{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:44:18Z","timestamp":1788374658883,"version":"build-2803163510"},"reference-count":68,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCT- Foundation for Science and Technology: the Strategic Project","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}]},{"name":"FCT- Foundation for Science and Technology: the Strategic Project","award":["UIDP\/04539\/2020 (CIBB)"],"award-info":[{"award-number":["UIDP\/04539\/2020 (CIBB)"]}]},{"name":"FCT- Foundation for Science and Technology: the Strategic Project","award":["2022.04526.PTDC"],"award-info":[{"award-number":["2022.04526.PTDC"]}]},{"name":"FCT project","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}]},{"name":"FCT project","award":["UIDP\/04539\/2020 (CIBB)"],"award-info":[{"award-number":["UIDP\/04539\/2020 (CIBB)"]}]},{"name":"FCT project","award":["2022.04526.PTDC"],"award-info":[{"award-number":["2022.04526.PTDC"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Cinnamaldehyde (CN) is an activator of NF-E2-related factor 2 (Nrf2), which has the potential to reduce endothelial dysfunction, oxidative stress and inflammation in metabolic disorders. Our main purpose was to evaluate the effects of CN on vascular dysfunction in metabolic syndrome rats. Normal Wistar (W) rats were divided into eight groups: (1) Wistar (W) rats; (2) W rats fed with a high-fat diet (WHFD); (3) W rats fed with a sucrose diet (WS); (4) WHFD fed with a sucrose diet (WHFDS); (5) W treated with CN (WCn); (6) WS treated with CN (WSCn); (7) WHFD treated with CN (WHFDCn); (8) WHFDS treated with CN (WHFDSCn). CN treatment with 20 mg\/kg\/day was administered for 8 weeks. Evaluation of metabolic profile, inflammation, endothelial function, oxidative stress, eNOS expression levels and Nrf2 activation was performed. The metabolic dysfunction was greatly exacerbated in the WHFDS rats, accompanied by significantly higher levels of vascular oxidative stress, inflammation, and endothelial dysfunction. In addition, the WHFDS rats displayed significantly reduced activity of Nrf2 at the vascular level. CN significantly reverted endothelial dysfunction in the aortas and the mesenteric arteries. In addition, CN significantly decreased vascular oxidative damage, inflammation at vascular and perivascular level and up-regulated Nrf2 activity in the arteries of WHFDS rats. Cinnamaldehyde, an activator of Nrf2, can be used to improve metabolic profile, and to revert endothelial dysfunction in obesity and metabolic syndrome.<\/jats:p>","DOI":"10.3390\/antiox12010082","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T03:31:17Z","timestamp":1672371077000},"page":"82","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cinnamaldehyde Supplementation Reverts Endothelial Dysfunction in Rat Models of Diet-Induced Obesity: Role of NF-E2-Related Factor-2"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0889-2977","authenticated-orcid":false,"given":"Cristina M.","family":"Sena","sequence":"first","affiliation":[{"name":"Institute of Physiology, iCBR, Faculty of Medicine, University of Coimbra, Sub-unidade 1, P\u00f3lo III, Azinhaga de Santa Comba, Celas, 3000-548 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Pereira","sequence":"additional","affiliation":[{"name":"Institute of Physiology, iCBR, Faculty of Medicine, University of Coimbra, Sub-unidade 1, P\u00f3lo III, Azinhaga de Santa Comba, Celas, 3000-548 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel M.","family":"Sei\u00e7a","sequence":"additional","affiliation":[{"name":"Institute of Physiology, iCBR, Faculty of Medicine, University of Coimbra, Sub-unidade 1, P\u00f3lo III, Azinhaga de Santa Comba, Celas, 3000-548 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022, October 17). Obesity and Overweigh. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-andoverweight."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"International Diabetes Federation Task Force on Epidemiology and Prevention, Hational Heart, Lung and Blood Institute, American Heart Association, World Heart Federation, International Atherosclerosis Society, & International Association for the Study of Obesity. Harmonizing the metabolic syndrome: A joint interim statement of the Inter-national Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/obr.12229","article-title":"Metabolic syndrome: A closer look at the growing epidemic and its associated pathologies","volume":"16","year":"2015","journal-title":"Obes. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11892-018-1101-6","article-title":"Pathogenesis of Lipid Disorders in Insulin Resistance: A Brief Review","volume":"18","author":"Bjornstad","year":"2018","journal-title":"Curr. Diabetes Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of Nrf2 in Oxidative Stress and Toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tibs.2014.02.002","article-title":"The Nrf2 regulatory network provides an interface between redox and intermediary metabolism","volume":"39","author":"Hayes","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41573-018-0008-x","article-title":"Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases","volume":"18","author":"Cuadrado","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.freeradbiomed.2008.04.023","article-title":"Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress","volume":"45","author":"Wondrak","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1021\/jf048116s","article-title":"Authentication and quantitative analysis on the chemical profile of cassia bark (cortex cinnamomi) by high-pressure liquid chromatography","volume":"53","author":"He","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.2337\/diacare.26.12.3215","article-title":"Cinnamon Improves Glucose and Lipids of People With Type 2 Diabetes","volume":"26","author":"Khan","year":"2003","journal-title":"Diabetes Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s00421-009-0986-9","article-title":"Changes in glucose tolerance and insulin sensitivity following 2 weeks of daily cinnamon ingestion in healthy humans","volume":"105","author":"Solomon","year":"2009","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jff.2014.07.014","article-title":"Improved islet function is associated with anti-inflammatory, antioxidant and hypoglycemic potential of cinnamaldehyde on metabolic syndrome induced by high tail fat in rats","volume":"10","author":"Farrokhfall","year":"2014","journal-title":"J. Funct. Foods"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1039\/C9FO00396G","article-title":"Cinnamaldehyde attenuates atherosclerosis via targeting the I\u03baB\/NF-\u03baB signaling pathway in high fat diet-induced ApoE \u2212\/\u2212 mice","volume":"10","author":"Li","year":"2019","journal-title":"Food Funct."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.fct.2007.02.031","article-title":"A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents","volume":"45","author":"Singh","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.taap.2008.01.021","article-title":"Cinnamaldehyde inhibits the tumor necrosis factor-alpha-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-kappaB activation: Effects upon IkappaB and Nrf2","volume":"229","author":"Liao","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s12272-010-0219-0","article-title":"Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) ex-tract in C57BL\/Ks db\/db mice","volume":"33","author":"Kim","year":"2010","journal-title":"Arch. Pharm. Res."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Lee, S.-C., Hsu, J.-S., Li, C.-C., Chen, K.-M., and Liu, C.-T. (2015). Protective Effect of Leaf Essential Oil from Cinnamomum osmophloeum Kanehira on Endotoxin-Induced Intestinal Injury in Mice Associated with Suppressed Local Expression of Molecules in the Signaling Pathways of TLR4 and NLRP3. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0120700"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1021\/jf034916b","article-title":"Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like Biological Activity","volume":"52","author":"Anderson","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF00400095","article-title":"Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: Regulation of glutathione synthesis and efflux","volume":"38","author":"Yoshida","year":"1995","journal-title":"Diabetologia"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0891-5849(97)00286-4","article-title":"Glutathione in human plasma: Decline in association with aging, age-related macular degeneration, and diabetes","volume":"24","author":"Samiec","year":"1998","journal-title":"Free Radic. Biol. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"7919","DOI":"10.1038\/srep07919","article-title":"Anti-obesity and anti-hyperglycemic effects of cinnamaldehyde via altered ghrelin secretion and functional impact on food intake and gastric emptying","volume":"5","author":"Camacho","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"14357","DOI":"10.1038\/s41598-017-14733-x","article-title":"The Sulforaphane and pyridoxamine supplementation normalize endothelial dysfunction associated with type 2 diabetes","volume":"7","author":"Pereira","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jep.2013.08.019","article-title":"Protective effects of cinnamic acid and cinnamic aldehyde on isoproterenol-induced acute myocardial ischemia in rats","volume":"150","author":"Song","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1093\/ajh\/hpaa024","article-title":"Cinnamaldehyde ameliorates vascular dysfunction in diabetic mice by activating Nrf2","volume":"33","author":"Wang","year":"2020","journal-title":"Am. J. Hypertens."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kim, M.-J., and Jeon, J.-H. (2022). Recent Advances in Understanding Nrf2 Agonism and Its Potential Clinical Application to Metabolic and Inflammatory Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052846"},{"key":"ref_26","first-page":"894","article-title":"Effects of \u03b1-lipoic acid on endothelial function in aged diabetic and high-fat fed rats","volume":"153","author":"Sena","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.phrs.2012.03.004","article-title":"Methylglyoxal promotes oxidative stress and endothelial dysfunction","volume":"65","author":"Sena","year":"2012","journal-title":"Pharmacol. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.33549\/physiolres.932554","article-title":"Effects of Atorvastatin and Insulin in Vascular Dysfunction Associated With Type 2 Diabetes","volume":"63","author":"Sena","year":"2014","journal-title":"Physiol. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s13105-015-0441-9","article-title":"Glucomannan and glucomannan plus spirulina added to pork significantly block dietary cholesterol effects on lipoproteinemia, arylesterase activity, and CYP7A1 expression in Zucker fa\/fa rats","volume":"71","author":"Bastida","year":"2015","journal-title":"J. Physiol. Biochem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12933-020-01035-2","article-title":"Association of the insulin resistance marker TyG index with the severity and mortality of COVID-19","volume":"19","author":"Ren","year":"2020","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1111\/bph.13756","article-title":"Adiponectin improves endothelial function in mesenteric arteries of rats fed a high-fat diet: Role of perivascular adipose tissue","volume":"174","author":"Sena","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1476-5381.2011.01230.x","article-title":"Metformin restores endothelial function in aorta of diabetic rats","volume":"163","author":"Sena","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.freeradbiomed.2019.11.002","article-title":"Increased inflammation, oxidative stress and a re-duction in antioxidant defense enzymes in perivascular adipose tissue contribute to vascular dysfunction in type 2 diabetes","volume":"146","author":"Azul","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1089\/ars.2017.7060","article-title":"Metabolic regulation of adipose tissue macrophage function in obesity and diabetes","volume":"29","author":"Appari","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"ref_35","first-page":"e1","article-title":"Nrf2 Regulates Antioxidant Gene Expression Evoked by Oxidized Phospholipids in Endothelial Cells and Murine Arteries In Vivo","volume":"103","author":"Kansanen","year":"2008","journal-title":"Circ. Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Guti\u00e9rrez-Cuevas, J., Galicia-Moreno, M., Monroy-Ram\u00edrez, H.C., Sandoval-Rodriguez, A., Garc\u00eda-Ba\u00f1uelos, J., Santos, A., and Armendariz-Borunda, J. (2022). The Role of NRF2 in Obesity-Associated Cardiovascular Risk Factors. Antioxidants, 11.","DOI":"10.3390\/antiox11020235"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.phymed.2006.11.005","article-title":"Cinnamaldehyde\u2014A potential antidiabetic agent","volume":"14","author":"Babu","year":"2007","journal-title":"Phytomedicine"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.biopha.2017.01.054","article-title":"Cinnamaldehyde potentially attenuates gestational hyperglycemia in rats through modulation of PPAR gamma, proinflammatory cytokines and oxidative stress","volume":"88","author":"Hosni","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Silva, M.L., Bernardo, M.A., Singh, J., and de Mesquita, M.F. (2022). Cinnamon as a Complementary Therapeutic Approach for Dysglycemia and Dyslipidemia Control in Type 2 Diabetes Mellitus and Its Molecular Mechanism of Action: A Review. Nutrients, 14.","DOI":"10.3390\/nu14132773"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/biof.1265","article-title":"Cinnamaldehyde supplementation prevents fasting-induced hyperphagia, lipid accumulation, and inflammation in high-fat diet-fed mice","volume":"42","author":"Khare","year":"2016","journal-title":"Biofactors"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s00210-018-1547-8","article-title":"Cinnamaldehyde exerts vasculoprotective effects in hypercholestrolemic rabbits","volume":"391","author":"Nour","year":"2018","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S0254-6272(13)60053-9","article-title":"Antihyperglycemic and antihyperlipidemic action of cinnamaldehyde in C57blks\/j Db\/db mice","volume":"32","author":"Li","year":"2012","journal-title":"J. Tradit. Chin. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.apsb.2017.06.005","article-title":"The reaction of cinnamaldehyde and cinnam(o)yl derivatives with thiols","volume":"7","author":"Autelitano","year":"2017","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.2337\/db11-0807","article-title":"Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy","volume":"60","author":"Zheng","year":"2011","journal-title":"Diabetes"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1159\/000479268","article-title":"Cinnamaldehyde Ameliorates Diet-Induced Obesity in Mice by Inducing Browning of White Adipose Tissue","volume":"42","author":"Zuo","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"9970678","DOI":"10.1155\/2021\/9970678","article-title":"The Effect of Cinnamaldehyde on iNOS Activity and NO-Induced Islet Insulin Secretion in High-Fat-Diet Rats","volume":"2021","author":"Ataie","year":"2021","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1097\/00029330-200811010-00003","article-title":"Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus","volume":"121","author":"Zhang","year":"2008","journal-title":"Chin. Med. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1142\/S0192415X15500512","article-title":"Cinnamaldehyde contributes to insulin sensitivity by activating PPAR\u03b4, PPAR\u03b3, and RXR","volume":"43","author":"Li","year":"2015","journal-title":"Am. J. Chin. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00210-018-1583-4","article-title":"Cinnamaldehyde ameliorates STZ-induced rat diabetes through modulation of IRS1\/PI3K\/AKT2 pathway and AGEs\/RAGE interaction","volume":"392","author":"Abdelmageed","year":"2019","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.phymed.2015.01.003","article-title":"Cinnamic acid exerts anti-diabetic activity by improving glucose tolerance in vivo and by stimulating insulin secretion in vitro","volume":"22","author":"Hafizur","year":"2015","journal-title":"Phytomedicine"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"5164","DOI":"10.1021\/jf200579h","article-title":"Cinnamaldehyde Enhances Nrf2 Nuclear Translocation to Upregulate Phase II Detoxifying Enzyme Expression in HepG2 Cells","volume":"59","author":"Huang","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"581348","DOI":"10.1155\/2008\/581348","article-title":"Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors","volume":"2008","author":"Sheng","year":"2008","journal-title":"PPAR Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1016\/j.bbadis.2013.08.006","article-title":"Endothelial dysfunction\u2014A major mediator of diabetic vascular disease","volume":"1832","author":"Sena","year":"2013","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","article-title":"Oxidative Stress and Diabetic Complications","volume":"107","author":"Giacco","year":"2010","journal-title":"Circ. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1016\/j.amjcard.2008.02.012","article-title":"Antioxidants in Cardiovascular Health and Disease: Key Lessons from Epidemiologic Studies","volume":"101","author":"Willcox","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0278-6915(99)00082-4","article-title":"Antioxidant Functions of Sulforaphane: A Potent Inducer of Phase II Detoxication Enzymes","volume":"37","author":"Fahey","year":"1999","journal-title":"Food Chem. Toxicol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.atherosclerosis.2010.01.035","article-title":"Protective effects of magnesium lithospermate B against diabetic atherosclerosis via Nrf2-ARE-NQO1 transcriptional pathway","volume":"211","author":"Hur","year":"2010","journal-title":"Atherosclerosis"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1016\/j.fct.2011.07.060","article-title":"Cinnamaldehyde protects from the hypertension associated with diabetes","volume":"49","author":"Fahmy","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/acr.20344","article-title":"Hyperuricemia and incident hypertension: A systematic review and meta-analysis","volume":"63","author":"Grayson","year":"2010","journal-title":"Arthritis Care Res."},{"key":"ref_60","first-page":"515","article-title":"The Effect of Cinnamon Extract and Long-Term Aerobic Training on Heart Function, Biochemical Alterations and Lipid Profile Following Exhaustive Exercise in Male Rats","volume":"4","author":"Badalzadeh","year":"2014","journal-title":"Adv. Pharm. Bull."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.fct.2007.07.016","article-title":"Cinnamaldehyde inhibits pro-inflammatory cytokines secretion from monocytes\/macrophages through suppression of intracellular signaling","volume":"46","author":"Chao","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"529359","DOI":"10.1155\/2010\/529359","article-title":"Regulatory Effect of Cinnamaldehyde on Monocyte\/Macrophage-Mediated Inflammatory Responses","volume":"2010","author":"Kim","year":"2010","journal-title":"Mediat. Inflamm."},{"key":"ref_63","first-page":"449","article-title":"Cinnamaldehyde protects against oxidative stress and inhibits the TNF-\u03b1-induced inflammatory response in human umbilical vein endothelial cells","volume":"46","author":"Kim","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1159\/000374074","article-title":"Cinnamaldehyde Prevents Endothelial Dysfunction Induced by High Glucose by Activating Nrf2","volume":"36","author":"Wang","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/cvr\/cvt125","article-title":"Defective Nrf2-dependent redox signalling contributes to microvascular dysfunction in type 2 diabetes","volume":"100","author":"Velmurugan","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1161\/HYPERTENSIONAHA.116.07518","article-title":"Internal Pudental Artery Dysfunction in Diabetes Mellitus Is Mediated by NOX1-Derived ROS-, Nrf2-, and Rho Kinase\u2013Dependent Mechanisms","volume":"68","author":"Neves","year":"2016","journal-title":"Hypertension"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12933-017-0513-y","article-title":"The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction","volume":"16","author":"Sharma","year":"2017","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"H363","DOI":"10.1152\/ajpheart.01134.2010","article-title":"Vascular oxidative stress in aging: A homeostatic failure due to dysregulation of NRF2-mediated antioxidant response","volume":"301","author":"Ungvari","year":"2011","journal-title":"Am. J. Physiol. Circ. Physiol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/1\/82\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:56:00Z","timestamp":1760147760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/1\/82"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,30]]},"references-count":68,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["antiox12010082"],"URL":"https:\/\/doi.org\/10.3390\/antiox12010082","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,30]]}}}