{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T04:26:08Z","timestamp":1781151968839,"version":"3.54.1"},"reference-count":68,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"J.A. DeS\u00e8ve Research Chair in Nutrition","award":["E8377"],"award-info":[{"award-number":["E8377"]}]},{"name":"J.A. DeS\u00e8ve Research Chair in Nutrition","award":["401240871"],"award-info":[{"award-number":["401240871"]}]},{"name":"Ontario Genomics Institute\/Genome Canada","award":["E8377"],"award-info":[{"award-number":["E8377"]}]},{"name":"Ontario Genomics Institute\/Genome Canada","award":["401240871"],"award-info":[{"award-number":["401240871"]}]},{"name":"NSERC-Diana Food Industrial Chair on prebiotic effects of polyphenols","award":["E8377"],"award-info":[{"award-number":["E8377"]}]},{"name":"NSERC-Diana Food Industrial Chair on prebiotic effects of polyphenols","award":["401240871"],"award-info":[{"award-number":["401240871"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>While the prevalence of metabolic syndrome (MetS) is steadily increasing worldwide, no optimal pharmacotherapy is readily available to address its multifaceted risk factors and halt its complications. This growing challenge mandates the development of other future curative directions. The purpose of the present study is to investigate the efficacy of cranberry proanthocyanidins (PACs) in improving MetS pathological conditions and liver complications; C57BL\/6J mice were fed either a standard chow or a high fat\/high sucrose (HFHS) diet with and without PACs (200 mg\/kg), delivered by daily gavage for 12 weeks. Our results show that PACs lowered HFHS-induced obesity, insulin resistance, and hyperlipidemia. In conjunction, PACs lessened circulatory markers of oxidative stress (OxS) and inflammation. Similarly, the anti-oxidative and anti-inflammatory capacities of PACs were noted in the liver in association with improved hepatic steatosis. Inhibition of lipogenesis and stimulation of beta-oxidation could account for PACs-mediated decline of fatty liver as evidenced not only by the expression of rate-limiting enzymes but also by the status of AMPK\u03b1 (the key sensor of cellular energy) and the powerful transcription factors (PPAR\u03b1, PGC1\u03b1, SREBP1c, ChREBP). Likewise, treatment with PACs resulted in the downregulation of critical enzymes of liver gluconeogenesis, a process contributing to increased rates of glucose production in type 2 diabetes. Our findings demonstrate that PACs prevented obesity and improved insulin resistance likely via suppression of OxS and inflammation while diminishing hyperlipidemia and fatty liver disease, as clear evidence for their strength of fighting the cluster of MetS abnormalities.<\/jats:p>","DOI":"10.3390\/antiox12010090","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T04:51:22Z","timestamp":1672635082000},"page":"90","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cranberry Proanthocyanidins as a Therapeutic Strategy to Curb Metabolic Syndrome and Fatty Liver-Associated Disorders"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2758-9305","authenticated-orcid":false,"given":"Francis","family":"Feldman","sequence":"first","affiliation":[{"name":"Research Centre, Sainte-Justine University Health Center, Montreal, QC H3T 1C5, Canada"},{"name":"Department of Nutrition, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Koudoufio","sequence":"additional","affiliation":[{"name":"Research Centre, Sainte-Justine University Health Center, Montreal, QC H3T 1C5, Canada"},{"name":"Department of Nutrition, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramy","family":"El-Jalbout","sequence":"additional","affiliation":[{"name":"Research Centre, Sainte-Justine University Health Center, Montreal, QC H3T 1C5, Canada"},{"name":"Department of Radiology, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde Foisy","family":"Sauv\u00e9","sequence":"additional","affiliation":[{"name":"Research Centre, Sainte-Justine University Health Center, Montreal, QC H3T 1C5, 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