{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:43:57Z","timestamp":1783745037282,"version":"3.55.0"},"reference-count":89,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Vitiligo is an autoimmune dermatosis frequently associated with other comorbidities, such as mental health disorders. It is unclear if vitiligo triggers mental disorders or if mental disorders trigger vitiligo, but each one affects and worsen the other, if present at the same time. Both mental health disorders and vitiligo present a multifactorial pathogenesis and often require prolonged periods of therapy, sometimes with poor results. Given the possible link of common pathogenetic factors and the need of integrated therapies, the aim of this review is to look at natural compounds as possible supplements for both conditions. The results yielded show a possible role of these supplements in ameliorating both conditions, thus helping these patients to achieve a better quality of life and reduce the need for prolonged therapies. The limitations regarding the relative lack of in vivo studies, and the increasing need to lighten the burden of these chronic diseases, suggests that it is mandatory to proceed with further trials.<\/jats:p>","DOI":"10.3390\/antiox12010176","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T02:28:44Z","timestamp":1673490524000},"page":"176","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Vitiligo and Mental Health: Natural Compounds\u2019 Usefulness"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5457-6246","authenticated-orcid":false,"given":"Luca","family":"Di Bartolomeo","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Dermatology, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2142-5054","authenticated-orcid":false,"given":"Paolo","family":"Custurone","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Dermatology, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Irrera","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Pharmacology, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3515-8441","authenticated-orcid":false,"given":"Francesco","family":"Borgia","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Dermatology, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1745-4338","authenticated-orcid":false,"given":"Federico","family":"Vaccaro","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Modena and Reggio Emilia, 41121 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Squadrito","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Pharmacology, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3787-5145","authenticated-orcid":false,"given":"Mario","family":"Vaccaro","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Dermatology, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0140-6736(14)60763-7","article-title":"Vitiligo","volume":"386","author":"Ezzedine","year":"2015","journal-title":"Lancet"},{"key":"ref_2","first-page":"164","article-title":"Photodynamic therapy in pediatric age: Current applications and future trends","volume":"13","author":"Altavilla","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Custurone, P., Di Bartolomeo, L., Irrera, N., Borgia, F., Altavilla, D., Bitto, A., Pallio, G., Squadrito, F., and Vaccaro, M. (2021). Role of Cytokines in Vitiligo: Pathogenesis and Possible Targets for Old and New Treatments. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111429"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1056\/NEJMoa2118828","article-title":"Two Phase 3, Randomized, Controlled Trials of Ruxolitinib Cream for Vitiligo","volume":"387","author":"Rosmarin","year":"2022","journal-title":"New Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Yousefian, F., Yadlapati, S., and Browning, J.C. (2022). The use of Janus kinase inhibitors and narrowband ultraviolet B combination therapy in non-segmental vitiligo. J. Cosmet. Dermatol., 1\u20133.","DOI":"10.1111\/jocd.15537"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Guglielmelli, P., Kiladjian, J.-J., Vannucchi, A.M., Duan, M., Meng, H., Pan, L., He, G., Verstovsek, S., Boyer, F., and Barraco, F. (2022). Efficacy and safety of ruxolitinib in patients with myelofibrosis and low platelet count (50 \u00d7 109\/L to <100 \u00d7 109\/L) at baseline: The final analysis of EXPAND. Ther. Adv. Hematol., 13.","DOI":"10.1177\/20406207221118429"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"840","DOI":"10.3324\/haematol.2017.180554","article-title":"A phase II study of the oral JAK1\/JAK2 inhibitor ruxolitinib in advanced relapsed\/refractory Hodgkin lymphoma","volume":"103","author":"Gastinne","year":"2018","journal-title":"Haematologica"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Sheikh, A., Rafique, W., Owais, R., Malik, F., and Ali, E. (2022). FDA approves Ruxolitinib (Opzelura) for Vitiligo Therapy: A breakthrough in the field of dermatology. Ann. Med. Surg., 81.","DOI":"10.1016\/j.amsu.2022.104499"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/1346-8138.15290","article-title":"Increased risk of psychiatric disorders in adult patients with vitiligo: A nationwide, population-based cohort study in Taiwan","volume":"47","author":"Chen","year":"2020","journal-title":"J. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1346-8138.2001.tb00004.x","article-title":"Psychiatric morbidity in vitiligo and psoriasis: A comparative study from India","volume":"28","author":"Mattoo","year":"2001","journal-title":"J. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/ced.14196","article-title":"Quality of life, emotion dysregulation, attention deficit and psychiatric comorbidity in children and adolescents with vitiligo","volume":"46","author":"Ucuz","year":"2020","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/jdv.15255","article-title":"Association of vitiligo with hospitalization for mental health disorders in US adults","volume":"33","author":"Patel","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"446","DOI":"10.2340\/00015555-1520","article-title":"Quality of Life and Emotional State in Vitiligo in an Estonian Sample: Comparison with Psoriasis and Healthy Controls","volume":"93","author":"Karelson","year":"2013","journal-title":"Acta Derm. Venereol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2340\/00015555-1981","article-title":"Stigmatisation, Avoidance Behaviour and Difficulties in Coping are Common among Adult Patients with Vitiligo","volume":"95","author":"Schallreuter","year":"2015","journal-title":"Acta Derm. Venereol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4314\/ajpsy.v12i4.49045","article-title":"The psychological impact of vitiligo in adult Sudanese patients","volume":"12","author":"Osman","year":"2009","journal-title":"Afr. J. Psychiatry"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/00926230600998482","article-title":"The Problems in Sexual Functions of Vitiligo and Chronic Urticaria Patients","volume":"33","author":"Sukan","year":"2007","journal-title":"J. Sex Marital. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12955-020-1278-7","article-title":"Evaluating prevalence of depression, anxiety and hopelessness in patients with Vitiligo on an Iranian population","volume":"18","author":"Hamidizadeh","year":"2020","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s40257-016-0172-x","article-title":"Social Anxiety and Quality of Life in Vitiligo and Acne Patients with Facial Involvement: A Cross-Sectional Controlled Study","volume":"17","author":"Salman","year":"2016","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_19","first-page":"2232","article-title":"Anxiety and depression in pediatric patients with vitiligo and alopecia areata and their parents: A cross-sectional controlled study","volume":"20","year":"2020","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_20","first-page":"360","article-title":"Depression, anxiety and health-related quality of life in children and adolescents with vitiligo","volume":"36","year":"2010","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/j.1468-3083.2009.03452.x","article-title":"Quality of life and psychological adaptation of Korean adolescents with vitiligo","volume":"24","author":"Choi","year":"2010","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3906\/sag-1812-84","article-title":"Association of serum cortisol and dehydroepiandrosterone sulfate (DHEAS) levels with psychological stress in patients with vitiligo","volume":"49","author":"Karaduman","year":"2019","journal-title":"Turk. J. Med Sci."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Gonda, X., Dome, P., Neill, J.C., and Tarazi, F.I. (2021). Novel antidepressant drugs: Beyond monoamine targets. CNS Spectrums, 1\u201310.","DOI":"10.1017\/S1092852921000791"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Goldberg, S.B., Pace, B.T., Nicholas, C.R., Raison, C.L., and Hutson, P.R. (2020). The experimental effects of psilocybin on symptoms of anxiety and depression: A meta-analysis. Psychiatry Res., 284.","DOI":"10.1016\/j.psychres.2020.112749"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/00952990.2018.1545024","article-title":"5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used in a naturalistic group setting is associated with unintended improvements in depression and anxiety","volume":"45","author":"Davis","year":"2019","journal-title":"Am. J. Drug Alcohol Abus."},{"key":"ref_26","unstructured":"Brunton, L.L., Lazo, J.S., and Parker, K.L. (2005). Drug therapy of depression and anxiety disorders. Goodman and Gilman\u2019s: The Pharmacological Basis of Therapeutics, McGraw-Hill Press. [11th ed.]."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"959","DOI":"10.4088\/JCP.v65n0712","article-title":"Incidence and Duration of Side Effects and Those Rated as Bothersome with Selective Serotonin Reuptake Inhibitor Treatment for Depression","volume":"65","author":"Hu","year":"2004","journal-title":"J. Clin. Psychiatry"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Alesci, A., Lauriano, E.R., Fumia, A., Irrera, N., Mastrantonio, E., Vaccaro, M., Gangemi, S., Santini, A., Cicero, N., and Pergolizzi, S. (2022). Relationship between Immune Cells, Depression, Stress, and Psoriasis: Could the Use of Natural Products Be Helpful?. Molecules, 27.","DOI":"10.3390\/molecules27061953"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00403-017-1746-z","article-title":"Oxidation products are increased in patients affected by non-segmental generalized vitiligo","volume":"309","author":"Vaccaro","year":"2017","journal-title":"Arch. Dermatol. Res."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Niu, C., and Aisa, H.A. (2017). Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo. Molecules, 22.","DOI":"10.3390\/molecules22081303"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.bbi.2020.11.007","article-title":"Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala","volume":"91","author":"Zheng","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.pnpbp.2012.10.022","article-title":"The role of pro-inflammatory cytokines in the neuroinflammation and neurogenesis of schizophrenia","volume":"48","author":"Na","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1742-2094-10-43","article-title":"Neuroinflammation and psychiatric illness","volume":"10","author":"Najjar","year":"2013","journal-title":"J. Neuroinflamm."},{"key":"ref_34","first-page":"7","article-title":"Depression: The case for a monoamine deficiency","volume":"61","author":"Delgado","year":"2000","journal-title":"J. Clin. Psychiatry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1007\/s12031-020-01754-x","article-title":"Unfolding the Role of BDNF as a Biomarker for Treatment of Depression","volume":"71","author":"Rana","year":"2020","journal-title":"J. Mol. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.freeradbiomed.2018.10.421","article-title":"Baicalein protects human vitiligo melanocytes from oxidative stress through activation of NF-E2-related factor2 (Nrf2) signaling pathway","volume":"129","author":"Ma","year":"2018","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Vaccaro, M., Irrera, N., Cutroneo, G., Rizzo, G., Vaccaro, F., Anastasi, G.P., Borgia, F., Cannav\u00f2, S.P., Altavilla, D., and Squadrito, F. (2017). Differential Expression of Nitric Oxide Synthase Isoforms nNOS and iNOS in Patients with Non-Segmental Generalized Vitiligo. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122533"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1248\/bpb.34.253","article-title":"Antidepressant Effects of a Plant-Derived Flavonoid Baicalein Involving Extracellular Signal-Regulated Kinases Cascade","volume":"34","author":"Xiong","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.3389\/fimmu.2021.689044","article-title":"Potential Implications of Quercetin in Autoimmune Diseases","volume":"12","author":"Shen","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.3892\/mmr.2015.3242","article-title":"Quercetin attenuates the effects of H2O2 on endoplasmic reticulum morphology and tyrosinase export from the endoplasmic reticulum in melanocytes","volume":"11","author":"Guan","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_41","first-page":"116","article-title":"Flavonoids enhance melanogenesis in human melanoma cells","volume":"39","author":"Takekoshi","year":"2014","journal-title":"Tokai J. Exp. Clin. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1046\/j.1600-0749.2003.00113.x","article-title":"Quercetin enhances melanogenesis by increasing the activity and synthesis of tyrosinase in human melanoma cells and in normal human melanocytes","volume":"17","author":"Nagata","year":"2004","journal-title":"Pigment Cell Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/mnfr.201500822","article-title":"Molecular mechanisms of flavonoids in melanin synthesis and the potential for the prevention and treatment of melanoma","volume":"60","author":"Meyskens","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"795","DOI":"10.33549\/physiolres.933776","article-title":"Quercetin Protects Against Stress-Induced Anxiety- and Depression-Like Behavior and Improves Memory in Male Mice","volume":"67","author":"Samad","year":"2018","journal-title":"Physiol. Res."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Guan, Y., Wang, J., Wu, X., Song, L., Wang, Y., Gong, M., and Li, B. (2021). Quercetin reverses chronic unpredictable mild stress-induced depression-like behavior in vivo by involving nuclear factor-E2-related factor 2. Brain Res., 1772.","DOI":"10.1016\/j.brainres.2021.147661"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Silva Dos Santos, J., Gon\u00e7alves Cirino, J.P., de Oliveira Carvalho, P., and Ortega, M.M. (2021). The Pharmacological Action of Kaempferol in Central Nervous System Diseases: A Review. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.565700"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/BF02968584","article-title":"Biphasic effects of kaempferol on the estrogenicity in human breast cancer cells","volume":"29","author":"Oh","year":"2006","journal-title":"Arch. Pharmacal Res."},{"key":"ref_48","first-page":"6195","article-title":"Kaempferol, a natural dietary flavonoid, suppresses 17\u03b2-estradiol-induced survivin expression and causes apoptotic cell death in endometrial cancer","volume":"16","author":"Chuwa","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jphs.2021.08.009","article-title":"Kaempferol, the melanogenic component of Sanguisorba officinalis, enhances dendricity and melanosome maturation\/transport in melanocytes","volume":"147","author":"Tang","year":"2021","journal-title":"J. Pharmacol. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s11011-019-0389-5","article-title":"Antidepressive effects of kaempferol mediated by reduction of oxidative stress, proinflammatory cytokines and up-regulation of AKT\/\u03b2-catenin cascade. Metab","volume":"34","author":"Gao","year":"2019","journal-title":"Brain Dis."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Ahmad, H., Rauf, K., Zada, W., McCarthy, M., Abbas, G., Anwar, F., and Shah, A.J. (2020). Kaempferol Facilitated Extinction Learning in Contextual Fear Conditioned Rats via Inhibition of Fatty-Acid Amide Hydrolase. Molecules, 25.","DOI":"10.3390\/molecules25204683"},{"key":"ref_52","first-page":"768","article-title":"Green tea in dermatology\u2013myths and facts","volume":"13","author":"Zink","year":"2015","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Chu, C., Deng, J., Man, Y., and Qu, Y. (2017). Green Tea Extracts Epigallocatechin-3-gallate for Different Treatments. BioMed Res. Int., 2017.","DOI":"10.1155\/2017\/5615647"},{"key":"ref_54","first-page":"191","article-title":"Papillomavirus skin infections and children: An overview on cutaneous and anogenital warts treatment","volume":"36","author":"Motolese","year":"2022","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e404","DOI":"10.1111\/ajd.13612","article-title":"Topical epigallocatechin-3-gallate in the treatment of vitiligo","volume":"62","author":"Hu","year":"2021","journal-title":"Australas. J. Dermatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.fitote.2014.08.007","article-title":"The therapeutic effects of EGCG on vitiligo","volume":"99","author":"Zhu","year":"2014","journal-title":"Fitoterapia"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/ced.12855","article-title":"Potent effects of peracetylated (-)-epigallocatechin-3-gallate against hydrogen peroxide-induced damage in human epidermal melanocytes via attenuation of oxidative stress and apoptosis","volume":"41","author":"Ning","year":"2016","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1248\/bpb.b15-00331","article-title":"Epigallocatechin-3-gallate (EGCG) Suppresses the Trafficking of Lymphocytes to Epidermal Melanocytes via Inhibition of JAK2: Its Implication for Vitiligo Treatment","volume":"38","author":"Ning","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"8780","DOI":"10.1039\/D0FO00524J","article-title":"Effects of EGCG on depression-related behavior and serotonin concentration in a rat model of chronic unpredictable mild stress","volume":"11","author":"Li","year":"2020","journal-title":"Food Funct."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Wang, J., Li, P., Qin, T., Sun, D., Zhao, X., and Zhang, B. (2020). Protective effect of epigallocatechin-3-gallate against neuroinflammation and anxiety-like behavior in a rat model of myocardial infarction. Brain Behav., 10.","DOI":"10.1002\/brb3.1633"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.brainres.2006.06.062","article-title":"Anxiolytic properties of green tea polyphenol (\u2212)-epigallocatechin gallate (EGCG)","volume":"1110","author":"Vignes","year":"2006","journal-title":"Brain Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1177\/2045125312464103","article-title":"Effect of epigallocatechin gallate supplementation in schizophrenia and bipolar disorder: An 8-week, randomized, double-blind, placebo-controlled study","volume":"3","author":"Loftis","year":"2012","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1002\/ptr.5640","article-title":"Effects of Turmeric (Curcuma longa) on Skin Health: A Systematic Review of the Clinical Evidence","volume":"30","author":"Vaughn","year":"2016","journal-title":"Phytother. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1089\/pho.2009.2637","article-title":"Tetrahydrocurcuminoid Cream Plus Targeted Narrowband UVB Phototherapy for Vitiligo: A Preliminary Randomized Controlled Study","volume":"28","author":"Asawanonda","year":"2010","journal-title":"Photomed. Laser Surg."},{"key":"ref_65","first-page":"116","article-title":"Curcumin Activates the Nrf2 Pathway and Induces Cellular Protection Against Oxidative Injury","volume":"20","author":"Ashrafizadeh","year":"2020","journal-title":"Curr. Mol. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.nutres.2020.01.005","article-title":"Curcumin mediates attenuation of pro-inflammatory interferon \u03b3 and interleukin 17 cytokine responses in psoriatic disease, strengthening its role as a dietary immunosuppressant","volume":"75","author":"Skyvalidas","year":"2020","journal-title":"Nutr. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/ptr.3517","article-title":"Curcumin Inhibits Melanogenesis in Human Melanocytes","volume":"26","author":"Tu","year":"2011","journal-title":"Phytother. Res."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Lv, J., Yang, Y., Jia, B., Li, S., Zhang, X., and Gao, R. (2021). The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.783730"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jad.2020.09.091","article-title":"The effect of oral curcumin supplementation on health-related quality of life: A systematic review and meta-analysis of randomized controlled trials","volume":"278","author":"Sadeghian","year":"2020","journal-title":"J. Affect. Disord."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Guti\u00e9rrez, M.S., Navarrete, F., Gasparyan, A., Austrich-Olivares, A., Sala, F., and Manzanares, J. (2020). Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders. Biomolecules, 10.","DOI":"10.3390\/biom10111575"},{"key":"ref_71","first-page":"93","article-title":"Cannabidiol Therapy for Refractory Epilepsy and Seizure Disorders","volume":"1264","author":"Golub","year":"2020","journal-title":"Cannabinoids Neuropsychiatr. Disord."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"927","DOI":"10.2147\/CCID.S286411","article-title":"Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders","volume":"13","author":"Baswan","year":"2020","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Atalay, S., Jarocka-Karpowicz, I., and Skrzydlewska, E. (2019). Antioxidative and Anti-Inflammatory Properties of Cannabidiol. Antioxidants, 9.","DOI":"10.3390\/antiox9010021"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00403-011-1126-z","article-title":"Inhibition of basal and ultraviolet B-induced melanogenesis by cannabinoid CB1 receptors: A keratinocyte-dependent effect","volume":"303","author":"Magina","year":"2011","journal-title":"Arch. Dermatol. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cbi.2017.06.005","article-title":"Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42\/44 MAPK","volume":"273","author":"Hwang","year":"2017","journal-title":"Chem. Interactions"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/jcph.1387","article-title":"A Review of Human Studies Assessing Cannabidiol\u2019s (CBD) Therapeutic Actions and Potential","volume":"59","author":"White","year":"2019","journal-title":"J. Clin. Pharmacol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/emm.2001.23","article-title":"Stimulation of melanogenesis by glycyrrhizin in B16 melanoma cells","volume":"33","author":"Jung","year":"2001","journal-title":"Exp. Mol. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/ptr.6852","article-title":"Glycyrrhizin: An old weapon against a novel coronavirus","volume":"35","author":"Chrzanowski","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_79","first-page":"5105","article-title":"Glycyrrhizin suppresses inflammation and cell apoptosis by inhibition of HMGB1 via p38\/p-JUK signaling pathway in attenuating intervertebral disc degeneration","volume":"11","author":"Liu","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/ijd.12392","article-title":"Increased serum levels of interleukin-23 circulating in patients with non-segmental generalized vitiligo","volume":"54","author":"Vaccaro","year":"2014","journal-title":"Int. J. Dermatol."},{"key":"ref_81","first-page":"253","article-title":"Glycyrrhizin protects human melanocytes from H2O2-induced oxidative damage via the Nrf2-dependent induction of HO-1","volume":"44","author":"Mou","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.0022-202X.2004.23606.x","article-title":"Glycyrrhizin Induces Melanogenesis by Elevating a cAMP Level in B16 Melanoma Cells","volume":"124","author":"Lee","year":"2005","journal-title":"J. Investig. Dermatol."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Mou, K., Han, D., Liu, W., and Li, P. (2016). Combination therapy of orally administered glycyrrhizin and UVB improved active-stage generalized vitiligo. Braz. J. Med. Biol. Res., 49.","DOI":"10.1590\/1414-431x20165354"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jad.2020.01.048","article-title":"Glycyrrhizic acid as an adjunctive treatment for depression through anti-inflammation: A randomized placebo-controlled clinical trial","volume":"265","author":"Cao","year":"2020","journal-title":"J. Affect. Disord."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jpsychires.2015.02.016","article-title":"High-mobility group box-1 was released actively and involved in LPS induced depressive-like behavior","volume":"64","author":"Wu","year":"2015","journal-title":"J. Psychiatr. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.pnpbp.2019.02.005","article-title":"High-mobility group box 1-mediated microglial activation induces anxiodepressive-like behaviors in mice with neuropathic pain","volume":"92","author":"Tomimura","year":"2019","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.chembiol.2007.04.001","article-title":"A Direct Inhibitor of HMGB1 Cytokine","volume":"14","author":"Girard","year":"2007","journal-title":"Chem. Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00403-016-1675-2","article-title":"IL-33 circulating serum levels are increased in patients with non-segmental generalized vitiligo","volume":"308","author":"Vaccaro","year":"2016","journal-title":"Arch. Dermatol. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/1440-1681.13173","article-title":"Glycyrrhizin treatment ameliorates post-traumatic stress disorder-like behaviours and restores circadian oscillation of intracranial serotonin","volume":"47","author":"Lai","year":"2019","journal-title":"Clin. Exp. Pharmacol. Physiol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/1\/176\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:03:26Z","timestamp":1760119406000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/1\/176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,11]]},"references-count":89,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["antiox12010176"],"URL":"https:\/\/doi.org\/10.3390\/antiox12010176","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,11]]}}}