, D., Jans, G., and Harreiter, J. (2013). DALI: Vitamin D and Lifestyle Intervention for Gestational Diabetes Mellitus (GDM) Prevention: An European Multicentre, Randomised Trial\u2014Study Protocol. BMC Pregnancy Childbirth, 13.","DOI":"10.1186\/1471-2393-13-142"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.2337\/dc15-0360","article-title":"Results from a European Multicenter Randomized Trial of Physical Activity and\/or Healthy Eating to Reduce the Risk of Gestational Diabetes Mellitus: The DALI Lifestyle Pilot","volume":"38","author":"Simmons","year":"2015","journal-title":"Diabetes Care"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Stadler, J.T., Lackner, S., M\u00f6rkl, S., Trakaki, A., Scharnagl, H., Borenich, A., Wonisch, W., Mangge, H., Zelzer, S., and Meier-Allard, N. (2021). Obesity Affects HDL Metabolism, Composition and Subclass Distribution. Biomedicines, 9.","DOI":"10.3390\/biomedicines9030242"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.bbalip.2019.06.007","article-title":"Allergic Rhinitis Is Associated with Complex Alterations in High-Density Lipoprotein Composition and Function","volume":"1864","author":"Trakaki","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell. Biol. Lipids"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1194\/jlr.D055947","article-title":"Protein Unfolding Allows Use of Commercial Antibodies in an Apolipoprotein M Sandwich ELISA","volume":"56","author":"Bosteen","year":"2015","journal-title":"J. Lipid Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.atherosclerosis.2011.11.031","article-title":"Apolipoprotein M Binds Oxidized Phospholipids and Increases the Antioxidant Effect of HDL","volume":"221","author":"Christoffersen","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref_31","first-page":"737","article-title":"Distinct Composition of Human Fetal HDL Attenuates Its Anti-Oxidative Capacity","volume":"1831","author":"Sreckovic","year":"2013","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Cell Biol. Lipids"},{"key":"ref_32","unstructured":"Feingold, K.R., Anawalt, B., Boyce, A., Chrousos, G., de Herder, W.W., Dungan, K., Grossman, A., Hershman, J.M., Hofland, J., and Kaltsas, G. (2000). Effect of Pregnancy on Lipid Metabolism and Lipoprotein Levels. Endotext, MDText.com, Inc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1210\/jcem-64-4-704","article-title":"Correlation of Hormones with Lipid and Lipoprotein Levels during Normal Pregnancy and Postpartum","volume":"64","author":"Desoye","year":"1987","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"159106","DOI":"10.1016\/j.bbalip.2021.159106","article-title":"Roles of Maternal HDL during Pregnancy","volume":"1867","author":"Woollett","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. Cell. Biol. Lipids"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00404-018-4824-3","article-title":"High-Density Lipoproteins (HDL) Composition and Function in Preeclampsia","volume":"298","author":"Einbinder","year":"2018","journal-title":"Arch. Gynecol. Obs."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1194\/jlr.M071985","article-title":"Increased Maternal and Fetal Cholesterol Efflux Capacity and Placental CYP27A1 Expression in Preeclampsia","volume":"58","author":"Mistry","year":"2017","journal-title":"J. Lipid Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.athplu.2022.01.003","article-title":"Effects of Pre-Eclampsia on HDL-Mediated Cholesterol Efflux Capacity after Pregnancy","volume":"48","author":"Kockx","year":"2022","journal-title":"Atheroscler. Plus"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2147\/VHRM.S165173","article-title":"Paraoxonase (PON)-1: A Brief Overview on Genetics, Structure, Polymorphisms and Clinical Relevance","volume":"14","author":"Shunmoogam","year":"2018","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.gene.2015.04.088","article-title":"Human Paraoxonase-1 (PON1): Gene Structure and Expression, Promiscuous Activities and Multiple Physiological Roles","volume":"567","author":"Mackness","year":"2015","journal-title":"Gene"},{"key":"ref_40","first-page":"1287","article-title":"Apolipoprotein M Promotes Mobilization of Cellular Cholesterol in Vivo","volume":"1831","author":"Christoffersen","year":"2013","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Cell Biol. Lipids"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nm1211","article-title":"Apolipoprotein M Is Required for Pre\u03b2-HDL Formation and Cholesterol Efflux to HDL and Protects against Atherosclerosis","volume":"11","author":"Wolfrum","year":"2005","journal-title":"Nat. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1161\/HYPERTENSIONAHA.121.18363","article-title":"Impaired Sphingosine-1-Phosphate Synthesis Induces Preeclampsia by Deactivating Trophoblastic YAP (Yes-Associated Protein) Through S1PR2 (Sphingosine-1-Phosphate Receptor-2)-Induced Actin Polymerizations","volume":"79","author":"Liao","year":"2022","journal-title":"Hypertension"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1001\/jama.299.11.1265","article-title":"Relationship of Paraoxonase 1 (PON1) Gene Polymorphisms and Functional Activity With Systemic Oxidative Stress and Cardiovascular Risk","volume":"299","author":"Bhattacharyya","year":"2008","journal-title":"JAMA"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.jacl.2018.08.007","article-title":"Feasibility of a Plasma Bioassay to Assess Oxidative Protection of Low-Density Lipoproteins by High-Density Lipoproteins","volume":"12","author":"Swertfeger","year":"2018","journal-title":"J. Clin. Lipidol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/1\/68\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:54:47Z","timestamp":1760147687000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/1\/68"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["antiox12010068"],"URL":"https:\/\/doi.org\/10.3390\/antiox12010068","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,29]]}}}